Coexpression cluster:C21

Full id: C21_cord_mycosis_hairy_xeroderma_adult_CD4_anaplastic

Phase1 CAGE Peaks

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Hg19::chr10:104156169..104156178,+	p@chr10:104156169..104156178 +
Hg19::chr10:109196502..109196516,-	p@chr10:109196502..109196516 -
Hg19::chr10:109197927..109197930,+	p@chr10:109197927..109197930 +
Hg19::chr10:109197952..109197957,+	p@chr10:109197952..109197957 +
Hg19::chr10:111190236..111190244,-	p@chr10:111190236..111190244 -
Hg19::chr10:111805635..111805642,-	p@chr10:111805635..111805642 -
Hg19::chr10:111805643..111805655,-	p@chr10:111805643..111805655 -
Hg19::chr10:11363142..11363166,+	p2@AF086447
Hg19::chr10:115478975..115478993,+	p12@CASP7
Hg19::chr10:116126820..116126833,-	p@chr10:116126820..116126833 -
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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p.value	FDR	nGenes	nPathway	Name
4.41958396189096e-06	0.00139879832393849	8	265	Cytokine-cytokine receptor interaction (KEGG):04060
0.000241538166127314	0.0117610507045069	4	86	Apoptosis (KEGG):04210
0.000463117162386291	0.0172443037523837	4	102	Toll-like receptor signaling pathway (KEGG):04620
1.82044243043083e-05	0.00230468011692542	6	155	Jak-STAT signaling pathway (KEGG):04630
0.000531913374485444	0.0187056203360715	3	45	Type I diabetes mellitus (KEGG):04940
0.000375081676360726	0.0158284467424226	3	40	NOD pathway (Wikipathways):WP1433
0.00150961754034394	0.0455041858589388	4	140	Regulation of toll-like receptor signaling pathway (Wikipathways):WP1449
0.000230920835147294	0.0117610507045069	4	85	Apoptosis (Wikipathways):WP254
0.000219923213271195	0.0117610507045069	5	155	Myometrial Relaxation and Contraction Pathways (Wikipathways):WP289
0.00017459328686974	0.0110517550588545	3	31	Inflammatory Response Pathway (Wikipathways):WP453
0.000463117162386291	0.0172443037523837	4	102	Toll-like receptor signaling pathway (Wikipathways):WP75
0.000588150706077688	0.019594705102483	10	816	TGF beta receptor up reg. targets (Netpath):NetPath_7
4.97466751400034e-05	0.00449852076623173	11	728	TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9
2.17842981574292e-07	0.000137894607336527	9	246	B Cell Receptor up reg. targets (Netpath):NetPath_12
7.58861832697053e-05	0.00600449425121543	7	291	T Cell Receptor up reg. targets (Netpath):NetPath_11
0.000144747517990267	0.0101805754319821	8	433	IL-2 up reg. targets (Netpath):NetPath_14
1.17592115203798e-05	0.0018608952231001	4	40	IL-3 up reg. targets (Netpath):NetPath_15
6.9703067792969e-06	0.00147073473043165	6	131	IL-5 up reg. targets (Netpath):NetPath_17
4.85589573567309e-05	0.00449852076623173	4	57	IL-7 up reg. targets (Netpath):NetPath_19
0.00065459895882015	0.0207180570466577	2	11	{SRF,11} (Static Module):NA
0.000287540278442325	0.0130009283038565	4	90	{TRAF2,90} (Static Module):NA

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0032502	developmental process	1.49500774582632e-07
GO:0048869	cellular developmental process	8.43475544657594e-06
GO:0030154	cell differentiation	8.43475544657594e-06
GO:0042108	positive regulation of cytokine biosynthetic process	1.58861084478819e-05
GO:0042981	regulation of apoptosis	3.01525924034047e-05
GO:0045727	positive regulation of translation	3.01525924034047e-05
GO:0043067	regulation of programmed cell death	3.01525924034047e-05
GO:0048856	anatomical structure development	3.01525924034047e-05
GO:0006915	apoptosis	3.01525924034047e-05
GO:0012501	programmed cell death	3.01525924034047e-05
GO:0042035	regulation of cytokine biosynthetic process	3.38194740179612e-05
GO:0031328	positive regulation of cellular biosynthetic process	3.38194740179612e-05
GO:0001816	cytokine production	3.38194740179612e-05
GO:0048518	positive regulation of biological process	3.38194740179612e-05
GO:0008219	cell death	3.38194740179612e-05
GO:0016265	death	3.38194740179612e-05
GO:0048468	cell development	3.43848244501795e-05
GO:0032501	multicellular organismal process	3.97653286535832e-05
GO:0042089	cytokine biosynthetic process	4.08793527046365e-05
GO:0042107	cytokine metabolic process	4.18323821284317e-05
GO:0048522	positive regulation of cellular process	4.39751204868381e-05
GO:0009891	positive regulation of biosynthetic process	4.39751204868381e-05
GO:0048523	negative regulation of cellular process	4.99493055698714e-05
GO:0048519	negative regulation of biological process	7.53024843162657e-05
GO:0006955	immune response	7.74224758446347e-05
GO:0002376	immune system process	8.7316395532495e-05
GO:0051247	positive regulation of protein metabolic process	9.41933570233053e-05
GO:0005515	protein binding	0.000110919809929319
GO:0050789	regulation of biological process	0.000125913431002938
GO:0043065	positive regulation of apoptosis	0.000140457546105976
GO:0043068	positive regulation of programmed cell death	0.000143032072665523
GO:0007275	multicellular organismal development	0.000200032693877108
GO:0048513	organ development	0.000200032693877108
GO:0006417	regulation of translation	0.000225269985772436
GO:0007154	cell communication	0.000332174770939847
GO:0031326	regulation of cellular biosynthetic process	0.000332174770939847
GO:0009889	regulation of biosynthetic process	0.000526917710568071
GO:0050794	regulation of cellular process	0.000603718383726097
GO:0045624	positive regulation of T-helper cell differentiation	0.000893072188027579
GO:0031325	positive regulation of cellular metabolic process	0.00103079348207043
GO:0044464	cell part	0.0011409662857749
GO:0065007	biological regulation	0.00114619649860008
GO:0048731	system development	0.00128764694845305
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	0.00131708534439334
GO:0009893	positive regulation of metabolic process	0.001410548363818
GO:0014706	striated muscle development	0.00158449807157633
GO:0007165	signal transduction	0.00161768696755108
GO:0004907	interleukin receptor activity	0.00173447883537934
GO:0045622	regulation of T-helper cell differentiation	0.00247527565454036
GO:0019965	interleukin binding	0.00271848924205856
GO:0048741	skeletal muscle fiber development	0.00298972826275766
GO:0048747	muscle fiber development	0.00298972826275766
GO:0042534	regulation of tumor necrosis factor biosynthetic process	0.00298972826275766
GO:0042533	tumor necrosis factor biosynthetic process	0.00298972826275766
GO:0044424	intracellular part	0.00316563976687119
GO:0001775	cell activation	0.00340958086088433
GO:0006917	induction of apoptosis	0.00353252198552042
GO:0042692	muscle cell differentiation	0.00353252198552042
GO:0012502	induction of programmed cell death	0.00353252198552042
GO:0002286	T cell activation during immune response	0.00385957739445904
GO:0002292	T cell differentiation during immune response	0.00385957739445904
GO:0002293	alpha-beta T cell differentiation during immune response	0.00385957739445904
GO:0002263	cell activation during immune response	0.00385957739445904
GO:0002294	CD4-positive, alpha-beta T cell differentiation during immune response	0.00385957739445904
GO:0042093	T-helper cell differentiation	0.00385957739445904
GO:0002366	leukocyte activation during immune response	0.00385957739445904
GO:0002285	lymphocyte activation during immune response	0.00385957739445904
GO:0005886	plasma membrane	0.00429899821630036
GO:0043367	CD4-positive, alpha beta T cell differentiation	0.00444399837717761
GO:0051881	regulation of mitochondrial membrane potential	0.00444399837717761
GO:0045086	positive regulation of interleukin-2 biosynthetic process	0.00444399837717761
GO:0043565	sequence-specific DNA binding	0.00529263843539813
GO:0031324	negative regulation of cellular metabolic process	0.00575268141348506
GO:0001836	release of cytochrome c from mitochondria	0.00594618373458173
GO:0032640	tumor necrosis factor production	0.00594618373458173
GO:0045595	regulation of cell differentiation	0.00632829546426433
GO:0031323	regulation of cellular metabolic process	0.00660163185068976
GO:0030552	cAMP binding	0.00660163185068976
GO:0044425	membrane part	0.00660163185068976
GO:0045076	regulation of interleukin-2 biosynthetic process	0.00747894415439232
GO:0007242	intracellular signaling cascade	0.00754971572414546
GO:0008283	cell proliferation	0.00754971572414546
GO:0007519	skeletal muscle development	0.00754971572414546
GO:0016020	membrane	0.00767182557346279
GO:0046632	alpha-beta T cell differentiation	0.00767182557346279
GO:0042246	tissue regeneration	0.00767182557346279
GO:0042094	interleukin-2 biosynthetic process	0.00767182557346279
GO:0015026	coreceptor activity	0.00767182557346279
GO:0004896	hematopoietin/interferon-class (D200-domain) cytokine receptor activity	0.00767182557346279
GO:0051246	regulation of protein metabolic process	0.00795037287864846
GO:0001558	regulation of cell growth	0.00821053994651576
GO:0009892	negative regulation of metabolic process	0.00920259387819634
GO:0016481	negative regulation of transcription	0.009228042657909
GO:0031099	regeneration	0.009228042657909
GO:0006916	anti-apoptosis	0.00932225822687075
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.00932225822687075
GO:0002250	adaptive immune response	0.00932225822687075
GO:0007517	muscle development	0.00952084001990232
GO:0046631	alpha-beta T cell activation	0.00967856012843892
GO:0008637	apoptotic mitochondrial changes	0.00967856012843892
GO:0031967	organelle envelope	0.0102313453710889
GO:0031975	envelope	0.0103195321465514
GO:0005789	endoplasmic reticulum membrane	0.0104863356898573
GO:0010468	regulation of gene expression	0.0104863356898573
GO:0045321	leukocyte activation	0.0105090527986157
GO:0016563	transcription activator activity	0.0105623175693176
GO:0032623	interleukin-2 production	0.0109314920119259
GO:0016208	AMP binding	0.0109314920119259
GO:0005622	intracellular	0.0109314920119259
GO:0042175	nuclear envelope-endoplasmic reticulum network	0.0109314920119259
GO:0012505	endomembrane system	0.0109547916133761
GO:0042127	regulation of cell proliferation	0.0109715880166056
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0113983960528402
GO:0019222	regulation of metabolic process	0.0114213029962913
GO:0009653	anatomical structure morphogenesis	0.0119891606259328
GO:0008632	apoptotic program	0.0121863702310502
GO:0019838	growth factor binding	0.0121863702310502
GO:0003700	transcription factor activity	0.0125549750258581
GO:0043229	intracellular organelle	0.0130593415690987
GO:0031090	organelle membrane	0.0130593415690987
GO:0043226	organelle	0.0130593415690987
GO:0040008	regulation of growth	0.0134345163758442
GO:0016049	cell growth	0.0134345163758442
GO:0030551	cyclic nucleotide binding	0.0135559172849289
GO:0045892	negative regulation of transcription, DNA-dependent	0.0137040041133225
GO:0008361	regulation of cell size	0.0143388068469794
GO:0019955	cytokine binding	0.0148365007816447
GO:0045445	myoblast differentiation	0.0148365007816447
GO:0044432	endoplasmic reticulum part	0.0148365007816447
GO:0005783	endoplasmic reticulum	0.0148365007816447
GO:0045554	regulation of TRAIL biosynthetic process	0.0148365007816447
GO:0051149	positive regulation of muscle cell differentiation	0.0148365007816447
GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	0.0148365007816447
GO:0005140	interleukin-9 receptor binding	0.0148365007816447
GO:0042225	interleukin-5 biosynthetic process	0.0148365007816447
GO:0032634	interleukin-5 production	0.0148365007816447
GO:0030526	granulocyte macrophage colony-stimulating factor receptor complex	0.0148365007816447
GO:0001532	interleukin-21 receptor activity	0.0148365007816447
GO:0045405	regulation of interleukin-5 biosynthetic process	0.0148365007816447
GO:0043017	positive regulation of lymphotoxin A biosynthetic process	0.0148365007816447
GO:0045556	positive regulation of TRAIL biosynthetic process	0.0148365007816447
GO:0045407	positive regulation of interleukin-5 biosynthetic process	0.0148365007816447
GO:0043416	regulation of skeletal muscle regeneration	0.0148365007816447
GO:0019977	interleukin-21 binding	0.0148365007816447
GO:0015853	adenine transport	0.0148365007816447
GO:0045553	TRAIL biosynthetic process	0.0148365007816447
GO:0051155	positive regulation of striated muscle cell differentiation	0.0148365007816447
GO:0043415	positive regulation of skeletal muscle regeneration	0.0148365007816447
GO:0042271	susceptibility to natural killer cell mediated cytotoxicity	0.0148365007816447
GO:0051153	regulation of striated muscle cell differentiation	0.0148365007816447
GO:0008434	vitamin D3 receptor activity	0.0148365007816447
GO:0043016	regulation of lymphotoxin A biosynthetic process	0.0148365007816447
GO:0032639	TRAIL production	0.0148365007816447
GO:0042802	identical protein binding	0.0148365007816447
GO:0046983	protein dimerization activity	0.0150917281923931
GO:0015758	glucose transport	0.0154932826258501
GO:0016021	integral to membrane	0.0156233320604472
GO:0043066	negative regulation of apoptosis	0.0162220196881869
GO:0042391	regulation of membrane potential	0.0162220196881869
GO:0008643	carbohydrate transport	0.0165875433420822
GO:0031224	intrinsic to membrane	0.0165875433420822
GO:0043069	negative regulation of programmed cell death	0.0165875433420822
GO:0008645	hexose transport	0.0167477849539627
GO:0015749	monosaccharide transport	0.0167477849539627
GO:0045087	innate immune response	0.0174662855189097
GO:0065008	regulation of biological quality	0.0175432616133144
GO:0050793	regulation of developmental process	0.0176409802980086
GO:0055082	cellular chemical homeostasis	0.0176969134404418
GO:0006873	cellular ion homeostasis	0.0176969134404418
GO:0048589	developmental growth	0.0215129134125044
GO:0031966	mitochondrial membrane	0.0217058515413011
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	0.0223387583004768
GO:0043231	intracellular membrane-bound organelle	0.0223387583004768
GO:0005164	tumor necrosis factor receptor binding	0.0223387583004768
GO:0003704	specific RNA polymerase II transcription factor activity	0.0223387583004768
GO:0015833	peptide transport	0.0223387583004768
GO:0043227	membrane-bound organelle	0.0223387583004768
GO:0009611	response to wounding	0.0223387583004768
GO:0030217	T cell differentiation	0.0223387583004768
GO:0032813	tumor necrosis factor receptor superfamily binding	0.0223387583004768
GO:0051952	regulation of amine transport	0.0223387583004768
GO:0004360	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	0.0223387583004768
GO:0008160	protein tyrosine phosphatase activator activity	0.0223387583004768
GO:0051953	negative regulation of amine transport	0.0223387583004768
GO:0051956	negative regulation of amino acid transport	0.0223387583004768
GO:0042637	catagen	0.0223387583004768
GO:0008269	JAK pathway signal transduction adaptor activity	0.0223387583004768
GO:0006863	purine transport	0.0223387583004768
GO:0004912	interleukin-3 receptor activity	0.0223387583004768
GO:0051955	regulation of amino acid transport	0.0223387583004768
GO:0005459	UDP-galactose transmembrane transporter activity	0.0223387583004768
GO:0002036	regulation of L-glutamate transport	0.0223387583004768
GO:0051902	negative regulation of mitochondrial depolarization	0.0223387583004768
GO:0045747	positive regulation of Notch signaling pathway	0.0223387583004768
GO:0004949	cannabinoid receptor activity	0.0223387583004768
GO:0045630	positive regulation of T-helper 2 cell differentiation	0.0223387583004768
GO:0016312	inositol bisphosphate phosphatase activity	0.0223387583004768
GO:0045627	positive regulation of T-helper 1 cell differentiation	0.0223387583004768
GO:0004240	mitochondrial processing peptidase activity	0.0223387583004768
GO:0019978	interleukin-3 binding	0.0223387583004768
GO:0005148	prolactin receptor binding	0.0223387583004768
GO:0005638	lamin filament	0.0223387583004768
GO:0002037	negative regulation of L-glutamate transport	0.0223387583004768
GO:0050801	ion homeostasis	0.0223387583004768
GO:0005740	mitochondrial envelope	0.0229951857836712
GO:0045941	positive regulation of transcription	0.0257881464991527
GO:0009605	response to external stimulus	0.0257881464991527
GO:0001932	regulation of protein amino acid phosphorylation	0.0257881464991527
GO:0033238	regulation of amine metabolic process	0.0266140592040035
GO:0006521	regulation of amino acid metabolic process	0.0266140592040035
GO:0007267	cell-cell signaling	0.0266140592040035
GO:0006366	transcription from RNA polymerase II promoter	0.0266140592040035
GO:0045597	positive regulation of cell differentiation	0.0274056030594895
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0280532702359227
GO:0009967	positive regulation of signal transduction	0.0287154921574366
GO:0005887	integral to plasma membrane	0.0287154921574366
GO:0046649	lymphocyte activation	0.0287154921574366
GO:0019976	interleukin-2 binding	0.0287154921574366
GO:0008339	MP kinase activity	0.0287154921574366
GO:0005594	collagen type IX	0.0287154921574366
GO:0005047	signal recognition particle binding	0.0287154921574366
GO:0045625	regulation of T-helper 1 cell differentiation	0.0287154921574366
GO:0042109	lymphotoxin A biosynthetic process	0.0287154921574366
GO:0042097	interleukin-4 biosynthetic process	0.0287154921574366
GO:0045663	positive regulation of myoblast differentiation	0.0287154921574366
GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process	0.0287154921574366
GO:0045404	positive regulation of interleukin-4 biosynthetic process	0.0287154921574366
GO:0004911	interleukin-2 receptor activity	0.0287154921574366
GO:0008268	receptor signaling protein tyrosine kinase signaling protein activity	0.0287154921574366
GO:0045402	regulation of interleukin-4 biosynthetic process	0.0287154921574366
GO:0004914	interleukin-5 receptor activity	0.0287154921574366
GO:0004875	complement receptor activity	0.0287154921574366
GO:0019980	interleukin-5 binding	0.0287154921574366
GO:0042825	TAP complex	0.0287154921574366
GO:0032641	lymphotoxin A production	0.0287154921574366
GO:0016081	synaptic vesicle docking during exocytosis	0.0287154921574366
GO:0005782	peroxisomal matrix	0.0287154921574366
GO:0048878	chemical homeostasis	0.0293547480395403
GO:0031226	intrinsic to plasma membrane	0.0296867931153594
GO:0042803	protein homodimerization activity	0.0296867931153594
GO:0005792	microsome	0.031469153460369
GO:0005125	cytokine activity	0.031469153460369
GO:0005624	membrane fraction	0.031469153460369
GO:0000267	cell fraction	0.0323568625903247
GO:0005737	cytoplasm	0.0327997561796075
GO:0042598	vesicular fraction	0.0340694946740813
GO:0005126	hematopoietin/interferon-class (D200-domain) cytokine receptor binding	0.0340694946740813
GO:0051046	regulation of secretion	0.0340694946740813
GO:0008593	regulation of Notch signaling pathway	0.0340694946740813
GO:0046977	TAP binding	0.0340694946740813
GO:0045423	regulation of granulocyte macrophage colony-stimulating factor biosynthetic process	0.0340694946740813
GO:0006002	fructose 6-phosphate metabolic process	0.0340694946740813
GO:0032633	interleukin-4 production	0.0340694946740813
GO:0043403	skeletal muscle regeneration	0.0340694946740813
GO:0042824	MHC class I peptide loading complex	0.0340694946740813
GO:0045063	T-helper 1 cell differentiation	0.0340694946740813
GO:0045628	regulation of T-helper 2 cell differentiation	0.0340694946740813
GO:0046325	negative regulation of glucose import	0.0340694946740813
GO:0005652	nuclear lamina	0.0340694946740813
GO:0046979	TAP2 binding	0.0340694946740813
GO:0015851	nucleobase transport	0.0340694946740813
GO:0051900	regulation of mitochondrial depolarization	0.0340694946740813
GO:0046978	TAP1 binding	0.0340694946740813
GO:0051147	regulation of muscle cell differentiation	0.0340694946740813
GO:0031403	lithium ion binding	0.0340694946740813
GO:0005131	growth hormone receptor binding	0.0340694946740813
GO:0048534	hemopoietic or lymphoid organ development	0.0341293557606267
GO:0044446	intracellular organelle part	0.0343495500712108
GO:0044422	organelle part	0.0353336985007209
GO:0002520	immune system development	0.038683223776192
GO:0042325	regulation of phosphorylation	0.0389018632124227
GO:0030098	lymphocyte differentiation	0.0389018632124227
GO:0005615	extracellular space	0.0390374584067696
GO:0051882	mitochondrial depolarization	0.0399774524393771
GO:0045410	positive regulation of interleukin-6 biosynthetic process	0.0399774524393771
GO:0008035	high-density lipoprotein binding	0.0399774524393771
GO:0046790	virion binding	0.0399774524393771
GO:0032604	granulocyte macrophage colony-stimulating factor production	0.0399774524393771
GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process	0.0399774524393771
GO:0045064	T-helper 2 cell differentiation	0.0399774524393771
GO:0005954	calcium- and calmodulin-dependent protein kinase complex	0.0399774524393771
GO:0048535	lymph node development	0.0399774524393771
GO:0046902	regulation of mitochondrial membrane permeability	0.0399774524393771
GO:0051094	positive regulation of developmental process	0.0418201482636928
GO:0051174	regulation of phosphorus metabolic process	0.0426960672384591
GO:0019220	regulation of phosphate metabolic process	0.0426960672384591
GO:0005635	nuclear envelope	0.0431566496498217
GO:0002449	lymphocyte mediated immunity	0.0450464672686323
GO:0017111	nucleoside-triphosphatase activity	0.0450464672686323
GO:0015165	pyrimidine nucleotide sugar transmembrane transporter activity	0.0450464672686323
GO:0050806	positive regulation of synaptic transmission	0.0450464672686323
GO:0008634	negative regulation of survival gene product activity	0.0450464672686323
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	0.0450464672686323
GO:0045661	regulation of myoblast differentiation	0.0450464672686323
GO:0015198	oligopeptide transporter activity	0.0450464672686323
GO:0005593	FACIT collagen	0.0450464672686323
GO:0001912	positive regulation of leukocyte mediated cytotoxicity	0.0450464672686323
GO:0016909	SAP kinase activity	0.0450464672686323
GO:0002347	response to tumor cell	0.0450464672686323
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	0.0450464672686323
GO:0001848	complement binding	0.0450464672686323
GO:0004872	receptor activity	0.0458888596894514
GO:0006959	humoral immune response	0.0471958199067331
GO:0019725	cellular homeostasis	0.0476177913335884
GO:0017016	Ras GTPase binding	0.0492732528790226
GO:0044459	plasma membrane part	0.0499005036276877

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
circulating cell	2.58e-74	6

Uber Anatomy

Ontology term	p-value	n
umbilical cord	4.18e-45	10
blastocyst	4.18e-45	10
blastula	4.18e-45	10
bilaminar disc	4.18e-45	10
inner cell mass	4.18e-45	10
cleaving embryo	4.18e-45	10
connecting stalk	4.18e-45	10
inner cell mass derived epiblast	4.18e-45	10
extraembryonic mesoderm	4.18e-45	10
blood	1.81e-30	15
haemolymphatic fluid	1.81e-30	15
organism substance	1.81e-30	15
extraembryonic structure	1.88e-19	24

Disease

Ontology term	p-value	n
non-Hodgkin lymphoma	6.58e-50	1
cutaneous T cell lymphoma	6.58e-50	1
mycosis fungoides	6.58e-50	1

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
MA0003.1	0
MA0004.1	0.171198
MA0006.1	0.0111926
MA0007.1	0.347846
MA0009.1	0.329904
MA0014.1	0
MA0017.1	0.319698
MA0019.1	0.865744
MA0024.1	0.0338073
MA0025.1	0.00973076
MA0027.1	0.6076
MA0028.1	3.81044e-06
MA0029.1	1.0141
MA0030.1	0.293008
MA0031.1	0.502338
MA0038.1	0.760615
MA0040.1	0.462534
MA0041.1	1.80246
MA0042.1	0.778645
MA0043.1	0.160688
MA0046.1	0.140489
MA0048.1	5.44775e-06
MA0050.1	1.35106
MA0051.1	0.44397
MA0052.1	0.0560521
MA0055.1	6.18731e-09
MA0056.1	0
MA0057.1	5.78685e-07
MA0058.1	0.0259632
MA0059.1	0.0718922
MA0060.1	2.24063e-05
MA0061.1	22.937
MA0063.1	0
MA0066.1	0.660075
MA0067.1	0.00943406
MA0068.1	0.140116
MA0069.1	0.510097
MA0070.1	1.31445
MA0071.1	2.82709
MA0072.1	0.2403
MA0073.1	4.11575e-13
MA0074.1	0.0624099
MA0076.1	7.9518e-07
MA0077.1	1.01342
MA0078.1	0.200515
MA0081.1	0.0129739
MA0083.1	1.38118
MA0084.1	1.09027
MA0087.1	0.869837
MA0088.1	3.1209e-08
MA0089.1	0
MA0090.1	0.0835263
MA0091.1	0.0187073
MA0092.1	0.0628246
MA0093.1	0.170077
MA0095.1	0
MA0098.1	0
MA0100.1	0.0232892
MA0101.1	26.2263
MA0103.1	0.00210485
MA0105.1	4.51474
MA0106.1	0.952145
MA0107.1	34.9844
MA0108.2	0.485704
MA0109.1	0
MA0111.1	0.0799772
MA0113.1	0.13589
MA0114.1	0.140244
MA0115.1	1.31035
MA0116.1	0.00242324
MA0117.1	0.240935
MA0119.1	0.147911
MA0122.1	0.211754
MA0124.1	0.624043
MA0125.1	0.63697
MA0130.1	0
MA0131.1	0.000316372
MA0132.1	0
MA0133.1	0
MA0135.1	0.012272
MA0136.1	0.148765
MA0139.1	4.36547e-08
MA0140.1	1.51701
MA0141.1	0.949881
MA0142.1	1.63118
MA0143.1	1.62524
MA0144.1	3.66051
MA0145.1	7.70617e-08
MA0146.1	0
MA0147.1	0.0883992
MA0148.1	4.14223
MA0149.1	6.82798e-05
MA0062.2	1.15039e-10
MA0035.2	1.35901
MA0039.2	0
MA0138.2	0.0555023
MA0002.2	0.626031
MA0137.2	5.5775
MA0104.2	0.00166594
MA0047.2	2.47695
MA0112.2	0.000469082
MA0065.2	0.00155596
MA0150.1	0.448097
MA0151.1	0
MA0152.1	0.941032
MA0153.1	0.0353662
MA0154.1	0.297618
MA0155.1	0.000252385
MA0156.1	0.0656017
MA0157.1	0.388224
MA0158.1	0
MA0159.1	0.00877458
MA0160.1	3.69843
MA0161.1	0
MA0162.1	5.98847e-14
MA0163.1	1.83222e-14
MA0164.1	3.89992
MA0080.2	0.273662
MA0018.2	0.227736
MA0099.2	0.831746
MA0079.2	0
MA0102.2	0.597017
MA0258.1	0.527895
MA0259.1	0.00225502
MA0442.1	0

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BATF#10538	109	3.44358027932697	6.32162555605888e-29	2.40081545981539e-26
BCL11A#53335	74	2.72287895936047	1.90422287495266e-14	3.22325985149401e-12
EBF1#1879	155	1.79053483945291	5.83461619300802e-13	8.43990970334577e-11
IRF4#3662	75	2.13176193450818	1.12106681839279e-09	1.03247881345789e-07
MEF2A#4205	71	1.72603034317085	7.6157795506734e-06	0.000217258781888222
NFKB1#4790	198	1.40938593773071	1.66536260087524e-07	9.19771574155522e-06

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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FF samples	Score

FF samples	Score
cord blood derived cell line:COBL-a 24h infection(-C) CNhs11049	0.92
cord blood derived cell line:COBL-a untreated CNhs11045	0.84
cord blood derived cell line:COBL-a 24h infection CNhs11050	0.83
mycosis fungoides, T cell lymphoma cell line:HuT 102 TIB-162 CNhs11858	0.08
Adipocyte - breast, donor1 CNhs11051	0.00
Adipocyte - breast, donor2 CNhs11969	0.00
Adipocyte - omental, donor1 CNhs11054	0.00
Adipocyte - omental, donor2 CNhs12067	0.00
Adipocyte - omental, donor3 CNhs12068	0.00
Adipocyte - perirenal, donor1 CNhs12069	0.00

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