FF:10631-108I1: Difference between revisions
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{{f5samples | {{f5samples | ||
| | |DRA_sample_Accession=CAGE@SAMD00005068 | ||
| | |accession_numbers=CAGE;DRX007867;DRR008739;DRZ000164;DRZ001549;DRZ011514;DRZ012899 | ||
| | |ancestors_in_anatomy_facet= | ||
| | |ancestors_in_cell_lineage_facet=CL:0000000,CL:0000003,CL:0000988,CL:0000548,CL:0002371,CL:0000542,CL:0000219,CL:0000945,CL:0000738,CL:0002087,CL:0002242,CL:0000255,CL:0000236,CL:0000785,CL:0000819 | ||
|ancestors_in_disease_facet=DOID:4,DOID:0050686,DOID:162,DOID:2531,DOID:0060058,DOID:14566,DOID:0060083,DOID:0060073,DOID:8675 | |||
|ancestors_in_ff_facet=FF:0000102,FF:0000003,FF:0000210,FF:0000101,FF:0000001,FF:0100104,FF:0101518,FF:0102521 | |||
|comment= | |||
|created_by= | |||
|creation_date= | |||
| | |data_phase=2 | ||
| | |datafreeze_phase=2 | ||
|def= | |||
|expression_enrichment_score=chr11:111249993..111250006,-!p1@POU2AF1!2.82!652.64!POU2AF1;;chr19:19281060..19281078,-!p2@MEF2BNB-MEF2B,p2@MEF2B!2.34!217.85!MEF2B;;chr16:85932760..85932775,+!p1@IRF8!2.17!147.61!IRF8;;chr19:50922187..50922204,+!p1@SPIB!2.06!114.76!SPIB;;chr6:391743..391759,+!p1@IRF4!2.02!102.72!IRF4;;chr3:189349162..189349207,+!p2@TP63!1.91!79.73!TP63;;chr2:100759010..100759035,-!p1@AFF3!1.90!79.00!AFF3;;chr2:100759037..100759058,-!p2@AFF3!1.81!63.86!AFF3;;chr11:47400078..47400106,-!p1@SPI1!1.79!61.12!SPI1;;chr7:50348268..50348366,+!p4@IKZF1!1.75!55.83!IKZF1;;chr9:37034469..37034474,-!p1@PAX5!1.57!35.76!PAX5;;chr9:20382446..20382493,-!p4@MLLT3!1.54!33.94!MLLT3;;chr6:91006518..91006570,-!p1@BACH2!1.53!73.53!BACH2;;chr6:135502408..135502459,+!p2@MYB!1.51!35.94!MYB;;chr3:71631151..71631194,-!p15@FOXP1!1.50!34.67!FOXP1;;chr17:38020392..38020477,-!p1@IKZF3!1.49!29.56!IKZF3;;chr5:134369905..134369972,-!p1@PITX1!1.46!41.78!PITX1;;chr17:37934204..37934241,-!p3@IKZF3!1.42!25.36!IKZF3;;chr2:185463247..185463263,+!p1@ZNF804A!1.37!38.86!ZNF804A;;chr20:50159198..50159299,-!p1@NFATC2!1.34!30.47!NFATC2;;chrX:131623026..131623039,-!p5@MBNL3!1.32!19.71!MBNL3;;chr19:50432453..50432468,+!p1@ATF5!1.31!1041.82!ATF5;;chr1:23857698..23857733,-!p1@E2F2!1.31!34.85!E2F2;;chr6:135502501..135502546,+!p1@MYB!1.31!22.99!MYB;;chr2:100758991..100759009,-!p3@AFF3!1.29!18.43!AFF3;;chr13:41593425..41593480,-!p1@ELF1!1.28!111.30!ELF1;;chr17:42295777..42295816,-!p7@UBTF!1.28!21.89!UBTF;;chr20:42295745..42295765,+!p1@MYBL2!1.27!278.97!MYBL2;;chr2:214015343..214015366,-!p3@IKZF2!1.25!16.97!IKZF2;;chr2:239148671..239148686,-!p1@HES6!1.24!59.66!HES6;;chr12:11905383..11905407,+!p11@ETV6!1.24!16.42!ETV6;;chr19:42636586..42636607,-!p1@POU2F2!1.21!42.15!POU2F2;;chr2:231090433..231090469,+!p1@SP140!1.20!14.78!SP140;;chr2:60780607..60780624,-!p2@BCL11A!1.19!44.34!BCL11A;;chr18:53089453..53089482,-!p11@TCF4!1.19!14.41!TCF4;;chr19:1652555..1652568,-!p2@TCF3!1.18!56.93!TCF3;;chr13:41593493..41593506,-!p8@ELF1!1.17!13.68!ELF1;;chr15:68115672..68115691,+!p1@SKOR1!1.16!13.32!SKOR1;;chr19:45579725..45579743,-!p1@ZNF296!1.15!58.75!ZNF296;;chr21:43256981..43257008,-!p2@PRDM15!1.15!13.14!PRDM15;;chr2:60778035..60778060,-!p4@BCL11A!1.14!15.51!BCL11A;;chr6:91006575..91006602,-!p2@BACH2!1.13!18.61!BACH2;;chr18:53089493..53089517,-!p15@TCF4!1.13!12.41!TCF4;;chr2:214013461..214013517,-!p6@IKZF2!1.12!12.22!IKZF2;;chr1:25256756..25256774,-!p1@RUNX3!1.11!22.26!RUNX3;;chr20:42295713..42295738,+!p2@MYBL2!1.10!68.97!MYBL2;;chr12:11905413..11905432,+!p14@ETV6!1.07!10.76!ETV6;;chr4:87857491..87857519,+!p10@AFF1!1.06!14.60!AFF1;;chr17:38020557..38020572,-!p4@IKZF3!1.06!10.58!IKZF3;;chr7:50343634..50343717,+!p2@IKZF1!1.06!10.40!IKZF1;;chr2:214015111..214015179,-!p1@IKZF2!1.03!17.70!IKZF2;;chr8:86099884..86099918,+!p4@E2F5!1.03!9.67!E2F5;;chr2:214016254..214016282,-!p7@IKZF2!1.01!9.31!IKZF2;;chr17:37934188..37934202,-!p8@IKZF3!1.01!9.31!IKZF3;;chr1:167298300..167298319,+!p2@POU2F1!1.01!9.12!POU2F1;;chr4:87857474..87857489,+!p7@AFF1!1.00!16.06!AFF1;;chr3:71631217..71631234,-!p33@FOXP1!1.00!8.94!FOXP1;;chr20:32274179..32274213,-!p1@E2F1!0.99!59.85!E2F1;;chrX:131624056..131624069,-!p2@MBNL3!0.99!12.04!MBNL3;;chr7:97840743..97840786,+!p1@BHLHA15!0.99!8.76!BHLHA15;;chr3:71631248..71631268,-!p26@FOXP1!0.99!8.76!FOXP1;;chr5:158526917..158526932,-!p1@EBF1!0.98!21.71!EBF1;;chr1:158978768..158978800,+!p8@IFI16!0.97!8.39!IFI16;;chr6:20402102..20402152,+!p1@E2F3!0.96!33.94!E2F3;;chr2:231090471..231090504,+!p2@SP140!0.96!8.21!SP140;;chr19:50435736..50435781,+!p3@ATF5!0.95!11.13!ATF5;;chr18:53089538..53089578,-!p14@TCF4!0.94!7.66!TCF4;;chr2:214014959..214015006,-!p4@IKZF2!0.94!7.66!IKZF2;;chr7:148581327..148581347,-!p2@EZH2!0.93!26.82!EZH2;;chr19:19779619..19779670,+!p1@ZNF101!0.93!21.71!ZNF101;;chr14:75988771..75988826,+!p1@BATF!0.93!10.22!BATF;;chr9:37027156..37027193,-!p4@PAX5!0.93!7.48!PAX5;;chr18:77155922..77155939,+!p1@NFATC1!0.92!20.62!NFATC1;;chr5:134369879..134369898,-!p2@PITX1!0.92!7.30!PITX1;;chr6:34204973..34204990,+!p4@HMGA1!0.91!98.89!HMGA1;;chr9:37034258..37034270,-!p3@PAX5!0.91!7.12!PAX5;;chr18:53089521..53089533,-!p22@TCF4!0.91!7.12!TCF4;;chr17:42295897..42295953,-!p10@UBTF!0.90!9.49!UBTF;;chr8:86089627..86089653,+!p3@E2F5!0.90!8.03!E2F5;;chr1:14057463..14057496,+!p4@PRDM2!0.90!6.93!PRDM2;;chr7:64838786..64838809,+!p2@ZNF92!0.89!40.14!ZNF92;;chr21:43283523..43283544,-!p3@PRDM15!0.89!6.75!PRDM15;;chr1:158979686..158979745,+!p1@IFI16!0.88!228.43!IFI16;;chr7:77428066..77428132,+!p2@PHTF2!0.88!44.34!PHTF2;;chr7:64363638..64363667,+!p1@ZNF273!0.88!34.67!ZNF273;;chr12:54447599..54447630,+!p3@HOXC4!0.87!8.03!HOXC4;;chr2:100759060..100759073,-!p8@AFF3!0.87!6.39!AFF3;;chrX:84499081..84499115,+!p2@ZNF711!0.86!9.31!ZNF711;;chr3:18486354..18486377,-!p2@SATB1!0.86!8.03!SATB1;;chr5:158526756..158526797,-!p3@EBF1!0.85!6.02!EBF1;;chr6:135513595..135513617,+!p4@MYB!0.85!6.02!MYB;;chr8:128748308..128748324,+!p2@MYC!0.84!175.70!MYC;;chr3:141747459..141747475,-!p1@TFDP2!0.83!51.09!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| |||
| | |ffid_belonging_in_development=CL:0000134,CL:0000051,CL:0000954 | ||
| | |||
| | |||
| | |||
| | |||
| | |||
| | |||
|fonse_cell_line=FF:0100104 | |fonse_cell_line=FF:0100104 | ||
|fonse_cell_line_closure=FF:0100104 | |fonse_cell_line_closure=FF:0100104 | ||
Line 66: | Line 40: | ||
|fonse_treatment= | |fonse_treatment= | ||
|fonse_treatment_closure= | |fonse_treatment_closure= | ||
|has_quality= | |has_quality= | ||
|is_a=CL:0000819;;EFO:0002091;;FF: | |hg19bam=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/diffuse%2520large%2520B-cell%2520lymphoma%2520cell%2520line%253aCTB-1.CNhs11741.10631-108I1.hg19.nobarcode.bam | ||
|hg19ctss=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/diffuse%2520large%2520B-cell%2520lymphoma%2520cell%2520line%253aCTB-1.CNhs11741.10631-108I1.hg19.ctss.bed.gz | |||
|hg19fasta=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/diffuse%2520large%2520B-cell%2520lymphoma%2520cell%2520line%253aCTB-1.CNhs11741.10631-108I1.hg19.nobarcode.rdna.fa.gz | |||
|hg38bam=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.cell_line.hCAGE/diffuse%2520large%2520B-cell%2520lymphoma%2520cell%2520line%253aCTB-1.CNhs11741.10631-108I1.hg38.nobarcode.bam | |||
|hg38ctss=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.cell_line.hCAGE/diffuse%2520large%2520B-cell%2520lymphoma%2520cell%2520line%253aCTB-1.CNhs11741.10631-108I1.hg38.nobarcode.ctss.bed.gz | |||
|id=FF:10631-108I1 | |||
|is_a=CL:0000819;;EFO:0002091;;FF:0000210;;FF:0102521 | |||
|is_obsolete= | |||
|library_id=CNhs11741 | |||
|library_id_phase_based=2:CNhs11741 | |||
|microRNAs= | |||
|microRNAs_nn= | |||
|microRNAs_nonnovel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer/#/human#cage;sample;10631 | |||
|microRNAs_novel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer_novel/#/human#cage;sample;10631 | |||
|name=diffuse large B-cell lymphoma cell line:CTB-1 | |||
|namespace=FANTOM5 | |namespace=FANTOM5 | ||
|part_of= | |part_of= | ||
|profile_cagescan=,,, | |||
|profile_hcage=CNhs11741,LSID819,release009,COMPLETED | |||
|profile_rnaseq= | |||
|profile_srnaseq=,,, | |||
|refex=http://refex.dbcls.jp/genelist.php?lang | |||
|repeat_enrich_byfamily=0,0.572502392332937,0,0,0,0,0,0.0776826723014192,0.189592591802658,-0.191206066078108,0.623098618885277,0,0,0,0.135103881494694,0,0,0,0,0,0,0.07278454461533,0.189592591802658,0,-0.018219128853734,0,0,0,0,0.811148791204699,0.661243266976917,0,0,0.417805684318623,0,0,0,0,0,0,0,0,0,0,0,0,-0.0728850457267141,0.421948117359166,0,0,0,0,0,0,0,0.0947853300810685,0,0,0,0,0,-0.0548856501811437,0,0.381141454122524,0,0,0.140657075174708,0,0,0,0,0,0,0,0,0,0,0.189592591802658,0,0,0.07278454461533,0,0,0,0,0,0,0,0,0,0,-0.430190732155975,0,0,0,0.0775187576214007,-0.107253189640857,0.160563895180354,0,0,0,-0.0980353512377064,0.630930753457939,0,0,0,0,0,0,0.238000702387805,0,0,0,0,0,0,0,0,0,0,0.557804097277695,0.238000702387805,0,0,-0.0562622698659916,-0.12141020312084,0,0,0.321127790360708,0,0,0 | |||
|repeat_enrich_byname=0,0,0,0.238000702387805,-0.0980353512377064,0,0,0,0,0,0,0,0,0,0,0,-0.247178875285564,0,-0.1529584283913,-0.00841126102877823,0.067551940747347,0,-0.390886814601905,0,0,0,0,0.07278454461533,0,0,0,0,-0.0553353223372348,0,-0.0504125515893149,0.119000351193902,0,0,0,0,-0.305472230898407,0,-0.055257709955607,-0.0683442610773682,0,0.07278454461533,0,0,-0.270240669334324,0,-0.120879483793741,-0.0827201683234173,0.231449765620814,-0.604215254858039,-0.055712496781182,0,0,0,-0.377346435957804,0.289976469007423,0,0,-0.121779851751874,0.350549244396836,0,0,-0.391044581551635,0,-0.30816616600961,-0.209930408449582,0,0.553577992915469,0,0,0,0,0,0.07278454461533,0,0,0.135103881494694,0,0,-0.0574934668214365,-0.0889878942911636,0.100357087914569,0,0,0,-0.569082053236693,0,0,-0.373286155956567,-0.0316312740970555,-0.0172219722197652,0.0964829649609779,0,-0.0643890246221079,-0.104823745482756,-0.284639343791822,0.0775187576214007,-0.147401849371139,-0.189981719549847,0,-0.0650382326735063,-0.154404290570064,-0.0363476295129425,-0.0923232617483543,0,-1.2314085082871,0.180373139007536,0,0,-0.0775089264793031,-0.192641394904493,0,0.0568206822670949,-0.35501083298208,-0.122444998564721,-0.551987085281808,-0.290130023414133,-0.275847080258486,-0.217023590540755,-0.0395325284566706,-0.219435750508789,0,-0.4215723249037,-0.0121220557942069,0,-0.0186654569513234,0.0126726420461561,-0.307778291742193,-0.0650638990811941,0,0.128989757342131,-0.0683442610773682,0,-0.598802600868482,0.222075097966108,0,-0.215144458558795,-0.127828287974308,0,0,0.135103881494694,0,0,0.278139516513513,0.0537137745779509,0.124542471461874,0,0.00395568361762544,-0.0151807197467671,0.142215166624065,0,0.00245479721718067,-0.146009897457394,-0.108481560558634,-0.292633804596236,0,0.0461927251009688,0.0485198998081984,-0.0922061517236729,-0.287290923897044,0.17955387557598,-0.137266016167614,-0.0242941219389873,0.0489205027636439,-0.788939864790226,0.0078847819874046,-0.0153422878599578,-0.0983289857321517,-0.461596633159214,-0.679498131621524,-0.072543961144669,0.012982043484388,0,-0.259965479247979,0,0.121700436992975,0,0.117432691307975,-0.350841159670582,0.429115084938957,0.144132277035107,0,-0.272087285759119,-0.715346393158644,0,-0.24468889631142,-0.0239875154535779,0,-0.0775825387193094,-0.697695966512583,0.679194255380457,-0.10259718437153,0,-0.717295613774327,0,0,-0.266702113091864,0.509705730991923,0,0.276211728005238,0.447699003160335,0.295236850454956,0.0191328080597596,0.07278454461533,0,-0.572915793377395,0.00946232969294125,0,-0.5331435192027,-0.103706020372186,-0.430190732155975,0.16862177587241,0,-0.108622809454255,0,0,0.0604729364226297,0,-0.141918030130192,0,0,0.10021110046289,0,0,0.067551940747347,0,0,0,0,0,0,0,0,0,0.0268875149972012,0.217669062116489,0,0.00040418749597193,0,0,0,0,0,-0.0188101100639378,0,0,-0.587032779705059,-0.101470786394574,0.234380617340999,0,0.036392272307665,0.036392272307665,0,-0.215723402553475,-0.130452017479394,0.135103881494694,0.0577298853050266,0,0,0,0,0.103451602013447,0,0,0.036392272307665,0,0.131862134748994,-0.0471902731726335,0,0,0,1.07226891511322,0,0,0,0,-0.0241107677823671,0.321127790360708,0,-0.0811678992888949,0,-0.13909161549513,-0.00879733493151152,0,0.196745575831039,-0.200113877936373,-1.02807023265195,0,0,-0.261347131789888,0,0.0192554720120275,0.18654094638381,0.0234715304036992,0.189592591802658,-0.0209247759461169,0,0,0,0,0.07278454461533,0,-0.214314512399756,0,0,0,0,0,0,0,0,0,0,0,-0.595980522891967,0.0428798248361832,0,0,0,0,0,0,0,0.0798381899761087,0.203269500334213,0,0,0,0,0,0,0,0,0.533872119451376,0,0,0,0,0,0.381141454122524,0,0,0,0,0.964647129774044,0,0,-0.204577587578184,0,0.00949926212818775,0,0,0,0,0,0.036392272307665,0,0.572502392332937,0,0,0,0.298629031323718,-0.191206066078108,0,0.135103881494694,0,0,0,0.189592591802658,0,-0.0368325958182852,0,0.28155010799651,0,0,-0.0410998290936473,0,0,0,-0.104796384789156,0,0.0776826723014192,0,0.07278454461533,0,0,0,0,0.324990523794274,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-0.0829064767520875,-0.0247755787802223,-0.28720751597291,-0.0632207254555128,0,0,-0.232628352633041,0,0,0,0,0,0,0.0876599271653755,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.238000702387805,0,0,0,0,0,0,0.0326938969422585,0,0,0,0,0,0,0,0.661243266976917,0,0.262987565457212,0.0685310853798278,0,0.0219605005535966,0,0,0,0,-0.0489099329741448,-0.246828127515482,-0.0674371610684235,0,0,0,-0.054385572482455,0,0,-0.0329050193664387,0,-0.0667773874189013,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-0.018219128853734,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.39087124941973,0.103944213055012,0,0,0,0,0,0,0.00238090903224842,0.07278454461533,0,0,0,0.07278454461533,0,0,0,0,0,0,0,0.036392272307665,0,0,0,0.067551940747347,0,0,0,0,0,0.705932753234657,0,0,0,-0.140301685041714,0,0,0,0,0,0,0.28155010799651,0,0.421948117359166,0,0,0,0,0.140775053998255,0,0,0,0,0,0,0.07278454461533,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.450948942897104,0,0,0,-0.0480308339329755,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| |||
|rna_box=108 | |||
|rna_catalog_number= | |||
|rna_concentration=1.80566 | |||
|rna_extraction_protocol=OP-RNA-extraction-totalRNA-miRNeasy_Mini-v1.0 | |||
|rna_lot_number= | |||
|rna_od260/230=2.15 | |||
|rna_od260/280=2.1 | |||
|rna_position=I1 | |||
|rna_rin= | |||
|rna_sample_type=total RNA | |||
|rna_tube_id=108I1 | |||
|rna_weight_ug=84.86602 | |||
|sample_age=70 | |||
|sample_category=cell lines | |||
|sample_cell_catalog=RCB1316 | |||
|sample_cell_line=CTB-1 | |||
|sample_cell_lot= | |||
|sample_cell_type=b cell | |||
|sample_collaboration=Yukio Nakamura (RIKEN BRC) | |||
|sample_company=RIKEN Bioresource centre | |||
|sample_description= | |||
|sample_dev_stage= | |||
|sample_disease=diffuse large B-cell lymphoma | |||
|sample_donor(cell lot)= | |||
|sample_ethnicity=J | |||
|sample_experimental_condition= | |||
|sample_gostat=GO:0044464;cell part;0!GO:0005622;intracellular;0!GO:0044424;intracellular part;3.16844357848456e-276!GO:0043227;membrane-bound organelle;5.7560991611591e-248!GO:0043231;intracellular membrane-bound organelle;1.26030067949396e-247!GO:0043226;organelle;7.97499365833923e-239!GO:0043229;intracellular organelle;2.28907477307141e-238!GO:0044422;organelle part;1.15397634928947e-172!GO:0044446;intracellular organelle part;8.57293980871529e-171!GO:0005737;cytoplasm;7.31810657716857e-154!GO:0005634;nucleus;6.27846368243805e-137!GO:0032991;macromolecular complex;2.5046267765271e-135!GO:0044237;cellular metabolic process;1.22636404458139e-124!GO:0044238;primary metabolic process;2.39375722839053e-120!GO:0044428;nuclear part;1.45740888429585e-117!GO:0043170;macromolecule metabolic process;6.61549963521756e-112!GO:0030529;ribonucleoprotein complex;2.5072147473962e-110!GO:0044444;cytoplasmic part;2.46418793429515e-109!GO:0043233;organelle lumen;3.99256759469256e-103!GO:0031974;membrane-enclosed lumen;3.99256759469256e-103!GO:0003723;RNA binding;5.76771280857918e-99!GO:0005739;mitochondrion;9.07235936528527e-83!GO:0006139;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;2.45727587407397e-79!GO:0043283;biopolymer metabolic process;3.63782736358216e-77!GO:0006396;RNA processing;3.65906532862611e-76!GO:0031981;nuclear lumen;8.45003240030781e-71!GO:0010467;gene expression;1.29790799365447e-70!GO:0043234;protein complex;3.30756112843635e-69!GO:0006259;DNA metabolic process;3.54103248632791e-63!GO:0006412;translation;5.01541652141201e-63!GO:0005515;protein binding;2.58687331489766e-61!GO:0005840;ribosome;5.06414634081666e-61!GO:0044429;mitochondrial part;7.71124381949034e-58!GO:0016071;mRNA metabolic process;2.30499965512403e-56!GO:0003676;nucleic acid binding;8.36158385480493e-54!GO:0003735;structural constituent of ribosome;2.03718708755364e-52!GO:0031967;organelle envelope;8.30379796796784e-51!GO:0031975;envelope;2.06985156122778e-50!GO:0008380;RNA splicing;4.58505065046646e-50!GO:0006397;mRNA processing;3.83680559145092e-49!GO:0044249;cellular biosynthetic process;6.60400483628494e-48!GO:0019538;protein metabolic process;1.14269178897068e-46!GO:0033279;ribosomal subunit;2.09599953475483e-45!GO:0005654;nucleoplasm;8.94917611951635e-45!GO:0022613;ribonucleoprotein complex biogenesis and assembly;7.12355263812739e-44!GO:0009058;biosynthetic process;7.70181637384773e-44!GO:0006996;organelle organization and biogenesis;1.69671143486582e-43!GO:0043228;non-membrane-bound organelle;1.97674359494407e-42!GO:0043232;intracellular non-membrane-bound organelle;1.97674359494407e-42!GO:0044267;cellular protein metabolic process;2.68803295000856e-42!GO:0044260;cellular macromolecule metabolic process;7.75727421730043e-42!GO:0009059;macromolecule biosynthetic process;1.19683837800354e-41!GO:0006974;response to DNA damage stimulus;1.26954572332229e-41!GO:0031090;organelle membrane;2.41518716449042e-41!GO:0007049;cell cycle;2.77333817243992e-40!GO:0033036;macromolecule localization;1.39475514636361e-39!GO:0015031;protein transport;5.97510284151659e-38!GO:0016043;cellular component organization and biogenesis;8.24874881746332e-38!GO:0005681;spliceosome;5.62488986841855e-37!GO:0016070;RNA metabolic process;1.09882788704642e-36!GO:0065003;macromolecular complex assembly;4.79930979093152e-36!GO:0005829;cytosol;5.81838650955119e-36!GO:0006281;DNA repair;6.65331265968845e-36!GO:0005694;chromosome;9.11183323454907e-36!GO:0045184;establishment of protein localization;1.61375917922452e-34!GO:0008104;protein localization;1.72124130596532e-34!GO:0044451;nucleoplasm part;2.36681188444135e-34!GO:0000166;nucleotide binding;4.74135175408015e-34!GO:0022402;cell cycle process;8.87270927434035e-34!GO:0005740;mitochondrial envelope;1.21436395702115e-33!GO:0046907;intracellular transport;3.67403758112466e-33!GO:0005830;cytosolic ribosome (sensu Eukaryota);1.25768107101701e-32!GO:0019866;organelle inner membrane;4.19119874881636e-32!GO:0022607;cellular component assembly;9.1575738979202e-32!GO:0000278;mitotic cell cycle;9.43907226285714e-32!GO:0031966;mitochondrial membrane;2.40685604199247e-31!GO:0044427;chromosomal part;3.37058622168908e-30!GO:0005743;mitochondrial inner membrane;6.30941839447346e-30!GO:0022403;cell cycle phase;2.91293472289629e-29!GO:0044445;cytosolic part;4.1269418027262e-29!GO:0031980;mitochondrial lumen;4.94393455362067e-29!GO:0005759;mitochondrial matrix;4.94393455362067e-29!GO:0006886;intracellular protein transport;1.55769288991823e-28!GO:0005730;nucleolus;1.19890232957178e-27!GO:0009719;response to endogenous stimulus;1.35624265940061e-27!GO:0051276;chromosome organization and biogenesis;1.60992434745995e-27!GO:0000087;M phase of mitotic cell cycle;9.1305322434503e-27!GO:0007067;mitosis;3.84621270730143e-26!GO:0006260;DNA replication;4.66998918500412e-26!GO:0000279;M phase;2.92595345201299e-25!GO:0044455;mitochondrial membrane part;3.73654596614524e-24!GO:0044265;cellular macromolecule catabolic process;4.22892988312033e-24!GO:0006119;oxidative phosphorylation;5.7962374909927e-24!GO:0005524;ATP binding;6.46199959308769e-24!GO:0016818;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;9.48912431949755e-24!GO:0016817;hydrolase activity, acting on acid anhydrides;1.13386820129675e-23!GO:0016462;pyrophosphatase activity;1.14836157285006e-23!GO:0016874;ligase activity;1.86350351750702e-23!GO:0015934;large ribosomal subunit;1.92365496698932e-23!GO:0032559;adenyl ribonucleotide binding;2.17097194019478e-23!GO:0017111;nucleoside-triphosphatase activity;2.94776542216936e-23!GO:0015935;small ribosomal subunit;3.16413438458251e-23!GO:0051301;cell division;3.70062177001981e-23!GO:0032553;ribonucleotide binding;5.9707970459813e-23!GO:0032555;purine ribonucleotide binding;5.9707970459813e-23!GO:0030554;adenyl nucleotide binding;1.1852463857453e-22!GO:0042254;ribosome biogenesis and assembly;1.19042703354808e-22!GO:0017076;purine nucleotide binding;1.71981617434123e-22!GO:0051649;establishment of cellular localization;3.34577665167736e-22!GO:0006512;ubiquitin cycle;4.12476235376594e-22!GO:0022618;protein-RNA complex assembly;6.01340690410014e-22!GO:0051641;cellular localization;1.38274401801558e-21!GO:0016887;ATPase activity;3.50786625983892e-21!GO:0042623;ATPase activity, coupled;2.18667107392591e-20!GO:0008134;transcription factor binding;2.36728212739861e-20!GO:0006325;establishment and/or maintenance of chromatin architecture;6.12534536805479e-20!GO:0006511;ubiquitin-dependent protein catabolic process;6.36132795122881e-20!GO:0019941;modification-dependent protein catabolic process;6.60747695616029e-20!GO:0043632;modification-dependent macromolecule catabolic process;6.60747695616029e-20!GO:0051603;proteolysis involved in cellular protein catabolic process;7.99795251626923e-20!GO:0043285;biopolymer catabolic process;1.2648650474289e-19!GO:0008135;translation factor activity, nucleic acid binding;1.74131158143006e-19!GO:0044257;cellular protein catabolic process;2.27301716741061e-19!GO:0006457;protein folding;2.43189353782727e-19!GO:0044248;cellular catabolic process;2.63498807922628e-19!GO:0009057;macromolecule catabolic process;2.92218838390398e-19!GO:0006323;DNA packaging;3.07713440635346e-19!GO:0005746;mitochondrial respiratory chain;3.43958135337992e-19!GO:0005761;mitochondrial ribosome;1.51097962434333e-18!GO:0000313;organellar ribosome;1.51097962434333e-18!GO:0000398;nuclear mRNA splicing, via spliceosome;1.60272270611982e-18!GO:0000375;RNA splicing, via transesterification reactions;1.60272270611982e-18!GO:0000377;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;1.60272270611982e-18!GO:0000502;proteasome complex (sensu Eukaryota);8.07014585446202e-18!GO:0031965;nuclear membrane;1.38738101820606e-17!GO:0005842;cytosolic large ribosomal subunit (sensu Eukaryota);2.3244371079275e-17!GO:0005635;nuclear envelope;2.98537517520956e-17!GO:0044453;nuclear membrane part;6.72473189824875e-17!GO:0050136;NADH dehydrogenase (quinone) activity;7.50800741593263e-17!GO:0003954;NADH dehydrogenase activity;7.50800741593263e-17!GO:0008137;NADH dehydrogenase (ubiquinone) activity;7.50800741593263e-17!GO:0004386;helicase activity;7.95761605278328e-17!GO:0016604;nuclear body;9.63626626693443e-17!GO:0016655;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor;1.22079299623287e-16!GO:0006605;protein targeting;1.45119745249322e-16!GO:0006403;RNA localization;2.30581042542048e-16!GO:0050657;nucleic acid transport;2.75308710923508e-16!GO:0051236;establishment of RNA localization;2.75308710923508e-16!GO:0050658;RNA transport;2.75308710923508e-16!GO:0006364;rRNA processing;4.7065861165857e-16!GO:0006399;tRNA metabolic process;5.19162563742562e-16!GO:0016568;chromatin modification;8.56122190237696e-16!GO:0005643;nuclear pore;9.64074608336752e-16!GO:0005843;cytosolic small ribosomal subunit (sensu Eukaryota);1.01977662519535e-15!GO:0016072;rRNA metabolic process;1.21895607653317e-15!GO:0008026;ATP-dependent helicase activity;3.65457180474799e-15!GO:0042775;organelle ATP synthesis coupled electron transport;4.14034441301451e-15!GO:0042773;ATP synthesis coupled electron transport;4.14034441301451e-15!GO:0043412;biopolymer modification;5.63438427321193e-15!GO:0051186;cofactor metabolic process;8.31742252035432e-15!GO:0030964;NADH dehydrogenase complex (quinone);8.57660447574544e-15!GO:0045271;respiratory chain complex I;8.57660447574544e-15!GO:0005747;mitochondrial respiratory chain complex I;8.57660447574544e-15!GO:0051726;regulation of cell cycle;1.12172820664774e-14!GO:0003743;translation initiation factor activity;1.64536121903628e-14!GO:0015931;nucleobase, nucleoside, nucleotide and nucleic acid transport;1.69232832927641e-14!GO:0003712;transcription cofactor activity;1.92401376864926e-14!GO:0030163;protein catabolic process;2.08958321488319e-14!GO:0012505;endomembrane system;2.2477543291195e-14!GO:0000074;regulation of progression through cell cycle;2.5267864869233e-14!GO:0006120;mitochondrial electron transport, NADH to ubiquinone;2.84534765379732e-14!GO:0000785;chromatin;6.35716451312161e-14!GO:0051028;mRNA transport;6.35716451312161e-14!GO:0006913;nucleocytoplasmic transport;1.37559426971511e-13!GO:0065002;intracellular protein transport across a membrane;1.4333414130336e-13!GO:0006261;DNA-dependent DNA replication;1.49299265682929e-13!GO:0051082;unfolded protein binding;1.5112704710578e-13!GO:0012501;programmed cell death;2.10696892991139e-13!GO:0006413;translational initiation;2.18187277883969e-13!GO:0006915;apoptosis;2.24244875878911e-13!GO:0046930;pore complex;2.53031154931233e-13!GO:0051169;nuclear transport;3.70332543532107e-13!GO:0009259;ribonucleotide metabolic process;6.50756645373861e-13!GO:0016779;nucleotidyltransferase activity;9.42352687369298e-13!GO:0000775;chromosome, pericentric region;1.14719741994373e-12!GO:0016607;nuclear speck;1.34356323660073e-12!GO:0006333;chromatin assembly or disassembly;2.65066055741237e-12!GO:0006163;purine nucleotide metabolic process;3.15651563977585e-12!GO:0006732;coenzyme metabolic process;4.28022171799021e-12!GO:0016651;oxidoreductase activity, acting on NADH or NADPH;4.58978431331332e-12!GO:0006464;protein modification process;4.6878905805435e-12!GO:0043687;post-translational protein modification;5.31600661180871e-12!GO:0006446;regulation of translational initiation;6.51056295208763e-12!GO:0009055;electron carrier activity;7.11087996549728e-12!GO:0003697;single-stranded DNA binding;7.58634820625674e-12!GO:0009260;ribonucleotide biosynthetic process;7.92446149116591e-12!GO:0006164;purine nucleotide biosynthetic process;1.00681151469091e-11!GO:0048770;pigment granule;1.41493996723705e-11!GO:0042470;melanosome;1.41493996723705e-11!GO:0008219;cell death;1.82812484368553e-11!GO:0016265;death;1.82812484368553e-11!GO:0016591;DNA-directed RNA polymerase II, holoenzyme;1.83862111711184e-11!GO:0043566;structure-specific DNA binding;1.83862111711184e-11!GO:0006366;transcription from RNA polymerase II promoter;2.15109003528598e-11!GO:0016876;ligase activity, forming aminoacyl-tRNA and related compounds;2.27132935944169e-11!GO:0004812;aminoacyl-tRNA ligase activity;2.27132935944169e-11!GO:0016875;ligase activity, forming carbon-oxygen bonds;2.27132935944169e-11!GO:0030532;small nuclear ribonucleoprotein complex;2.60983232501633e-11!GO:0009150;purine ribonucleotide metabolic process;3.03778106866702e-11!GO:0043038;amino acid activation;4.38755531042386e-11!GO:0006418;tRNA aminoacylation for protein translation;4.38755531042386e-11!GO:0043039;tRNA aminoacylation;4.38755531042386e-11!GO:0009152;purine ribonucleotide biosynthetic process;9.85654358796256e-11!GO:0009056;catabolic process;1.56166427372494e-10!GO:0065004;protein-DNA complex assembly;2.13022625196537e-10!GO:0016879;ligase activity, forming carbon-nitrogen bonds;2.70876674498458e-10!GO:0008639;small protein conjugating enzyme activity;2.86742003154815e-10!GO:0005819;spindle;3.24318868708451e-10!GO:0017038;protein import;4.22555219559995e-10!GO:0000075;cell cycle checkpoint;6.93139277203999e-10!GO:0046961;hydrogen ion transporting ATPase activity, rotational mechanism;8.84441265137081e-10!GO:0008094;DNA-dependent ATPase activity;9.15520709564467e-10!GO:0004842;ubiquitin-protein ligase activity;9.97023646643263e-10!GO:0006461;protein complex assembly;1.00023949655487e-09!GO:0044432;endoplasmic reticulum part;1.07506849608358e-09!GO:0019222;regulation of metabolic process;1.51341079762379e-09!GO:0005657;replication fork;1.64105949564716e-09!GO:0019787;small conjugating protein ligase activity;1.83612530680867e-09!GO:0006310;DNA recombination;1.95506726206139e-09!GO:0016740;transferase activity;2.28249943491087e-09!GO:0009199;ribonucleoside triphosphate metabolic process;3.60095317309282e-09!GO:0009141;nucleoside triphosphate metabolic process;3.62538933338243e-09!GO:0019829;cation-transporting ATPase activity;3.66803466105526e-09!GO:0055086;nucleobase, nucleoside and nucleotide metabolic process;3.82207295500028e-09!GO:0015078;hydrogen ion transmembrane transporter activity;4.53349286221557e-09!GO:0015630;microtubule cytoskeleton;4.86326651121807e-09!GO:0009142;nucleoside triphosphate biosynthetic process;5.62757715564065e-09!GO:0009201;ribonucleoside triphosphate biosynthetic process;5.62757715564065e-09!GO:0009060;aerobic respiration;5.64107720575737e-09!GO:0051325;interphase;5.93245565615419e-09!GO:0046933;hydrogen ion transporting ATP synthase activity, rotational mechanism;6.00655734874995e-09!GO:0005667;transcription factor complex;6.27508312249783e-09!GO:0050794;regulation of cellular process;6.27508312249783e-09!GO:0048193;Golgi vesicle transport;7.10396629179137e-09!GO:0005813;centrosome;7.7946968387873e-09!GO:0009205;purine ribonucleoside triphosphate metabolic process;8.23249756352651e-09!GO:0009144;purine nucleoside triphosphate metabolic process;8.23249756352651e-09!GO:0005783;endoplasmic reticulum;8.74365798728463e-09!GO:0016787;hydrolase activity;8.87206542536281e-09!GO:0005839;proteasome core complex (sensu Eukaryota);9.91436515321741e-09!GO:0042175;nuclear envelope-endoplasmic reticulum network;1.0206969727473e-08!GO:0003899;DNA-directed RNA polymerase activity;1.07148697974313e-08!GO:0051329;interphase of mitotic cell cycle;1.08101769488636e-08!GO:0016741;transferase activity, transferring one-carbon groups;1.17259144626684e-08!GO:0005815;microtubule organizing center;1.19419774633172e-08!GO:0045333;cellular respiration;1.27964200182477e-08!GO:0051188;cofactor biosynthetic process;1.29748121899736e-08!GO:0009206;purine ribonucleoside triphosphate biosynthetic process;1.33183304996653e-08!GO:0009145;purine nucleoside triphosphate biosynthetic process;1.33183304996653e-08!GO:0042981;regulation of apoptosis;1.38601948623589e-08!GO:0008168;methyltransferase activity;1.47043771104357e-08!GO:0003713;transcription coactivator activity;1.68315292478538e-08!GO:0043067;regulation of programmed cell death;2.02184752682476e-08!GO:0005789;endoplasmic reticulum membrane;2.02633314590861e-08!GO:0000245;spliceosome assembly;2.07857439386855e-08!GO:0008565;protein transporter activity;2.08730298944759e-08!GO:0032446;protein modification by small protein conjugation;2.38459016741659e-08!GO:0015986;ATP synthesis coupled proton transport;2.44757653160626e-08!GO:0015985;energy coupled proton transport, down electrochemical gradient;2.44757653160626e-08!GO:0016881;acid-amino acid ligase activity;3.03060769037526e-08!GO:0007005;mitochondrion organization and biogenesis;3.88930817825035e-08!GO:0031323;regulation of cellular metabolic process;5.17727449647072e-08!GO:0016567;protein ubiquitination;5.26171330317955e-08!GO:0004298;threonine endopeptidase activity;5.52685490583571e-08!GO:0006793;phosphorus metabolic process;6.42992933689596e-08!GO:0006796;phosphate metabolic process;6.42992933689596e-08!GO:0009117;nucleotide metabolic process;6.58171245930835e-08!GO:0016563;transcription activator activity;7.76846445695933e-08!GO:0007051;spindle organization and biogenesis;8.00644491666784e-08!GO:0006099;tricarboxylic acid cycle;8.47866799554112e-08!GO:0046356;acetyl-CoA catabolic process;8.47866799554112e-08!GO:0046034;ATP metabolic process;9.07669454276858e-08!GO:0016772;transferase activity, transferring phosphorus-containing groups;1.03616649647878e-07!GO:0031202;RNA splicing factor activity, transesterification mechanism;1.05290691581699e-07!GO:0006084;acetyl-CoA metabolic process;1.12195375342166e-07!GO:0006754;ATP biosynthetic process;1.21665807774923e-07!GO:0006753;nucleoside phosphate metabolic process;1.21665807774923e-07!GO:0016469;proton-transporting two-sector ATPase complex;1.48219080736351e-07!GO:0006350;transcription;1.60403234006378e-07!GO:0016310;phosphorylation;1.70912000817951e-07!GO:0003682;chromatin binding;1.79743438732891e-07!GO:0045259;proton-transporting ATP synthase complex;1.88591699269937e-07!GO:0000151;ubiquitin ligase complex;1.93396224013299e-07!GO:0003724;RNA helicase activity;2.28010343375702e-07!GO:0006302;double-strand break repair;2.31910135579848e-07!GO:0051168;nuclear export;2.78249672362604e-07!GO:0006752;group transfer coenzyme metabolic process;4.99929010265953e-07!GO:0009108;coenzyme biosynthetic process;5.31460864749836e-07!GO:0015077;monovalent inorganic cation transmembrane transporter activity;6.06176523607051e-07!GO:0003678;DNA helicase activity;7.2993126569447e-07!GO:0044452;nucleolar part;7.44329480908113e-07!GO:0007059;chromosome segregation;9.1111720930449e-07!GO:0005762;mitochondrial large ribosomal subunit;9.45682453158727e-07!GO:0000315;organellar large ribosomal subunit;9.45682453158727e-07!GO:0009109;coenzyme catabolic process;1.00408335394629e-06!GO:0004518;nuclease activity;1.19614102420871e-06!GO:0031497;chromatin assembly;1.47335394209059e-06!GO:0003690;double-stranded DNA binding;1.51536966888466e-06!GO:0019899;enzyme binding;1.6156033229181e-06!GO:0006401;RNA catabolic process;1.62016744763382e-06!GO:0008033;tRNA processing;1.81133454742551e-06!GO:0051170;nuclear import;1.94503224755476e-06!GO:0051246;regulation of protein metabolic process;2.00907363340192e-06!GO:0006334;nucleosome assembly;2.3426507692919e-06!GO:0043623;cellular protein complex assembly;2.39771078743479e-06!GO:0004527;exonuclease activity;2.91024002543588e-06!GO:0003684;damaged DNA binding;3.13491117794316e-06!GO:0000228;nuclear chromosome;3.47312013362375e-06!GO:0000314;organellar small ribosomal subunit;3.47312013362375e-06!GO:0005763;mitochondrial small ribosomal subunit;3.47312013362375e-06!GO:0031324;negative regulation of cellular metabolic process;3.52926694093477e-06!GO:0051187;cofactor catabolic process;4.27032505736024e-06!GO:0045934;negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;4.32687409221542e-06!GO:0006606;protein import into nucleus;4.35128241351633e-06!GO:0016564;transcription repressor activity;4.84350215324048e-06!GO:0010468;regulation of gene expression;5.20392612154155e-06!GO:0051052;regulation of DNA metabolic process;5.22119910637886e-06!GO:0000776;kinetochore;6.11012708944178e-06!GO:0003677;DNA binding;7.4691801167395e-06!GO:0006402;mRNA catabolic process;8.00002217701665e-06!GO:0019219;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;9.2303990795716e-06!GO:0016363;nuclear matrix;9.62151429905787e-06!GO:0043681;protein import into mitochondrion;1.0763543462531e-05!GO:0065009;regulation of a molecular function;1.35260818962775e-05!GO:0007093;mitotic cell cycle checkpoint;1.35767340166201e-05!GO:0008186;RNA-dependent ATPase activity;1.46398478197017e-05!GO:0006888;ER to Golgi vesicle-mediated transport;1.51510616367355e-05!GO:0030530;heterogeneous nuclear ribonucleoprotein complex;1.81464867491306e-05!GO:0006613;cotranslational protein targeting to membrane;1.81464867491306e-05!GO:0045786;negative regulation of progression through cell cycle;2.35514264178271e-05!GO:0009165;nucleotide biosynthetic process;2.50505903158594e-05!GO:0007088;regulation of mitosis;2.78769934857562e-05!GO:0030880;RNA polymerase complex;2.80230816891826e-05!GO:0006383;transcription from RNA polymerase III promoter;3.05579312341494e-05!GO:0032508;DNA duplex unwinding;3.18866973652189e-05!GO:0032392;DNA geometric change;3.18866973652189e-05!GO:0043065;positive regulation of apoptosis;3.23200941114135e-05!GO:0015405;P-P-bond-hydrolysis-driven transmembrane transporter activity;3.23792251986001e-05!GO:0015399;primary active transmembrane transporter activity;3.23792251986001e-05!GO:0006091;generation of precursor metabolites and energy;3.69447255932446e-05!GO:0006626;protein targeting to mitochondrion;3.71345528992955e-05!GO:0043021;ribonucleoprotein binding;3.74887531064107e-05!GO:0000079;regulation of cyclin-dependent protein kinase activity;3.77490261821937e-05!GO:0003729;mRNA binding;3.9548496499182e-05!GO:0006284;base-excision repair;3.98700838015565e-05!GO:0050789;regulation of biological process;4.03788520929531e-05!GO:0003714;transcription corepressor activity;4.27963151359692e-05!GO:0043068;positive regulation of programmed cell death;4.65525969878948e-05!GO:0004004;ATP-dependent RNA helicase activity;4.69562983347657e-05!GO:0042625;ATPase activity, coupled to transmembrane movement of ions;4.93328526006821e-05!GO:0004674;protein serine/threonine kinase activity;5.09575614407359e-05!GO:0006352;transcription initiation;6.27655098910743e-05!GO:0006405;RNA export from nucleus;6.41977292311162e-05!GO:0016853;isomerase activity;6.9950789241657e-05!GO:0055029;nuclear DNA-directed RNA polymerase complex;7.29369473110349e-05!GO:0000428;DNA-directed RNA polymerase complex;7.29369473110349e-05!GO:0005753;mitochondrial proton-transporting ATP synthase complex;7.29369473110349e-05!GO:0006357;regulation of transcription from RNA polymerase II promoter;7.32002642391345e-05!GO:0016481;negative regulation of transcription;7.41993896097174e-05!GO:0016192;vesicle-mediated transport;8.37654080278052e-05!GO:0016251;general RNA polymerase II transcription factor activity;8.42083643442276e-05!GO:0016491;oxidoreductase activity;8.51725281384185e-05!GO:0006414;translational elongation;8.95456129624475e-05!GO:0032774;RNA biosynthetic process;9.20835185510492e-05!GO:0045454;cell redox homeostasis;9.29431996090932e-05!GO:0006268;DNA unwinding during replication;0.000100808861432915!GO:0031072;heat shock protein binding;0.000102183450763129!GO:0006351;transcription, DNA-dependent;0.00011862258893864!GO:0030120;vesicle coat;0.000120315846091803!GO:0030662;coated vesicle membrane;0.000120315846091803!GO:0006839;mitochondrial transport;0.000122357479164638!GO:0042770;DNA damage response, signal transduction;0.000128768200586922!GO:0003711;transcription elongation regulator activity;0.000132837426243775!GO:0006818;hydrogen transport;0.000137691982086738!GO:0005684;U2-dependent spliceosome;0.000148144583282695!GO:0005793;ER-Golgi intermediate compartment;0.000155187451690776!GO:0000184;mRNA catabolic process, nonsense-mediated decay;0.000161381900256543!GO:0006612;protein targeting to membrane;0.000170683549951167!GO:0006917;induction of apoptosis;0.00017108092767111!GO:0015992;proton transport;0.000175432610704741!GO:0007006;mitochondrial membrane organization and biogenesis;0.000182007841550637!GO:0048475;coated membrane;0.000185350585142631!GO:0030117;membrane coat;0.000185350585142631!GO:0000049;tRNA binding;0.000195300243626062!GO:0005852;eukaryotic translation initiation factor 3 complex;0.000221816999918116!GO:0009892;negative regulation of metabolic process;0.000222275227140415!GO:0005768;endosome;0.000230041902444128!GO:0006520;amino acid metabolic process;0.000235008693723855!GO:0012502;induction of programmed cell death;0.000239839297234534!GO:0015631;tubulin binding;0.000240021103857684!GO:0007052;mitotic spindle organization and biogenesis;0.000240071864206072!GO:0005794;Golgi apparatus;0.000246420478889276!GO:0051427;hormone receptor binding;0.000249097194798074!GO:0032200;telomere organization and biogenesis;0.000250089577555905!GO:0000723;telomere maintenance;0.000250089577555905!GO:0009451;RNA modification;0.000271379737882686!GO:0045449;regulation of transcription;0.000322941183373216!GO:0006289;nucleotide-excision repair;0.000355523397746025!GO:0043596;nuclear replication fork;0.000365568953546575!GO:0043492;ATPase activity, coupled to movement of substances;0.000373304495201746!GO:0000922;spindle pole;0.000392213773993786!GO:0004003;ATP-dependent DNA helicase activity;0.000403129371800866!GO:0031570;DNA integrity checkpoint;0.000408825305530505!GO:0008757;S-adenosylmethionine-dependent methyltransferase activity;0.000412133018468766!GO:0019752;carboxylic acid metabolic process;0.000423915573393755!GO:0008276;protein methyltransferase activity;0.000440386612454422!GO:0033178;proton-transporting two-sector ATPase complex, catalytic domain;0.000467757370874155!GO:0045261;proton-transporting ATP synthase complex, catalytic core F(1);0.000474548663759309!GO:0035257;nuclear hormone receptor binding;0.00047778723291575!GO:0006082;organic acid metabolic process;0.000497103590831539!GO:0042626;ATPase activity, coupled to transmembrane movement of substances;0.000501765623027734!GO:0005885;Arp2/3 protein complex;0.000524908796841043!GO:0006338;chromatin remodeling;0.000529582474341705!GO:0000793;condensed chromosome;0.000529582474341705!GO:0048523;negative regulation of cellular process;0.000561328264428562!GO:0032259;methylation;0.00056613917519168!GO:0016820;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;0.000575070637609911!GO:0000059;protein import into nucleus, docking;0.000580277536050257!GO:0005876;spindle microtubule;0.00058153531560662!GO:0045263;proton-transporting ATP synthase complex, coupling factor F(o);0.000594283820678981!GO:0033177;proton-transporting two-sector ATPase complex, proton-transporting domain;0.000594283820678981!GO:0050790;regulation of catalytic activity;0.000614012540471066!GO:0043069;negative regulation of programmed cell death;0.000634586165091348!GO:0000082;G1/S transition of mitotic cell cycle;0.000685579469456766!GO:0003887;DNA-directed DNA polymerase activity;0.000695520055065431!GO:0044454;nuclear chromosome part;0.000714966326360374!GO:0015980;energy derivation by oxidation of organic compounds;0.000739286708363178!GO:0006417;regulation of translation;0.000759194028225205!GO:0022890;inorganic cation transmembrane transporter activity;0.000762218859242713!GO:0016859;cis-trans isomerase activity;0.000776176282764384!GO:0016679;oxidoreductase activity, acting on diphenols and related substances as donors;0.000780031973252027!GO:0016681;oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor;0.000780031973252027!GO:0008121;ubiquinol-cytochrome-c reductase activity;0.000780031973252027!GO:0000819;sister chromatid segregation;0.000787793415699525!GO:0043066;negative regulation of apoptosis;0.000796200670043212!GO:0006270;DNA replication initiation;0.000806460608964853!GO:0051252;regulation of RNA metabolic process;0.000811296375433054!GO:0000070;mitotic sister chromatid segregation;0.000825727173128168!GO:0000792;heterochromatin;0.000825727173128168!GO:0006007;glucose catabolic process;0.000846153936097597!GO:0003755;peptidyl-prolyl cis-trans isomerase activity;0.000849978646014855!GO:0006275;regulation of DNA replication;0.000939632467416801!GO:0000287;magnesium ion binding;0.000947112562340447!GO:0009124;nucleoside monophosphate biosynthetic process;0.000996998880263944!GO:0009123;nucleoside monophosphate metabolic process;0.000996998880263944!GO:0016796;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters;0.00101553475124205!GO:0008632;apoptotic program;0.00104225800426446!GO:0016126;sterol biosynthetic process;0.00107639691799062!GO:0008408;3'-5' exonuclease activity;0.00107711177192236!GO:0005770;late endosome;0.00110960040351345!GO:0031124;mRNA 3'-end processing;0.00115388219855891!GO:0000910;cytokinesis;0.00116940346280653!GO:0051087;chaperone binding;0.0011929225452194!GO:0000781;chromosome, telomeric region;0.00119807734685168!GO:0051920;peroxiredoxin activity;0.00122661254568652!GO:0000226;microtubule cytoskeleton organization and biogenesis;0.00125340307221692!GO:0005048;signal sequence binding;0.00126409478760498!GO:0051540;metal cluster binding;0.00128243857622475!GO:0051536;iron-sulfur cluster binding;0.00128243857622475!GO:0016281;eukaryotic translation initiation factor 4F complex;0.00134580346956701!GO:0005838;proteasome regulatory particle (sensu Eukaryota);0.00134830218639744!GO:0006916;anti-apoptosis;0.00136576803294318!GO:0043414;biopolymer methylation;0.00137097164824566!GO:0000725;recombinational repair;0.00137824232744446!GO:0000724;double-strand break repair via homologous recombination;0.00137824232744446!GO:0006367;transcription initiation from RNA polymerase II promoter;0.00138648734910622!GO:0007017;microtubule-based process;0.00142070286922092!GO:0031123;RNA 3'-end processing;0.0014354905764149!GO:0006695;cholesterol biosynthetic process;0.0014719766712254!GO:0009112;nucleobase metabolic process;0.0014719766712254!GO:0016272;prefoldin complex;0.00149702179486685!GO:0008017;microtubule binding;0.00158727920481765!GO:0006611;protein export from nucleus;0.00172352310451793!GO:0006950;response to stress;0.00173269726664718!GO:0006144;purine base metabolic process;0.00174555280350112!GO:0046483;heterocycle metabolic process;0.00175262507018283!GO:0008022;protein C-terminus binding;0.00176479911172628!GO:0048500;signal recognition particle;0.00178085127009864!GO:0000077;DNA damage checkpoint;0.00188027814759801!GO:0006595;polyamine metabolic process;0.00191217231896585!GO:0019783;small conjugating protein-specific protease activity;0.00191753335182522!GO:0005665;DNA-directed RNA polymerase II, core complex;0.00192528968598539!GO:0044450;microtubule organizing center part;0.00199055329515852!GO:0000786;nucleosome;0.00202535094240986!GO:0006891;intra-Golgi vesicle-mediated transport;0.00206092065649944!GO:0008312;7S RNA binding;0.00210084056279334!GO:0004532;exoribonuclease activity;0.00210084056279334!GO:0016896;exoribonuclease activity, producing 5'-phosphomonoesters;0.00210084056279334!GO:0008139;nuclear localization sequence binding;0.00210276614699971!GO:0016676;oxidoreductase activity, acting on heme group of donors, oxygen as acceptor;0.00210276614699971!GO:0015002;heme-copper terminal oxidase activity;0.00210276614699971!GO:0016675;oxidoreductase activity, acting on heme group of donors;0.00210276614699971!GO:0004129;cytochrome-c oxidase activity;0.00210276614699971!GO:0019867;outer membrane;0.00214644699552313!GO:0031326;regulation of cellular biosynthetic process;0.00215465635626026!GO:0051539;4 iron, 4 sulfur cluster binding;0.00225299515203823!GO:0009161;ribonucleoside monophosphate metabolic process;0.00228312683016528!GO:0009156;ribonucleoside monophosphate biosynthetic process;0.00228312683016528!GO:0003746;translation elongation factor activity;0.00233540787706596!GO:0004843;ubiquitin-specific protease activity;0.00238521329461732!GO:0006220;pyrimidine nucleotide metabolic process;0.00239160954876365!GO:0031968;organelle outer membrane;0.00242086796316212!GO:0007007;inner mitochondrial membrane organization and biogenesis;0.00242086796316212!GO:0005769;early endosome;0.00259256491979646!GO:0042393;histone binding;0.0026387633880836!GO:0006400;tRNA modification;0.00268777808664979!GO:0043601;nuclear replisome;0.00276874468343439!GO:0030894;replisome;0.00276874468343439!GO:0005758;mitochondrial intermembrane space;0.00279775456220421!GO:0051320;S phase;0.00320128342516094!GO:0016407;acetyltransferase activity;0.0034289516103563!GO:0009116;nucleoside metabolic process;0.00344294088259816!GO:0030384;phosphoinositide metabolic process;0.00346335801549738!GO:0016197;endosome transport;0.00359701700000975!GO:0008654;phospholipid biosynthetic process;0.00380121479390835!GO:0042054;histone methyltransferase activity;0.00384649404454697!GO:0043161;proteasomal ubiquitin-dependent protein catabolic process;0.00393074026462728!GO:0047485;protein N-terminus binding;0.00405700922298243!GO:0043488;regulation of mRNA stability;0.00413228674827172!GO:0043487;regulation of RNA stability;0.00413228674827172!GO:0004221;ubiquitin thiolesterase activity;0.0043145565146309!GO:0005786;signal recognition particle, endoplasmic reticulum targeting;0.00436101959496257!GO:0006730;one-carbon compound metabolic process;0.00439016731149779!GO:0005663;DNA replication factor C complex;0.00439016731149779!GO:0000152;nuclear ubiquitin ligase complex;0.00439679681435544!GO:0000726;non-recombinational repair;0.00441398982923659!GO:0000178;exosome (RNase complex);0.0044551205900172!GO:0006614;SRP-dependent cotranslational protein targeting to membrane;0.00446060168845219!GO:0045047;protein targeting to ER;0.00446060168845219!GO:0005669;transcription factor TFIID complex;0.0044905675666148!GO:0008629;induction of apoptosis by intracellular signals;0.00451078675521539!GO:0048519;negative regulation of biological process;0.00489144466576689!GO:0000339;RNA cap binding;0.00504149159157573!GO:0051053;negative regulation of DNA metabolic process;0.00526042846299378!GO:0005741;mitochondrial outer membrane;0.00529884510584302!GO:0033116;ER-Golgi intermediate compartment membrane;0.00544655392226305!GO:0046474;glycerophospholipid biosynthetic process;0.00572525377163196!GO:0006378;mRNA polyadenylation;0.00582415376033839!GO:0048471;perinuclear region of cytoplasm;0.00582708372139995!GO:0046365;monosaccharide catabolic process;0.00591256808723075!GO:0007249;I-kappaB kinase/NF-kappaB cascade;0.00600859172710871!GO:0009889;regulation of biosynthetic process;0.00606779328828739!GO:0006650;glycerophospholipid metabolic process;0.00608823922850307!GO:0006519;amino acid and derivative metabolic process;0.00616315208387062!GO:0031647;regulation of protein stability;0.00630370402149111!GO:0016279;protein-lysine N-methyltransferase activity;0.006404458871096!GO:0018024;histone-lysine N-methyltransferase activity;0.006404458871096!GO:0016278;lysine N-methyltransferase activity;0.006404458871096!GO:0006740;NADPH regeneration;0.00642073908765155!GO:0006098;pentose-phosphate shunt;0.00642073908765155!GO:0016584;nucleosome positioning;0.0065388834324608!GO:0008234;cysteine-type peptidase activity;0.00672128415549475!GO:0043284;biopolymer biosynthetic process;0.00675483128808509!GO:0006355;regulation of transcription, DNA-dependent;0.00679753493681461!GO:0007004;telomere maintenance via telomerase;0.00683110133648107!GO:0007021;tubulin folding;0.00692511411259302!GO:0004536;deoxyribonuclease activity;0.00700438993758662!GO:0046164;alcohol catabolic process;0.00731296655604232!GO:0031577;spindle checkpoint;0.00740747869814118!GO:0030521;androgen receptor signaling pathway;0.00740747869814118!GO:0003702;RNA polymerase II transcription factor activity;0.00746600024152747!GO:0003725;double-stranded RNA binding;0.0075392265229298!GO:0006278;RNA-dependent DNA replication;0.0076565054078221!GO:0005773;vacuole;0.00766779314919731!GO:0051656;establishment of organelle localization;0.00773901030894441!GO:0005874;microtubule;0.00776605204217815!GO:0005637;nuclear inner membrane;0.00778187823009543!GO:0045892;negative regulation of transcription, DNA-dependent;0.00779547157371269!GO:0031970;organelle envelope lumen;0.00796186537706463!GO:0006406;mRNA export from nucleus;0.00800619123049372!GO:0009303;rRNA transcription;0.00831483569486877!GO:0005798;Golgi-associated vesicle;0.00839106918915307!GO:0043022;ribosome binding;0.00841092926178342!GO:0006376;mRNA splice site selection;0.00841092926178342!GO:0000389;nuclear mRNA 3'-splice site recognition;0.00841092926178342!GO:0044440;endosomal part;0.00862176236329157!GO:0010008;endosome membrane;0.00862176236329157!GO:0005832;chaperonin-containing T-complex;0.00866479040714753!GO:0046489;phosphoinositide biosynthetic process;0.00905190807997205!GO:0016790;thiolester hydrolase activity;0.0092287784625855!GO:0042719;mitochondrial intermembrane space protein transporter complex;0.0092287784625855!GO:0045039;protein import into mitochondrial inner membrane;0.0092287784625855!GO:0016893;endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters;0.00927347318500052!GO:0042802;identical protein binding;0.00937023045652642!GO:0019320;hexose catabolic process;0.0097435974998066!GO:0019843;rRNA binding;0.0099410638754931!GO:0035258;steroid hormone receptor binding;0.0101429794413376!GO:0045935;positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;0.0102162610387818!GO:0007243;protein kinase cascade;0.0103299928468987!GO:0007050;cell cycle arrest;0.0105459430139581!GO:0035267;NuA4 histone acetyltransferase complex;0.010671980925395!GO:0048487;beta-tubulin binding;0.0107698559581806!GO:0016569;covalent chromatin modification;0.0109160081118957!GO:0030663;COPI coated vesicle membrane;0.011269094825136!GO:0030126;COPI vesicle coat;0.011269094825136!GO:0009127;purine nucleoside monophosphate biosynthetic process;0.011269094825136!GO:0009167;purine ribonucleoside monophosphate metabolic process;0.011269094825136!GO:0009126;purine nucleoside monophosphate metabolic process;0.011269094825136!GO:0009168;purine ribonucleoside monophosphate biosynthetic process;0.011269094825136!GO:0016891;endoribonuclease activity, producing 5'-phosphomonoesters;0.0113062085423366!GO:0008652;amino acid biosynthetic process;0.0114640450984417!GO:0043631;RNA polyadenylation;0.0114954960740836!GO:0030518;steroid hormone receptor signaling pathway;0.0116004936751597!GO:0000307;cyclin-dependent protein kinase holoenzyme complex;0.0119547193420334!GO:0000209;protein polyubiquitination;0.0119944016108687!GO:0051338;regulation of transferase activity;0.0120849265710277!GO:0000323;lytic vacuole;0.012390949763568!GO:0005764;lysosome;0.012390949763568!GO:0006096;glycolysis;0.0124339528865353!GO:0000175;3'-5'-exoribonuclease activity;0.0129429402717949!GO:0006266;DNA ligation;0.0131892244286345!GO:0043549;regulation of kinase activity;0.0133008496875447!GO:0004523;ribonuclease H activity;0.0135326145712727!GO:0030330;DNA damage response, signal transduction by p53 class mediator;0.0135423223707129!GO:0005732;small nucleolar ribonucleoprotein complex;0.0135839332785468!GO:0032981;mitochondrial respiratory chain complex I assembly;0.0136818597746665!GO:0010257;NADH dehydrogenase complex assembly;0.0136818597746665!GO:0033108;mitochondrial respiratory chain complex assembly;0.0136818597746665!GO:0043189;H4/H2A histone acetyltransferase complex;0.0136818597746665!GO:0003924;GTPase activity;0.0143137298553838!GO:0048522;positive regulation of cellular process;0.014327071267637!GO:0019210;kinase inhibitor activity;0.0144230013338459!GO:0031625;ubiquitin protein ligase binding;0.0145704375125413!GO:0005525;GTP binding;0.0146139182624124!GO:0004520;endodeoxyribonuclease activity;0.0146139182624124!GO:0030433;ER-associated protein catabolic process;0.0146139182624124!GO:0006515;misfolded or incompletely synthesized protein catabolic process;0.0146139182624124!GO:0045941;positive regulation of transcription;0.0149283808082907!GO:0051297;centrosome organization and biogenesis;0.0150753934094644!GO:0031023;microtubule organizing center organization and biogenesis;0.0150753934094644!GO:0016627;oxidoreductase activity, acting on the CH-CH group of donors;0.0156716975521627!GO:0000118;histone deacetylase complex;0.0156980986216208!GO:0006301;postreplication repair;0.0158528614044898!GO:0046426;negative regulation of JAK-STAT cascade;0.0161619424896505!GO:0004860;protein kinase inhibitor activity;0.0162806580939008!GO:0000123;histone acetyltransferase complex;0.0162806580939008!GO:0033170;DNA-protein loading ATPase activity;0.0163915833082339!GO:0003689;DNA clamp loader activity;0.0163915833082339!GO:0009081;branched chain family amino acid metabolic process;0.0166507832596478!GO:0001824;blastocyst development;0.0167648092278797!GO:0006118;electron transport;0.0171107364934073!GO:0050662;coenzyme binding;0.0171107364934073!GO:0046112;nucleobase biosynthetic process;0.0178296555767846!GO:0004540;ribonuclease activity;0.0179089348448011!GO:0015036;disulfide oxidoreductase activity;0.0180290808485289!GO:0008287;protein serine/threonine phosphatase complex;0.0181982031971969!GO:0043122;regulation of I-kappaB kinase/NF-kappaB cascade;0.0181982031971969!GO:0046966;thyroid hormone receptor binding;0.0185552715217152!GO:0008180;signalosome;0.0185638484501996!GO:0005092;GDP-dissociation inhibitor activity;0.018585981808125!GO:0004722;protein serine/threonine phosphatase activity;0.0187260574114295!GO:0051789;response to protein stimulus;0.0197645886824233!GO:0006986;response to unfolded protein;0.0197645886824233!GO:0007346;regulation of progression through mitotic cell cycle;0.0197900554809854!GO:0019205;nucleobase, nucleoside, nucleotide kinase activity;0.0201272177328494!GO:0005680;anaphase-promoting complex;0.020188897378372!GO:0051287;NAD binding;0.0204189918303967!GO:0032404;mismatch repair complex binding;0.0204909120897189!GO:0000930;gamma-tubulin complex;0.0208705637533934!GO:0008213;protein amino acid alkylation;0.0209630664632684!GO:0006479;protein amino acid methylation;0.0209630664632684!GO:0019104;DNA N-glycosylase activity;0.0209730859622479!GO:0045120;pronucleus;0.0210863474103612!GO:0031252;leading edge;0.021095090648827!GO:0051640;organelle localization;0.021095090648827!GO:0007094;mitotic cell cycle spindle assembly checkpoint;0.0214630215294685!GO:0008159;positive transcription elongation factor activity;0.0215323343260026!GO:0000096;sulfur amino acid metabolic process;0.0215323343260026!GO:0030867;rough endoplasmic reticulum membrane;0.0216406641332325!GO:0044431;Golgi apparatus part;0.0219353792610082!GO:0008170;N-methyltransferase activity;0.0219687393462693!GO:0005850;eukaryotic translation initiation factor 2 complex;0.0219687393462693!GO:0005689;U12-dependent spliceosome;0.0219691213419977!GO:0016765;transferase activity, transferring alkyl or aryl (other than methyl) groups;0.0224469255007273!GO:0016862;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;0.0224469255007273!GO:0016585;chromatin remodeling complex;0.0227980511675817!GO:0005652;nuclear lamina;0.0229125456599408!GO:0040029;regulation of gene expression, epigenetic;0.0231301020687996!GO:0008299;isoprenoid biosynthetic process;0.0231532488550393!GO:0045859;regulation of protein kinase activity;0.0233994340741977!GO:0008156;negative regulation of DNA replication;0.0235316673997627!GO:0032039;integrator complex;0.0235678676807361!GO:0008097;5S rRNA binding;0.0236948685844865!GO:0030137;COPI-coated vesicle;0.0239383297058837!GO:0006368;RNA elongation from RNA polymerase II promoter;0.0239812886986815!GO:0030508;thiol-disulfide exchange intermediate activity;0.0240108367603622!GO:0001522;pseudouridine synthesis;0.0242381319287581!GO:0005869;dynactin complex;0.0244149765883312!GO:0005521;lamin binding;0.0250494542012785!GO:0006356;regulation of transcription from RNA polymerase I promoter;0.0251952921447565!GO:0043123;positive regulation of I-kappaB kinase/NF-kappaB cascade;0.0256242371693949!GO:0042113;B cell activation;0.0259206129329583!GO:0007010;cytoskeleton organization and biogenesis;0.0259696645036583!GO:0000119;mediator complex;0.0260633257308741!GO:0030658;transport vesicle membrane;0.0260986157172804!GO:0065007;biological regulation;0.0261552125350153!GO:0004748;ribonucleoside-diphosphate reductase activity;0.0262637114850161!GO:0016728;oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor;0.0262637114850161!GO:0006596;polyamine biosynthetic process;0.026342786513369!GO:0009262;deoxyribonucleotide metabolic process;0.0269750950334772!GO:0033261;regulation of progression through S phase;0.0271529361434971!GO:0051318;G1 phase;0.0276183403290348!GO:0044438;microbody part;0.0276813349122493!GO:0044439;peroxisomal part;0.0276813349122493!GO:0009893;positive regulation of metabolic process;0.0279333392257417!GO:0042532;negative regulation of tyrosine phosphorylation of STAT protein;0.0280615986619894!GO:0042518;negative regulation of tyrosine phosphorylation of Stat3 protein;0.0280615986619894!GO:0050732;negative regulation of peptidyl-tyrosine phosphorylation;0.0280615986619894!GO:0008538;proteasome activator activity;0.0280722387882544!GO:0045815;positive regulation of gene expression, epigenetic;0.0291490736987695!GO:0005487;nucleocytoplasmic transporter activity;0.0296821346774809!GO:0004402;histone acetyltransferase activity;0.0302058222793336!GO:0004468;lysine N-acetyltransferase activity;0.0302058222793336!GO:0016301;kinase activity;0.0302058222793336!GO:0006607;NLS-bearing substrate import into nucleus;0.0304906875958583!GO:0000790;nuclear chromatin;0.0309596609685134!GO:0006497;protein amino acid lipidation;0.0310032108189107!GO:0006303;double-strand break repair via nonhomologous end joining;0.0314168803717696!GO:0051348;negative regulation of transferase activity;0.0324991587002895!GO:0006298;mismatch repair;0.0325260207915928!GO:0045005;maintenance of fidelity during DNA-dependent DNA replication;0.0325260207915928!GO:0016570;histone modification;0.032536708542481!GO:0031371;ubiquitin conjugating enzyme complex;0.0326400263061441!GO:0003857;3-hydroxyacyl-CoA dehydrogenase activity;0.0330772836886552!GO:0022415;viral reproductive process;0.0332300484352179!GO:0008536;Ran GTPase binding;0.0335539864379179!GO:0007098;centrosome cycle;0.033932556635497!GO:0000084;S phase of mitotic cell cycle;0.0340530874300427!GO:0046982;protein heterodimerization activity;0.0343838981678762!GO:0008637;apoptotic mitochondrial changes;0.0345624023719898!GO:0033673;negative regulation of kinase activity;0.0355591975450498!GO:0006469;negative regulation of protein kinase activity;0.0355591975450498!GO:0016408;C-acyltransferase activity;0.0357982161190259!GO:0006379;mRNA cleavage;0.0357982161190259!GO:0004659;prenyltransferase activity;0.0358281230084685!GO:0043281;regulation of caspase activity;0.0359228200064048!GO:0000080;G1 phase of mitotic cell cycle;0.0359825209547465!GO:0046822;regulation of nucleocytoplasmic transport;0.0359825209547465!GO:0008143;poly(A) binding;0.0366369529792923!GO:0045730;respiratory burst;0.0371958892686919!GO:0007265;Ras protein signal transduction;0.0372824792784828!GO:0000097;sulfur amino acid biosynthetic process;0.0374539208040641!GO:0006221;pyrimidine nucleotide biosynthetic process;0.0376167209533421!GO:0016417;S-acyltransferase activity;0.0376299162617969!GO:0004448;isocitrate dehydrogenase activity;0.0378455678911464!GO:0031903;microbody membrane;0.0378455678911464!GO:0005778;peroxisomal membrane;0.0378455678911464!GO:0005784;translocon complex;0.0380006552289998!GO:0008320;protein transmembrane transporter activity;0.038331280769303!GO:0043087;regulation of GTPase activity;0.0385043594866149!GO:0045947;negative regulation of translational initiation;0.0397494927857205!GO:0002763;positive regulation of myeloid leukocyte differentiation;0.0403117327990063!GO:0005774;vacuolar membrane;0.0405317309152583!GO:0046128;purine ribonucleoside metabolic process;0.0406418516624082!GO:0042278;purine nucleoside metabolic process;0.0406418516624082!GO:0045792;negative regulation of cell size;0.0407231678704321!GO:0051336;regulation of hydrolase activity;0.0410190984097481!GO:0006779;porphyrin biosynthetic process;0.0411656618194847!GO:0033014;tetrapyrrole biosynthetic process;0.0411656618194847!GO:0004519;endonuclease activity;0.0414238766735288!GO:0000122;negative regulation of transcription from RNA polymerase II promoter;0.0419509111062589!GO:0042162;telomeric DNA binding;0.0419509111062589!GO:0001832;blastocyst growth;0.0420804241866075!GO:0050178;phenylpyruvate tautomerase activity;0.0423338824146573!GO:0017134;fibroblast growth factor binding;0.0429282867533587!GO:0004239;methionyl aminopeptidase activity;0.0441055841261695!GO:0019901;protein kinase binding;0.0441081046044954!GO:0008173;RNA methyltransferase activity;0.0441635811731468!GO:0030118;clathrin coat;0.0445618331806188!GO:0043130;ubiquitin binding;0.0450963135209785!GO:0032182;small conjugating protein binding;0.0450963135209785!GO:0030983;mismatched DNA binding;0.0450963135209785!GO:0009067;aspartate family amino acid biosynthetic process;0.0451472764260977!GO:0006919;caspase activation;0.0452602204963035!GO:0042809;vitamin D receptor binding;0.0454236850505631!GO:0030911;TPR domain binding;0.0456531972396639!GO:0022884;macromolecule transmembrane transporter activity;0.0456531972396639!GO:0015450;P-P-bond-hydrolysis-driven protein transmembrane transporter activity;0.0456531972396639!GO:0042769;DNA damage response, detection of DNA damage;0.0459172282323146!GO:0030515;snoRNA binding;0.0460563809780833!GO:0016788;hydrolase activity, acting on ester bonds;0.0466059821845295!GO:0006354;RNA elongation;0.0466360067176223!GO:0030027;lamellipodium;0.047186239624571!GO:0030660;Golgi-associated vesicle membrane;0.0474487829987066!GO:0006767;water-soluble vitamin metabolic process;0.0475123431005829!GO:0030374;ligand-dependent nuclear receptor transcription coactivator activity;0.0481691176325737!GO:0031503;protein complex localization;0.0483222279970692!GO:0008610;lipid biosynthetic process;0.0486250431205411!GO:0006415;translational termination;0.0488620554194666!GO:0005658;alpha DNA polymerase:primase complex;0.0496720135461043 | |||
|sample_id=10631 | |||
|sample_note= | |||
|sample_sex=male | |||
|sample_species=Human (Homo sapiens) | |||
|sample_strain= | |||
|sample_tissue=blood | |||
|top_motifs=AIRE:2.82906087073;MYB:2.44787290899;ZBTB16:2.2744355247;POU2F1..3:2.17741458301;E2F1..5:2.06889511928;POU5F1:1.96700351618;TOPORS:1.93161633278;PBX1:1.88130074602;CDX1,2,4:1.88042335445;IKZF2:1.8085511082;YY1:1.78609320866;PITX1..3:1.73479183767;PAX6:1.71276715432;BREu{core}:1.66956563641;NKX6-1,2:1.65028200021;OCT4_SOX2{dimer}:1.51526190236;PAX4:1.41587005716;PDX1:1.39929976709;VSX1,2:1.30214385583;FOXM1:1.29081862345;EVI1:1.28862003159;NFY{A,B,C}:1.23714468058;TEF:1.21264998748;FOX{I1,J2}:1.13825749264;HOX{A6,A7,B6,B7}:1.09191048589;FOXP1:1.04567715111;ZNF143:1.03742309564;FOXA2:1.02676438766;NRF1:0.98492103423;FOX{F1,F2,J1}:0.902057718466;RXR{A,B,G}_{NR1H2,PPAR}dimers:0.892001272998;DMAP1_NCOR{1,2}_SMARC:0.873259050428;ZNF384:0.80785184824;NANOG{mouse}:0.802084687249;POU3F1..4:0.796055701876;ELK1,4_GABP{A,B1}:0.777800639765;T:0.775135201781;ELF1,2,4:0.75780532834;CUX2:0.757447733761;FOXD3:0.723528823264;BPTF:0.714892234821;GFI1:0.630807578423;NKX3-1:0.609563304928;ARID5B:0.600817849672;PAX3,7:0.599862792039;LMO2:0.591407567269;CDC5L:0.564714851451;POU1F1:0.552191351461;FOXP3:0.531446807835;bHLH_family:0.528947267302;UFEwm:0.487510582413;NR5A1,2:0.443786490514;GATA6:0.42519519515;SOX{8,9,10}:0.331606642842;CREB1:0.326776265796;ZEB1:0.322213596403;NKX2-1,4:0.313628710415;AR:0.311763387339;FOXO1,3,4:0.295648189829;HNF4A_NR2F1,2:0.291950722219;RFX2..5_RFXANK_RFXAP:0.287482143622;SPI1:0.278122100754;NKX2-2,8:0.266168017411;SNAI1..3:0.26002204066;GATA4:0.257344002196;TFDP1:0.223298476077;ALX1:0.221615572986;NFKB1_REL_RELA:0.221272512726;SPIB:0.210545837323;MYOD1:0.205617337429;RUNX1..3:0.204305554187;FOXQ1:0.191396772665;ALX4:0.176412935804;IRF1,2:0.118461199364;STAT5{A,B}:0.111459817706;AHR_ARNT_ARNT2:0.0997508491352;ONECUT1,2:0.0899430071555;TGIF1:0.0677672805552;ARNT_ARNT2_BHLHB2_MAX_MYC_USF1:0.0671582758006;SOX17:0.0258868100623;HOX{A5,B5}:-0.0384983027279;TLX2:-0.0478589873579;SOX5:-0.0632585988754;ATF5_CREB3:-0.079096973527;KLF4:-0.097319544631;RBPJ:-0.109277567865;FOXL1:-0.150227901365;CRX:-0.161113143673;NKX3-2:-0.165900998729;HOXA9_MEIS1:-0.199088671352;ETS1,2:-0.20092457974;HOX{A4,D4}:-0.219516212613;HSF1,2:-0.226329997089;SPZ1:-0.291526665474;GCM1,2:-0.302176739887;ZFP161:-0.338781220907;PRRX1,2:-0.346052015363;MEF2{A,B,C,D}:-0.360242748049;HAND1,2:-0.375857578953;ATF4:-0.376931309579;HMGA1,2:-0.384651760261;RFX1:-0.390838553901;HNF1A:-0.395123984053;LEF1_TCF7_TCF7L1,2:-0.463557263;FOXN1:-0.485474885571;DBP:-0.494403736488;NR6A1:-0.503902391737;CEBPA,B_DDIT3:-0.508849681972;NFE2L1:-0.529009377735;RXRA_VDR{dimer}:-0.535928991371;IRF7:-0.536426228388;HES1:-0.551076298904;HIF1A:-0.552640248142;EN1,2:-0.573798945066;NKX2-3_NKX2-5:-0.590176973301;LHX3,4:-0.597074979688;NFIL3:-0.606101641173;RORA:-0.608692326997;NANOG:-0.612970452639;PRDM1:-0.624880527422;MYFfamily:-0.626278295814;POU6F1:-0.640535325454;HMX1:-0.642905162755;PAX2:-0.689136872076;SOX2:-0.702035332681;PPARG:-0.711668434361;TBP:-0.712912499522;FOSL2:-0.724581731961;NR1H4:-0.759477066773;TP53:-0.767340773244;ZIC1..3:-0.771292346876;GZF1:-0.802896152768;HBP1_HMGB_SSRP1_UBTF:-0.829367077124;SREBF1,2:-0.835480942801;PAX8:-0.836265711642;FOS_FOS{B,L1}_JUN{B,D}:-0.856614496473;RREB1:-0.868483881474;ESR1:-0.876046106315;SMAD1..7,9:-0.889714081457;EP300:-0.901715551933;NFE2:-0.914317744333;MYBL2:-0.920136086705;ESRRA:-0.954561585344;GFI1B:-0.957791562421;ZNF423:-0.95944568479;BACH2:-0.98668181445;HLF:-1.00118639519;NFIX:-1.00373514062;IKZF1:-1.03687252004;NHLH1,2:-1.04632423404;FOX{D1,D2}:-1.04696542217;ATF2:-1.0544176388;PAX1,9:-1.05921187669;REST:-1.07639464501;TAL1_TCF{3,4,12}:-1.11688000075;ZNF148:-1.12240744425;HIC1:-1.13099553563;MTE{core}:-1.14245750313;NR3C1:-1.19573632856;ZNF238:-1.21638146659;JUN:-1.21647778909;ADNP_IRX_SIX_ZHX:-1.23299985056;EBF1:-1.25468668525;XBP1:-1.27368411818;GTF2A1,2:-1.28131462437;PATZ1:-1.28522645119;MED-1{core}:-1.29825521859;NFATC1..3:-1.31373696649;RXR{A,B,G}:-1.35459666465;MZF1:-1.37963428641;NFE2L2:-1.43589022955;TFAP4:-1.45198609009;MTF1:-1.47871047775;PAX5:-1.50173189019;STAT1,3:-1.53886283189;ZBTB6:-1.55488010819;TBX4,5:-1.5621116216;MAFB:-1.6006449685;MAZ:-1.60912354649;GTF2I:-1.6263152786;SRF:-1.6355669517;GLI1..3:-1.68269322293;STAT2,4,6:-1.71782404254;TEAD1:-1.72285730111;EGR1..3:-1.79990253112;TFAP2B:-1.86120903893;XCPE1{core}:-1.98332117971;TFAP2{A,C}:-2.01683976058;TLX1..3_NFIC{dimer}:-2.0599934011;ATF6:-2.10328929078;TFCP2:-2.14972568703;SP1:-2.43701936681 | |||
|xref= | |||
|zenbu_report=https://fantom.gsc.riken.jp/zenbu/reports/#miRNA_expression_atlas_human;search_select_hide=table111:FF:10631-108I1;search_select_hide=table117:FF:10631-108I1 | |||
}} | }} |
Latest revision as of 14:31, 3 June 2020
Name: | diffuse large B-cell lymphoma cell line:CTB-1 |
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Species: | Human (Homo sapiens) |
Library ID: | CNhs11741 |
Sample type: | cell lines |
Genomic View: | UCSC |
RefEX: | Specific genes |
CAGEd-oPOSSUM: | link |
ZENBU report : | link |
Additional information | ||||||||||||||||||||||||||||
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Sample information
RNA information
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CAGE Accession numbers | ||||||||||||||||||||||||||||||||||||||||||||||
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Download raw sequence, BAM & CTSS | ||||||||||||||
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Relative expression to median (log10)
Transcription factors with enriched expression in this sampleRanked list of transcription factor promoter expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed.
Co-expression clusters with enriched expression in this sampleRanked list of co-expression cluster expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed. <br>Analyst:NA <br><br>link to dataset.<br>data
Repeat families with enriched expression in this sample<b>Summary:</b>Ranked list of repeat family expression in this sample relative tothe median expression in the FANTOM5 collection is shown. Value is log10transformed.<br><b>Analyst:</b>NA<br><br>link to dataset.<br>data
TFBS(DNA)motifs over-represented in proximal region of promoters active in this sample
JASPAR motifs<b>Summary:</b>Association of JASPAR motif to the promoter expression in thissample. Pearson's correlation between the number of TFBSs estimated byusing the position-weight matrix for each promoter and its expression isexpressed as Z-score by taking the ones based on random position-weightmatrix, and the tail probability of the normal distribution correspondingto the Z-score is taken as the resulting P-value. Lower P-value indicatesmore (non-random) association of the motif to promoter expression<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data
library id: CNhs11741
FANTOM5 phase1 novel unique motifs<b>Summary:</b>Association of the 169 novel and unique motifs discovered in FANTOM5 phase1 in this sample. Among the de-novo motifs discovered by DMF, HOMER,ChIPMunk, and ScanAll, only novel motifs are selected after comparison with known motif sets, and their clustering based on MACRO-APE resulted in169 novel and unique motifs. Their association to the promoter expression is evaluated in the same way to the JASPAR motif above<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data
library id: CNhs11741
Novel motif | Logo | P-value |
---|---|---|
1 | 1 | 0.0527 |
10 | 10 | 0.00685 |
100 | 100 | 0.103 |
101 | 101 | 0.211 |
102 | 102 | 0.71 |
103 | 103 | 0.542 |
104 | 104 | 0.772 |
105 | 105 | 0.747 |
106 | 106 | 0.704 |
107 | 107 | 0.568 |
108 | 108 | 0.741 |
109 | 109 | 0.404 |
11 | 11 | 0.0968 |
110 | 110 | 0.151 |
111 | 111 | 0.0356 |
112 | 112 | 0.721 |
113 | 113 | 0.782 |
114 | 114 | 0.491 |
115 | 115 | 0.35 |
116 | 116 | 0.598 |
117 | 117 | 0.0224 |
118 | 118 | 0.164 |
119 | 119 | 0.19 |
12 | 12 | 0.458 |
120 | 120 | 0.354 |
121 | 121 | 0.976 |
122 | 122 | 0.839 |
123 | 123 | 1.01965e-4 |
124 | 124 | 0.283 |
125 | 125 | 0.139 |
126 | 126 | 0.752 |
127 | 127 | 0.999 |
128 | 128 | 0.355 |
129 | 129 | 0.822 |
13 | 13 | 0.213 |
130 | 130 | 0.446 |
131 | 131 | 0.632 |
132 | 132 | 0.694 |
133 | 133 | 0.577 |
134 | 134 | 0.764 |
135 | 135 | 0.533 |
136 | 136 | 0.0823 |
137 | 137 | 0.856 |
138 | 138 | 0.506 |
139 | 139 | 0.281 |
14 | 14 | 0.847 |
140 | 140 | 0.289 |
141 | 141 | 0.0588 |
142 | 142 | 0.395 |
143 | 143 | 0.761 |
144 | 144 | 0.589 |
145 | 145 | 0.38 |
146 | 146 | 0.987 |
147 | 147 | 0.433 |
148 | 148 | 0.115 |
149 | 149 | 0.706 |
15 | 15 | 0.288 |
150 | 150 | 0.856 |
151 | 151 | 0.944 |
152 | 152 | 0.0119 |
153 | 153 | 0.869 |
154 | 154 | 0.747 |
155 | 155 | 0.017 |
156 | 156 | 0.7 |
157 | 157 | 0.246 |
158 | 158 | 0.853 |
159 | 159 | 0.316 |
16 | 16 | 0.647 |
160 | 160 | 0.322 |
161 | 161 | 0.0309 |
162 | 162 | 0.626 |
163 | 163 | 0.497 |
164 | 164 | 0.0565 |
165 | 165 | 0.882 |
166 | 166 | 0.979 |
167 | 167 | 0.0389 |
168 | 168 | 0.968 |
169 | 169 | 0.596 |
17 | 17 | 0.871 |
18 | 18 | 0.669 |
19 | 19 | 0.881 |
2 | 2 | 0.25 |
20 | 20 | 0.364 |
21 | 21 | 0.0453 |
22 | 22 | 0.433 |
23 | 23 | 0.073 |
24 | 24 | 0.818 |
25 | 25 | 0.0993 |
26 | 26 | 0.0326 |
27 | 27 | 0.99 |
28 | 28 | 0.939 |
29 | 29 | 0.0152 |
3 | 3 | 0.184 |
30 | 30 | 0.0749 |
31 | 31 | 0.839 |
32 | 32 | 0.651 |
33 | 33 | 0.599 |
34 | 34 | 0.338 |
35 | 35 | 0.179 |
36 | 36 | 0.052 |
37 | 37 | 0.657 |
38 | 38 | 0.651 |
39 | 39 | 0.268 |
4 | 4 | 0.529 |
40 | 40 | 0.298 |
41 | 41 | 0.817 |
42 | 42 | 0.205 |
43 | 43 | 0.615 |
44 | 44 | 0.0272 |
45 | 45 | 0.205 |
46 | 46 | 0.105 |
47 | 47 | 0.0429 |
48 | 48 | 0.123 |
49 | 49 | 0.132 |
5 | 5 | 0.66 |
50 | 50 | 0.835 |
51 | 51 | 0.671 |
52 | 52 | 0.183 |
53 | 53 | 0.65 |
54 | 54 | 0.837 |
55 | 55 | 0.442 |
56 | 56 | 0.95 |
57 | 57 | 0.0974 |
58 | 58 | 0.256 |
59 | 59 | 0.727 |
6 | 6 | 0.767 |
60 | 60 | 0.585 |
61 | 61 | 0.217 |
62 | 62 | 0.246 |
63 | 63 | 0.68 |
64 | 64 | 0.203 |
65 | 65 | 0.626 |
66 | 66 | 0.205 |
67 | 67 | 0.965 |
68 | 68 | 0.391 |
69 | 69 | 0.823 |
7 | 7 | 0.316 |
70 | 70 | 0.823 |
71 | 71 | 0.0215 |
72 | 72 | 0.726 |
73 | 73 | 0.356 |
74 | 74 | 0.854 |
75 | 75 | 0.00878 |
76 | 76 | 0.0382 |
77 | 77 | 0.293 |
78 | 78 | 0.221 |
79 | 79 | 0.563 |
8 | 8 | 0.133 |
80 | 80 | 0.283 |
81 | 81 | 0.11 |
82 | 82 | 0.96 |
83 | 83 | 0.966 |
84 | 84 | 0.911 |
85 | 85 | 0.14 |
86 | 86 | 0.583 |
87 | 87 | 0.431 |
88 | 88 | 0.861 |
89 | 89 | 0.691 |
9 | 9 | 0.295 |
90 | 90 | 8.97078e-4 |
91 | 91 | 0.569 |
92 | 92 | 0.25 |
93 | 93 | 0.919 |
94 | 94 | 0.427 |
95 | 95 | 0.456 |
96 | 96 | 0.876 |
97 | 97 | 0.0538 |
98 | 98 | 0.33 |
99 | 99 | 0.323 |
de novo motifs identified by HOMER in promoters active in this sample<b>Summary:</b>The result of HOMER in this sample is shown.<br><b>Analyst:</b>NA <br>
library id: CNhs11741
FANTOM5 (FF) ontology
Direct parent terms
is_a relathionship
CL:0000819 B-1 B cell
EFO:0002091 biological replicate
FF:0000210 human sample
FF:0102521 diffuse large B-cell lymphoma cell sample
Ancestor terms (non development)<b>Summary:</b>Connected ontology terms with is_a, part_of or located_in relationship <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source data<br>data
CL: Cell type
0000000 (cell), 0000000 (cell)
0000003 (native cell)
0000988 (hematopoietic cell)
0000548 (animal cell)
0002371 (somatic cell)
0000542 (lymphocyte)
0000219 (motile cell)
0000945 (lymphocyte of B lineage)
0000738 (leukocyte)
0002087 (nongranular leukocyte)
0002242 (nucleate cell)
0000255 (eukaryotic cell)
0000236 (B cell)
0000785 (mature B cell)
0000819 (B-1 B cell)
DOID: Disease
4 (disease)
0050686 (organ system cancer)
162 (cancer)
2531 (hematologic cancer)
0060058 (lymphoma)
14566 (disease of cellular proliferation)
0060083 (immune system cancer)
0060073 (lymphatic system cancer)
8675 (lymphosarcoma)
FF: FANTOM5
0000102 (sample by type)
0000003 (cell line sample)
0000210 (human sample)
0000101 (sample by species)
0000001 (sample)
0100104 (lymphoma cell line sample)
0101518 (B-lymphoma cell line sample)
0102521 (diffuse large B-cell lymphoma cell sample)
Ancestor terms (development)<b>Summary:</b>Connected ontology terms with develops_from, derives_from or preceded_by relationship <br><b>Analyst:</b> Hideya Kawaji <br><br>link to source data<br>data
CL:0000134 (mesenchymal cell)
CL:0000051 (common lymphoid progenitor)
CL:0000954 (small pre-B-II cell)