MCL coexpression mm9:202
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0032944 | regulation of mononuclear cell proliferation | 0.00475871526897105 |
| GO:0050670 | regulation of lymphocyte proliferation | 0.00475871526897105 |
| GO:0032943 | mononuclear cell proliferation | 0.00555133419886413 |
| GO:0046651 | lymphocyte proliferation | 0.00555133419886413 |
| GO:0045076 | regulation of interleukin-2 biosynthetic process | 0.00555133419886413 |
| GO:0051249 | regulation of lymphocyte activation | 0.00555133419886413 |
| GO:0050865 | regulation of cell activation | 0.00555133419886413 |
| GO:0042094 | interleukin-2 biosynthetic process | 0.00555133419886413 |
| GO:0032623 | interleukin-2 production | 0.0056357446767541 |
| GO:0030041 | actin filament polymerization | 0.0057446821543281 |
| GO:0030888 | regulation of B cell proliferation | 0.00804288610178782 |
| GO:0042100 | B cell proliferation | 0.0122743599463278 |
| GO:0030036 | actin cytoskeleton organization and biogenesis | 0.0173835408549393 |
| GO:0030029 | actin filament-based process | 0.0185098557713758 |
| GO:0050864 | regulation of B cell activation | 0.0185098557713758 |
| GO:0051258 | protein polymerization | 0.0186270750013696 |
| GO:0008154 | actin polymerization and/or depolymerization | 0.0186270750013696 |
| GO:0042129 | regulation of T cell proliferation | 0.0186270750013696 |
| GO:0046649 | lymphocyte activation | 0.0186270750013696 |
| GO:0045610 | regulation of hemocyte differentiation | 0.0186270750013696 |
| GO:0042386 | hemocyte differentiation | 0.0186270750013696 |
| GO:0004633 | phosphopantothenoylcysteine decarboxylase activity | 0.0186270750013696 |
| GO:0042035 | regulation of cytokine biosynthetic process | 0.0218420849105439 |
| GO:0045321 | leukocyte activation | 0.0218420849105439 |
| GO:0042098 | T cell proliferation | 0.0244722713607449 |
| GO:0001775 | cell activation | 0.0246598869635554 |
| GO:0042089 | cytokine biosynthetic process | 0.0264246680723444 |
| GO:0042107 | cytokine metabolic process | 0.0264246680723444 |
| GO:0050863 | regulation of T cell activation | 0.0264246680723444 |
| GO:0004144 | diacylglycerol O-acyltransferase activity | 0.0264246680723444 |
| GO:0051014 | actin filament severing | 0.0264246680723444 |
| GO:0051239 | regulation of multicellular organismal process | 0.0384332951015432 |
| GO:0030695 | GTPase regulator activity | 0.0424162388366757 |
| GO:0042113 | B cell activation | 0.0424162388366757 |
| GO:0003846 | 2-acylglycerol O-acyltransferase activity | 0.0454617984365382 |
| GO:0006651 | diacylglycerol biosynthetic process | 0.0454617984365382 |
| GO:0042127 | regulation of cell proliferation | 0.0480240436370861 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| lymphoid lineage restricted progenitor cell | 1.55e-11 | 12 |
| hematopoietic lineage restricted progenitor cell | 4.64e-11 | 25 |
| T cell | 2.19e-10 | 11 |
| pro-T cell | 2.19e-10 | 11 |
| lymphocyte | 2.29e-10 | 13 |
| common lymphoid progenitor | 2.29e-10 | 13 |
| hematopoietic cell | 2.56e-09 | 32 |
| hematopoietic oligopotent progenitor cell | 2.56e-09 | 32 |
| hematopoietic stem cell | 2.56e-09 | 32 |
| angioblastic mesenchymal cell | 2.56e-09 | 32 |
| hematopoietic multipotent progenitor cell | 2.56e-09 | 32 |
| mature alpha-beta T cell | 9.43e-09 | 9 |
| alpha-beta T cell | 9.43e-09 | 9 |
| immature T cell | 9.43e-09 | 9 |
| mature T cell | 9.43e-09 | 9 |
| immature alpha-beta T cell | 9.43e-09 | 9 |
| CD4-positive, alpha-beta T cell | 8.99e-08 | 8 |
| nucleate cell | 9.21e-08 | 16 |
| megakaryocyte progenitor cell | 1.15e-07 | 6 |
| megakaryocyte | 1.15e-07 | 6 |
| leukocyte | 4.16e-07 | 17 |
| nongranular leukocyte | 4.16e-07 | 17 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
