MCL coexpression mm9:2671

Phase1 CAGE Peaks

	Short description
Mm9::chr11:44213562..44213568,+	p1@Il12b
Mm9::chr19:29485468..29485471,+	p1@Pdcd1lg2
Mm9::chr4:132528250..132528258,+	p@chr4:132528250..132528258 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042102	positive regulation of T cell proliferation	7.15561495875796e-05
GO:0032946	positive regulation of mononuclear cell proliferation	7.15561495875796e-05
GO:0050671	positive regulation of lymphocyte proliferation	7.15561495875796e-05
GO:0042129	regulation of T cell proliferation	7.15561495875796e-05
GO:0050870	positive regulation of T cell activation	7.15561495875796e-05
GO:0032944	regulation of mononuclear cell proliferation	7.35471221882306e-05
GO:0050670	regulation of lymphocyte proliferation	7.35471221882306e-05
GO:0042098	T cell proliferation	7.35471221882306e-05
GO:0051251	positive regulation of lymphocyte activation	7.73804873447081e-05
GO:0050863	regulation of T cell activation	7.73804873447081e-05
GO:0032943	mononuclear cell proliferation	8.9181044682564e-05
GO:0046651	lymphocyte proliferation	8.9181044682564e-05
GO:0051249	regulation of lymphocyte activation	0.000103440012158916
GO:0050865	regulation of cell activation	0.000103440012158916
GO:0042110	T cell activation	0.000182337431008882
GO:0008284	positive regulation of cell proliferation	0.000381355448383418
GO:0046649	lymphocyte activation	0.000401760441206012
GO:0042164	interleukin-12 alpha subunit binding	0.000401760441206012
GO:0045321	leukocyte activation	0.00044031826617175
GO:0001775	cell activation	0.000481597451958488
GO:0019972	interleukin-12 binding	0.000657408166816525
GO:0043514	interleukin-12 complex	0.000657408166816525
GO:0051239	regulation of multicellular organismal process	0.000663278546769362
GO:0042127	regulation of cell proliferation	0.000826864458343372
GO:0008283	cell proliferation	0.00168772667236566
GO:0042130	negative regulation of T cell proliferation	0.00365253616668558
GO:0002376	immune system process	0.00365253616668558
GO:0048522	positive regulation of cellular process	0.00365253616668558
GO:0050868	negative regulation of T cell activation	0.00429169744975049
GO:0048518	positive regulation of biological process	0.00429169744975049
GO:0050672	negative regulation of lymphocyte proliferation	0.00429169744975049
GO:0032945	negative regulation of mononuclear cell proliferation	0.00429169744975049
GO:0051250	negative regulation of lymphocyte activation	0.00547494953051047
GO:0019965	interleukin binding	0.00764973974782912
GO:0004896	hematopoietin/interferon-class (D200-domain) cytokine receptor activity	0.0111412619257483
GO:0019955	cytokine binding	0.0134346406708379
GO:0042803	protein homodimerization activity	0.0196864757885286
GO:0008285	negative regulation of cell proliferation	0.0223843188330641
GO:0042802	identical protein binding	0.0317441951522043
GO:0046983	protein dimerization activity	0.0356036715371746
GO:0004872	receptor activity	0.0366321694933641
GO:0005125	cytokine activity	0.0366321694933641
GO:0060089	molecular transducer activity	0.0399967575331794
GO:0004871	signal transducer activity	0.0399967575331794
GO:0050794	regulation of cellular process	0.0433918005514947

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
hemopoietic organ	2.05e-32	29
immune organ	2.05e-32	29
thymus	6.88e-28	23
neck	6.88e-28	23
respiratory system epithelium	6.88e-28	23
hemolymphoid system gland	6.88e-28	23
pharyngeal epithelium	6.88e-28	23
thymic region	6.88e-28	23
pharyngeal gland	6.88e-28	23
entire pharyngeal arch endoderm	6.88e-28	23
thymus primordium	6.88e-28	23
early pharyngeal endoderm	6.88e-28	23
pharynx	1.30e-26	24
gland of gut	1.30e-26	24
upper respiratory tract	1.30e-26	24
chordate pharynx	1.30e-26	24
pharyngeal arch system	1.30e-26	24
pharyngeal region of foregut	1.30e-26	24
mixed endoderm/mesoderm-derived structure	2.71e-26	35
hemolymphoid system	1.86e-23	48
immune system	1.86e-23	48
segment of respiratory tract	2.36e-23	27
hematopoietic system	2.59e-22	45
blood island	2.59e-22	45
respiratory tract	5.83e-19	41
respiratory system	1.96e-18	42
organ segment	2.17e-17	35
craniocervical region	7.86e-17	36
foregut	6.80e-14	80
anterior region of body	1.21e-13	43
gut epithelium	1.08e-11	55
endo-epithelium	1.84e-11	69
endocrine gland	1.79e-10	60
lateral plate mesoderm	7.79e-10	87
subdivision of digestive tract	1.05e-09	114
digestive system	1.81e-09	116
digestive tract	1.81e-09	116
primitive gut	1.81e-09	116
gland	1.93e-09	65
organ part	2.09e-09	99
unilaminar epithelium	2.98e-09	66
endoderm-derived structure	3.07e-09	118
endoderm	3.07e-09	118
presumptive endoderm	3.07e-09	118
endocrine system	3.09e-08	72
organism subdivision	2.34e-07	150
primordium	9.90e-07	134

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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