Coexpression cluster:C10

Full id: C10_occipital_temporal_parietal_brain_duodenum_Neurons_Neural

Phase1 CAGE Peaks

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Hg19::chr10:103880341..103880357,-	p9@LDB1
Hg19::chr10:104179450..104179484,-	p3@PSD
Hg19::chr10:104179492..104179507,-	p8@PSD
Hg19::chr10:104179682..104179717,-	p7@PSD
Hg19::chr10:105036887..105036903,+	p1@INA
Hg19::chr10:105036909..105036920,+	p3@INA
Hg19::chr10:10504250..10504278,+	p@chr10:10504250..10504278 +
Hg19::chr10:10504285..10504300,-	p2@ENST00000435106
Hg19::chr10:10504367..10504380,+	p@chr10:10504367..10504380 +
Hg19::chr10:10504464..10504475,+	p@chr10:10504464..10504475 +
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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p.value	FDR	nGenes	nPathway	Name
1.50639613609536e-06	0.000476774377074182	9	87	ErbB signaling pathway (KEGG):04012
4.03493974149437e-05	0.00363855950489331	9	130	Axon guidance (KEGG):04360
0.000140886082119045	0.00990898777570619	7	90	Gap junction (KEGG):04540
0.000248948414545059	0.0143258496733657	6	70	Long-term potentiation (KEGG):04720
4.51163032377388e-06	0.00095195399831629	10	126	Glutamatergic synapse (KEGG):04724
0.000540350719019034	0.028503500428254	7	112	Wnt Signaling Pathway NetPath (Wikipathways):WP363
0.000795690400175516	0.0387440017931617	3	15	GPCRs, Class C Metabotropic glutamate, pheromone (Wikipathways):WP501
4.59849542482566e-05	0.00363855950489331	5	32	Hypothetical Network for Drug Addiction (Wikipathways):WP666
8.01823943464713e-06	0.00101510911242633	12	197	Synaptic Transmission (Reactome):REACT_13685
5.4385689802965e-14	3.44261416452769e-11	24	265	Axon guidance (Reactome):REACT_18266
2.33856132254937e-05	0.00246718219528959	5	28	{DLG4,28} (Static Module):NA
0.000219863517977324	0.0139173606879646	3	10	{PAK2,10} (Static Module):NA
6.8388258594864e-06	0.00101510911242633	10	132	{RAC1,133} (Static Module):NA

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007399	nervous system development	0
GO:0048731	system development	3.42916750319792e-38
GO:0048856	anatomical structure development	3.66233684922925e-34
GO:0007275	multicellular organismal development	1.51604183866946e-30
GO:0032501	multicellular organismal process	3.53092113255232e-25
GO:0032502	developmental process	6.77432320723079e-25
GO:0030182	neuron differentiation	3.5557282734419e-16
GO:0005856	cytoskeleton	9.02523401205732e-16
GO:0048699	generation of neurons	6.64483131866011e-15
GO:0022008	neurogenesis	3.450544579738e-14
GO:0005515	protein binding	3.52779871747566e-14
GO:0044464	cell part	4.66400648694327e-13
GO:0048869	cellular developmental process	4.82965222239229e-13
GO:0030154	cell differentiation	4.82965222239229e-13
GO:0016020	membrane	6.70703301551283e-13
GO:0005886	plasma membrane	2.29518497285206e-12
GO:0007267	cell-cell signaling	2.90829318129329e-12
GO:0031175	neurite development	6.8168318272438e-12
GO:0016043	cellular component organization and biogenesis	1.80595350629252e-11
GO:0044425	membrane part	2.19105363050995e-11
GO:0048666	neuron development	4.64857080063647e-11
GO:0007010	cytoskeleton organization and biogenesis	5.27810979863882e-11
GO:0009653	anatomical structure morphogenesis	7.98231720510016e-11
GO:0008092	cytoskeletal protein binding	9.0025853354009e-11
GO:0000902	cell morphogenesis	9.10035609909797e-11
GO:0032989	cellular structure morphogenesis	9.10035609909797e-11
GO:0007154	cell communication	8.49180039197281e-10
GO:0007268	synaptic transmission	9.2065834010474e-10
GO:0007409	axonogenesis	1.50834744457238e-09
GO:0048858	cell projection morphogenesis	2.25711452284648e-09
GO:0032990	cell part morphogenesis	2.25711452284648e-09
GO:0030030	cell projection organization and biogenesis	2.25711452284648e-09
GO:0048667	neuron morphogenesis during differentiation	2.47960641877007e-09
GO:0048812	neurite morphogenesis	2.47960641877007e-09
GO:0000904	cellular morphogenesis during differentiation	4.47760845004081e-09
GO:0019226	transmission of nerve impulse	6.53387227446778e-09
GO:0031224	intrinsic to membrane	8.9114154883612e-09
GO:0044459	plasma membrane part	1.24743624720511e-08
GO:0030054	cell junction	1.2796607339596e-08
GO:0007417	central nervous system development	1.45911773509788e-08
GO:0016021	integral to membrane	1.45911773509788e-08
GO:0005737	cytoplasm	6.48839158082037e-08
GO:0007420	brain development	1.49530239446313e-07
GO:0007165	signal transduction	2.397293477489e-07
GO:0048468	cell development	3.91241223927337e-07
GO:0050789	regulation of biological process	8.58264685933664e-07
GO:0031114	regulation of microtubule depolymerization	8.71715035020438e-07
GO:0007026	negative regulation of microtubule depolymerization	8.71715035020438e-07
GO:0044424	intracellular part	9.8327962522705e-07
GO:0030295	protein kinase activator activity	1.08054308042338e-06
GO:0007019	microtubule depolymerization	1.08054308042338e-06
GO:0031111	negative regulation of microtubule polymerization or depolymerization	1.08054308042338e-06
GO:0043005	neuron projection	1.16449174378467e-06
GO:0065007	biological regulation	1.17555022143405e-06
GO:0051261	protein depolymerization	3.9839689816965e-06
GO:0007017	microtubule-based process	4.34238409436252e-06
GO:0031110	regulation of microtubule polymerization or depolymerization	4.43509360761182e-06
GO:0044456	synapse part	5.41727200793187e-06
GO:0031109	microtubule polymerization or depolymerization	7.99276122061449e-06
GO:0051129	negative regulation of cellular component organization and biogenesis	8.72132651833816e-06
GO:0050794	regulation of cellular process	8.72620938362211e-06
GO:0019209	kinase activator activity	8.94222759115674e-06
GO:0030426	growth cone	8.94222759115674e-06
GO:0005874	microtubule	1.14198782680398e-05
GO:0005622	intracellular	1.14198782680398e-05
GO:0030427	site of polarized growth	1.15000456113826e-05
GO:0007411	axon guidance	1.31339501353869e-05
GO:0007242	intracellular signaling cascade	1.39609022316097e-05
GO:0045211	postsynaptic membrane	1.88628029485488e-05
GO:0042995	cell projection	1.88628029485488e-05
GO:0015630	microtubule cytoskeleton	2.07344557160584e-05
GO:0004157	dihydropyrimidinase activity	5.16732416657154e-05
GO:0043228	non-membrane-bound organelle	6.08075555053569e-05
GO:0043232	intracellular non-membrane-bound organelle	6.08075555053569e-05
GO:0048523	negative regulation of cellular process	6.70586829170916e-05
GO:0005794	Golgi apparatus	6.70586829170916e-05
GO:0051248	negative regulation of protein metabolic process	7.63700270790536e-05
GO:0008021	synaptic vesicle	7.63700270790536e-05
GO:0019887	protein kinase regulator activity	8.00499495895361e-05
GO:0043226	organelle	8.26553474901764e-05
GO:0007163	establishment and/or maintenance of cell polarity	8.89723992926584e-05
GO:0043229	intracellular organelle	0.000140733398828741
GO:0006996	organelle organization and biogenesis	0.000141440384189975
GO:0048519	negative regulation of biological process	0.000163086275392608
GO:0043025	cell soma	0.000221870794344543
GO:0019207	kinase regulator activity	0.000222937724045669
GO:0031226	intrinsic to plasma membrane	0.000256283592696472
GO:0030159	receptor signaling complex scaffold activity	0.000259713722908952
GO:0048513	organ development	0.00027604822223895
GO:0030425	dendrite	0.000317005482636633
GO:0032947	protein complex scaffold	0.000392116652612512
GO:0015631	tubulin binding	0.000434867215621882
GO:0051128	regulation of cellular component organization and biogenesis	0.000465643828722441
GO:0007215	glutamate signaling pathway	0.000465643828722441
GO:0009892	negative regulation of metabolic process	0.000592315701652324
GO:0005887	integral to plasma membrane	0.000642634834106947
GO:0044430	cytoskeletal part	0.000735041808147006
GO:0019894	kinesin binding	0.00077130632065477
GO:0008017	microtubule binding	0.00101079337789295
GO:0030136	clathrin-coated vesicle	0.00106376615285904
GO:0045055	regulated secretory pathway	0.00144841610062207
GO:0044431	Golgi apparatus part	0.00148952086116649
GO:0000139	Golgi membrane	0.0015412146462981
GO:0012505	endomembrane system	0.00163451632020952
GO:0007218	neuropeptide signaling pathway	0.00177325011504058
GO:0042734	presynaptic membrane	0.00183099184926607
GO:0003779	actin binding	0.00214371155596119
GO:0006928	cell motility	0.00227375902564883
GO:0051674	localization of cell	0.00227375902564883
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	0.00227864865597557
GO:0051641	cellular localization	0.00251317441237717
GO:0005875	microtubule associated complex	0.00266508657201481
GO:0030424	axon	0.00272576136131084
GO:0051010	microtubule plus-end binding	0.00272576136131084
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	0.00272576136131084
GO:0005078	MAP-kinase scaffold activity	0.00272576136131084
GO:0016477	cell migration	0.00298121402305956
GO:0000226	microtubule cytoskeleton organization and biogenesis	0.00352907957177657
GO:0030135	coated vesicle	0.00408213018131941
GO:0003001	generation of a signal involved in cell-cell signaling	0.00454661699894548
GO:0007269	neurotransmitter secretion	0.00483651981731951
GO:0051246	regulation of protein metabolic process	0.00487381307161995
GO:0051649	establishment of cellular localization	0.00490493729234046
GO:0030971	receptor tyrosine kinase binding	0.00502924929939348
GO:0005828	kinetochore microtubule	0.00502924929939348
GO:0022610	biological adhesion	0.00539048178996356
GO:0007155	cell adhesion	0.00539048178996356
GO:0019222	regulation of metabolic process	0.00566045210233311
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	0.00627938142265481
GO:0019198	transmembrane receptor protein phosphatase activity	0.00627938142265481
GO:0001505	regulation of neurotransmitter levels	0.00685724278682288
GO:0017124	SH3 domain binding	0.0072278715921299
GO:0030695	GTPase regulator activity	0.00766673766676316
GO:0018065	protein-cofactor linkage	0.0077731373112513
GO:0005200	structural constituent of cytoskeleton	0.00977442865904356
GO:0019904	protein domain specific binding	0.00977442865904356
GO:0016524	latrotoxin receptor activity	0.0106075277809639
GO:0030296	protein tyrosine kinase activator activity	0.0112552299957482
GO:0007018	microtubule-based movement	0.0115703401418131
GO:0050793	regulation of developmental process	0.0126384934951925
GO:0009966	regulation of signal transduction	0.013237548769626
GO:0007264	small GTPase mediated signal transduction	0.0136080790256467
GO:0045045	secretory pathway	0.0137597429228049
GO:0008066	glutamate receptor activity	0.0144267813414993
GO:0050770	regulation of axonogenesis	0.0144267813414993
GO:0031301	integral to organelle membrane	0.0144794849764786
GO:0007158	neuron adhesion	0.0146063834955669
GO:0001578	microtubule bundle formation	0.0146063834955669
GO:0019899	enzyme binding	0.0157987679119271
GO:0051258	protein polymerization	0.0159461568274189
GO:0031982	vesicle	0.0161800661997234
GO:0008134	transcription factor binding	0.0161800661997234
GO:0005085	guanyl-nucleotide exchange factor activity	0.0168059667178649
GO:0030705	cytoskeleton-dependent intracellular transport	0.0169836482925688
GO:0022836	gated channel activity	0.0177901140393509
GO:0005881	cytoplasmic microtubule	0.018251067615488
GO:0003730	mRNA 3'-UTR binding	0.018251067615488
GO:0031300	intrinsic to organelle membrane	0.0208250063540242
GO:0046903	secretion	0.0208250063540242
GO:0002062	chondrocyte differentiation	0.0226322752557863
GO:0008047	enzyme activator activity	0.0226322752557863
GO:0019932	second-messenger-mediated signaling	0.0239151923102481
GO:0044422	organelle part	0.0245234818656668
GO:0003924	GTPase activity	0.0270188420115136
GO:0001540	beta-amyloid binding	0.0272827096468203
GO:0005083	small GTPase regulator activity	0.0292386846782992
GO:0051056	regulation of small GTPase mediated signal transduction	0.0295275304745269
GO:0005231	excitatory extracellular ligand-gated ion channel activity	0.0309693485069638
GO:0001764	neuron migration	0.0309693485069638
GO:0019717	synaptosome	0.0309693485069638
GO:0016247	channel regulator activity	0.0309693485069638
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.0309693485069638
GO:0005246	calcium channel regulator activity	0.0316009420462899
GO:0031988	membrane-bound vesicle	0.0343176994981004
GO:0008373	sialyltransferase activity	0.0350552337150717
GO:0050767	regulation of neurogenesis	0.0350552337150717
GO:0019935	cyclic-nucleotide-mediated signaling	0.0357379919857634
GO:0045767	regulation of anti-apoptosis	0.0360377507174353
GO:0016358	dendrite development	0.0360377507174353
GO:0030516	regulation of axon extension	0.0360377507174353
GO:0044446	intracellular organelle part	0.0360377507174353
GO:0050877	neurological system process	0.0360377507174353
GO:0031410	cytoplasmic vesicle	0.0364945411492439
GO:0032940	secretion by cell	0.0385177209255228
GO:0004860	protein kinase inhibitor activity	0.0385836920973071
GO:0045761	regulation of adenylate cyclase activity	0.0409239831444474
GO:0003712	transcription cofactor activity	0.0415760387557223
GO:0051339	regulation of lyase activity	0.0428830180717856
GO:0031279	regulation of cyclase activity	0.0428830180717856
GO:0019210	kinase inhibitor activity	0.0428830180717856
GO:0003008	system process	0.0438511399644669

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
neuronal stem cell	7.47e-10	8

Uber Anatomy

Ontology term	p-value	n
central nervous system	5.68e-108	81
neural tube	4.75e-107	56
neural rod	4.75e-107	56
future spinal cord	4.75e-107	56
neural keel	4.75e-107	56
nervous system	2.19e-103	89
regional part of nervous system	7.87e-99	53
regional part of brain	7.87e-99	53
regional part of forebrain	9.11e-86	41
forebrain	9.11e-86	41
anterior neural tube	9.11e-86	41
future forebrain	9.11e-86	41
brain	1.32e-85	68
future brain	1.32e-85	68
telencephalon	3.47e-82	34
brain grey matter	3.89e-82	34
gray matter	3.89e-82	34
cerebral hemisphere	5.49e-77	32
regional part of telencephalon	1.32e-76	32
neural plate	4.48e-73	82
presumptive neural plate	4.48e-73	82
neurectoderm	3.58e-69	86
regional part of cerebral cortex	1.84e-65	22
neocortex	2.85e-59	20
pre-chordal neural plate	3.06e-58	61
ecto-epithelium	7.17e-58	104
cerebral cortex	3.58e-57	25
pallium	3.58e-57	25
ectoderm-derived structure	1.82e-52	171
ectoderm	1.82e-52	171
presumptive ectoderm	1.82e-52	171
adult organism	2.47e-49	114
structure with developmental contribution from neural crest	2.08e-45	132
organ system subdivision	1.75e-37	223
basal ganglion	7.60e-27	9
nuclear complex of neuraxis	7.60e-27	9
aggregate regional part of brain	7.60e-27	9
collection of basal ganglia	7.60e-27	9
cerebral subcortex	7.60e-27	9
neural nucleus	5.73e-26	9
nucleus of brain	5.73e-26	9
tube	1.86e-23	192
posterior neural tube	1.46e-21	15
chordal neural plate	1.46e-21	15
telencephalic nucleus	1.18e-20	7
gyrus	1.59e-19	6
anatomical cluster	4.50e-19	373
brainstem	4.03e-17	6
temporal lobe	4.46e-17	6
limbic system	7.55e-17	5
occipital lobe	1.01e-16	5
parietal lobe	1.30e-16	5
anatomical conduit	1.56e-16	240
segmental subdivision of hindbrain	1.64e-14	12
hindbrain	1.64e-14	12
presumptive hindbrain	1.64e-14	12
segmental subdivision of nervous system	2.71e-13	13
corpus striatum	5.70e-13	4
striatum	5.70e-13	4
ventral part of telencephalon	5.70e-13	4
future corpus striatum	5.70e-13	4
organ part	2.73e-12	218
epithelium	4.35e-12	306
cell layer	7.32e-12	309
frontal cortex	7.54e-11	3
caudate-putamen	4.21e-10	3
dorsal striatum	4.21e-10	3
pons	1.16e-09	3
spinal cord	1.57e-09	3
dorsal region element	1.57e-09	3
dorsum	1.57e-09	3
medulla oblongata	3.62e-09	3
myelencephalon	3.62e-09	3
future myelencephalon	3.62e-09	3
multi-tissue structure	5.06e-09	342
regional part of metencephalon	3.48e-08	9
metencephalon	3.48e-08	9
future metencephalon	3.48e-08	9
germ layer	3.64e-08	560
germ layer / neural crest	3.64e-08	560
embryonic tissue	3.64e-08	560
presumptive structure	3.64e-08	560
germ layer / neural crest derived structure	3.64e-08	560
epiblast (generic)	3.64e-08	560
embryo	3.69e-08	592
embryonic structure	5.20e-08	564
developing anatomical structure	5.88e-08	581
amygdala	6.46e-08	2
middle frontal gyrus	8.41e-08	2
middle temporal gyrus	8.98e-08	2
Ammon's horn	9.28e-08	2
lobe parts of cerebral cortex	9.28e-08	2
hippocampal formation	9.28e-08	2
limbic lobe	9.28e-08	2
caudate nucleus	3.04e-07	2
future caudate nucleus	3.04e-07	2
anatomical system	5.06e-07	624
dorsal plus ventral thalamus	5.32e-07	2
locus ceruleus	5.32e-07	2

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
MA0003.1	14.7177
MA0004.1	0.00191132
MA0006.1	5.54178
MA0007.1	0.0103024
MA0009.1	0.191321
MA0014.1	31.4814
MA0017.1	5.56002e-07
MA0019.1	0.499776
MA0024.1	0.579643
MA0025.1	0.00962795
MA0027.1	0.429819
MA0028.1	4.10625e-05
MA0029.1	0.119621
MA0030.1	0.0117072
MA0031.1	0.00470435
MA0038.1	0.191964
MA0040.1	0.773826
MA0041.1	2.63229
MA0042.1	0.988746
MA0043.1	0.00183867
MA0046.1	0.0811989
MA0048.1	5.25117
MA0050.1	0.0191447
MA0051.1	0.292195
MA0052.1	0.477401
MA0055.1	7.72663
MA0056.1	0
MA0057.1	29.5526
MA0058.1	0.00021986
MA0059.1	0.186404
MA0060.1	1.09669e-05
MA0061.1	0.00342366
MA0063.1	0
MA0066.1	0.0103081
MA0067.1	0.0419852
MA0068.1	11.4949
MA0069.1	1.60384
MA0070.1	1.12385
MA0071.1	0.00215925
MA0072.1	0.451385
MA0073.1	88.1319
MA0074.1	0.168843
MA0076.1	1.06484e-11
MA0077.1	0.0481755
MA0078.1	0.350308
MA0081.1	0.00517247
MA0083.1	0.00226582
MA0084.1	0.249386
MA0087.1	0.211144
MA0088.1	2.02882
MA0089.1	0
MA0090.1	0.0218571
MA0091.1	0.0388117
MA0092.1	0.358043
MA0093.1	2.0262e-05
MA0095.1	0
MA0098.1	0
MA0100.1	0.00382596
MA0101.1	0.000354122
MA0103.1	0.00110273
MA0105.1	2.24296
MA0106.1	0.290051
MA0107.1	0.0019567
MA0108.2	0.0845114
MA0109.1	0
MA0111.1	0.328295
MA0113.1	0.0112866
MA0114.1	3.32851e-06
MA0115.1	0.000405533
MA0116.1	0.0444897
MA0117.1	0.757067
MA0119.1	0.00684639
MA0122.1	0.00444397
MA0124.1	0.429914
MA0125.1	0.247783
MA0130.1	0
MA0131.1	0.838394
MA0132.1	0
MA0133.1	0
MA0135.1	2.70799
MA0136.1	5.35787e-05
MA0139.1	1.60257
MA0140.1	0.000257168
MA0141.1	2.59045e-07
MA0142.1	0.0289298
MA0143.1	0.198345
MA0144.1	3.91842e-05
MA0145.1	0.000238594
MA0146.1	0.00695128
MA0147.1	1.04504
MA0148.1	0.112866
MA0149.1	17.5042
MA0062.2	2.46868e-14
MA0035.2	0.0124197
MA0039.2	9.6335
MA0138.2	0.852631
MA0002.2	3.58976e-09
MA0137.2	0.00431826
MA0104.2	2.34022
MA0047.2	0.0432939
MA0112.2	0.00548737
MA0065.2	0.239907
MA0150.1	7.80128e-08
MA0151.1	0
MA0152.1	0.8538
MA0153.1	0.202535
MA0154.1	0.000297303
MA0155.1	1.67766
MA0156.1	2.23595e-10
MA0157.1	0.00780596
MA0158.1	0
MA0159.1	0.0207527
MA0160.1	0.000174594
MA0161.1	0
MA0162.1	23.5685
MA0163.1	3.83027
MA0164.1	0.430656
MA0080.2	1.55706e-08
MA0018.2	0.00387809
MA0099.2	3.48515e-10
MA0079.2	179.87
MA0102.2	0.0387817
MA0258.1	5.12652e-05
MA0259.1	0.977634
MA0442.1	0

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CTBP2#1488	65	3.22516220099393	5.89293308213173e-16	1.12926979479772e-13
RAD21#5885	171	1.40087879440113	5.24778122595753e-06	0.000160536913725184
SUZ12#23512	85	3.37012767202559	1.1269426449015e-21	3.08106709138397e-19
ZNF263#10127	220	1.43101674061895	3.42365937445953e-08	2.28767473710287e-06

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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FF samples	Score

FF samples	Score
occipital lobe, fetal, donor1 CNhs11784	1.01
parietal lobe, fetal, donor1 CNhs11782	0.99
temporal lobe, fetal, donor1, tech_rep1 CNhs11772	0.97
duodenum, fetal, donor1, tech_rep2 CNhs12996	0.87
brain, fetal, pool1 CNhs11797	0.84
amygdala - adult, donor10196 CNhs13793	0.47
medial frontal gyrus - adult, donor10196 CNhs13796	0.44
occipital lobe, adult, donor1 CNhs11787	0.42
Neurons, donor1 CNhs12338	0.41
amygdala, adult, donor10252 CNhs12311	0.41

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