MCL coexpression mm9:1862

Phase1 CAGE Peaks

	Short description
Mm9::chr10:110601850..110601867,+	p1@Osbpl8
Mm9::chr1:173770688..173770701,+	p4@Cd84
Mm9::chr1:173770738..173770772,+	p1@Cd84
Mm9::chr2:3341395..3341479,+	p1@Dclre1c

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity	0.0129841669862488
GO:0008409	5'-3' exonuclease activity	0.0324533040229507
GO:0004520	endodeoxyribonuclease activity	0.0340461036786531
GO:0032200	telomere organization and biogenesis	0.0340461036786531
GO:0000723	telomere maintenance	0.0340461036786531
GO:0004536	deoxyribonuclease activity	0.0340461036786531
GO:0006302	double-strand break repair	0.0340461036786531
GO:0010212	response to ionizing radiation	0.0340461036786531

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic cell	2.69e-09	32
hematopoietic oligopotent progenitor cell	2.69e-09	32
hematopoietic stem cell	2.69e-09	32
angioblastic mesenchymal cell	2.69e-09	32
hematopoietic multipotent progenitor cell	2.69e-09	32
hematopoietic lineage restricted progenitor cell	5.90e-08	25
leukocyte	7.13e-08	17
nongranular leukocyte	7.13e-08	17
lymphoid lineage restricted progenitor cell	2.86e-07	12
connective tissue cell	3.38e-07	46
mesenchymal cell	3.38e-07	46
mature alpha-beta T cell	8.39e-07	9
alpha-beta T cell	8.39e-07	9
immature T cell	8.39e-07	9
mature T cell	8.39e-07	9
immature alpha-beta T cell	8.39e-07	9
lymphocyte	9.18e-07	13
common lymphoid progenitor	9.18e-07	13

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	2.96e-17	48
immune system	2.96e-17	48
hematopoietic system	1.85e-16	45
blood island	1.85e-16	45
lateral plate mesoderm	5.54e-11	87
mixed endoderm/mesoderm-derived structure	5.17e-10	35
hemopoietic organ	5.70e-10	29
immune organ	5.70e-10	29
foregut	1.14e-09	80
endo-epithelium	1.77e-08	69
gut epithelium	5.19e-08	55
mesoderm	8.27e-08	120
mesoderm-derived structure	8.27e-08	120
presumptive mesoderm	8.27e-08	120
gland of gut	8.66e-08	24
bone element	1.17e-07	22
skeletal element	1.17e-07	22
skeletal system	1.17e-07	22
thymus	1.42e-07	23
neck	1.42e-07	23
respiratory system epithelium	1.42e-07	23
hemolymphoid system gland	1.42e-07	23
pharyngeal epithelium	1.42e-07	23
thymic region	1.42e-07	23
pharyngeal gland	1.42e-07	23
entire pharyngeal arch endoderm	1.42e-07	23
thymus primordium	1.42e-07	23
early pharyngeal endoderm	1.42e-07	23
unilaminar epithelium	1.59e-07	66
pharynx	1.71e-07	24
upper respiratory tract	1.71e-07	24
chordate pharynx	1.71e-07	24
pharyngeal arch system	1.71e-07	24
pharyngeal region of foregut	1.71e-07	24
bone marrow	2.00e-07	16
gland	2.48e-07	65
musculoskeletal system	3.23e-07	32
connective tissue	3.38e-07	46

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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