FF:10400-106A4: Difference between revisions
From FANTOM5_SSTAR
(Created page with "{{f5samples
|id=FF:10400-106A4
|name=acute myeloid leukemia (FAB M5) cell line:THP-1, biol_rep1, tech_rep1 (revived)
|sample_id=10400
|rna_tube_id=106A4
|rna_box=106
|rn...") |
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{{f5samples | {{f5samples | ||
| | |DRA_sample_Accession=CAGE@SAMD00005601 | ||
| | |accession_numbers=CAGE;DRX007814;DRR008686;DRZ000111;DRZ001496;DRZ011461;DRZ012846 | ||
| | |ancestors_in_anatomy_facet= | ||
| | |ancestors_in_cell_lineage_facet=CL:0000000,CL:0000003,CL:0000988,CL:0000548,CL:0000763,CL:0002371,CL:0000766,CL:0000219,CL:0000738,CL:0002087,CL:0000255,CL:0000576 | ||
|ancestors_in_disease_facet=DOID:4,DOID:0050686,DOID:162,DOID:2531,DOID:14566,DOID:0060083,DOID:1240,DOID:8692 | |||
|ancestors_in_ff_facet=FF:0000102,FF:0000003,FF:0000210,FF:0000101,FF:0000001,FF:0100737,FF:0101370,FF:0101035,FF:0101883,FF:0102332,FF:0100740 | |||
|comment= | |||
|created_by= | |||
|creation_date= | |||
|data_phase=2 | |||
| | |datafreeze_phase=2 | ||
|def= | |||
|expression_enrichment_score=chr16:85932760..85932775,+!p1@IRF8!2.52!332.83!IRF8;;chr11:47400078..47400106,-!p1@SPI1!2.29!193.93!SPI1;;chr6:135502501..135502546,+!p1@MYB!2.06!136.44!MYB;;chr2:68592406..68592424,+!p1@PLEK!1.97!92.83!PLEK;;chr9:96717629..96717644,-!p1@BARX1!1.86!71.80!BARX1;;chr12:54778471..54778528,-!p1@ZNF385A!1.83!66.88!ZNF385A;;chr7:115670804..115670825,-!p1@TFEC!1.73!52.79!TFEC;;chr6:135502408..135502459,+!p2@MYB!1.69!54.80!MYB;;chr19:33793430..33793447,-!p1@CEBPA!1.63!167.09!CEBPA;;chr3:18486354..18486377,-!p2@SATB1!1.60!48.09!SATB1;;chr1:92951607..92951661,-!p1@GFI1!1.60!38.70!GFI1;;chr10:31288398..31288455,-!p2@ZNF438!1.59!44.06!ZNF438;;chr2:63277948..63277974,+!p1@OTX1!1.52!32.43!OTX1;;chr2:200322654..200322707,-!p2@SATB2!1.50!44.06!SATB2;;chr1:156460436..156460462,-!p7@MEF2D!1.50!30.64!MEF2D;;chr7:50344289..50344323,+!p1@IKZF1!1.50!30.42!IKZF1;;chr13:72441315..72441454,-!p1@DACH1!1.49!57.93!DACH1;;chr1:92949331..92949377,-!p2@GFI1!1.49!30.20!GFI1;;chr1:41157363..41157416,+!p1@NFYC!1.40!441.31!NFYC;;chr1:41157421..41157482,+!p2@NFYC!1.40!268.64!NFYC;;chr2:175199675..175199688,+!p1@SP9!1.40!24.16!SP9;;chr6:85473156..85473210,-!p2@TBX18!1.39!28.63!TBX18;;chr7:27205136..27205164,-!p1@HOXA9!1.38!22.81!HOXA9;;chr5:72744594..72744609,-!p1@FOXD1!1.35!95.06!FOXD1;;chr1:40942922..40942997,+!p1@ZNF642!1.35!55.02!ZNF642;;chr1:40997285..40997352,+!p1@ZNF684!1.34!71.58!ZNF684;;chr14:75988771..75988826,+!p1@BATF!1.34!27.96!BATF;;chr7:137620650..137620677,-!p3@CREB3L2!1.34!21.03!CREB3L2;;chr2:145277640..145277771,-!p1@ZEB2!1.33!262.60!ZEB2;;chr7:137620684..137620711,-!p4@CREB3L2!1.33!20.35!CREB3L2;;chr6:135516877..135516900,+!p5@MYB!1.30!19.01!MYB;;chr11:47400062..47400077,-!p2@SPI1!1.30!19.01!SPI1;;chr5:88178983..88179012,-!p1@MEF2C!1.28!134.88!MEF2C;;chr6:135502472..135502489,+!p3@MYB!1.28!18.12!MYB;;chr1:50889103..50889145,-!p1@DMRTA2!1.27!17.45!DMRTA2;;chr18:55102598..55102623,+!p1@ONECUT2!1.26!17.22!ONECUT2;;chr7:113726357..113726443,+!p1@FOXP2!1.25!28.41!FOXP2;;chr7:128577972..128578047,+!p1@IRF5!1.25!26.17!IRF5;;chr1:40997363..40997392,+!p2@ZNF684!1.25!21.70!ZNF684;;chr6:34204973..34204990,+!p4@HMGA1!1.24!212.94!HMGA1;;chr7:27224795..27224840,-!p2@HOXA11!1.22!15.66!HOXA11;;chr7:27224842..27224872,-!p1@HOXA11!1.22!15.66!HOXA11;;chr7:27205106..27205134,-!p2@HOXA9!1.22!15.43!HOXA9;;chr1:156470515..156470542,-!p2@MEF2D!1.20!77.62!MEF2D;;chr1:3569072..3569093,+!p1@TP73!1.20!14.99!TP73;;chr3:157824001..157824078,-!p2@SHOX2!1.20!14.99!SHOX2;;chr2:63277978..63277995,+!p2@OTX1!1.19!14.54!OTX1;;chr7:50343634..50343717,+!p2@IKZF1!1.19!14.32!IKZF1;;chr18:55102628..55102646,+!p2@ONECUT2!1.18!14.09!ONECUT2;;chr18:22932080..22932170,-!p1@ZNF521!1.17!58.60!ZNF521;;chr10:31288370..31288393,-!p3@ZNF438!1.17!13.87!ZNF438;;chr7:27213893..27213954,-!p1@HOXA10!1.17!13.87!HOXA10;;chr2:100759037..100759058,-!p2@AFF3!1.17!13.64!AFF3;;chr1:156460473..156460486,-!p12@MEF2D!1.16!13.42!MEF2D;;chr3:18480217..18480239,-!p3@SATB1!1.15!12.97!SATB1;;chr1:247171316..247171336,-!p3@ZNF695!1.14!19.24!ZNF695;;chr16:54319010..54319041,-!p8@IRX3!1.14!12.75!IRX3;;chr13:41593425..41593480,-!p1@ELF1!1.12!77.62!ELF1;;chr11:47399996..47400014,-!p4@SPI1!1.11!11.85!SPI1;;chr1:92952473..92952489,-!p3@GFI1!1.11!11.85!GFI1;;chr16:54320646..54320672,-!p2@IRX3!1.10!17.67!IRX3;;chr18:22805268..22805280,-!p8@ZNF521!1.10!11.63!ZNF521;;chr11:47399947..47399961,-!p3@SPI1!1.09!11.41!SPI1;;chr3:157824202..157824211,-!p3@SHOX2!1.09!11.18!SHOX2;;chr16:54320617..54320643,-!p3@IRX3!1.08!14.09!IRX3;;chr1:167298300..167298319,+!p2@POU2F1!1.07!10.74!POU2F1;;chr2:68592394..68592405,+!p2@PLEK!1.04!10.07!PLEK;;chr7:50344251..50344288,+!p3@IKZF1!1.04!10.07!IKZF1;;chr2:200322229..200322251,-!p3@SATB2!1.04!9.84!SATB2;;chr17:41277372..41277418,-!p1@BRCA1!1.03!36.24!BRCA1;;chr1:247242048..247242098,-!p1@ZNF670,p1@ZNF695!1.03!35.56!ZNF670;;chr17:79881332..79881348,-!p3@MAFG!1.03!14.32!MAFG;;chr21:34442439..34442455,+!p1@OLIG1!1.02!9.39!OLIG1;;chr11:47400032..47400043,-!p5@SPI1!1.02!9.39!SPI1;;chr16:54320280..54320291,-!p9@IRX3!1.01!9.17!IRX3;;chr6:135516909..135516925,+!p6@MYB!1.01!9.17!MYB;;chr1:167298384..167298412,+!p3@POU2F1!1.01!9.17!POU2F1;;chr20:42295745..42295765,+!p1@MYBL2!1.00!148.97!MYBL2;;chr1:40627038..40627071,+!p1@RLF!1.00!121.46!RLF;;chr11:128563948..128564003,+!p1@FLI1!1.00!110.05!FLI1;;chr16:54320675..54320715,-!p1@IRX3!1.00!19.91!IRX3;;chr2:145277882..145277967,-!p3@ZEB2!1.00!15.88!ZEB2;;chr1:156470494..156470505,-!p3@MEF2D!1.00!13.20!MEF2D;;chr12:54694758..54694805,-!p1@NFE2!1.00!10.96!NFE2;;chrY:21906594..21906622,-!p1@KDM5D!1.00!8.95!KDM5D;;chr7:27239703..27239715,-!p1@HOXA13!0.98!8.50!HOXA13;;chr16:54320158..54320200,-!p5@IRX3!0.97!12.08!IRX3;;chr1:167298425..167298440,+!p8@POU2F1!0.97!8.28!POU2F1;;chrX:66763856..66763896,+!p1@AR!0.96!11.85!AR;;chr18:22804637..22804660,-!p10@ZNF521!0.96!8.05!ZNF521;;chr11:47400045..47400060,-!p6@SPI1!0.96!8.05!SPI1;;chr16:54320322..54320343,-!p7@IRX3!0.95!7.83!IRX3;;chr1:92949505..92949543,-!p5@GFI1!0.95!7.83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D1A!0.21!10.29!ARID1A;;chr12:133532864..133532899,-!p1@ZNF605!0.21!10.07!ZNF605;;chr14:89883509..89883587,-!p2@FOXN3!0.21!9.39!FOXN3;;chr3:40518599..40518664,+!p1@ZNF619!0.21!7.83!ZNF619;;chr6:43139041..43139094,+!p3@SRF!0.21!7.60!SRF;;chrX:47342565..47342638,-!p1@ZNF41!0.21!7.60!ZNF41;;chr2:178128199..178128245,-!p3@NFE2L2!0.21!7.16!NFE2L2;;chr6:34205372..34205412,+!p5@HMGA1!0.21!6.71!HMGA1;;chr16:31085514..31085576,-!p1@ZNF668!0.21!5.37!ZNF668;;chr19:53238260..53238312,-!p1@ZNF611!0.21!4.47!ZNF611;;chr19:23870007..23870022,-!p2@ZNF675!0.21!4.03!ZNF675;;chr10:44101850..44101896,+!p1@ZNF485!0.21!3.80!ZNF485;;chr15:66994663..66994680,+!p1@SMAD6!0.21!2.68!SMAD6;;chr19:47615426..47615439,-!p5@ZC3H4!0.21!2.68!ZC3H4;;chr19:52430697..52430749,+!p1@ZNF613!0.21!2.68!ZNF613;;chr19:53970970..53971021,+!p1@ZNF813!0.21!2.68!ZNF813;;chr4:76439649..76439662,+!p2@THAP6!0.21!2.68!THAP6;;chr2:75937794..75937867,-!p2@GCFC2!0.21!2.46!GCFC2;;chr6:7108855..7108903,+!p5@RREB1!0.21!2.46!RREB1;;chr7:99070527..99070542,+!p2@ZNF789!0.21!2.46!ZNF789;;chr16:3313791..3313834,+!p2@ZNF263!0.21!2.46!ZNF263;;chr19:21324863..21324874,+!p2@ZNF431!0.21!1.79!ZNF431;;chr12:53574398..53574412,+!p3@ZNF740!0.21!1.79!ZNF740;;chr5:142783792..142783842,-!p5@NR3C1!0.21!1.79!NR3C1;;chr4:87968203..87968221,+!p11@AFF1!0.21!1.57!AFF1;;chr10:21823381..21823399,+!p4@MLLT10!0.21!1.57!MLLT10;;chr10:94449649..94449664,+!p3@HHEX!0.21!1.34!HHEX;;chr1:67396022..67396041,+!p6@MIER1!0.21!1.34!MIER1;;chr20:33413523..33413534,-!p3@NCOA6!0.21!1.12!NCOA6;;chr17:42295897..42295953,-!p10@UBTF!0.21!1.12!UBTF;;chr18:53255839..53255854,-!p13@TCF4!0.21!0.89!TCF4;;chr7:100076873..100076880,-!p6@TSC22D4!0.21!0.89!TSC22D4;;chr8:81397876..81397898,+!p5@ZBTB10!0.21!0.89!ZBTB10;;chr1:149858461..149858479,+!p1@BOLA1!0.20!567.69!BOLA1;;chr2:37458692..37458745,-!p1@CEBPZ!0.20!54.13!CEBPZ;;chr16:67596417..67596497,+!p1@CTCF!0.20!48.99!CTCF;;chr17:40719102..40719141,+!p1@MLX!0.20!45.41!MLX;;chr18:32924372..32924430,-!p1@ZNF24!0.20!43.39!ZNF24;;chr19:11071685..11071798,+!p1@SMARCA4!0.20!40.04!SMARCA4;;chr16:67226019..67226127,+!p1@E2F4!0.20!18.12!E2F4;;chr5:138629389..138629416,+!p4@MATR3!0.20!17.22!MATR3;;chr1:151431909..151431987,-!p1@POGZ!0.20!16.55!POGZ;;chr22:41601296..41601355,+!p1@L3MBTL2!0.20!15.88!L3MBTL2;;chr16:29817617..29817664,+!p4@MAZ!0.20!14.54!MAZ;;chr11:118992269..118992334,+!p1@HINFP!0.20!11.63!HINFP;;chr2:113033164..113033219,+!p1@ZC3H6!0.20!11.41!ZC3H6;;chr19:52490043..52490113,-!p1@ZNF350!0.20!10.51!ZNF350;;chr2:174828892..174828972,-!p2@SP3!0.20!9.84!SP3;;chr6:35227480..35227546,+!p1@ZNF76!0.20!8.72!ZNF76;;chr15:50647370..50647405,-!p2@GABPB1!0.20!7.16!GABPB1;;chr1:149871114..149871134,+!p3@BOLA1!0.20!4.92!BOLA1;;chr1:151043216..151043256,+!p1@GABPB2!0.20!4.25!GABPB2;;chr1:67396044..67396071,+!p3@MIER1!0.20!4.25!MIER1;;chr6:157098579..157098634,+!p4@ARID1B!0.20!2.46!ARID1B;;chr19:36980455..36980469,-!p2@ZNF566!0.20!2.24!ZNF566;;chr12:53774035..53774058,+!p4@SP1!0.20!2.01!SP1;;chr15:57025812..57025819,-!p4@ZNF280D!0.20!1.34!ZNF280D;;chr16:30569604..30569629,-!p3@ZNF764!0.20!1.34!ZNF764;;chr1:158985493..158985535,+!p4@IFI16!0.20!1.34!IFI16;;chr4:87928105..87928126,+!p13@AFF1!0.20!1.34!AFF1;;chr11:6947647..6947698,+!p2@ZNF215!0.20!1.12!ZNF215;;chrX:84498989..84499003,+!p1@ZNF711!0.20!1.12!ZNF711;;chr1:158979680..158979683,+!p9@IFI16!0.20!1.12!IFI16;;chr16:30546275..30546297,-!p2@ZNF747!0.20!1.12!ZNF747;;chr15:37392593..37392607,-!p13@MEIS2!0.20!0.89!MEIS2;;chr19:36980474..36980485,-!p4@ZNF566!0.20!0.89!ZNF566;;chr10:22292509..22292523,-!p4@DNAJC1!0.20!0.89!DNAJC1;; | |||
| | |ffid_belonging_in_development=CL:0000049,CL:0000134 | ||
| | |||
| | |||
| | |||
| | |||
| | |||
| | |||
| | |||
|fonse_cell_line=FF:0101035 | |fonse_cell_line=FF:0101035 | ||
|fonse_cell_line_closure=FF:0101035 | |fonse_cell_line_closure=FF:0101035 | ||
Line 67: | Line 40: | ||
|fonse_treatment= | |fonse_treatment= | ||
|fonse_treatment_closure= | |fonse_treatment_closure= | ||
|has_quality= | |||
|hg19bam=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/acute%2520myeloid%2520leukemia%2520%2528FAB%2520M5%2529%2520cell%2520line%253aTHP-1%2520%2528revived%2529.CNhs10723.10400-106A4.hg19.nobarcode.bam | |||
|hg19ctss=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/acute%2520myeloid%2520leukemia%2520%2528FAB%2520M5%2529%2520cell%2520line%253aTHP-1%2520%2528revived%2529.CNhs10723.10400-106A4.hg19.ctss.bed.gz | |||
|hg19fasta=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/acute%2520myeloid%2520leukemia%2520%2528FAB%2520M5%2529%2520cell%2520line%253aTHP-1%2520%2528revived%2529.CNhs10723.10400-106A4.hg19.nobarcode.rdna.fa.gz | |||
|hg38bam=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.cell_line.hCAGE/acute%2520myeloid%2520leukemia%2520%2528FAB%2520M5%2529%2520cell%2520line%253aTHP-1%2520%2528revived%2529.CNhs10723.10400-106A4.hg38.nobarcode.bam | |||
|hg38ctss=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.cell_line.hCAGE/acute%2520myeloid%2520leukemia%2520%2528FAB%2520M5%2529%2520cell%2520line%253aTHP-1%2520%2528revived%2529.CNhs10723.10400-106A4.hg38.nobarcode.ctss.bed.gz | |||
|id=FF:10400-106A4 | |||
|is_a=EFO:0002091;;FF:0000210;;FF:0101370;;FF:0101883 | |||
|is_obsolete= | |||
|library_id=CNhs10723 | |||
|library_id_phase_based=2:CNhs10723 | |||
|microRNAs= | |||
|microRNAs_nn= | |||
|microRNAs_nonnovel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer/#/human#cage;sample;10400 | |||
|microRNAs_novel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer_novel/#/human#cage;sample;10400 | |||
|name=acute myeloid leukemia (FAB M5) cell line:THP-1 (revived) | |||
|namespace=FANTOM5 | |||
|part_of= | |||
|profile_cagescan=,,, | |||
|profile_hcage=CNhs10723,LSID691,release008,COMPLETED | |||
|profile_rnaseq= | |||
|profile_srnaseq=,,, | |||
|refex=http://refex.dbcls.jp/genelist.php?lang | |||
|repeat_enrich_byfamily=0,0,0,0,0,0.326003978124479,0,0.165685948038092,0.0876664805795525,-0.116787901863639,-0.282403560576942,0,0,0,0,0,0,0,0,0,0.0876664805795525,0,0,0,-0.153323010348428,0,0,0,0,0,-0.0979578962680575,0,0,-0.132956589778862,0,0,0,0,0,0,0.36007328402346,0,0,0,0,0,-0.121957035316301,0,0,0,0,0,0,0,0,-0.0242150211128343,0,0,0,0.566332977255099,0,-0.00947015499158227,0.0876664805795525,-0.0969923612426051,0,0,-0.097343627213097,0,0,0,0,0,0,0,0,0,0,0.160574230329875,0,0,0.0876664805795525,0,0,0,0,0.111491905590767,0,0,0,0,0,-0.391504348009836,0,0,0,0.319555183105718,-0.130910287530932,0,0,0,0,-0.0980353512377064,-0.138477200800895,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-0.0160864787575235,0,0,0,-0.152701961220218,-0.442362558086961,0,0,0,0,0,0 | |||
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| |||
|rna_box=106 | |||
|rna_catalog_number= | |||
|rna_concentration=0.98864 | |||
|rna_extraction_protocol=OP-RNA-extraction-totalRNA-miRNeasy_Mini-v1.0 | |||
|rna_lot_number= | |||
|rna_od260/230=2.04 | |||
|rna_od260/280=2.096666667 | |||
|rna_position=A4 | |||
|rna_rin=9.9 | |||
|rna_sample_type=total RNA | |||
|rna_tube_id=106A4 | |||
|rna_weight_ug=49.432 | |||
|sample_age=1 | |||
|sample_category=cell lines | |||
|sample_cell_catalog= | |||
|sample_cell_line=THP-1 | |||
|sample_cell_lot= | |||
|sample_cell_type=monoblast | |||
|sample_collaboration=FANTOM5 OSC CORE (contact: Al Forrest) | |||
|sample_company= | |||
|sample_description= | |||
|sample_dev_stage=1 year old child | |||
|sample_disease=acute myeloid leukemia (FAB M5) | |||
|sample_donor(cell lot)= | |||
|sample_ethnicity=J | |||
|sample_experimental_condition=FREEZOME | |||
|sample_gostat=GO:0044464;cell part;0!GO:0005622;intracellular;0!GO:0044424;intracellular part;7.2998723954611e-271!GO:0043227;membrane-bound organelle;8.2465342864874e-242!GO:0043231;intracellular membrane-bound organelle;1.43715637820848e-241!GO:0043226;organelle;4.60349942263659e-228!GO:0043229;intracellular organelle;1.84105749340721e-227!GO:0044422;organelle part;1.3642645815257e-160!GO:0005737;cytoplasm;1.10198726678502e-159!GO:0044446;intracellular organelle part;6.27633066636548e-159!GO:0005634;nucleus;3.92160676012254e-123!GO:0044237;cellular metabolic process;4.83835984617031e-123!GO:0044238;primary metabolic process;1.14876880355686e-119!GO:0044444;cytoplasmic part;3.30979036599647e-118!GO:0032991;macromolecular complex;1.85977231372525e-115!GO:0043170;macromolecule metabolic process;4.65145130122322e-114!GO:0044428;nuclear part;4.10281415926272e-100!GO:0030529;ribonucleoprotein complex;8.18995161950751e-98!GO:0043233;organelle lumen;3.21516261993014e-89!GO:0031974;membrane-enclosed lumen;3.21516261993014e-89!GO:0003723;RNA binding;2.03322994861943e-87!GO:0043283;biopolymer metabolic process;8.92508111701784e-74!GO:0005739;mitochondrion;1.07636852636081e-70!GO:0006139;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;2.57725551611538e-69!GO:0010467;gene expression;7.19127253076127e-65!GO:0006396;RNA processing;8.80011476254476e-62!GO:0005515;protein binding;1.44740289874658e-59!GO:0043234;protein complex;3.43980902000709e-58!GO:0031981;nuclear lumen;4.01619030831894e-57!GO:0006412;translation;3.82799393298956e-55!GO:0005840;ribosome;8.13401170412502e-54!GO:0044429;mitochondrial part;1.74373400792376e-50!GO:0016071;mRNA metabolic process;3.00040896961653e-49!GO:0006259;DNA metabolic process;9.6433533287403e-49!GO:0003676;nucleic acid binding;7.86410443601574e-48!GO:0019538;protein metabolic process;1.06029540071768e-47!GO:0003735;structural constituent of ribosome;1.89769600605878e-47!GO:0031967;organelle envelope;4.01786765337237e-47!GO:0031975;envelope;1.06143135606459e-46!GO:0033036;macromolecule localization;9.12397121904877e-45!GO:0031090;organelle membrane;1.12258647560565e-44!GO:0008380;RNA splicing;1.15956081932444e-44!GO:0016043;cellular component organization and biogenesis;1.72533409044283e-44!GO:0009058;biosynthetic process;3.92951403905529e-44!GO:0044260;cellular macromolecule metabolic process;1.49762091359096e-43!GO:0006397;mRNA processing;1.49762091359096e-43!GO:0044267;cellular protein metabolic process;2.78658980824696e-43!GO:0015031;protein transport;4.4122155907097e-43!GO:0044249;cellular biosynthetic process;6.2845936889709e-43!GO:0009059;macromolecule biosynthetic process;2.43120138298256e-42!GO:0045184;establishment of protein localization;4.90179931839618e-41!GO:0033279;ribosomal subunit;3.16549551052777e-40!GO:0008104;protein localization;9.11105066603281e-40!GO:0006996;organelle organization and biogenesis;7.87398456954176e-39!GO:0005829;cytosol;4.21108194456276e-38!GO:0065003;macromolecular complex assembly;1.95191040029755e-36!GO:0005654;nucleoplasm;3.7948639541533e-36!GO:0022613;ribonucleoprotein complex biogenesis and assembly;1.1761163109942e-35!GO:0007049;cell cycle;4.43131560884584e-35!GO:0043228;non-membrane-bound organelle;5.22767285980361e-34!GO:0043232;intracellular non-membrane-bound organelle;5.22767285980361e-34!GO:0016070;RNA metabolic process;5.78293491951518e-34!GO:0046907;intracellular transport;2.04363315236409e-33!GO:0005681;spliceosome;5.8629369327408e-33!GO:0022607;cellular component assembly;3.25413741789517e-31!GO:0005740;mitochondrial envelope;5.01459499016209e-31!GO:0005830;cytosolic ribosome (sensu Eukaryota);1.1889172904308e-29!GO:0006974;response to DNA damage stimulus;1.47405165247e-29!GO:0005694;chromosome;3.05164268887595e-29!GO:0019866;organelle inner membrane;5.59542997613945e-29!GO:0006886;intracellular protein transport;5.59542997613945e-29!GO:0031966;mitochondrial membrane;9.10627529197121e-29!GO:0044451;nucleoplasm part;1.11497542867444e-28!GO:0022402;cell cycle process;2.84292937584352e-28!GO:0000278;mitotic cell cycle;1.36612500146301e-27!GO:0000166;nucleotide binding;1.59648793656028e-27!GO:0005743;mitochondrial inner membrane;5.51982046009196e-27!GO:0006281;DNA repair;8.67570960037364e-27!GO:0051649;establishment of cellular localization;6.07122962517003e-26!GO:0044445;cytosolic part;6.57111535775594e-26!GO:0044427;chromosomal part;1.81641318807937e-25!GO:0051641;cellular localization;3.00090261264343e-25!GO:0051276;chromosome organization and biogenesis;2.88897939747722e-24!GO:0006119;oxidative phosphorylation;5.4541509289515e-24!GO:0022403;cell cycle phase;2.05684366979236e-23!GO:0000087;M phase of mitotic cell cycle;6.29545161183324e-23!GO:0031980;mitochondrial lumen;9.45089602546092e-23!GO:0005759;mitochondrial matrix;9.45089602546092e-23!GO:0007067;mitosis;1.88451248343414e-22!GO:0044265;cellular macromolecule catabolic process;1.90462569965099e-21!GO:0015935;small ribosomal subunit;4.07215402933736e-21!GO:0044455;mitochondrial membrane part;5.68571237012066e-21!GO:0006457;protein folding;7.44304994717111e-21!GO:0016874;ligase activity;1.10018128031477e-20!GO:0016818;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;1.14669696549573e-20!GO:0051301;cell division;1.20595705710773e-20!GO:0016817;hydrolase activity, acting on acid anhydrides;1.21031270132062e-20!GO:0022618;protein-RNA complex assembly;1.39938912567317e-20!GO:0016462;pyrophosphatase activity;2.21635747486183e-20!GO:0015934;large ribosomal subunit;3.44584255590954e-20!GO:0000279;M phase;6.99788407348571e-20!GO:0009719;response to endogenous stimulus;8.05567029509485e-20!GO:0005730;nucleolus;8.41587433437362e-20!GO:0017111;nucleoside-triphosphatase activity;1.23290019479824e-19!GO:0006260;DNA replication;4.98420916810654e-19!GO:0006325;establishment and/or maintenance of chromatin architecture;9.03047471667217e-19!GO:0048770;pigment granule;1.36169965230729e-18!GO:0042470;melanosome;1.36169965230729e-18!GO:0006512;ubiquitin cycle;1.55782328437161e-18!GO:0043285;biopolymer catabolic process;1.92129162401488e-18!GO:0006323;DNA packaging;4.45817183689482e-18!GO:0005746;mitochondrial respiratory chain;5.41621996779633e-18!GO:0032553;ribonucleotide binding;5.782047386156e-18!GO:0032555;purine ribonucleotide binding;5.782047386156e-18!GO:0009057;macromolecule catabolic process;7.58024693193723e-18!GO:0017076;purine nucleotide binding;1.23313930271757e-17!GO:0044248;cellular catabolic process;1.37099233891328e-17!GO:0051186;cofactor metabolic process;3.18350281555642e-17!GO:0012505;endomembrane system;3.90923910500663e-17!GO:0005524;ATP binding;6.96423338345795e-17!GO:0005635;nuclear envelope;7.5790658917393e-17!GO:0051603;proteolysis involved in cellular protein catabolic process;7.70828963132658e-17!GO:0006511;ubiquitin-dependent protein catabolic process;1.02114418075477e-16!GO:0019941;modification-dependent protein catabolic process;1.15299051452943e-16!GO:0043632;modification-dependent macromolecule catabolic process;1.15299051452943e-16!GO:0008135;translation factor activity, nucleic acid binding;1.21731796336646e-16!GO:0032559;adenyl ribonucleotide binding;1.43557157471358e-16!GO:0016655;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor;2.18857195105111e-16!GO:0044257;cellular protein catabolic process;2.21598001885373e-16!GO:0005843;cytosolic small ribosomal subunit (sensu Eukaryota);2.90197328154628e-16!GO:0000502;proteasome complex (sensu Eukaryota);3.10133982110233e-16!GO:0030554;adenyl nucleotide binding;5.05785358461621e-16!GO:0042254;ribosome biogenesis and assembly;5.77950409826028e-16!GO:0050136;NADH dehydrogenase (quinone) activity;7.13950701172035e-16!GO:0003954;NADH dehydrogenase activity;7.13950701172035e-16!GO:0008137;NADH dehydrogenase (ubiquinone) activity;7.13950701172035e-16!GO:0000398;nuclear mRNA splicing, via spliceosome;1.00940330812027e-15!GO:0000375;RNA splicing, via transesterification reactions;1.00940330812027e-15!GO:0000377;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;1.00940330812027e-15!GO:0006605;protein targeting;1.74325958275638e-15!GO:0050657;nucleic acid transport;2.69100174559585e-15!GO:0051236;establishment of RNA localization;2.69100174559585e-15!GO:0050658;RNA transport;2.69100174559585e-15!GO:0031965;nuclear membrane;2.91925828144739e-15!GO:0005761;mitochondrial ribosome;3.48781296605364e-15!GO:0000313;organellar ribosome;3.48781296605364e-15!GO:0016604;nuclear body;3.87140658113169e-15!GO:0044453;nuclear membrane part;3.87734031819595e-15!GO:0006403;RNA localization;4.45394603102055e-15!GO:0008134;transcription factor binding;1.01955274571249e-14!GO:0016887;ATPase activity;1.28232437327036e-14!GO:0006732;coenzyme metabolic process;1.37876097147657e-14!GO:0042623;ATPase activity, coupled;1.38007795887154e-14!GO:0043412;biopolymer modification;1.5289182049196e-14!GO:0051082;unfolded protein binding;2.58745428585162e-14!GO:0042775;organelle ATP synthesis coupled electron transport;2.90218146227239e-14!GO:0042773;ATP synthesis coupled electron transport;2.90218146227239e-14!GO:0005643;nuclear pore;4.41794572174917e-14!GO:0005842;cytosolic large ribosomal subunit (sensu Eukaryota);4.99577269381126e-14!GO:0006913;nucleocytoplasmic transport;6.85566009001738e-14!GO:0030964;NADH dehydrogenase complex (quinone);7.51319842578835e-14!GO:0045271;respiratory chain complex I;7.51319842578835e-14!GO:0005747;mitochondrial respiratory chain complex I;7.51319842578835e-14!GO:0051726;regulation of cell cycle;1.13426966965089e-13!GO:0000074;regulation of progression through cell cycle;1.45301195291388e-13!GO:0051169;nuclear transport;1.53076735373102e-13!GO:0030163;protein catabolic process;1.68556021694733e-13!GO:0044432;endoplasmic reticulum part;2.0440131167757e-13!GO:0006120;mitochondrial electron transport, NADH to ubiquinone;2.07337481689066e-13!GO:0003743;translation initiation factor activity;3.03538901945952e-13!GO:0051028;mRNA transport;3.39123727440154e-13!GO:0006413;translational initiation;3.80920025112398e-13!GO:0000785;chromatin;7.59492574704612e-13!GO:0006333;chromatin assembly or disassembly;7.68043504283241e-13!GO:0016568;chromatin modification;8.62168791079006e-13!GO:0004386;helicase activity;8.64431960068296e-13!GO:0006399;tRNA metabolic process;2.02784223364192e-12!GO:0015931;nucleobase, nucleoside, nucleotide and nucleic acid transport;2.55997619741099e-12!GO:0016607;nuclear speck;3.0685071511157e-12!GO:0006464;protein modification process;3.25605909407156e-12!GO:0016651;oxidoreductase activity, acting on NADH or NADPH;5.14289822511356e-12!GO:0046930;pore complex;5.73360787936815e-12!GO:0065004;protein-DNA complex assembly;1.12707905056753e-11!GO:0000775;chromosome, pericentric region;1.37936898557142e-11!GO:0065002;intracellular protein transport across a membrane;1.69011015122047e-11!GO:0006446;regulation of translational initiation;1.83880639803987e-11!GO:0009259;ribonucleotide metabolic process;2.68250712422424e-11!GO:0006364;rRNA processing;3.7557362345609e-11!GO:0016192;vesicle-mediated transport;4.07309307565699e-11!GO:0008026;ATP-dependent helicase activity;4.13505436227859e-11!GO:0050794;regulation of cellular process;5.78517572592315e-11!GO:0006163;purine nucleotide metabolic process;6.40918880717616e-11!GO:0016072;rRNA metabolic process;6.72203332365199e-11!GO:0048193;Golgi vesicle transport;7.52968688979599e-11!GO:0005783;endoplasmic reticulum;7.67912605748704e-11!GO:0046961;hydrogen ion transporting ATPase activity, rotational mechanism;1.16106098306431e-10!GO:0043687;post-translational protein modification;1.16106098306431e-10!GO:0019222;regulation of metabolic process;1.24121201796412e-10!GO:0051188;cofactor biosynthetic process;1.44753037480539e-10!GO:0006366;transcription from RNA polymerase II promoter;1.46617450205175e-10!GO:0016591;DNA-directed RNA polymerase II, holoenzyme;1.62520851617397e-10!GO:0012501;programmed cell death;2.09812804270295e-10!GO:0006915;apoptosis;2.52541078415472e-10!GO:0009260;ribonucleotide biosynthetic process;2.85919859290682e-10!GO:0006164;purine nucleotide biosynthetic process;3.09193777870585e-10!GO:0016779;nucleotidyltransferase activity;3.45300027460893e-10!GO:0042175;nuclear envelope-endoplasmic reticulum network;3.59358125225578e-10!GO:0009056;catabolic process;3.64895082871725e-10!GO:0009055;electron carrier activity;4.14686661291898e-10!GO:0008639;small protein conjugating enzyme activity;4.36192312463941e-10!GO:0016879;ligase activity, forming carbon-nitrogen bonds;4.36192312463941e-10!GO:0009150;purine ribonucleotide metabolic process;5.10683244493855e-10!GO:0043566;structure-specific DNA binding;5.80870948108098e-10!GO:0005789;endoplasmic reticulum membrane;6.74361163217072e-10!GO:0008565;protein transporter activity;9.61494049142842e-10!GO:0004842;ubiquitin-protein ligase activity;1.1446179434091e-09!GO:0005819;spindle;1.14749399889331e-09!GO:0003712;transcription cofactor activity;1.1779461984897e-09!GO:0046933;hydrogen ion transporting ATP synthase activity, rotational mechanism;1.4343791309099e-09!GO:0016876;ligase activity, forming aminoacyl-tRNA and related compounds;1.56171278729026e-09!GO:0004812;aminoacyl-tRNA ligase activity;1.56171278729026e-09!GO:0016875;ligase activity, forming carbon-oxygen bonds;1.56171278729026e-09!GO:0019787;small conjugating protein ligase activity;1.56171278729026e-09!GO:0009060;aerobic respiration;1.72242221609323e-09!GO:0016787;hydrolase activity;1.9250039789066e-09!GO:0006334;nucleosome assembly;1.94031828433471e-09!GO:0017038;protein import;1.94031828433471e-09!GO:0008219;cell death;2.00502213706252e-09!GO:0016265;death;2.00502213706252e-09!GO:0006461;protein complex assembly;2.18371114181366e-09!GO:0009152;purine ribonucleotide biosynthetic process;2.40135285319554e-09!GO:0043038;amino acid activation;2.44029194282053e-09!GO:0006418;tRNA aminoacylation for protein translation;2.44029194282053e-09!GO:0043039;tRNA aminoacylation;2.44029194282053e-09!GO:0009199;ribonucleoside triphosphate metabolic process;2.89974956114098e-09!GO:0009141;nucleoside triphosphate metabolic process;3.40447104216891e-09!GO:0006261;DNA-dependent DNA replication;4.05309120288733e-09!GO:0015986;ATP synthesis coupled proton transport;4.62193470130599e-09!GO:0015985;energy coupled proton transport, down electrochemical gradient;4.62193470130599e-09!GO:0031497;chromatin assembly;4.63617931695632e-09!GO:0009142;nucleoside triphosphate biosynthetic process;5.07115196923993e-09!GO:0009201;ribonucleoside triphosphate biosynthetic process;5.07115196923993e-09!GO:0030532;small nuclear ribonucleoprotein complex;5.07733180474421e-09!GO:0009108;coenzyme biosynthetic process;5.99208794062884e-09!GO:0003697;single-stranded DNA binding;8.25891811411348e-09!GO:0009205;purine ribonucleoside triphosphate metabolic process;8.25891811411348e-09!GO:0009144;purine nucleoside triphosphate metabolic process;8.25891811411348e-09!GO:0015630;microtubule cytoskeleton;1.02503650204228e-08!GO:0016881;acid-amino acid ligase activity;1.52843760653588e-08!GO:0009206;purine ribonucleoside triphosphate biosynthetic process;1.52843760653588e-08!GO:0009145;purine nucleoside triphosphate biosynthetic process;1.52843760653588e-08!GO:0019829;cation-transporting ATPase activity;1.65846178117064e-08!GO:0045333;cellular respiration;1.69435837391655e-08!GO:0031323;regulation of cellular metabolic process;1.84041061706685e-08!GO:0055086;nucleobase, nucleoside and nucleotide metabolic process;2.22352346198374e-08!GO:0051329;interphase of mitotic cell cycle;4.39774365529962e-08!GO:0046034;ATP metabolic process;4.84387993601243e-08!GO:0007051;spindle organization and biogenesis;5.10828826272081e-08!GO:0005813;centrosome;5.12025528483748e-08!GO:0051325;interphase;5.120475384538e-08!GO:0032446;protein modification by small protein conjugation;6.03158894276616e-08!GO:0005815;microtubule organizing center;6.66356102846527e-08!GO:0006754;ATP biosynthetic process;6.68851590568704e-08!GO:0006753;nucleoside phosphate metabolic process;6.68851590568704e-08!GO:0005839;proteasome core complex (sensu Eukaryota);7.81488923020179e-08!GO:0016567;protein ubiquitination;9.65325717006342e-08!GO:0006099;tricarboxylic acid cycle;1.15241009536524e-07!GO:0046356;acetyl-CoA catabolic process;1.15241009536524e-07!GO:0005657;replication fork;1.22999975807316e-07!GO:0015078;hydrogen ion transmembrane transporter activity;1.25116731288081e-07!GO:0005794;Golgi apparatus;1.58987072153671e-07!GO:0031202;RNA splicing factor activity, transesterification mechanism;1.61157930359934e-07!GO:0006350;transcription;2.13424038459869e-07!GO:0000075;cell cycle checkpoint;2.2807341475562e-07!GO:0051246;regulation of protein metabolic process;2.48803798461958e-07!GO:0016740;transferase activity;2.559218575649e-07!GO:0050789;regulation of biological process;2.74143085917939e-07!GO:0003713;transcription coactivator activity;2.93985228394694e-07!GO:0005793;ER-Golgi intermediate compartment;2.96847018909895e-07!GO:0006084;acetyl-CoA metabolic process;3.12510803071359e-07!GO:0007059;chromosome segregation;3.29063320847998e-07!GO:0004298;threonine endopeptidase activity;3.48870361937753e-07!GO:0016469;proton-transporting two-sector ATPase complex;4.22099869651351e-07!GO:0051170;nuclear import;4.81231431017155e-07!GO:0009117;nucleotide metabolic process;5.13964794263289e-07!GO:0000151;ubiquitin ligase complex;6.49299525947055e-07!GO:0000245;spliceosome assembly;6.62455301389434e-07!GO:0009109;coenzyme catabolic process;6.95905532536536e-07!GO:0005667;transcription factor complex;7.81402378838642e-07!GO:0006752;group transfer coenzyme metabolic process;8.55350373928733e-07!GO:0051168;nuclear export;8.82304387300493e-07!GO:0045259;proton-transporting ATP synthase complex;8.82846723880285e-07!GO:0016363;nuclear matrix;9.85610633513074e-07!GO:0043623;cellular protein complex assembly;1.03815804862859e-06!GO:0030120;vesicle coat;1.12519078691429e-06!GO:0030662;coated vesicle membrane;1.12519078691429e-06!GO:0048475;coated membrane;1.20572786962684e-06!GO:0030117;membrane coat;1.20572786962684e-06!GO:0005773;vacuole;1.36038145942979e-06!GO:0006606;protein import into nucleus;1.44325051317696e-06!GO:0008094;DNA-dependent ATPase activity;1.44980146530797e-06!GO:0010468;regulation of gene expression;1.51951135760368e-06!GO:0042981;regulation of apoptosis;1.80620370387946e-06!GO:0006302;double-strand break repair;1.87771074439035e-06!GO:0007005;mitochondrion organization and biogenesis;1.89394992011446e-06!GO:0003677;DNA binding;1.91250176088147e-06!GO:0006888;ER to Golgi vesicle-mediated transport;2.1620376031917e-06!GO:0000323;lytic vacuole;2.21773711859135e-06!GO:0005764;lysosome;2.21773711859135e-06!GO:0051187;cofactor catabolic process;2.37509425431164e-06!GO:0006793;phosphorus metabolic process;2.48757220005677e-06!GO:0006796;phosphate metabolic process;2.48757220005677e-06!GO:0043067;regulation of programmed cell death;2.56141697005696e-06!GO:0003899;DNA-directed RNA polymerase activity;2.92545518665304e-06!GO:0006401;RNA catabolic process;3.64737986106778e-06!GO:0000776;kinetochore;3.83983809803295e-06!GO:0006613;cotranslational protein targeting to membrane;3.85519477091154e-06!GO:0019219;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;5.05477214924354e-06!GO:0007088;regulation of mitosis;5.40392690668182e-06!GO:0006310;DNA recombination;5.48223943319712e-06!GO:0003690;double-stranded DNA binding;5.59455118889228e-06!GO:0015077;monovalent inorganic cation transmembrane transporter activity;5.64427209163801e-06!GO:0051427;hormone receptor binding;6.26759889327287e-06!GO:0005768;endosome;1.12855840707649e-05!GO:0003724;RNA helicase activity;1.18308226959106e-05!GO:0016563;transcription activator activity;1.34319927513798e-05!GO:0035257;nuclear hormone receptor binding;1.3587261112339e-05!GO:0005762;mitochondrial large ribosomal subunit;1.46630019505458e-05!GO:0000315;organellar large ribosomal subunit;1.46630019505458e-05!GO:0016491;oxidoreductase activity;1.64530810483438e-05!GO:0016853;isomerase activity;2.34154318745074e-05!GO:0032774;RNA biosynthetic process;2.36131170556662e-05!GO:0031324;negative regulation of cellular metabolic process;2.49817816652604e-05!GO:0006612;protein targeting to membrane;2.50953446189235e-05!GO:0003729;mRNA binding;2.71338686774904e-05!GO:0045934;negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;2.96380144012532e-05!GO:0006351;transcription, DNA-dependent;3.41842557409211e-05!GO:0016741;transferase activity, transferring one-carbon groups;3.76303438750368e-05!GO:0005788;endoplasmic reticulum lumen;3.78325828705261e-05!GO:0043021;ribonucleoprotein binding;4.00949573667182e-05!GO:0005798;Golgi-associated vesicle;4.36049313870777e-05!GO:0045786;negative regulation of progression through cell cycle;4.73773330951537e-05!GO:0048523;negative regulation of cellular process;5.08569999286995e-05!GO:0000786;nucleosome;5.17833387049783e-05!GO:0008168;methyltransferase activity;5.51795975703297e-05!GO:0008654;phospholipid biosynthetic process;6.16459658538669e-05!GO:0044452;nucleolar part;6.22428376518983e-05!GO:0009165;nucleotide biosynthetic process;6.43850900781925e-05!GO:0000059;protein import into nucleus, docking;8.60860443418065e-05!GO:0016310;phosphorylation;9.30181545329739e-05!GO:0007093;mitotic cell cycle checkpoint;9.37247445530173e-05!GO:0030530;heterogeneous nuclear ribonucleoprotein complex;9.52420214092141e-05!GO:0004518;nuclease activity;0.000104650055130193!GO:0006357;regulation of transcription from RNA polymerase II promoter;0.000107280187984189!GO:0006405;RNA export from nucleus;0.000108463618808255!GO:0003755;peptidyl-prolyl cis-trans isomerase activity;0.000132880258707615!GO:0046489;phosphoinositide biosynthetic process;0.000135154424114644!GO:0042625;ATPase activity, coupled to transmembrane movement of ions;0.000136723555381827!GO:0003684;damaged DNA binding;0.000146725951675605!GO:0005885;Arp2/3 protein complex;0.000146974863597558!GO:0016859;cis-trans isomerase activity;0.000153813905896859!GO:0006414;translational elongation;0.000157411944065164!GO:0004527;exonuclease activity;0.000161508740667243!GO:0003678;DNA helicase activity;0.000169171907011386!GO:0031988;membrane-bound vesicle;0.000174460233907805!GO:0045449;regulation of transcription;0.000175111688424259!GO:0008033;tRNA processing;0.000180829592754214!GO:0000228;nuclear chromosome;0.0001810043783283!GO:0009892;negative regulation of metabolic process;0.000185946290176381!GO:0030880;RNA polymerase complex;0.000186658125642832!GO:0032508;DNA duplex unwinding;0.000204275120641503!GO:0032392;DNA geometric change;0.000204275120641503!GO:0006383;transcription from RNA polymerase III promoter;0.000204963732005458!GO:0016772;transferase activity, transferring phosphorus-containing groups;0.000204963732005458!GO:0007052;mitotic spindle organization and biogenesis;0.000210905268623914!GO:0000314;organellar small ribosomal subunit;0.000222527837870708!GO:0005763;mitochondrial small ribosomal subunit;0.000222527837870708!GO:0006950;response to stress;0.000228818653678167!GO:0005753;mitochondrial proton-transporting ATP synthase complex;0.000231396505106966!GO:0008186;RNA-dependent ATPase activity;0.000236404704621436!GO:0006091;generation of precursor metabolites and energy;0.000245809082799945!GO:0015980;energy derivation by oxidation of organic compounds;0.000254393948232532!GO:0016564;transcription repressor activity;0.000263316958260427!GO:0015992;proton transport;0.000283195452262837!GO:0030384;phosphoinositide metabolic process;0.000285053684239663!GO:0031982;vesicle;0.000299275630765818!GO:0006268;DNA unwinding during replication;0.000299706455256065!GO:0003682;chromatin binding;0.000305103728517533!GO:0007249;I-kappaB kinase/NF-kappaB cascade;0.000311266208641129!GO:0006402;mRNA catabolic process;0.000312130135016571!GO:0006818;hydrogen transport;0.000314664863348674!GO:0043681;protein import into mitochondrion;0.000314664863348674!GO:0016765;transferase activity, transferring alkyl or aryl (other than methyl) groups;0.000316086986119274!GO:0016023;cytoplasmic membrane-bound vesicle;0.000319635643915718!GO:0043123;positive regulation of I-kappaB kinase/NF-kappaB cascade;0.000349210209445498!GO:0016481;negative regulation of transcription;0.000376670832956713!GO:0016251;general RNA polymerase II transcription factor activity;0.000378436307990725!GO:0005852;eukaryotic translation initiation factor 3 complex;0.000399988114886939!GO:0055029;nuclear DNA-directed RNA polymerase complex;0.000400798350746591!GO:0000428;DNA-directed RNA polymerase complex;0.000400798350746591!GO:0000082;G1/S transition of mitotic cell cycle;0.000420271644444003!GO:0030867;rough endoplasmic reticulum membrane;0.000428591169398204!GO:0043122;regulation of I-kappaB kinase/NF-kappaB cascade;0.000470303622880578!GO:0045261;proton-transporting ATP synthase complex, catalytic core F(1);0.000484428181574231!GO:0051052;regulation of DNA metabolic process;0.000487371895751483!GO:0048519;negative regulation of biological process;0.000522269512164572!GO:0045454;cell redox homeostasis;0.000534889480411216!GO:0033178;proton-transporting two-sector ATPase complex, catalytic domain;0.000543933003525147!GO:0046474;glycerophospholipid biosynthetic process;0.000544714704315881!GO:0051252;regulation of RNA metabolic process;0.000587518619537936!GO:0019752;carboxylic acid metabolic process;0.000590647799789175!GO:0019899;enzyme binding;0.000612932630289152!GO:0031252;leading edge;0.000633424650031494!GO:0006082;organic acid metabolic process;0.00064301577437045!GO:0043069;negative regulation of programmed cell death;0.000648834330086029!GO:0006626;protein targeting to mitochondrion;0.000655794012476862!GO:0065009;regulation of a molecular function;0.000665891686370079!GO:0065007;biological regulation;0.000665891686370079!GO:0043596;nuclear replication fork;0.000665891686370079!GO:0031072;heat shock protein binding;0.000681641229031874!GO:0004004;ATP-dependent RNA helicase activity;0.000684571296279978!GO:0044440;endosomal part;0.000686987992312923!GO:0010008;endosome membrane;0.000686987992312923!GO:0030658;transport vesicle membrane;0.000724977635602876!GO:0031410;cytoplasmic vesicle;0.000767723907703027!GO:0016679;oxidoreductase activity, acting on diphenols and related substances as donors;0.000783797079491552!GO:0016681;oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor;0.000783797079491552!GO:0008121;ubiquinol-cytochrome-c reductase activity;0.000783797079491552!GO:0043066;negative regulation of apoptosis;0.000797681661620083!GO:0003924;GTPase activity;0.000807228064915313!GO:0016281;eukaryotic translation initiation factor 4F complex;0.000827455912935687!GO:0006916;anti-apoptosis;0.000881469187569899!GO:0005525;GTP binding;0.000901328094044643!GO:0015405;P-P-bond-hydrolysis-driven transmembrane transporter activity;0.000904598698973753!GO:0015399;primary active transmembrane transporter activity;0.000904598698973753!GO:0000819;sister chromatid segregation;0.00091236277362961!GO:0048500;signal recognition particle;0.000944482240852247!GO:0031124;mRNA 3'-end processing;0.00099314865391379!GO:0000922;spindle pole;0.00109173932212535!GO:0005770;late endosome;0.00113061874596213!GO:0006352;transcription initiation;0.00122984352401265!GO:0031968;organelle outer membrane;0.00125590381769329!GO:0000070;mitotic sister chromatid segregation;0.00127971196577165!GO:0003702;RNA polymerase II transcription factor activity;0.00128496791339524!GO:0044431;Golgi apparatus part;0.00128496791339524!GO:0051920;peroxiredoxin activity;0.00130569559055913!GO:0005741;mitochondrial outer membrane;0.0014530287134988!GO:0005684;U2-dependent spliceosome;0.00149049755285833!GO:0008312;7S RNA binding;0.00149979041993786!GO:0005769;early endosome;0.00156783363218014!GO:0033367;protein localization in mast cell secretory granule;0.001635409458812!GO:0033365;protein localization in organelle;0.001635409458812!GO:0033371;T cell secretory granule organization and biogenesis;0.001635409458812!GO:0033373;maintenance of protease localization in mast cell secretory granule;0.001635409458812!GO:0033375;protease localization in T cell secretory granule;0.001635409458812!GO:0042629;mast cell granule;0.001635409458812!GO:0033377;maintenance of protein localization in T cell secretory granule;0.001635409458812!GO:0033364;mast cell secretory granule organization and biogenesis;0.001635409458812!GO:0033380;granzyme B localization in T cell secretory granule;0.001635409458812!GO:0033379;maintenance of protease localization in T cell secretory granule;0.001635409458812!GO:0033370;maintenance of protein localization in mast cell secretory granule;0.001635409458812!GO:0033368;protease localization in mast cell secretory granule;0.001635409458812!GO:0033366;protein localization in secretory granule;0.001635409458812!GO:0033382;maintenance of granzyme B localization in T cell secretory granule;0.001635409458812!GO:0033374;protein localization in T cell secretory granule;0.001635409458812!GO:0045045;secretory pathway;0.0016507208802765!GO:0000079;regulation of cyclin-dependent protein kinase activity;0.00167814719740519!GO:0030660;Golgi-associated vesicle membrane;0.00169277060004004!GO:0006270;DNA replication initiation;0.00169753397961121!GO:0007006;mitochondrial membrane organization and biogenesis;0.00169905397813355!GO:0006650;glycerophospholipid metabolic process;0.00175739138153835!GO:0019867;outer membrane;0.00176411062196941!GO:0006355;regulation of transcription, DNA-dependent;0.00184905577183833!GO:0006839;mitochondrial transport;0.0019065386543013!GO:0042393;histone binding;0.0019303498809536!GO:0009112;nucleobase metabolic process;0.00195112246848562!GO:0006506;GPI anchor biosynthetic process;0.00195796775355082!GO:0005876;spindle microtubule;0.00199685185009325!GO:0006611;protein export from nucleus;0.00203820016707028!GO:0006497;protein amino acid lipidation;0.00205096165848986!GO:0000792;heterochromatin;0.00213243177277455!GO:0005048;signal sequence binding;0.00215734088159042!GO:0006614;SRP-dependent cotranslational protein targeting to membrane;0.00220269548021496!GO:0045047;protein targeting to ER;0.00220269548021496!GO:0042802;identical protein binding;0.00221032568069792!GO:0046483;heterocycle metabolic process;0.00221032568069792!GO:0045263;proton-transporting ATP synthase complex, coupling factor F(o);0.00221032568069792!GO:0033177;proton-transporting two-sector ATPase complex, proton-transporting domain;0.00221032568069792!GO:0043601;nuclear replisome;0.00221032568069792!GO:0030894;replisome;0.00221032568069792!GO:0000152;nuclear ubiquitin ligase complex;0.00244080014106895!GO:0000226;microtubule cytoskeleton organization and biogenesis;0.00247880589410735!GO:0030663;COPI coated vesicle membrane;0.00253755538557564!GO:0030126;COPI vesicle coat;0.00253755538557564!GO:0019843;rRNA binding;0.002594620916571!GO:0000049;tRNA binding;0.00266577277109003!GO:0032940;secretion by cell;0.00267993922388126!GO:0005838;proteasome regulatory particle (sensu Eukaryota);0.00272509020980231!GO:0051087;chaperone binding;0.00287662008812201!GO:0006505;GPI anchor metabolic process;0.00291368484514681!GO:0000725;recombinational repair;0.00306747969177091!GO:0000724;double-strand break repair via homologous recombination;0.00306747969177091!GO:0008276;protein methyltransferase activity;0.00306747969177091!GO:0005786;signal recognition particle, endoplasmic reticulum targeting;0.00306953913663082!GO:0043284;biopolymer biosynthetic process;0.00322239339289742!GO:0046467;membrane lipid biosynthetic process;0.00341012069394268!GO:0006417;regulation of translation;0.00347333557110099!GO:0032200;telomere organization and biogenesis;0.00347434074323297!GO:0000723;telomere maintenance;0.00347434074323297!GO:0000184;mRNA catabolic process, nonsense-mediated decay;0.00358916316264447!GO:0044454;nuclear chromosome part;0.00364806734337557!GO:0042158;lipoprotein biosynthetic process;0.00376266491861639!GO:0044262;cellular carbohydrate metabolic process;0.00381190290023429!GO:0046966;thyroid hormone receptor binding;0.00390680134097921!GO:0006891;intra-Golgi vesicle-mediated transport;0.00397087914239844!GO:0006338;chromatin remodeling;0.0039903812665911!GO:0031123;RNA 3'-end processing;0.00401263673730284!GO:0005665;DNA-directed RNA polymerase II, core complex;0.00407277737846554!GO:0007017;microtubule-based process;0.00420854993147708!GO:0030118;clathrin coat;0.00423635603141021!GO:0047485;protein N-terminus binding;0.004411152374935!GO:0000339;RNA cap binding;0.00461926155860307!GO:0031570;DNA integrity checkpoint;0.00464809628756815!GO:0016197;endosome transport;0.00468280230794096!GO:0003711;transcription elongation regulator activity;0.00471571154888922!GO:0043492;ATPase activity, coupled to movement of substances;0.00477763707293539!GO:0007034;vacuolar transport;0.00478165743148151!GO:0005774;vacuolar membrane;0.00479372633090963!GO:0008047;enzyme activator activity;0.00483581515135974!GO:0000178;exosome (RNase complex);0.00491228115684849!GO:0006595;polyamine metabolic process;0.00494983767932045!GO:0006520;amino acid metabolic process;0.00495331592881625!GO:0006406;mRNA export from nucleus;0.00495755335651502!GO:0043488;regulation of mRNA stability;0.00519849469652523!GO:0043487;regulation of RNA stability;0.00519849469652523!GO:0005669;transcription factor TFIID complex;0.00531239576173123!GO:0005758;mitochondrial intermembrane space;0.00534800934324402!GO:0008632;apoptotic program;0.00547157885374879!GO:0006144;purine base metabolic process;0.00550371258615107!GO:0016272;prefoldin complex;0.00569140910538018!GO:0005637;nuclear inner membrane;0.00578018287073794!GO:0000910;cytokinesis;0.00583488209057481!GO:0030521;androgen receptor signaling pathway;0.00594314784739943!GO:0007021;tubulin folding;0.00595144561820348!GO:0043065;positive regulation of apoptosis;0.00600714894847741!GO:0042626;ATPase activity, coupled to transmembrane movement of substances;0.00609863948627171!GO:0046983;protein dimerization activity;0.00618329975027379!GO:0030176;integral to endoplasmic reticulum membrane;0.00619905473558445!GO:0022890;inorganic cation transmembrane transporter activity;0.00623368204700686!GO:0032984;macromolecular complex disassembly;0.00623368204700686!GO:0016820;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;0.00623368204700686!GO:0008610;lipid biosynthetic process;0.00623579111072447!GO:0050662;coenzyme binding;0.00623579111072447!GO:0006284;base-excision repair;0.0062626916236445!GO:0051539;4 iron, 4 sulfur cluster binding;0.00635448784279532!GO:0035258;steroid hormone receptor binding;0.00642067885849957!GO:0007040;lysosome organization and biogenesis;0.00649029421460283!GO:0031577;spindle checkpoint;0.00652289912907982!GO:0031326;regulation of cellular biosynthetic process;0.00660195311397851!GO:0015631;tubulin binding;0.00661739553060865!GO:0004437;inositol or phosphatidylinositol phosphatase activity;0.00667193460164655!GO:0008757;S-adenosylmethionine-dependent methyltransferase activity;0.00669480087672905!GO:0043161;proteasomal ubiquitin-dependent protein catabolic process;0.00673883950130359!GO:0000726;non-recombinational repair;0.00689179872524751!GO:0006289;nucleotide-excision repair;0.00693207943025669!GO:0000096;sulfur amino acid metabolic process;0.0069372952045474!GO:0003887;DNA-directed DNA polymerase activity;0.0070009842028014!GO:0033116;ER-Golgi intermediate compartment membrane;0.00726049207320718!GO:0000139;Golgi membrane;0.00726130283730989!GO:0051540;metal cluster binding;0.00728310885381231!GO:0051536;iron-sulfur cluster binding;0.00728310885381231!GO:0016584;nucleosome positioning;0.00729660419473315!GO:0006378;mRNA polyadenylation;0.00730269845578121!GO:0009451;RNA modification;0.00735916373965151!GO:0006376;mRNA splice site selection;0.00739301409582076!GO:0000389;nuclear mRNA 3'-splice site recognition;0.00739301409582076!GO:0043068;positive regulation of programmed cell death;0.0075490351134552!GO:0008408;3'-5' exonuclease activity;0.00760081048334448!GO:0032603;fractalkine production;0.00763191080778936!GO:0050725;positive regulation of interleukin-1 beta biosynthetic process;0.00763191080778936!GO:0050752;regulation of fractalkine biosynthetic process;0.00763191080778936!GO:0045362;positive regulation of interleukin-1 biosynthetic process;0.00763191080778936!GO:0050754;positive regulation of fractalkine biosynthetic process;0.00763191080778936!GO:0001774;microglial cell activation;0.00763191080778936!GO:0050756;fractalkine metabolic process;0.00763191080778936!GO:0005766;primary lysosome;0.00763191080778936!GO:0050751;fractalkine biosynthetic process;0.00763191080778936!GO:0042222;interleukin-1 biosynthetic process;0.00763191080778936!GO:0050722;regulation of interleukin-1 beta biosynthetic process;0.00763191080778936!GO:0045360;regulation of interleukin-1 biosynthetic process;0.00763191080778936!GO:0042582;azurophil granule;0.00763191080778936!GO:0050720;interleukin-1 beta biosynthetic process;0.00763191080778936!GO:0032561;guanyl ribonucleotide binding;0.00763199465496454!GO:0019001;guanyl nucleotide binding;0.00763199465496454!GO:0030137;COPI-coated vesicle;0.00778086883964893!GO:0051287;NAD binding;0.00783090771695012!GO:0007243;protein kinase cascade;0.00783946545933374!GO:0005905;coated pit;0.00835145790094858!GO:0003714;transcription corepressor activity;0.00847614198072076!GO:0016891;endoribonuclease activity, producing 5'-phosphomonoesters;0.00847614198072076!GO:0048522;positive regulation of cellular process;0.00881966063177851!GO:0016796;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters;0.00891677622050726!GO:0000781;chromosome, telomeric region;0.00895951871357049!GO:0005832;chaperonin-containing T-complex;0.00906206609610045!GO:0051053;negative regulation of DNA metabolic process;0.00906462652541499!GO:0005791;rough endoplasmic reticulum;0.00915430922199213!GO:0016018;cyclosporin A binding;0.00920544015253526!GO:0009116;nucleoside metabolic process;0.00926505480893598!GO:0043022;ribosome binding;0.00926505480893598!GO:0016893;endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters;0.00931500289168449!GO:0050790;regulation of catalytic activity;0.00946147726753709!GO:0005874;microtubule;0.00961399191017864!GO:0004003;ATP-dependent DNA helicase activity;0.00965966462191204!GO:0003746;translation elongation factor activity;0.00989425690044612!GO:0016279;protein-lysine N-methyltransferase activity;0.00989425690044612!GO:0018024;histone-lysine N-methyltransferase activity;0.00989425690044612!GO:0016278;lysine N-methyltransferase activity;0.00989425690044612!GO:0004177;aminopeptidase activity;0.00995200399805442!GO:0016676;oxidoreductase activity, acting on heme group of donors, oxygen as acceptor;0.00995200399805442!GO:0015002;heme-copper terminal oxidase activity;0.00995200399805442!GO:0016675;oxidoreductase activity, acting on heme group of donors;0.00995200399805442!GO:0004129;cytochrome-c oxidase activity;0.00995200399805442!GO:0051789;response to protein stimulus;0.00995200399805442!GO:0006986;response to unfolded protein;0.00995200399805442!GO:0032259;methylation;0.010162398669675!GO:0044437;vacuolar part;0.0105961384062762!GO:0042054;histone methyltransferase activity;0.0106807154256849!GO:0016791;phosphoric monoester hydrolase activity;0.0106963077712633!GO:0043241;protein complex disassembly;0.0107243873632727!GO:0043414;biopolymer methylation;0.0109456316473556!GO:0005765;lysosomal membrane;0.0109798454663037!GO:0004674;protein serine/threonine kinase activity;0.0110021612739996!GO:0000118;histone deacetylase complex;0.0111760821109097!GO:0016862;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;0.0112293368533009!GO:0007010;cytoskeleton organization and biogenesis;0.0112341500779175!GO:0009124;nucleoside monophosphate biosynthetic process;0.01131167432184!GO:0009123;nucleoside monophosphate metabolic process;0.01131167432184!GO:0008139;nuclear localization sequence binding;0.0114867940677721!GO:0031970;organelle envelope lumen;0.011529938363397!GO:0004540;ribonuclease activity;0.0115817991509704!GO:0006767;water-soluble vitamin metabolic process;0.0116104867583368!GO:0008097;5S rRNA binding;0.0116881840138377!GO:0042770;DNA damage response, signal transduction;0.0116965541895686!GO:0016311;dephosphorylation;0.0118370296662785!GO:0048471;perinuclear region of cytoplasm;0.0129796938432832!GO:0016569;covalent chromatin modification;0.0129796938432832!GO:0006007;glucose catabolic process;0.0135607351328576!GO:0006733;oxidoreduction coenzyme metabolic process;0.0138672488226662!GO:0006509;membrane protein ectodomain proteolysis;0.0138761807575274!GO:0033619;membrane protein proteolysis;0.0138761807575274!GO:0004576;oligosaccharyl transferase activity;0.0141928935593076!GO:0000790;nuclear chromatin;0.0143936706475671!GO:0008250;oligosaccharyl transferase complex;0.0149369172305887!GO:0006890;retrograde vesicle-mediated transport, Golgi to ER;0.0149651485893603!GO:0030119;AP-type membrane coat adaptor complex;0.0150048562628206!GO:0004532;exoribonuclease activity;0.0150724060780995!GO:0016896;exoribonuclease activity, producing 5'-phosphomonoesters;0.0150724060780995!GO:0007050;cell cycle arrest;0.015229326857111!GO:0000209;protein polyubiquitination;0.0155393901492489!GO:0008234;cysteine-type peptidase activity;0.0156275321601742!GO:0003857;3-hydroxyacyl-CoA dehydrogenase activity;0.0156384076215781!GO:0001726;ruffle;0.0157352296763651!GO:0007033;vacuole organization and biogenesis;0.0157994698676745!GO:0000077;DNA damage checkpoint;0.0161388360143445!GO:0008180;signalosome;0.0164322811214668!GO:0030041;actin filament polymerization;0.0165011298554248!GO:0006607;NLS-bearing substrate import into nucleus;0.0168987744201742!GO:0007094;mitotic cell cycle spindle assembly checkpoint;0.0169190818088627!GO:0005777;peroxisome;0.017029924920483!GO:0042579;microbody;0.017029924920483!GO:0030518;steroid hormone receptor signaling pathway;0.0173508857240693!GO:0032039;integrator complex;0.0174235520743455!GO:0006917;induction of apoptosis;0.0175769129812341!GO:0004579;dolichyl-diphosphooligosaccharide-protein glycotransferase activity;0.0181152720440117!GO:0048487;beta-tubulin binding;0.0181927421159266!GO:0030134;ER to Golgi transport vesicle;0.0183336078896154!GO:0002084;protein depalmitoylation;0.0186091766211379!GO:0022411;cellular component disassembly;0.0186850859680871!GO:0006220;pyrimidine nucleotide metabolic process;0.0191325318096675!GO:0005680;anaphase-promoting complex;0.019622265654416!GO:0030133;transport vesicle;0.019622265654416!GO:0003923;GPI-anchor transamidase activity;0.0200371304442703!GO:0016255;attachment of GPI anchor to protein;0.0200371304442703!GO:0042765;GPI-anchor transamidase complex;0.0200371304442703!GO:0006367;transcription initiation from RNA polymerase II promoter;0.0201878580224794!GO:0046112;nucleobase biosynthetic process;0.0204629856830913!GO:0005869;dynactin complex;0.0205696832172631!GO:0000287;magnesium ion binding;0.0206126211072045!GO:0009889;regulation of biosynthetic process;0.0207636419944491!GO:0000086;G2/M transition of mitotic cell cycle;0.0213313878243103!GO:0030131;clathrin adaptor complex;0.0214497828411085!GO:0043624;cellular protein complex disassembly;0.0215464421651862!GO:0008144;drug binding;0.0224053564646612!GO:0030127;COPII vesicle coat;0.0224876391972662!GO:0012507;ER to Golgi transport vesicle membrane;0.0224876391972662!GO:0006672;ceramide metabolic process;0.0224984970391804!GO:0007041;lysosomal transport;0.0224984970391804!GO:0012502;induction of programmed cell death;0.0225289688108165!GO:0046365;monosaccharide catabolic process;0.0229104012774129!GO:0004520;endodeoxyribonuclease activity;0.0234551555741239!GO:0003725;double-stranded RNA binding;0.0240702070008272!GO:0030125;clathrin vesicle coat;0.0247427034477877!GO:0030665;clathrin coated vesicle membrane;0.0247427034477877!GO:0006275;regulation of DNA replication;0.0247427034477877!GO:0009161;ribonucleoside monophosphate metabolic process;0.0248761709453919!GO:0009156;ribonucleoside monophosphate biosynthetic process;0.0248761709453919!GO:0030508;thiol-disulfide exchange intermediate activity;0.0250729015493834!GO:0005658;alpha DNA polymerase:primase complex;0.0251561978512597!GO:0016788;hydrolase activity, acting on ester bonds;0.0251706410470804!GO:0018196;peptidyl-asparagine modification;0.0251991101069479!GO:0018279;protein amino acid N-linked glycosylation via asparagine;0.0251991101069479!GO:0016126;sterol biosynthetic process;0.0253027960781529!GO:0043524;negative regulation of neuron apoptosis;0.0255399468194623!GO:0035267;NuA4 histone acetyltransferase complex;0.0257823735100248!GO:0006730;one-carbon compound metabolic process;0.0263924494869558!GO:0031371;ubiquitin conjugating enzyme complex;0.0263990683422753!GO:0006266;DNA ligation;0.02680935581662!GO:0046982;protein heterodimerization activity;0.02680935581662!GO:0008538;proteasome activator activity;0.02680935581662!GO:0032981;mitochondrial respiratory chain complex I assembly;0.0268169287695875!GO:0010257;NADH dehydrogenase complex assembly;0.0268169287695875!GO:0033108;mitochondrial respiratory chain complex assembly;0.0268169287695875!GO:0005996;monosaccharide metabolic process;0.0270342397299829!GO:0004523;ribonuclease H activity;0.0272522560021098!GO:0007004;telomere maintenance via telomerase;0.0273636128772812!GO:0016667;oxidoreductase activity, acting on sulfur group of donors;0.0276021844411708!GO:0016408;C-acyltransferase activity;0.0276209378417042!GO:0006596;polyamine biosynthetic process;0.0276264511842554!GO:0008637;apoptotic mitochondrial changes;0.0277003395592573!GO:0009303;rRNA transcription;0.0281648546844004!GO:0005784;translocon complex;0.0285648379614599!GO:0000793;condensed chromosome;0.0286724729063208!GO:0016570;histone modification;0.0288499764262066!GO:0016627;oxidoreductase activity, acting on the CH-CH group of donors;0.0289808483755607!GO:0043189;H4/H2A histone acetyltransferase complex;0.0295014695353035!GO:0008022;protein C-terminus binding;0.0296390659959104!GO:0019318;hexose metabolic process;0.0297032263704902!GO:0005663;DNA replication factor C complex;0.0300704073781543!GO:0002763;positive regulation of myeloid leukocyte differentiation;0.0304331647735183!GO:0008536;Ran GTPase binding;0.030913868829083!GO:0005853;eukaryotic translation elongation factor 1 complex;0.0310321178940763!GO:0030433;ER-associated protein catabolic process;0.0312242026831147!GO:0006515;misfolded or incompletely synthesized protein catabolic process;0.0312242026831147!GO:0006516;glycoprotein catabolic process;0.0315737688127485!GO:0051656;establishment of organelle localization;0.0316921083277187!GO:0007007;inner mitochondrial membrane organization and biogenesis;0.0320239460120463!GO:0046164;alcohol catabolic process;0.0320922815938254!GO:0004261;cathepsin G activity;0.0325462283361162!GO:0030132;clathrin coat of coated pit;0.03268473755537!GO:0000123;histone acetyltransferase complex;0.0327746753895926!GO:0050681;androgen receptor binding;0.0329230750365449!GO:0005850;eukaryotic translation initiation factor 2 complex;0.0333951042216506!GO:0019320;hexose catabolic process;0.0334487785991963!GO:0045892;negative regulation of transcription, DNA-dependent;0.0336581643591006!GO:0019206;nucleoside kinase activity;0.0342094136747332!GO:0006301;postreplication repair;0.0350629470278708!GO:0043631;RNA polyadenylation;0.0351894369215638!GO:0030130;clathrin coat of trans-Golgi network vesicle;0.0360214474945607!GO:0012510;trans-Golgi network transport vesicle membrane;0.0360214474945607!GO:0044450;microtubule organizing center part;0.0361398661959585!GO:0003756;protein disulfide isomerase activity;0.0363921983285216!GO:0016864;intramolecular oxidoreductase activity, transposing S-S bonds;0.0363921983285216!GO:0044438;microbody part;0.0366617433708204!GO:0044439;peroxisomal part;0.0366617433708204!GO:0004448;isocitrate dehydrogenase activity;0.0375044758723425!GO:0031647;regulation of protein stability;0.0383183948063806!GO:0016407;acetyltransferase activity;0.0386242746965211!GO:0006643;membrane lipid metabolic process;0.0386726877862376!GO:0008156;negative regulation of DNA replication;0.0392419451231441!GO:0030911;TPR domain binding;0.0401630251390339!GO:0019783;small conjugating protein-specific protease activity;0.0402341472988698!GO:0015036;disulfide oxidoreductase activity;0.040271246662725!GO:0006779;porphyrin biosynthetic process;0.040271246662725!GO:0033014;tetrapyrrole biosynthetic process;0.040271246662725!GO:0006458;'de novo' protein folding;0.0403903075784884!GO:0051084;'de novo' posttranslational protein folding;0.0403903075784884!GO:0000097;sulfur amino acid biosynthetic process;0.0404163587200499!GO:0006400;tRNA modification;0.0404840995748278!GO:0005975;carbohydrate metabolic process;0.0418784077208156!GO:0004721;phosphoprotein phosphatase activity;0.0423256145901576!GO:0031625;ubiquitin protein ligase binding;0.0423256145901576!GO:0006303;double-strand break repair via nonhomologous end joining;0.0423588278285699!GO:0004843;ubiquitin-specific protease activity;0.0427017167243556!GO:0006356;regulation of transcription from RNA polymerase I promoter;0.0430370040252945!GO:0046519;sphingoid metabolic process;0.0434811458590684!GO:0030036;actin cytoskeleton organization and biogenesis;0.0436229647423278!GO:0000119;mediator complex;0.0438442352744178!GO:0019377;glycolipid catabolic process;0.0443169428572066!GO:0046479;glycosphingolipid catabolic process;0.0443341825372988!GO:0016180;snRNA processing;0.0445485119142838!GO:0016073;snRNA metabolic process;0.0445485119142838!GO:0017166;vinculin binding;0.0445485119142838!GO:0015923;mannosidase activity;0.0445485119142838!GO:0006278;RNA-dependent DNA replication;0.0445485119142838!GO:0006695;cholesterol biosynthetic process;0.0447423241038605!GO:0042026;protein refolding;0.0448253641134125!GO:0048037;cofactor binding;0.0455638764935922!GO:0007096;regulation of exit from mitosis;0.0455638764935922!GO:0010458;exit from mitosis;0.0455638764935922!GO:0006740;NADPH regeneration;0.0457098638603957!GO:0006098;pentose-phosphate shunt;0.0457098638603957!GO:0006379;mRNA cleavage;0.0468364074672823!GO:0022406;membrane docking;0.0470403094364042!GO:0048278;vesicle docking;0.0470403094364042!GO:0031903;microbody membrane;0.0481646340374902!GO:0005778;peroxisomal membrane;0.0481646340374902!GO:0004659;prenyltransferase activity;0.0497831613183411 | |||
|sample_id=10400 | |||
|sample_note=machine failed, remainder reloaded, low amount | |||
|sample_sex=male | |||
|sample_species=Human (Homo sapiens) | |||
|sample_strain= | |||
|sample_tissue=blood | |||
|top_motifs=MYB:2.43481198124;E2F1..5:1.72879375763;RXR{A,B,G}_{NR1H2,PPAR}dimers:1.48630102769;YY1:1.44084424573;NANOG:1.3793160003;NFY{A,B,C}:1.13259634578;NRF1:1.00330389517;ELF1,2,4:0.995537968108;DMAP1_NCOR{1,2}_SMARC:0.958015971078;FOXA2:0.949648249069;ELK1,4_GABP{A,B1}:0.949470254901;NR6A1:0.923397465491;PPARG:0.912407326694;SPIB:0.904205573025;STAT1,3:0.89275731707;CUX2:0.861423225238;SPI1:0.860284817925;POU5F1:0.841353283133;FOXP3:0.808804975761;NKX2-2,8:0.786203983355;CRX:0.780321610627;NFIL3:0.727680534828;PAX5:0.687179875423;RFX2..5_RFXANK_RFXAP:0.669047837818;ARID5B:0.628458860763;ZNF143:0.619876788142;PRRX1,2:0.586267343524;BREu{core}:0.575215497405;NKX3-2:0.561778004826;ETS1,2:0.557731499892;POU1F1:0.530785780462;NANOG{mouse}:0.515550076987;OCT4_SOX2{dimer}:0.488239481312;AIRE:0.421619388138;NR5A1,2:0.41322278795;GATA6:0.391512655064;HOX{A6,A7,B6,B7}:0.383266402089;TEF:0.346781214846;EN1,2:0.340725519968;HOX{A4,D4}:0.322659446078;HOX{A5,B5}:0.314453803713;ALX1:0.289362367156;CDX1,2,4:0.24865393318;CEBPA,B_DDIT3:0.229846256718;MYOD1:0.228405393985;POU2F1..3:0.204503659789;NKX2-3_NKX2-5:0.190366505027;HBP1_HMGB_SSRP1_UBTF:0.182229530088;ARNT_ARNT2_BHLHB2_MAX_MYC_USF1:0.172972575476;PAX8:0.166469396416;RXRA_VDR{dimer}:0.152329956125;GCM1,2:0.148988369424;HLF:0.136435721992;RUNX1..3:0.128767661529;GFI1:0.110115537841;HNF4A_NR2F1,2:0.108444507216;PRDM1:0.0953417428251;bHLH_family:0.0795230065256;AR:0.043308115137;NKX3-1:0.0270905276529;SOX{8,9,10}:0.0116607665357;DBP:-0.00105628980506;FOXN1:-0.00170432739049;KLF4:-0.0062411111519;PAX3,7:-0.0114899713883;SREBF1,2:-0.0222551634876;SRF:-0.0298802891082;ESRRA:-0.0458440792387;HNF1A:-0.0583561100279;STAT5{A,B}:-0.0702797052929;FOXQ1:-0.0748444490127;IRF1,2:-0.0778933965202;HAND1,2:-0.0845316256699;TFDP1:-0.0872055371437;IRF7:-0.0977912732027;TAL1_TCF{3,4,12}:-0.0996273249719;HES1:-0.10914250374;NFE2L2:-0.12866101238;MTF1:-0.153155134946;EP300:-0.158481905828;RORA:-0.1794746848;TGIF1:-0.191531996199;REST:-0.193874354363;SOX17:-0.196028491178;IKZF2:-0.20741699692;POU3F1..4:-0.212590567774;MEF2{A,B,C,D}:-0.218558791942;PBX1:-0.219040592649;NFE2L1:-0.226596795903;ZEB1:-0.234005427222;CREB1:-0.245430889035;VSX1,2:-0.255710219306;LEF1_TCF7_TCF7L1,2:-0.270538212581;ZFP161:-0.275988873742;PAX2:-0.279690406259;NKX2-1,4:-0.291398891084;GATA4:-0.295241991974;MYBL2:-0.29605757127;PITX1..3:-0.297855560785;SOX5:-0.317500804041;ATF5_CREB3:-0.324824909401;NFKB1_REL_RELA:-0.329650114095;ZNF238:-0.33193895245;POU6F1:-0.351333131672;FOXP1:-0.365847958522;RBPJ:-0.369717530823;ESR1:-0.376640873316;ZNF423:-0.397627800599;HIF1A:-0.404379147931;NFE2:-0.413129658604;PDX1:-0.425173416093;FOS_FOS{B,L1}_JUN{B,D}:-0.435241388834;TOPORS:-0.439115766823;FOSL2:-0.442513790472;FOX{F1,F2,J1}:-0.448817378938;HMGA1,2:-0.44952704847;TFAP2{A,C}:-0.452403930661;HSF1,2:-0.458353708027;TLX2:-0.466475118665;LMO2:-0.467817742037;AHR_ARNT_ARNT2:-0.478239145928;NR1H4:-0.497555691465;XBP1:-0.510281936413;PAX4:-0.51464806866;PAX6:-0.534323835394;FOXD3:-0.539798577028;MTE{core}:-0.54361523253;BACH2:-0.546904131577;RFX1:-0.55156460866;T:-0.563970255552;SNAI1..3:-0.575653658252;NHLH1,2:-0.594059343195;XCPE1{core}:-0.596242440343;TFAP4:-0.604801996298;TBX4,5:-0.608156670032;EVI1:-0.614165132425;LHX3,4:-0.630745763935;MZF1:-0.631871351754;ZNF148:-0.633116318428;SPZ1:-0.638836201282;MYFfamily:-0.639440299864;PAX1,9:-0.656750258537;ONECUT1,2:-0.675146316544;ATF4:-0.676394662342;ATF6:-0.682313663819;ATF2:-0.692099256158;ZBTB16:-0.693633434461;TBP:-0.697737343357;IKZF1:-0.698257880139;HOXA9_MEIS1:-0.700038041825;NKX6-1,2:-0.707490778661;ADNP_IRX_SIX_ZHX:-0.708831742161;GZF1:-0.717810346801;RXR{A,B,G}:-0.752077575954;FOXM1:-0.763270441666;GTF2I:-0.795509065664;UFEwm:-0.833947346656;NFIX:-0.88540937482;MED-1{core}:-0.891668395412;SOX2:-0.911904550119;ZBTB6:-0.918135901848;ZNF384:-0.929152936628;GTF2A1,2:-0.936282361781;TP53:-0.940819728954;NR3C1:-0.949570620092;SP1:-0.958125777406;FOXL1:-0.967318759732;HIC1:-0.977689804579;TEAD1:-0.999815021122;EGR1..3:-1.02299863976;MAFB:-1.03418599985;ZIC1..3:-1.05579760389;STAT2,4,6:-1.06161082622;TLX1..3_NFIC{dimer}:-1.07701758825;FOXO1,3,4:-1.08799080385;FOX{I1,J2}:-1.08993748505;EBF1:-1.09429985037;MAZ:-1.11714659045;TFAP2B:-1.11916094842;RREB1:-1.1268211775;PATZ1:-1.22766385297;HMX1:-1.23919660193;GLI1..3:-1.24082480676;TFCP2:-1.29112145887;NFATC1..3:-1.29216605485;GFI1B:-1.30547150329;JUN:-1.3446638255;CDC5L:-1.38639678317;BPTF:-1.40422757256;ALX4:-1.43159225749;SMAD1..7,9:-1.55715965489;FOX{D1,D2}:-1.61591336182 | |||
|xref= | |||
|zenbu_report=https://fantom.gsc.riken.jp/zenbu/reports/#miRNA_expression_atlas_human;search_select_hide=table111:FF:10400-106A4;search_select_hide=table117:FF:10400-106A4 | |||
}} | }} |
Latest revision as of 13:59, 3 June 2020
Name: | acute myeloid leukemia (FAB M5) cell line:THP-1 (revived) |
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Species: | Human (Homo sapiens) |
Library ID: | CNhs10723 |
Sample type: | cell lines |
Genomic View: | UCSC |
RefEX: | Specific genes |
CAGEd-oPOSSUM: | link |
ZENBU report : | link |
Additional information | ||||||||||||||||||||||||||||
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Sample information
RNA information
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CAGE Accession numbers | ||||||||||||||||||||||||||||||||||||||||||||||
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Download raw sequence, BAM & CTSS | ||||||||||||||
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Relative expression to median (log10)
Transcription factors with enriched expression in this sampleRanked list of transcription factor promoter expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed.
Co-expression clusters with enriched expression in this sampleRanked list of co-expression cluster expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed. <br>Analyst:NA <br><br>link to dataset.<br>data
Repeat families with enriched expression in this sample<b>Summary:</b>Ranked list of repeat family expression in this sample relative tothe median expression in the FANTOM5 collection is shown. Value is log10transformed.<br><b>Analyst:</b>NA<br><br>link to dataset.<br>data
TFBS(DNA)motifs over-represented in proximal region of promoters active in this sample
JASPAR motifs<b>Summary:</b>Association of JASPAR motif to the promoter expression in thissample. Pearson's correlation between the number of TFBSs estimated byusing the position-weight matrix for each promoter and its expression isexpressed as Z-score by taking the ones based on random position-weightmatrix, and the tail probability of the normal distribution correspondingto the Z-score is taken as the resulting P-value. Lower P-value indicatesmore (non-random) association of the motif to promoter expression<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data
library id: CNhs10723
FANTOM5 phase1 novel unique motifs<b>Summary:</b>Association of the 169 novel and unique motifs discovered in FANTOM5 phase1 in this sample. Among the de-novo motifs discovered by DMF, HOMER,ChIPMunk, and ScanAll, only novel motifs are selected after comparison with known motif sets, and their clustering based on MACRO-APE resulted in169 novel and unique motifs. Their association to the promoter expression is evaluated in the same way to the JASPAR motif above<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data
library id: CNhs10723
Novel motif | Logo | P-value |
---|---|---|
1 | 1 | 0.0677 |
10 | 10 | 0.0245 |
100 | 100 | 0.281 |
101 | 101 | 0.399 |
102 | 102 | 0.633 |
103 | 103 | 0.182 |
104 | 104 | 0.533 |
105 | 105 | 0.817 |
106 | 106 | 0.0318 |
107 | 107 | 0.0735 |
108 | 108 | 0.211 |
109 | 109 | 0.0201 |
11 | 11 | 0.161 |
110 | 110 | 0.272 |
111 | 111 | 0.628 |
112 | 112 | 0.682 |
113 | 113 | 0.248 |
114 | 114 | 0.539 |
115 | 115 | 0.334 |
116 | 116 | 0.87 |
117 | 117 | 0.0653 |
118 | 118 | 0.116 |
119 | 119 | 0.782 |
12 | 12 | 0.724 |
120 | 120 | 0.469 |
121 | 121 | 0.763 |
122 | 122 | 0.0708 |
123 | 123 | 0.404 |
124 | 124 | 0.287 |
125 | 125 | 0.497 |
126 | 126 | 0.437 |
127 | 127 | 0.0458 |
128 | 128 | 0.0793 |
129 | 129 | 0.292 |
13 | 13 | 9.13312e-4 |
130 | 130 | 0.262 |
131 | 131 | 0.0167 |
132 | 132 | 0.867 |
133 | 133 | 0.438 |
134 | 134 | 0.496 |
135 | 135 | 0.227 |
136 | 136 | 0.124 |
137 | 137 | 0.353 |
138 | 138 | 0.965 |
139 | 139 | 0.669 |
14 | 14 | 0.812 |
140 | 140 | 0.0446 |
141 | 141 | 0.706 |
142 | 142 | 0.553 |
143 | 143 | 0.445 |
144 | 144 | 0.787 |
145 | 145 | 0.711 |
146 | 146 | 0.806 |
147 | 147 | 0.0927 |
148 | 148 | 0.05 |
149 | 149 | 0.0894 |
15 | 15 | 0.303 |
150 | 150 | 0.741 |
151 | 151 | 0.429 |
152 | 152 | 0.0417 |
153 | 153 | 0.764 |
154 | 154 | 0.547 |
155 | 155 | 0.204 |
156 | 156 | 0.823 |
157 | 157 | 0.64 |
158 | 158 | 0.512 |
159 | 159 | 0.43 |
16 | 16 | 0.828 |
160 | 160 | 0.848 |
161 | 161 | 0.0525 |
162 | 162 | 0.625 |
163 | 163 | 0.668 |
164 | 164 | 0.503 |
165 | 165 | 0.013 |
166 | 166 | 0.382 |
167 | 167 | 0.564 |
168 | 168 | 0.904 |
169 | 169 | 0.932 |
17 | 17 | 0.504 |
18 | 18 | 0.738 |
19 | 19 | 0.752 |
2 | 2 | 0.218 |
20 | 20 | 0.386 |
21 | 21 | 0.484 |
22 | 22 | 0.672 |
23 | 23 | 0.0104 |
24 | 24 | 0.0272 |
25 | 25 | 0.294 |
26 | 26 | 0.707 |
27 | 27 | 0.402 |
28 | 28 | 0.913 |
29 | 29 | 0.0233 |
3 | 3 | 0.0241 |
30 | 30 | 0.2 |
31 | 31 | 0.408 |
32 | 32 | 0.0807 |
33 | 33 | 0.502 |
34 | 34 | 0.718 |
35 | 35 | 0.651 |
36 | 36 | 0.0573 |
37 | 37 | 0.342 |
38 | 38 | 0.271 |
39 | 39 | 0.23 |
4 | 4 | 0.239 |
40 | 40 | 0.278 |
41 | 41 | 0.956 |
42 | 42 | 0.1 |
43 | 43 | 0.831 |
44 | 44 | 0.606 |
45 | 45 | 0.348 |
46 | 46 | 0.293 |
47 | 47 | 0.0603 |
48 | 48 | 0.0508 |
49 | 49 | 0.735 |
5 | 5 | 0.919 |
50 | 50 | 0.795 |
51 | 51 | 0.775 |
52 | 52 | 0.0907 |
53 | 53 | 0.656 |
54 | 54 | 0.609 |
55 | 55 | 0.717 |
56 | 56 | 0.609 |
57 | 57 | 0.307 |
58 | 58 | 0.204 |
59 | 59 | 0.562 |
6 | 6 | 0.491 |
60 | 60 | 0.454 |
61 | 61 | 0.199 |
62 | 62 | 0.409 |
63 | 63 | 0.984 |
64 | 64 | 0.311 |
65 | 65 | 0.577 |
66 | 66 | 0.00289 |
67 | 67 | 0.401 |
68 | 68 | 0.0883 |
69 | 69 | 0.623 |
7 | 7 | 0.0754 |
70 | 70 | 0.188 |
71 | 71 | 0.106 |
72 | 72 | 0.943 |
73 | 73 | 0.844 |
74 | 74 | 0.775 |
75 | 75 | 0.0524 |
76 | 76 | 0.184 |
77 | 77 | 0.65 |
78 | 78 | 0.0206 |
79 | 79 | 0.241 |
8 | 8 | 0.563 |
80 | 80 | 0.499 |
81 | 81 | 0.422 |
82 | 82 | 0.824 |
83 | 83 | 0.396 |
84 | 84 | 0.831 |
85 | 85 | 0.0324 |
86 | 86 | 0.67 |
87 | 87 | 0.0226 |
88 | 88 | 0.387 |
89 | 89 | 0.617 |
9 | 9 | 0.407 |
90 | 90 | 0.0502 |
91 | 91 | 0.0439 |
92 | 92 | 0.101 |
93 | 93 | 0.765 |
94 | 94 | 0.708 |
95 | 95 | 0.00312 |
96 | 96 | 0.764 |
97 | 97 | 0.614 |
98 | 98 | 0.685 |
99 | 99 | 0.33 |
de novo motifs identified by HOMER in promoters active in this sample<b>Summary:</b>The result of HOMER in this sample is shown.<br><b>Analyst:</b>NA <br>
library id: CNhs10723
FANTOM5 (FF) ontology
Direct parent terms
is_a relathionship
EFO:0002091 biological replicate
FF:0000210 human sample
FF:0101370 THP-1 cell sample
FF:0101883 acute myeloid leukemia cell line sample
Ancestor terms (non development)<b>Summary:</b>Connected ontology terms with is_a, part_of or located_in relationship <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source data<br>data
CL: Cell type
0000000 (cell), 0000000 (cell)
0000003 (native cell)
0000988 (hematopoietic cell)
0000548 (animal cell)
0000763 (myeloid cell)
0002371 (somatic cell)
0000766 (myeloid leukocyte)
0000219 (motile cell)
0000738 (leukocyte)
0002087 (nongranular leukocyte)
0000255 (eukaryotic cell)
0000576 (monocyte)
DOID: Disease
4 (disease)
0050686 (organ system cancer)
162 (cancer)
2531 (hematologic cancer)
14566 (disease of cellular proliferation)
0060083 (immune system cancer)
1240 (leukemia)
8692 (myeloid leukemia)
FF: FANTOM5
0000102 (sample by type)
0000003 (cell line sample)
0000210 (human sample)
0000101 (sample by species)
0000001 (sample)
0100737 (leukemia cell line sample)
0101370 (THP-1 cell sample)
0101035 (hematopoietic cell line sample)
0101883 (acute myeloid leukemia cell line sample)
0102332 (monocytic leukemia cell line sample)
0100740 (myeloid leukemia cell line sample)
Ancestor terms (development)<b>Summary:</b>Connected ontology terms with develops_from, derives_from or preceded_by relationship <br><b>Analyst:</b> Hideya Kawaji <br><br>link to source data<br>data
CL:0000049 (common myeloid progenitor)
CL:0000134 (mesenchymal cell)