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CL:0000553

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Name:megakaryocyte progenitor cell
Namespace:FANTOM
Definition:"The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464]
Xrefs:
links:

BTO:0001164

FMA:84235
Synonyms: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498]
"colony-forming unit-megakaryocyte" EXACT []
"Meg-CFC" EXACT [PMCID:PMC1794060]
"megacaryoblast" EXACT []
"megacaryocyte progenitor cell" EXACT []
"megakaryoblast" EXACT []
"megakaryocytic progenitor cell" EXACT [PMID:12482498]
"promegacaryocyte" RELATED []
"promegakaryocyte" RELATED []
Comments:Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data


Parents

is_a:CL:0000763(myeloid cell),CL:0000839(myeloid lineage restricted progenitor cell)
develops_from:CL:0000050(megakaryocyte-erythroid progenitor cell)



Children


is a:CL:0002024 (Kit-positive megakaryocyte progenitor cell)
develops from:CL:0000556 (megakaryocyte)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.




Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000553 (megakaryocyte progenitor cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data