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Coexpression cluster:C2401: Difference between revisions

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|gostat_on_coexpression_clusters=GO:0001822!kidney development!0.0276698457553279!6928$GO:0001655!urogenital system development!0.0276698457553279!6928
|gostat_on_coexpression_clusters=GO:0001822!kidney development!0.0276698457553279!6928$GO:0001655!urogenital system development!0.0276698457553279!6928
|id=C2401
|id=C2401
|ontology_enrichment_celltype=CL:1000497!2.12e-18!18;CL:0002518!2.12e-18!18;CL:1000449!4.45e-16!16;CL:0002681!1.51e-12!13;CL:0002584!1.51e-12!13;CL:0000066!2.59e-12!254;CL:1000507!3.00e-12!12;CL:1000494!3.00e-12!12;CL:1000612!3.21e-08!7;CL:1000746!3.21e-08!7
|ontology_enrichment_celltype=CL:1000497!1.27e-23!17;CL:0002518!1.27e-23!17;CL:1000507!8.59e-22!10;CL:1000494!8.59e-22!10;CL:1000449!1.00e-19!15;CL:0002681!6.53e-14!12;CL:0002584!6.53e-14!12;CL:0000066!1.43e-13!253;CL:0000239!1.10e-07!3;CL:1000615!1.10e-07!3;CL:0002306!1.10e-07!3;CL:0000223!1.39e-07!58
|ontology_enrichment_disease=DOID:305!5.20e-11!106;DOID:299!5.03e-10!25
|ontology_enrichment_disease=DOID:305!1.92e-13!106;DOID:299!2.27e-13!25;DOID:0050687!2.08e-08!143
|ontology_enrichment_uberon=UBERON:0001008!3.20e-25!45;UBERON:0006554!1.88e-24!44;UBERON:0005172!1.06e-23!55;UBERON:0005173!1.06e-23!55;UBERON:0002113!1.45e-21!27;UBERON:0003918!1.45e-21!27;UBERON:0005095!1.45e-21!27;UBERON:0007687!1.45e-21!27;UBERON:0002417!5.38e-21!61;UBERON:0000916!5.38e-21!61;UBERON:0000489!1.25e-19!32;UBERON:0000058!3.01e-19!26;UBERON:0000080!5.29e-18!18;UBERON:0002120!5.29e-18!18;UBERON:0004875!5.29e-18!18;UBERON:0005721!5.29e-18!18;UBERON:0005754!5.29e-18!18;UBERON:0007297!5.29e-18!18;UBERON:0006555!3.87e-17!17;UBERON:0005103!3.87e-17!17;UBERON:0000083!3.87e-17!17;UBERON:0009201!3.87e-17!17;UBERON:0004819!3.87e-17!17;UBERON:0006553!3.87e-17!17;UBERON:0003074!3.87e-17!17;UBERON:0003060!3.87e-17!17;UBERON:0003887!4.03e-16!21;UBERON:0005177!4.37e-16!107;UBERON:0004211!4.45e-16!16;UBERON:0001285!4.45e-16!16;UBERON:0007684!4.45e-16!16;UBERON:0003220!4.45e-16!16;UBERON:0004208!4.45e-16!16;UBERON:0004876!1.51e-15!20;UBERON:0003064!2.72e-15!37;UBERON:0004119!8.71e-15!169;UBERON:0000925!8.71e-15!169;UBERON:0006595!8.71e-15!169;UBERON:0004921!1.55e-14!129;UBERON:0004185!1.55e-14!129;UBERON:0000466!3.06e-13!126;UBERON:0001225!1.51e-12!13;UBERON:0008987!1.51e-12!13;UBERON:0009569!1.86e-12!113;UBERON:0009773!3.00e-12!12;UBERON:0001231!3.00e-12!12;UBERON:0004810!3.00e-12!12;UBERON:0001007!2.29e-11!155;UBERON:0001555!2.29e-11!155;UBERON:0007026!2.29e-11!155;UBERON:0000077!3.09e-11!130;UBERON:0003886!8.32e-11!63;UBERON:0001851!9.61e-11!16;UBERON:0003104!1.46e-10!238;UBERON:0009142!1.46e-10!238;UBERON:0000353!4.59e-10!17;UBERON:0005911!2.97e-09!82;UBERON:0009497!3.02e-09!25;UBERON:0000015!3.02e-09!25;UBERON:0002423!3.02e-09!25;UBERON:0006235!3.02e-09!25;UBERON:0004161!3.02e-09!25;UBERON:0009856!5.47e-09!26;UBERON:0001737!9.48e-09!9;UBERON:0002553!1.00e-08!70;UBERON:0007499!3.10e-08!25;UBERON:0000074!3.21e-08!7;UBERON:0001229!3.21e-08!7;UBERON:0001230!3.21e-08!7;UBERON:0005749!3.21e-08!7;UBERON:0004199!3.21e-08!7;UBERON:0004209!3.21e-08!7;UBERON:0004198!3.21e-08!7;UBERON:0000464!3.67e-08!104;UBERON:0009854!4.54e-08!23;UBERON:0005409!6.51e-08!35;UBERON:0000062!1.11e-07!511;UBERON:0001041!1.24e-07!98;UBERON:0008835!2.55e-07!22;UBERON:0003894!2.55e-07!22;UBERON:0003929!6.65e-07!54
|ontology_enrichment_uberon=UBERON:0006554!2.41e-23!47;UBERON:0001008!1.08e-22!48;UBERON:0004810!8.59e-22!10;UBERON:0006555!1.61e-21!16;UBERON:0004819!1.61e-21!16;UBERON:0002113!2.16e-21!26;UBERON:0003918!2.16e-21!26;UBERON:0011143!2.16e-21!26;UBERON:0005095!2.16e-21!26;UBERON:0007687!2.16e-21!26;UBERON:0005172!3.96e-20!54;UBERON:0005173!3.96e-20!54;UBERON:0004211!1.00e-19!15;UBERON:0009773!1.00e-19!15;UBERON:0001231!1.00e-19!15;UBERON:0001285!1.00e-19!15;UBERON:0007684!1.00e-19!15;UBERON:0004208!1.00e-19!15;UBERON:0000489!4.17e-19!31;UBERON:0002417!2.53e-17!60;UBERON:0000916!2.53e-17!60;UBERON:0004921!9.70e-16!118;UBERON:0005177!1.01e-15!101;UBERON:0004119!3.69e-14!160;UBERON:0000925!3.69e-14!160;UBERON:0006595!3.69e-14!160;UBERON:0001225!6.53e-14!12;UBERON:0008987!6.53e-14!12;UBERON:0001007!1.57e-12!145;UBERON:0001555!1.57e-12!145;UBERON:0007026!1.57e-12!145;UBERON:0001737!1.17e-11!9;UBERON:0001851!1.08e-10!15;UBERON:0000353!1.08e-10!15;UBERON:0009569!2.33e-10!112;UBERON:0005409!4.25e-10!25;UBERON:0000058!4.65e-09!19;UBERON:0001041!1.13e-08!87;UBERON:0005911!3.55e-08!82;UBERON:0002100!4.25e-08!199;UBERON:0006853!1.10e-07!3;UBERON:0007685!1.10e-07!3;UBERON:0004134!1.10e-07!3;UBERON:0000160!1.13e-07!17;UBERON:0009497!1.57e-07!25;UBERON:0000015!1.57e-07!25;UBERON:0002423!1.57e-07!25;UBERON:0006235!1.57e-07!25;UBERON:0004161!1.57e-07!25;UBERON:0003929!2.67e-07!54;UBERON:0003104!3.58e-07!160;UBERON:0009142!3.58e-07!160;UBERON:0002108!5.06e-07!4;UBERON:0000481!5.66e-07!342;UBERON:0005103!8.34e-07!8;UBERON:0000083!8.34e-07!8;UBERON:0009201!8.34e-07!8;UBERON:0006553!8.34e-07!8;UBERON:0003074!8.34e-07!8;UBERON:0003060!8.34e-07!8
|tf_chipseq_enrich=BCL11A#53335;2:14.1847275518035:0.00710832858529874:0.0296208246865904!HNF4A#3172;2:11.5661451814768:0.0105758568176249:0.039068050020371!HNF4G#3174;2:14.3767112632234:0.00692416998043918:0.0293035654666945
|tf_chipseq_enrich=BCL11A#53335;2:14.1847275518035:0.00710832858529874:0.0296208246865904!HNF4A#3172;2:11.5661451814768:0.0105758568176249:0.039068050020371!HNF4G#3174;2:14.3767112632234:0.00692416998043918:0.0293035654666945
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}}
}}

Revision as of 13:59, 19 October 2012


Full id: C2401_serous_Renal_renal_signet_mesothelioma_kidney_clear



Phase1 CAGE Peaks

Hg19::chr17:36065029..36065045,-p@chr17:36065029..36065045
-
Hg19::chr17:36105042..36105060,-p1@HNF1B
Hg19::chr17:36105163..36105191,+p1@ENST00000558143
Hg19::chr18:3456189..3456200,+p@chr18:3456189..3456200
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0001822kidney development0.0276698457553279
GO:0001655urogenital system development0.0276698457553279



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
urinary system structure2.41e-2347
renal system1.08e-2248
nephron tubule epithelium8.59e-2210
excretory tube1.61e-2116
kidney epithelium1.61e-2116
kidney2.16e-2126
kidney mesenchyme2.16e-2126
upper urinary tract2.16e-2126
kidney rudiment2.16e-2126
kidney field2.16e-2126
abdomen element3.96e-2054
abdominal segment element3.96e-2054
nephron epithelium1.00e-1915
renal tubule1.00e-1915
nephron tubule1.00e-1915
nephron1.00e-1915
uriniferous tubule1.00e-1915
nephrogenic mesenchyme1.00e-1915
cavitated compound organ4.17e-1931
abdominal segment of trunk2.53e-1760
abdomen2.53e-1760
subdivision of digestive tract9.70e-16118
trunk region element1.01e-15101
endoderm-derived structure3.69e-14160
endoderm3.69e-14160
presumptive endoderm3.69e-14160
cortex of kidney6.53e-1412
renal parenchyma6.53e-1412
digestive system1.57e-12145
digestive tract1.57e-12145
primitive gut1.57e-12145
larynx1.17e-119
cortex1.08e-1015
parenchyma1.08e-1015
subdivision of trunk2.33e-10112
gastrointestinal system4.25e-1025
duct4.65e-0919
foregut1.13e-0887
endo-epithelium3.55e-0882
trunk4.25e-08199
renal cortex tubule1.10e-073
region of nephron tubule1.10e-073
proximal tubule1.10e-073
intestine1.13e-0717
epithelium of foregut-midgut junction1.57e-0725
anatomical boundary1.57e-0725
hepatobiliary system1.57e-0725
foregut-midgut junction1.57e-0725
septum transversum1.57e-0725
gut epithelium2.67e-0754
mesenchyme3.58e-07160
entire embryonic mesenchyme3.58e-07160
small intestine5.06e-074
multi-tissue structure5.66e-07342
mesonephric epithelium8.34e-078
mesonephric tubule8.34e-078
nephric duct8.34e-078
renal duct8.34e-078
mesonephric duct8.34e-078
pronephric duct8.34e-078
Disease
Ontology termp-valuen
carcinoma1.92e-13106
adenocarcinoma2.27e-1325
cell type cancer2.08e-08143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335214.18472755180350.007108328585298740.0296208246865904
HNF4A#3172211.56614518147680.01057585681762490.039068050020371
HNF4G#3174214.37671126322340.006924169980439180.0293035654666945



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.