Coexpression cluster:C107

Full id: C107_Neutrophils_CD14_Eosinophils_Monocytederived_Whole_Peripheral_blood

Phase1 CAGE Peaks

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Hg19::chr10:30725492..30725508,+	p1@ENST00000517117
Hg19::chr10:36812448..36812461,+	p@chr10:36812448..36812461 +
Hg19::chr10:6268163..6268176,+	p@chr10:6268163..6268176 +
Hg19::chr10:70856882..70856896,+	p8@SRGN
Hg19::chr10:70863664..70863702,+	p@chr10:70863664..70863702 +
Hg19::chr10:70863704..70863715,+	p@chr10:70863704..70863715 +
Hg19::chr10:70863827..70863945,+	p@chr10:70863827..70863945 +
Hg19::chr10:70863991..70864065,+	p@chr10:70863991..70864065 +
Hg19::chr10:70864200..70864224,+	p@chr10:70864200..70864224 +
Hg19::chr10:70864321..70864461,+	p@chr10:70864321..70864461 +
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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p.value	FDR	nGenes	nPathway	Name
0.000399284027715807	0.0140414883080059	3	137	Natural killer cell mediated cytotoxicity (KEGG):04650
2.10806633184702e-05	0.00190629426865595	3	51	Malaria (KEGG):05144
2.7961012221032e-05	0.00221241509198916	3	56	Staphylococcus aureus infection (KEGG):05150
0.000827571050037749	0.0275711828775734	3	176	Influenza A (KEGG):05164
0.000123480847932684	0.00601256744164529	3	92	Rheumatoid arthritis (KEGG):05323
3.61744606966908e-05	0.00254427040233392	3	61	Selenium Pathway (Wikipathways):WP15
0.00137025589297375	0.039488154037708	2	52	Vitamin B12 Metabolism (Wikipathways):WP1533
0.000158098556145312	0.00667175906933219	3	100	Senescence and Autophagy (Wikipathways):WP615
0.00126753776840728	0.039488154037708	2	50	Type II interferon signaling (IFNG) (Wikipathways):WP619
0.000366113029826168	0.0136323263458803	3	133	T Cell Receptor Signaling Pathway (Wikipathways):WP69
1.31693457438319e-05	0.00138936597597427	6	511	Signaling in Immune system (Reactome):REACT_6900
0.00137241609609728	0.039488154037708	4	466	Hemostasis (Reactome):REACT_604
0.00017682353653931	0.00699558116433646	6	816	TGF beta receptor up reg. targets (Netpath):NetPath_7
6.13226721795312e-07	9.70431287241081e-05	8	728	TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9
5.64966556451738e-07	9.70431287241081e-05	5	155	IL-1 up reg. targets (Netpath):NetPath_13
8.17819163062055e-05	0.00431399608515234	5	433	IL-2 up reg. targets (Netpath):NetPath_14
1.31367905060236e-05	0.00138936597597427	5	295	IL-2 down reg. targets (Netpath):NetPath_14
7.62220659880978e-05	0.00431399608515234	4	217	IL-4 up reg. targets (Netpath):NetPath_16
4.63242987303954e-10	2.93232810963403e-07	6	90	IL-4 down reg. targets (Netpath):NetPath_16
2.44960860146816e-07	7.75301122364673e-05	5	131	IL-5 up reg. targets (Netpath):NetPath_17
8.14764635786901e-05	0.00431399608515234	3	80	IL-6 up reg. targets (Netpath):NetPath_18
0.00164389721031691	0.0452429101795916	2	57	IL-7 up reg. targets (Netpath):NetPath_19
0.000143788099166343	0.00650127619802109	2	17	{RARA,17} (Static Module):NA

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001816	cytokine production	2.2290398649873e-11
GO:0006952	defense response	5.433798875121e-06
GO:0009605	response to external stimulus	6.7497786026716e-06
GO:0006954	inflammatory response	1.96328965111205e-05
GO:0042035	regulation of cytokine biosynthetic process	2.0964285662949e-05
GO:0065007	biological regulation	2.0964285662949e-05
GO:0005515	protein binding	2.0964285662949e-05
GO:0042089	cytokine biosynthetic process	2.0964285662949e-05
GO:0042107	cytokine metabolic process	2.0964285662949e-05
GO:0042221	response to chemical stimulus	2.55364701945347e-05
GO:0009611	response to wounding	6.35925373718454e-05
GO:0002274	myeloid leukocyte activation	7.85130404390194e-05
GO:0045084	positive regulation of interleukin-12 biosynthetic process	9.83625055051188e-05
GO:0048519	negative regulation of biological process	0.000142006681156699
GO:0050789	regulation of biological process	0.000142006681156699
GO:0006955	immune response	0.000142006681156699
GO:0045075	regulation of interleukin-12 biosynthetic process	0.000142006681156699
GO:0042090	interleukin-12 biosynthetic process	0.000142006681156699
GO:0006950	response to stress	0.000153439360301109
GO:0042108	positive regulation of cytokine biosynthetic process	0.000170360441221724
GO:0042330	taxis	0.000173301283204169
GO:0006935	chemotaxis	0.000173301283204169
GO:0032615	interleukin-12 production	0.000277555723537233
GO:0031325	positive regulation of cellular metabolic process	0.000278623758926738
GO:0002376	immune system process	0.000278623758926738
GO:0045727	positive regulation of translation	0.000278623758926738
GO:0006366	transcription from RNA polymerase II promoter	0.000278623758926738
GO:0045321	leukocyte activation	0.000324159245032858
GO:0007626	locomotory behavior	0.000324159245032858
GO:0006417	regulation of translation	0.000326708765467945
GO:0009893	positive regulation of metabolic process	0.000326708765467945
GO:0031328	positive regulation of cellular biosynthetic process	0.000338234990026411
GO:0031326	regulation of cellular biosynthetic process	0.000413274490095933
GO:0032501	multicellular organismal process	0.000414243486747844
GO:0006357	regulation of transcription from RNA polymerase II promoter	0.000421937304622257
GO:0001775	cell activation	0.000458987569102588
GO:0009891	positive regulation of biosynthetic process	0.000465367139162871
GO:0009889	regulation of biosynthetic process	0.000492523719130039
GO:0048523	negative regulation of cellular process	0.000492523719130039
GO:0042088	T-helper 1 type immune response	0.000700069451730291
GO:0051247	positive regulation of protein metabolic process	0.000751520218800036
GO:0050794	regulation of cellular process	0.000814844471591072
GO:0045941	positive regulation of transcription	0.00118150492484849
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.00132280558750138
GO:0007610	behavior	0.00138184988058552
GO:0048522	positive regulation of cellular process	0.00151586155017615
GO:0009620	response to fungus	0.00153817121316647
GO:0050663	cytokine secretion	0.00167262002127017
GO:0010468	regulation of gene expression	0.00169125801383065
GO:0031323	regulation of cellular metabolic process	0.00209283920943127
GO:0048518	positive regulation of biological process	0.00245247638102661
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	0.00255052842973593
GO:0045185	maintenance of protein localization	0.00258323322401245
GO:0006355	regulation of transcription, DNA-dependent	0.00260130132644168
GO:0019222	regulation of metabolic process	0.00303547485230157
GO:0006351	transcription, DNA-dependent	0.00303547485230157
GO:0032774	RNA biosynthetic process	0.00303547485230157
GO:0048513	organ development	0.00317548114244536
GO:0051246	regulation of protein metabolic process	0.00418751893043749
GO:0045449	regulation of transcription	0.0046738062421673
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.00523251555619257
GO:0001817	regulation of cytokine production	0.00544137798478529
GO:0051235	maintenance of localization	0.00544137798478529
GO:0006350	transcription	0.0057694572000471
GO:0006915	apoptosis	0.0057694572000471
GO:0012501	programmed cell death	0.0057694572000471
GO:0051707	response to other organism	0.0057694572000471
GO:0010467	gene expression	0.0057694572000471
GO:0008219	cell death	0.0057694572000471
GO:0016265	death	0.0057694572000471
GO:0045893	positive regulation of transcription, DNA-dependent	0.0057694572000471
GO:0033371	T cell secretory granule organization and biogenesis	0.0057694572000471
GO:0033377	maintenance of protein localization in T cell secretory granule	0.0057694572000471
GO:0033365	protein localization in organelle	0.0057694572000471
GO:0033370	maintenance of protein localization in mast cell secretory granule	0.0057694572000471
GO:0002335	mature B cell differentiation	0.0057694572000471
GO:0033367	protein localization in mast cell secretory granule	0.0057694572000471
GO:0033366	protein localization in secretory granule	0.0057694572000471
GO:0002312	B cell activation during immune response	0.0057694572000471
GO:0016046	detection of fungus	0.0057694572000471
GO:0033382	maintenance of granzyme B localization in T cell secretory granule	0.0057694572000471
GO:0033373	maintenance of protease localization in mast cell secretory granule	0.0057694572000471
GO:0033380	granzyme B localization in T cell secretory granule	0.0057694572000471
GO:0033379	maintenance of protease localization in T cell secretory granule	0.0057694572000471
GO:0032996	Bcl3-Bcl10 complex	0.0057694572000471
GO:0033364	mast cell secretory granule organization and biogenesis	0.0057694572000471
GO:0008383	manganese superoxide dismutase activity	0.0057694572000471
GO:0033368	protease localization in mast cell secretory granule	0.0057694572000471
GO:0002313	mature B cell differentiation during immune response	0.0057694572000471
GO:0019371	cyclooxygenase pathway	0.0057694572000471
GO:0033374	protein localization in T cell secretory granule	0.0057694572000471
GO:0033375	protease localization in T cell secretory granule	0.0057694572000471
GO:0002315	marginal zone B cell differentiation	0.0057694572000471
GO:0043066	negative regulation of apoptosis	0.00590418382699472
GO:0043069	negative regulation of programmed cell death	0.00606776012889687
GO:0009306	protein secretion	0.00689378387994926
GO:0032502	developmental process	0.00702996740489555
GO:0016070	RNA metabolic process	0.00795523672046586
GO:0030155	regulation of cell adhesion	0.00894330730733729
GO:0019932	second-messenger-mediated signaling	0.00894749628732592
GO:0002268	follicular dendritic cell differentiation	0.00971286054594151
GO:0033257	Bcl3/NF-kappaB2 complex	0.00971286054594151
GO:0042629	mast cell granule	0.00971286054594151
GO:0033363	secretory granule organization and biogenesis	0.00971286054594151
GO:0046696	lipopolysaccharide receptor complex	0.00971286054594151
GO:0033256	I-kappaB/NF-kappaB complex	0.00971286054594151
GO:0002266	follicular dendritic cell activation	0.00971286054594151
GO:0005153	interleukin-8 receptor binding	0.00971286054594151
GO:0001315	age-dependent response to reactive oxygen species	0.00971286054594151
GO:0045415	negative regulation of interleukin-8 biosynthetic process	0.00971286054594151
GO:0007165	signal transduction	0.00971286054594151
GO:0048731	system development	0.00982317753055583
GO:0009607	response to biotic stimulus	0.00982317753055583
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.0101775419916928
GO:0002250	adaptive immune response	0.0101775419916928
GO:0051649	establishment of cellular localization	0.0103766203444414
GO:0051641	cellular localization	0.0114864701962215
GO:0007275	multicellular organismal development	0.0118899996931101
GO:0050858	negative regulation of antigen receptor-mediated signaling pathway	0.0124682133320994
GO:0045082	positive regulation of interleukin-10 biosynthetic process	0.0124682133320994
GO:0004944	C5a anaphylatoxin receptor activity	0.0124682133320994
GO:0010225	response to UV-C	0.0124682133320994
GO:0001530	lipopolysaccharide binding	0.0124682133320994
GO:0004666	prostaglandin-endoperoxide synthase activity	0.0124682133320994
GO:0050860	negative regulation of T cell receptor signaling pathway	0.0124682133320994
GO:0042091	interleukin-10 biosynthetic process	0.0124682133320994
GO:0019730	antimicrobial humoral response	0.0124682133320994
GO:0045074	regulation of interleukin-10 biosynthetic process	0.0124682133320994
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	0.0124682133320994
GO:0002521	leukocyte differentiation	0.0125621045497277
GO:0051704	multi-organism process	0.012643356332854
GO:0030674	protein binding, bridging	0.012643356332854
GO:0043405	regulation of MAP kinase activity	0.013095735842446
GO:0042742	defense response to bacterium	0.0135523882118116
GO:0008283	cell proliferation	0.0141965606161204
GO:0048869	cellular developmental process	0.0141965606161204
GO:0030154	cell differentiation	0.0141965606161204
GO:0007154	cell communication	0.0141965606161204
GO:0048468	cell development	0.0141965606161204
GO:0005087	Ran guanyl-nucleotide exchange factor activity	0.0141965606161204
GO:0002467	germinal center formation	0.0141965606161204
GO:0045091	regulation of retroviral genome replication	0.0141965606161204
GO:0019369	arachidonic acid metabolic process	0.0141965606161204
GO:0004942	anaphylatoxin receptor activity	0.0141965606161204
GO:0001892	embryonic placenta development	0.0141965606161204
GO:0004992	platelet activating factor receptor activity	0.0141965606161204
GO:0000303	response to superoxide	0.0141965606161204
GO:0042832	defense response to protozoan	0.0141965606161204
GO:0050710	negative regulation of cytokine secretion	0.0141965606161204
GO:0030502	negative regulation of bone mineralization	0.0141965606161204
GO:0048536	spleen development	0.0141965606161204
GO:0009617	response to bacterium	0.0148078715922745
GO:0007243	protein kinase cascade	0.0152684925342779
GO:0005737	cytoplasm	0.0163191090114548
GO:0042640	anagen	0.016636871488105
GO:0051457	maintenance of protein localization in nucleus	0.016636871488105
GO:0045064	T-helper 2 cell differentiation	0.016636871488105
GO:0032613	interleukin-10 production	0.016636871488105
GO:0001562	response to protozoan	0.016636871488105
GO:0032729	positive regulation of interferon-gamma production	0.016636871488105
GO:0000305	response to oxygen radical	0.016636871488105
GO:0006979	response to oxidative stress	0.0176996877048507
GO:0007242	intracellular signaling cascade	0.0185885031211321
GO:0032649	regulation of interferon-gamma production	0.0191248024712713
GO:0050709	negative regulation of protein secretion	0.0191248024712713
GO:0045090	retroviral genome replication	0.0191248024712713
GO:0042119	neutrophil activation	0.0191248024712713
GO:0050856	regulation of T cell receptor signaling pathway	0.0191248024712713
GO:0048015	phosphoinositide-mediated signaling	0.0195290363614825
GO:0048856	anatomical structure development	0.0196642202669524
GO:0048820	hair follicle maturation	0.0217847238095414
GO:0045671	negative regulation of osteoclast differentiation	0.0217847238095414
GO:0007249	I-kappaB kinase/NF-kappaB cascade	0.0220501452142255
GO:0045184	establishment of protein localization	0.0236494678176184
GO:0045414	regulation of interleukin-8 biosynthetic process	0.0236494678176184
GO:0030279	negative regulation of ossification	0.0236494678176184
GO:0045576	mast cell activation	0.0236494678176184
GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	0.0236494678176184
GO:0042534	regulation of tumor necrosis factor biosynthetic process	0.0236494678176184
GO:0042533	tumor necrosis factor biosynthetic process	0.0236494678176184
GO:0050930	induction of positive chemotaxis	0.0236494678176184
GO:0043231	intracellular membrane-bound organelle	0.0254693686739627
GO:0043227	membrane-bound organelle	0.0254693686739627
GO:0045670	regulation of osteoclast differentiation	0.0254693686739627
GO:0042116	macrophage activation	0.0254693686739627
GO:0042228	interleukin-8 biosynthetic process	0.0254693686739627
GO:0002762	negative regulation of myeloid leukocyte differentiation	0.0254693686739627
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	0.0254693686739627
GO:0004784	superoxide dismutase activity	0.0254693686739627
GO:0008104	protein localization	0.0257040568900661
GO:0030097	hemopoiesis	0.0257040568900661
GO:0044424	intracellular part	0.0257040568900661
GO:0050926	regulation of positive chemotaxis	0.0257040568900661
GO:0045408	regulation of interleukin-6 biosynthetic process	0.0257040568900661
GO:0001516	prostaglandin biosynthetic process	0.0257040568900661
GO:0002286	T cell activation during immune response	0.0257040568900661
GO:0050854	regulation of antigen receptor-mediated signaling pathway	0.0257040568900661
GO:0046457	prostanoid biosynthetic process	0.0257040568900661
GO:0002292	T cell differentiation during immune response	0.0257040568900661
GO:0002293	alpha-beta T cell differentiation during immune response	0.0257040568900661
GO:0002263	cell activation during immune response	0.0257040568900661
GO:0002294	CD4-positive, alpha-beta T cell differentiation during immune response	0.0257040568900661
GO:0042092	T-helper 2 type immune response	0.0257040568900661
GO:0042093	T-helper cell differentiation	0.0257040568900661
GO:0002366	leukocyte activation during immune response	0.0257040568900661
GO:0002285	lymphocyte activation during immune response	0.0257040568900661
GO:0050927	positive regulation of positive chemotaxis	0.0257040568900661
GO:0050918	positive chemotaxis	0.0257040568900661
GO:0048534	hemopoietic or lymphoid organ development	0.0272051820618708
GO:0050921	positive regulation of chemotaxis	0.0272051820618708
GO:0051101	regulation of DNA binding	0.0272051820618708
GO:0043367	CD4-positive, alpha beta T cell differentiation	0.0272051820618708
GO:0046851	negative regulation of bone remodeling	0.0272051820618708
GO:0030316	osteoclast differentiation	0.0272051820618708
GO:0032637	interleukin-8 production	0.0272051820618708
GO:0030500	regulation of bone mineralization	0.0272051820618708
GO:0033036	macromolecule localization	0.0272051820618708
GO:0005615	extracellular space	0.027363362714516
GO:0002520	immune system development	0.0283656632143117
GO:0050920	regulation of chemotaxis	0.0283656632143117
GO:0042348	NF-kappaB import into nucleus	0.0283656632143117
GO:0042226	interleukin-6 biosynthetic process	0.0283656632143117
GO:0030593	neutrophil chemotaxis	0.0283656632143117
GO:0051605	protein maturation via proteolysis	0.0283656632143117
GO:0042345	regulation of NF-kappaB import into nucleus	0.0283656632143117
GO:0050832	defense response to fungus	0.0283656632143117
GO:0001836	release of cytochrome c from mitochondria	0.0303148621582159
GO:0032640	tumor necrosis factor production	0.0303148621582159
GO:0045069	regulation of viral genome replication	0.0303148621582159
GO:0042981	regulation of apoptosis	0.0319019423321378
GO:0051604	protein maturation	0.0322118294305836
GO:0009595	detection of biotic stimulus	0.0322118294305836
GO:0043067	regulation of programmed cell death	0.032391407482829
GO:0005764	lysosome	0.0331077455322376
GO:0000323	lytic vacuole	0.0332796856566326
GO:0032635	interleukin-6 production	0.0336292571048591
GO:0001890	placenta development	0.0336292571048591
GO:0002761	regulation of myeloid leukocyte differentiation	0.0336292571048591
GO:0030330	DNA damage response, signal transduction by p53 class mediator	0.034832489986551
GO:0050707	regulation of cytokine secretion	0.034832489986551
GO:0046632	alpha-beta T cell differentiation	0.034832489986551
GO:0042036	negative regulation of cytokine biosynthetic process	0.034832489986551
GO:0007202	phospholipase C activation	0.034832489986551
GO:0016050	vesicle organization and biogenesis	0.034832489986551
GO:0045444	fat cell differentiation	0.034832489986551
GO:0006917	induction of apoptosis	0.0348486356483192
GO:0012502	induction of programmed cell death	0.0350188135331035
GO:0016564	transcription repressor activity	0.0351888414433236
GO:0050792	regulation of viral reproduction	0.0356839973157255
GO:0050852	T cell receptor signaling pathway	0.0356839973157255
GO:0006692	prostanoid metabolic process	0.0356839973157255
GO:0031901	early endosome membrane	0.0356839973157255
GO:0051048	negative regulation of secretion	0.0356839973157255
GO:0006693	prostaglandin metabolic process	0.0356839973157255
GO:0022405	hair cycle process	0.0364856949867669
GO:0032609	interferon-gamma production	0.0364856949867669
GO:0042633	hair cycle	0.0364856949867669
GO:0022404	molting cycle process	0.0364856949867669
GO:0001942	hair follicle development	0.0364856949867669
GO:0042303	molting cycle	0.0364856949867669
GO:0045638	negative regulation of myeloid cell differentiation	0.0364856949867669
GO:0008285	negative regulation of cell proliferation	0.0364856949867669
GO:0045786	negative regulation of progression through cell cycle	0.0364856949867669
GO:0016043	cellular component organization and biogenesis	0.0366472503545525
GO:0046631	alpha-beta T cell activation	0.0377687402963367
GO:0030278	regulation of ossification	0.0377687402963367
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	0.0377687402963367
GO:0008637	apoptotic mitochondrial changes	0.0377687402963367
GO:0005773	vacuole	0.038105137103877
GO:0045859	regulation of protein kinase activity	0.0390129481834106
GO:0042542	response to hydrogen peroxide	0.0390129481834106
GO:0030282	bone mineralization	0.0390129481834106
GO:0005626	insoluble fraction	0.0390129481834106
GO:0006412	translation	0.0390929441439382
GO:0043549	regulation of kinase activity	0.0400328905409625
GO:0006801	superoxide metabolic process	0.0402108885406451
GO:0042990	regulation of transcription factor import into nucleus	0.0402108885406451
GO:0042991	transcription factor import into nucleus	0.0402108885406451
GO:0065009	regulation of a molecular function	0.0406298812614006
GO:0051338	regulation of transferase activity	0.0408596433951566
GO:0033157	regulation of intracellular protein transport	0.041219363387219
GO:0042306	regulation of protein import into nucleus	0.041219363387219
GO:0030139	endocytic vesicle	0.041219363387219
GO:0000060	protein import into nucleus, translocation	0.041219363387219
GO:0001819	positive regulation of cytokine production	0.0426329487877967
GO:0030595	leukocyte chemotaxis	0.0426329487877967
GO:0043065	positive regulation of apoptosis	0.0426329487877967
GO:0043068	positive regulation of programmed cell death	0.0431091079967831
GO:0046850	regulation of bone remodeling	0.0439882509742389
GO:0032507	maintenance of cellular protein localization	0.0439882509742389
GO:0044249	cellular biosynthetic process	0.0439882509742389
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0439882509742389
GO:0031347	regulation of defense response	0.0447366974570079
GO:0050727	regulation of inflammatory response	0.0447366974570079
GO:0032386	regulation of intracellular transport	0.0447366974570079
GO:0051241	negative regulation of multicellular organismal process	0.0447366974570079
GO:0051651	maintenance of cellular localization	0.0447366974570079
GO:0050708	regulation of protein secretion	0.0461966376457733
GO:0016599	caveolar membrane	0.0461966376457733
GO:0051239	regulation of multicellular organismal process	0.0472621212070386
GO:0000302	response to reactive oxygen species	0.0474780523200585
GO:0050851	antigen receptor-mediated signaling pathway	0.0474780523200585
GO:0005887	integral to plasma membrane	0.0485736303885399
GO:0016044	membrane organization and biogenesis	0.0485736303885399
GO:0051223	regulation of protein transport	0.0485736303885399
GO:0051098	regulation of binding	0.0485736303885399
GO:0031226	intrinsic to plasma membrane	0.0494799751479102
GO:0046822	regulation of nucleocytoplasmic transport	0.0494799751479102
GO:0019079	viral genome replication	0.0494799751479102
GO:0005901	caveola	0.0494799751479102
GO:0030183	B cell differentiation	0.0494799751479102

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
classical monocyte	4.05e-93	42
CD14-positive, CD16-negative classical monocyte	4.05e-93	42
defensive cell	1.34e-92	48
phagocyte	1.34e-92	48
myeloid leukocyte	3.56e-88	72
macrophage dendritic cell progenitor	1.18e-78	61
monopoietic cell	3.87e-78	59
monocyte	3.87e-78	59
monoblast	3.87e-78	59
promonocyte	3.87e-78	59
granulocyte monocyte progenitor cell	9.75e-77	67
myeloid lineage restricted progenitor cell	9.43e-75	66
leukocyte	1.49e-67	136
nongranular leukocyte	1.80e-59	115
myeloid cell	2.99e-56	108
common myeloid progenitor	2.99e-56	108
hematopoietic lineage restricted progenitor cell	4.53e-56	120
hematopoietic stem cell	1.88e-51	168
angioblastic mesenchymal cell	1.88e-51	168
hematopoietic oligopotent progenitor cell	9.75e-49	161
hematopoietic multipotent progenitor cell	9.75e-49	161
hematopoietic cell	5.75e-48	177
stuff accumulating cell	3.71e-45	87
intermediate monocyte	1.38e-15	9
CD14-positive, CD16-positive monocyte	1.38e-15	9
mesenchymal cell	1.81e-15	354
connective tissue cell	7.61e-15	361
motile cell	1.18e-12	386
granulocyte	3.83e-11	8
multi fate stem cell	5.25e-10	427
somatic stem cell	1.21e-09	433
stem cell	3.54e-09	441
neutrophil	7.78e-09	3
blood cell	7.21e-08	11
single nucleate cell	1.02e-07	3
mononuclear cell	1.02e-07	3
natural killer cell	2.50e-07	3
pro-NK cell	2.50e-07	3

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	1.37e-78	98
blood island	1.37e-78	98
hemolymphoid system	7.29e-70	108
bone marrow	4.31e-66	76
bone element	2.79e-60	82
immune system	2.16e-58	93
skeletal element	9.94e-54	90
skeletal system	5.26e-47	100
lateral plate mesoderm	6.08e-31	203
musculoskeletal system	9.54e-23	167
mesoderm	4.69e-15	315
mesoderm-derived structure	4.69e-15	315
presumptive mesoderm	4.69e-15	315
connective tissue	5.38e-14	371
blood	3.21e-11	15
haemolymphatic fluid	3.21e-11	15
organism substance	3.21e-11	15

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
MA0003.1	2.81584e-14
MA0004.1	0.00608749
MA0006.1	0.113957
MA0007.1	0.0281868
MA0009.1	0.264004
MA0014.1	8.19678e-15
MA0017.1	0.147413
MA0019.1	0.505921
MA0024.1	0.0531496
MA0025.1	0.810886
MA0027.1	1.19827
MA0028.1	0.000465746
MA0029.1	0.061567
MA0030.1	0.15241
MA0031.1	0.207764
MA0038.1	0.0726003
MA0040.1	2.01726
MA0041.1	0.880288
MA0042.1	1.85959
MA0043.1	0.26442
MA0046.1	0.0236623
MA0048.1	0.00356235
MA0050.1	0.180328
MA0051.1	0.350482
MA0052.1	0.0661032
MA0055.1	0.000400034
MA0056.1	0
MA0057.1	0.000181905
MA0058.1	0.00580739
MA0059.1	0.295979
MA0060.1	5.96131e-07
MA0061.1	0.190684
MA0063.1	0
MA0066.1	0.139439
MA0067.1	0.133805
MA0068.1	0.371628
MA0069.1	0.244931
MA0070.1	0.0926055
MA0071.1	0.0910146
MA0072.1	0.225438
MA0073.1	0.107122
MA0074.1	0.0299644
MA0076.1	0.0194468
MA0077.1	0.415001
MA0078.1	0.181204
MA0081.1	0.052354
MA0083.1	0.0270626
MA0084.1	1.2573
MA0087.1	1.02465
MA0088.1	0.0151452
MA0089.1	0
MA0090.1	0.310707
MA0091.1	0.00640894
MA0092.1	0.924791
MA0093.1	0.000973146
MA0095.1	0
MA0098.1	0
MA0100.1	0.0847493
MA0101.1	0.0832564
MA0103.1	0.369407
MA0105.1	0.0659236
MA0106.1	0.112385
MA0107.1	0.136111
MA0108.2	0.363761
MA0109.1	0
MA0111.1	0.637802
MA0113.1	0.549833
MA0114.1	0.083889
MA0115.1	0.325356
MA0116.1	0.0147633
MA0117.1	0.0332939
MA0119.1	0.0383641
MA0122.1	0.354237
MA0124.1	0.990124
MA0125.1	0.197644
MA0130.1	0
MA0131.1	0.0449409
MA0132.1	0
MA0133.1	0
MA0135.1	0.305544
MA0136.1	0.0786254
MA0139.1	0.000507373
MA0140.1	0.0433463
MA0141.1	0.394054
MA0142.1	0.492028
MA0143.1	0.373639
MA0144.1	0.173234
MA0145.1	0.000349724
MA0146.1	0.00145119
MA0147.1	0.0289542
MA0148.1	0.392786
MA0149.1	0.492889
MA0062.2	4.61243e-06
MA0035.2	0.251265
MA0039.2	4.65495e-09
MA0138.2	0.183007
MA0002.2	0.868621
MA0137.2	0.430129
MA0104.2	0.000801925
MA0047.2	0.859789
MA0112.2	0.0706781
MA0065.2	0.0888801
MA0150.1	1.04727
MA0151.1	0
MA0152.1	0.74957
MA0153.1	0.0486099
MA0154.1	0.00378425
MA0155.1	0.00953078
MA0156.1	0.00515154
MA0157.1	0.418652
MA0158.1	0
MA0159.1	0.0755506
MA0160.1	0.612112
MA0161.1	0
MA0162.1	1.15719e-15
MA0163.1	4.14228e-05
MA0164.1	0.407414
MA0080.2	0.120586
MA0018.2	0.206319
MA0099.2	0.168756
MA0079.2	0
MA0102.2	0.265831
MA0258.1	0.50732
MA0259.1	0.00102101
MA0442.1	0

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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FF samples	Score

FF samples	Score
Neutrophils, donor2 CNhs11959	1.16
CD14+ monocytes - treated with Salmonella, donor1 CNhs13471	0.92
CD14+ monocytes - treated with Group A streptococci, donor1 CNhs13469	0.83
CD14+ monocytes - treated with Trehalose dimycolate (TDM), donor1 CNhs13467	0.78
CD14+ monocytes - treated with lipopolysaccharide, donor1 CNhs13470	0.77
CD14+ monocytes - treated with BCG, donor1 CNhs13465	0.76
CD14+ monocytes - treated with Trehalose dimycolate (TDM), donor2 CNhs13483	0.76
CD14+ monocytes - treated with Group A streptococci, donor3 CNhs13492	0.74
Neutrophils, donor1 CNhs10862	0.74
CD14+ monocytes - treated with Salmonella, donor3 CNhs13493	0.73

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