MCL coexpression mm9:2768

Phase1 CAGE Peaks

	Short description
Mm9::chr12:112404696..112404731,+	p3@Traf3
Mm9::chr9:7872814..7872876,-	p1@Birc3
Mm9::chrX:34683959..34683976,+	p@chrX:34683959..34683976 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042981	regulation of apoptosis	0.00691262605285871
GO:0043067	regulation of programmed cell death	0.00691262605285871
GO:0006915	apoptosis	0.00691262605285871
GO:0012501	programmed cell death	0.00691262605285871
GO:0008219	cell death	0.00691262605285871
GO:0016265	death	0.00691262605285871
GO:0048468	cell development	0.01785002838149
GO:0048869	cellular developmental process	0.0289969427809783
GO:0030154	cell differentiation	0.0289969427809783
GO:0006916	anti-apoptosis	0.0289969427809783
GO:0008270	zinc ion binding	0.0311891338571884
GO:0046914	transition metal ion binding	0.0400161514098527
GO:0043066	negative regulation of apoptosis	0.0400161514098527
GO:0043069	negative regulation of programmed cell death	0.0400161514098527

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
lymphoid lineage restricted progenitor cell	1.72e-07	12
hematopoietic cell	2.90e-07	32
hematopoietic oligopotent progenitor cell	2.90e-07	32
hematopoietic stem cell	2.90e-07	32
angioblastic mesenchymal cell	2.90e-07	32
hematopoietic multipotent progenitor cell	2.90e-07	32
T cell	7.63e-07	11
pro-T cell	7.63e-07	11

Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	7.29e-21	118
endoderm	7.29e-21	118
presumptive endoderm	7.29e-21	118
digestive system	1.61e-20	116
digestive tract	1.61e-20	116
primitive gut	1.61e-20	116
subdivision of digestive tract	2.91e-19	114
gut epithelium	2.79e-11	55
unilaminar epithelium	3.29e-11	66
hemolymphoid system	5.92e-11	48
immune system	5.92e-11	48
endo-epithelium	5.98e-11	69
organ component layer	1.04e-09	24
foregut	1.50e-09	80
hematopoietic system	2.70e-09	45
blood island	2.70e-09	45
gastrointestinal system	7.14e-09	47
intestine	8.52e-09	31
mixed endoderm/mesoderm-derived structure	1.95e-08	35
mucosa	8.48e-08	15
hemopoietic organ	1.74e-07	29
immune organ	1.74e-07	29
segment of respiratory tract	8.70e-07	27

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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