MCL coexpression mm9:291
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0002423 | natural killer cell mediated immune response to tumor cell | 0.00481183074451149 |
| GO:0002855 | regulation of natural killer cell mediated immune response to tumor cell | 0.00481183074451149 |
| GO:0002420 | natural killer cell mediated cytotoxicity directed against tumor cell target | 0.00481183074451149 |
| GO:0002858 | regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | 0.00481183074451149 |
| GO:0002860 | positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | 0.00481183074451149 |
| GO:0002715 | regulation of natural killer cell mediated immunity | 0.00481183074451149 |
| GO:0002857 | positive regulation of natural killer cell mediated immune response to tumor cell | 0.00481183074451149 |
| GO:0002717 | positive regulation of natural killer cell mediated immunity | 0.00481183074451149 |
| GO:0002355 | detection of tumor cell | 0.00481183074451149 |
| GO:0001816 | cytokine production | 0.00481183074451149 |
| GO:0050715 | positive regulation of cytokine secretion | 0.0083165258331406 |
| GO:0050714 | positive regulation of protein secretion | 0.00952622026592251 |
| GO:0007288 | sperm axoneme assembly | 0.00952622026592251 |
| GO:0035084 | flagellum axoneme biogenesis | 0.00952622026592251 |
| GO:0002831 | regulation of response to biotic stimulus | 0.00952622026592251 |
| GO:0002833 | positive regulation of response to biotic stimulus | 0.00952622026592251 |
| GO:0050707 | regulation of cytokine secretion | 0.00952622026592251 |
| GO:0002836 | positive regulation of response to tumor cell | 0.00952622026592251 |
| GO:0002837 | regulation of immune response to tumor cell | 0.00952622026592251 |
| GO:0002839 | positive regulation of immune response to tumor cell | 0.00952622026592251 |
| GO:0009595 | detection of biotic stimulus | 0.00952622026592251 |
| GO:0035082 | axoneme biogenesis | 0.00952622026592251 |
| GO:0002834 | regulation of response to tumor cell | 0.00952622026592251 |
| GO:0002418 | immune response to tumor cell | 0.00952622026592251 |
| GO:0009296 | flagellum biogenesis | 0.0105509646398961 |
| GO:0050663 | cytokine secretion | 0.0105509646398961 |
| GO:0002347 | response to tumor cell | 0.0114289592046159 |
| GO:0043064 | flagellum organization and biogenesis | 0.0114289592046159 |
| GO:0048584 | positive regulation of response to stimulus | 0.0126098834243107 |
| GO:0001578 | microtubule bundle formation | 0.0132694311939168 |
| GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity | 0.0132694311939168 |
| GO:0051047 | positive regulation of secretion | 0.0142815032029731 |
| GO:0042269 | regulation of natural killer cell mediated cytotoxicity | 0.0161261630405946 |
| GO:0001912 | positive regulation of leukocyte mediated cytotoxicity | 0.0161261630405946 |
| GO:0050708 | regulation of protein secretion | 0.0163127774808018 |
| GO:0042267 | natural killer cell mediated cytotoxicity | 0.0163127774808018 |
| GO:0002705 | positive regulation of leukocyte mediated immunity | 0.0163127774808018 |
| GO:0001910 | regulation of leukocyte mediated cytotoxicity | 0.0163127774808018 |
| GO:0007595 | lactation | 0.0163127774808018 |
| GO:0031341 | regulation of cell killing | 0.0163127774808018 |
| GO:0002708 | positive regulation of lymphocyte mediated immunity | 0.0163127774808018 |
| GO:0002228 | natural killer cell mediated immunity | 0.0163127774808018 |
| GO:0002699 | positive regulation of immune effector process | 0.0169937756025796 |
| GO:0002703 | regulation of leukocyte mediated immunity | 0.0172515121539335 |
| GO:0002706 | regulation of lymphocyte mediated immunity | 0.0172515121539335 |
| GO:0005164 | tumor necrosis factor receptor binding | 0.0174871009337694 |
| GO:0032813 | tumor necrosis factor receptor superfamily binding | 0.0174871009337694 |
| GO:0002697 | regulation of immune effector process | 0.0180720717382586 |
| GO:0030317 | sperm motility | 0.0195624664669679 |
| GO:0001906 | cell killing | 0.0196881681189481 |
| GO:0001909 | leukocyte mediated cytotoxicity | 0.0196881681189481 |
| GO:0006955 | immune response | 0.0207701369682652 |
| GO:0009306 | protein secretion | 0.0258117505595694 |
| GO:0005102 | receptor binding | 0.0302297207628627 |
| GO:0007286 | spermatid development | 0.0345406479594895 |
| GO:0008037 | cell recognition | 0.0345406479594895 |
| GO:0048515 | spermatid differentiation | 0.0345406479594895 |
| GO:0048583 | regulation of response to stimulus | 0.0345406479594895 |
| GO:0030031 | cell projection biogenesis | 0.0370258177043377 |
| GO:0051046 | regulation of secretion | 0.039081647890833 |
| GO:0002376 | immune system process | 0.039081647890833 |
| GO:0000226 | microtubule cytoskeleton organization and biogenesis | 0.0468966974512348 |
| GO:0005515 | protein binding | 0.0481297991126234 |
| GO:0051606 | detection of stimulus | 0.0488354565099019 |
| GO:0048609 | reproductive process in a multicellular organism | 0.0488354565099019 |
| GO:0032504 | multicellular organism reproduction | 0.0488354565099019 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.0149616 |
| MA0004.1 | 0.0975472 |
| MA0006.1 | 0.126346 |
| MA0007.1 | 0.0901516 |
| MA0009.1 | 0.400415 |
| MA0014.1 | 0.0606528 |
| MA0017.1 | 0.152143 |
| MA0019.1 | 0.257924 |
| MA0024.1 | 0.956106 |
| MA0025.1 | 0.602538 |
| MA0027.1 | 1.97512 |
| MA0028.1 | 0.0338476 |
| MA0029.1 | 0.347243 |
| MA0030.1 | 0.352483 |
| MA0031.1 | 0.32434 |
| MA0038.1 | 0.534712 |
| MA0040.1 | 0.410788 |
| MA0041.1 | 0.0630027 |
| MA0042.1 | 0.461097 |
| MA0043.1 | 0.482118 |
| MA0046.1 | 0.430358 |
| MA0048.1 | 0.512122 |
| MA0050.1 | 1.23694 |
| MA0051.1 | 0.548815 |
| MA0052.1 | 0.417501 |
| MA0055.1 | 0.575466 |
| MA0056.1 | 0 |
| MA0057.1 | 0.290249 |
| MA0058.1 | 0.0551302 |
| MA0059.1 | 1.24282 |
| MA0060.1 | 0.0130333 |
| MA0061.1 | 0.211915 |
| MA0063.1 | 0 |
| MA0066.1 | 0.174169 |
| MA0067.1 | 0.70379 |
| MA0068.1 | 0.472812 |
| MA0069.1 | 0.417784 |
| MA0070.1 | 0.409709 |
| MA0071.1 | 0.117424 |
| MA0072.1 | 0.402681 |
| MA0073.1 | 6.11494e-06 |
| MA0074.1 | 0.151856 |
| MA0076.1 | 0.0450749 |
| MA0077.1 | 0.384853 |
| MA0078.1 | 0.60168 |
| MA0081.1 | 0.0694651 |
| MA0083.1 | 0.481435 |
| MA0084.1 | 1.01381 |
| MA0087.1 | 0.444612 |
| MA0088.1 | 0.0384374 |
| MA0089.1 | 0 |
| MA0090.1 | 0.277096 |
| MA0091.1 | 1.14651 |
| MA0092.1 | 0.0811967 |
| MA0093.1 | 0.0363286 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.144919 |
| MA0101.1 | 0.227319 |
| MA0103.1 | 0.372103 |
| MA0105.1 | 0.0239388 |
| MA0106.1 | 0.214456 |
| MA0107.1 | 0.359846 |
| MA0108.2 | 0.274781 |
| MA0109.1 | 0 |
| MA0111.1 | 0.295446 |
| MA0113.1 | 0.195372 |
| MA0114.1 | 0.0181479 |
| MA0115.1 | 0.484531 |
| MA0116.1 | 0.299509 |
| MA0117.1 | 0.45687 |
| MA0119.1 | 0.0637713 |
| MA0122.1 | 0.473843 |
| MA0124.1 | 0.654966 |
| MA0125.1 | 1.4359 |
| MA0130.1 | 0 |
| MA0131.1 | 0.254613 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.513709 |
| MA0136.1 | 0.164081 |
| MA0139.1 | 0.254691 |
| MA0140.1 | 0.873507 |
| MA0141.1 | 0.184267 |
| MA0142.1 | 0.313054 |
| MA0143.1 | 1.12336 |
| MA0144.1 | 0.409964 |
| MA0145.1 | 0.0169355 |
| MA0146.1 | 0.00492696 |
| MA0147.1 | 1.05922 |
| MA0148.1 | 1.69725 |
| MA0149.1 | 0.0658075 |
| MA0062.2 | 0.025994 |
| MA0035.2 | 1.42349 |
| MA0039.2 | 0.00552665 |
| MA0138.2 | 0.248854 |
| MA0002.2 | 0.995442 |
| MA0137.2 | 0.406246 |
| MA0104.2 | 1.08476 |
| MA0047.2 | 1.02179 |
| MA0112.2 | 0.0169336 |
| MA0065.2 | 0.304072 |
| MA0150.1 | 0.302005 |
| MA0151.1 | 0 |
| MA0152.1 | 0.533676 |
| MA0153.1 | 0.528268 |
| MA0154.1 | 0.500497 |
| MA0155.1 | 0.542146 |
| MA0156.1 | 0.38713 |
| MA0157.1 | 0.288518 |
| MA0158.1 | 0 |
| MA0159.1 | 0.25085 |
| MA0160.1 | 0.348502 |
| MA0161.1 | 0 |
| MA0162.1 | 0.0202783 |
| MA0163.1 | 0.0337879 |
| MA0164.1 | 0.954895 |
| MA0080.2 | 0.361601 |
| MA0018.2 | 0.1704 |
| MA0099.2 | 0.244313 |
| MA0079.2 | 7.10415e-05 |
| MA0102.2 | 1.06444 |
| MA0258.1 | 0.0719402 |
| MA0259.1 | 0.0853817 |
| MA0442.1 | 0 |
