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Coexpression cluster:C918: Difference between revisions

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|tfbs_overrepresentation_for_novel_motifs=0.312007,0.479568,0.305225,1.12193,0.267236,0.439064,0.511871,0.953643,0.487494,0.119197,0.410439,0.553754,0.127813,0.500805,0.266007,0.287179,0.728104,0.218596,1.36174,0.818932,1.49268,0.141777,0.431698,0.726652,0.347482,0.575764,1.19851,0.429643,0.270022,0.329945,0.389837,0.764231,0.190489,1.31175,0.23642,0.126309,0.233607,0.440165,1.14973,0.14756,0.235191,0.97787,1.44736,0.264644,0.0550925,0.333541,0.51292,0.4002,1.8483,0.270138,0.589559,0.524278,0.257164,0.839846,0.99088,0.503626,0.752594,0.472204,1.12004,0.47124,0.804523,0.5152,0.162346,0.700946,0.532513,0.667267,1.07848,1.44489,0.754027,1.28328,0.362234,2.94844,0.0724994,0.988898,0.124338,0.367887,0.69735,0.684401,0.750836,0.341765,0.858505,0.699894,0.532172,0.963219,0.937974,0.0150019,10.0529,0.320664,0.614883,1.54397,1.17124,0.911274,0.78075,0.571859,0.267904,1.76977,0.136404,0.82268,0.619373,0.0858425,3.35844,0.775192,0.817185,0.731699,0.656016,0.406162,0.716172,0.49749,0.347247,0.252953,0.315525,0.814459,0.300169,0.41935,1.12352,0.232218,0.0194997,0.388709,0.664981,0.577715,0.980696,0.612519,0.436445,0.543065,1.23356,0.685145,0.50576,0.785662,1.02292,1.13275,0.911957,1.01734,1.03718,0.539846,1.18405,0.307751,0.384215,0.430179,1.14186,1.99816,1.59626,1.10478,0.507423,1.91629,0.657732,0.464114,0.641461,1.83907,0.37143,0.193834,0.233597,0.0382049,0.912334,0.155464,0.514733,1.31376,0.599133,0.254737,0.347536,0.858697,1.10357,0.894035,0.750062,0.323817,0.673453,0.531409,0.183544,0.510589,0.100451
|tfbs_overrepresentation_jaspar=MA0003.1;0.0913842,MA0004.1;1.06719,MA0006.1;0.733408,MA0007.1;0.397529,MA0009.1;0.870971,MA0014.1;0.0324647,MA0017.1;0.301634,MA0019.1;0.558663,MA0024.1;0.766783,MA0025.1;1.00397,MA0027.1;2.48103,MA0028.1;0.280275,MA0029.1;0.785955,MA0030.1;0.774581,MA0031.1;0.710608,MA0038.1;0.514558,MA0040.1;0.791764,MA0041.1;0.433167,MA0042.1;0.402577,MA0043.1;0.871285,MA0046.1;0.860127,MA0048.1;0.948258,MA0050.1;0.403421,MA0051.1;0.510444,MA0052.1;0.795605,MA0055.1;2.85007,MA0056.1;0,MA0057.1;0.539841,MA0058.1;0.325084,MA0059.1;0.865474,MA0060.1;0.162248,MA0061.1;0.139804,MA0063.1;0,MA0066.1;0.514973,MA0067.1;1.18766,MA0068.1;0.719601,MA0069.1;0.856287,MA0070.1;0.845142,MA0071.1;0.47692,MA0072.1;0.840664,MA0073.1;12.1644,MA0074.1;2.19307,MA0076.1;0.339975,MA0077.1;0.832987,MA0078.1;0.607575,MA0081.1;0.865814,MA0083.1;0.878452,MA0084.1;1.37471,MA0087.1;0.838229,MA0088.1;0.158781,MA0089.1;0,MA0090.1;0.353576,MA0091.1;0.417885,MA0092.1;0.993944,MA0093.1;0.26836,MA0095.1;0,MA0098.1;0,MA0100.1;0.528088,MA0101.1;0.271368,MA0103.1;0.714036,MA0105.1;0.0643619,MA0106.1;0.554855,MA0107.1;0.205358,MA0108.2;0.707575,MA0109.1;0,MA0111.1;0.959847,MA0113.1;0.57094,MA0114.1;0.200901,MA0115.1;1.11137,MA0116.1;0.208403,MA0117.1;0.908433,MA0119.1;0.308914,MA0122.1;0.934245,MA0124.1;1.06995,MA0125.1;0.986127,MA0130.1;0,MA0131.1;0.625452,MA0132.1;0,MA0133.1;0,MA0135.1;0.90122,MA0136.1;0.521435,MA0139.1;0.406919,MA0140.1;2.07572,MA0141.1;0.322254,MA0142.1;0.679161,MA0143.1;0.571113,MA0144.1;0.1885,MA0145.1;0.046841,MA0146.1;0.51271,MA0147.1;0.607251,MA0148.1;0.439278,MA0149.1;0.464973,MA0062.2;0.135498,MA0035.2;2.07344,MA0039.2;0.109483,MA0138.2;0.608783,MA0002.2;0.152495,MA0137.2;0.28622,MA0104.2;0.486672,MA0047.2;0.542971,MA0112.2;1.04513,MA0065.2;0.182082,MA0150.1;0.34802,MA0151.1;0,MA0152.1;0.480711,MA0153.1;0.969315,MA0154.1;0.225151,MA0155.1;0.645215,MA0156.1;0.288314,MA0157.1;0.652111,MA0158.1;0,MA0159.1;0.212043,MA0160.1;0.453945,MA0161.1;0,MA0162.1;0.0533066,MA0163.1;0.216998,MA0164.1;0.583138,MA0080.2;0.268439,MA0018.2;0.556211,MA0099.2;0.481058,MA0079.2;0.0127399,MA0102.2;1.41188,MA0258.1;0.532421,MA0259.1;0.624802,MA0442.1;0
}}
}}

Revision as of 19:33, 22 January 2013


Full id: C918_Keratinocyte_Mammary_Prostate_Urothelial_salivary_Corneal_Sebocyte



Phase1 CAGE Peaks

Hg19::chr17:38632693..38632717,-p@chr17:38632693..38632717
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Hg19::chr17:38632736..38632762,-p@chr17:38632736..38632762
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Hg19::chr17:38632800..38632814,-p@chr17:38632800..38632814
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Hg19::chr17:38633152..38633204,-p@chr17:38633152..38633204
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Hg19::chr17:38633210..38633225,-p@chr17:38633210..38633225
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Hg19::chr17:38633789..38633809,+p@chr17:38633789..38633809
+
Hg19::chr17:38643475..38643497,+p@chr17:38643475..38643497
+
Hg19::chr17:38643498..38643544,+p@chr17:38643498..38643544
+
Hg19::chr17:73750837..73750879,-p@chr17:73750837..73750879
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
endoderm-derived structure1.10e-34160
endoderm1.10e-34160
presumptive endoderm1.10e-34160
respiratory system1.26e-2574
digestive system3.36e-23145
digestive tract3.36e-23145
primitive gut3.36e-23145
orifice1.37e-1936
foregut1.24e-1887
subdivision of digestive tract3.07e-18118
oral opening9.86e-1722
respiratory tract2.85e-1654
larynx4.20e-159
extraembryonic membrane7.84e-1514
membranous layer7.84e-1514
mouth1.43e-1329
stomodeum1.43e-1329
segment of respiratory tract4.17e-1347
surface structure1.08e-1299
upper respiratory tract1.35e-1219
chorion1.55e-127
respiratory primordium1.10e-1138
endoderm of foregut1.10e-1138
saliva-secreting gland6.75e-116
gland of oral region6.75e-116
gland of foregut6.75e-116
oral gland6.75e-116
oral cavity6.75e-116
urothelium6.14e-105
gland1.13e-0959
head8.65e-0956
endo-epithelium8.89e-0982
mucosa1.53e-0820
subdivision of head2.15e-0849
organ2.34e-08503
exocrine gland2.44e-0831
exocrine system2.44e-0831
transitional epithelium3.51e-086
mouth mucosa6.44e-0813
placenta8.27e-084
allantois8.27e-084
urinary system structure9.17e-0847
organ component layer1.07e-0766
renal system1.65e-0748
extraembryonic structure1.75e-0724
anterior region of body2.00e-0762
craniocervical region2.00e-0762
mucosa of oral region2.83e-074
respiratory system mucosa2.83e-074
organ part6.33e-07218
Disease
Ontology termp-valuen
carcinoma3.39e-15106
cell type cancer1.40e-08143
squamous cell carcinoma1.61e-0814


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0913842
MA0004.11.06719
MA0006.10.733408
MA0007.10.397529
MA0009.10.870971
MA0014.10.0324647
MA0017.10.301634
MA0019.10.558663
MA0024.10.766783
MA0025.11.00397
MA0027.12.48103
MA0028.10.280275
MA0029.10.785955
MA0030.10.774581
MA0031.10.710608
MA0038.10.514558
MA0040.10.791764
MA0041.10.433167
MA0042.10.402577
MA0043.10.871285
MA0046.10.860127
MA0048.10.948258
MA0050.10.403421
MA0051.10.510444
MA0052.10.795605
MA0055.12.85007
MA0056.10
MA0057.10.539841
MA0058.10.325084
MA0059.10.865474
MA0060.10.162248
MA0061.10.139804
MA0063.10
MA0066.10.514973
MA0067.11.18766
MA0068.10.719601
MA0069.10.856287
MA0070.10.845142
MA0071.10.47692
MA0072.10.840664
MA0073.112.1644
MA0074.12.19307
MA0076.10.339975
MA0077.10.832987
MA0078.10.607575
MA0081.10.865814
MA0083.10.878452
MA0084.11.37471
MA0087.10.838229
MA0088.10.158781
MA0089.10
MA0090.10.353576
MA0091.10.417885
MA0092.10.993944
MA0093.10.26836
MA0095.10
MA0098.10
MA0100.10.528088
MA0101.10.271368
MA0103.10.714036
MA0105.10.0643619
MA0106.10.554855
MA0107.10.205358
MA0108.20.707575
MA0109.10
MA0111.10.959847
MA0113.10.57094
MA0114.10.200901
MA0115.11.11137
MA0116.10.208403
MA0117.10.908433
MA0119.10.308914
MA0122.10.934245
MA0124.11.06995
MA0125.10.986127
MA0130.10
MA0131.10.625452
MA0132.10
MA0133.10
MA0135.10.90122
MA0136.10.521435
MA0139.10.406919
MA0140.12.07572
MA0141.10.322254
MA0142.10.679161
MA0143.10.571113
MA0144.10.1885
MA0145.10.046841
MA0146.10.51271
MA0147.10.607251
MA0148.10.439278
MA0149.10.464973
MA0062.20.135498
MA0035.22.07344
MA0039.20.109483
MA0138.20.608783
MA0002.20.152495
MA0137.20.28622
MA0104.20.486672
MA0047.20.542971
MA0112.21.04513
MA0065.20.182082
MA0150.10.34802
MA0151.10
MA0152.10.480711
MA0153.10.969315
MA0154.10.225151
MA0155.10.645215
MA0156.10.288314
MA0157.10.652111
MA0158.10
MA0159.10.212043
MA0160.10.453945
MA0161.10
MA0162.10.0533066
MA0163.10.216998
MA0164.10.583138
MA0080.20.268439
MA0018.20.556211
MA0099.20.481058
MA0079.20.0127399
MA0102.21.41188
MA0258.10.532421
MA0259.10.624802
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203353.763300959012890.005242178461590750.0242874579163373
HDAC2#306645.9624978829450.002864271980786230.0155237001246151
POLR2A#543092.147453176558070.001029412892608020.0072868952888091
TCF7L2#693444.786745139172150.006382053991234720.027783882317239



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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