FF:11862-125A8: Difference between revisions
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{{f5samples | {{f5samples | ||
| | |DRA_sample_Accession=CAGE@SAMD00004744 | ||
| | |accession_numbers=CAGE;DRX008156;DRR009028;DRZ000453;DRZ001838;DRZ011803;DRZ013188 | ||
| | |ancestors_in_anatomy_facet= | ||
|ancestors_in_cell_lineage_facet=CL:0000000,CL:0000003,CL:0000988,CL:0000548,CL:0000763,CL:0002371,CL:0000766,CL:0000219,CL:0000325,CL:0000473,CL:0000234,CL:0000738,CL:0002087,CL:0000255,CL:0000576,CL:0000860,CL:0002057 | |||
|ancestors_in_cell_lineage_facet=CL:0000000,CL:0000003,CL: | |||
|ancestors_in_disease_facet= | |ancestors_in_disease_facet= | ||
| | |ancestors_in_ff_facet=FF:0000102,FF:0000210,FF:0000002,FF:0000101,FF:0000001,FF:0000625,FF:0000350,FF:0000631,FF:0011444 | ||
|comment= | |||
|created_by= | |||
|creation_date= | |||
|data_phase=2 | |||
|datafreeze_phase=2 | |||
|def= | |||
|expression_enrichment_score=chr2:68592406..68592424,+!p1@PLEK!3.72!5200.34!PLEK;;chr16:85932760..85932775,+!p1@IRF8!2.97!937.66!IRF8;;chr11:47400078..47400106,-!p1@SPI1!2.68!473.10!SPI1;;chr10:64576105..64576133,-!p1@EGR2!2.64!856.51!EGR2;;chr10:35484053..35484076,+!p1@CREM!2.62!985.90!CREM;;chr12:54778471..54778528,-!p1@ZNF385A!2.47!295.97!ZNF385A;;chr7:115670804..115670825,-!p1@TFEC!2.31!203.26!TFEC;;chr20:39317868..39317884,-!p1@MAFB!2.26!2021.55!MAFB;;chr11:47399947..47399961,-!p3@SPI1!2.19!152.26!SPI1;;chr11:64764435..64764449,-!p1@BATF2!2.14!184.42!BATF2;;chr6:106534192..106534224,+!p1@PRDM1!2.10!339.94!PRDM1;;chr6:36355431..36355466,-!p1@ETV7!2.06!114.57!ETV7;;chr7:128577972..128578047,+!p1@IRF5!2.00!153.01!IRF5;;chr21:36260295..36260310,-!p3@RUNX1!1.99!152.26!RUNX1;;chr5:131826457..131826514,-!p1@IRF1!1.98!3454.17!IRF1;;chr11:47400062..47400077,-!p2@SPI1!1.98!95.22!SPI1;;chr2:70142232..70142251,+!p1@MXD1!1.94!464.31!MXD1;;chr10:35484090..35484104,+!p6@CREM!1.94!85.42!CREM;;chr1:221052776..221052799,+!p1@HLX!1.93!147.99!HLX;;chr17:45810594..45810608,+!p1@TBX21!1.93!83.16!TBX21;;chr11:47399996..47400014,-!p4@SPI1!1.91!79.65!SPI1;;chr11:615942..615957,-!p1@IRF7!1.86!643.70!IRF7;;chr1:25256756..25256774,-!p1@RUNX3!1.84!125.62!RUNX3;;chr21:34442439..34442455,+!p1@OLIG1!1.84!68.59!OLIG1;;chr1:158985493..158985535,+!p4@IFI16!1.83!99.24!IFI16;;chr19:45971246..45971265,+!p1@FOSB!1.81!1118.56!FOSB;;chr6:106534230..106534254,+!p2@PRDM1!1.80!152.01!PRDM1;;chr1:221052733..221052749,+!p2@HLX!1.80!79.90!HLX;;chr10:64018918..64018936,+!p2@ZNF365!1.80!62.81!ZNF365;;chr16:31885093..31885165,+!p1@ZNF267!1.79!875.60!ZNF267;;chr10:31288398..31288455,-!p2@ZNF438!1.79!69.60!ZNF438;;chr2:68592394..68592405,+!p2@PLEK!1.79!61.30!PLEK;;chr11:65430554..65430579,-!p3@RELA!1.76!139.44!RELA;;chr3:12329397..12329433,+!p2@PPARG!1.74!118.59!PPARG;;chr2:231084639..231084654,-!p2@SP110!1.73!84.92!SP110;;chr2:145277640..145277771,-!p1@ZEB2!1.72!655.01!ZEB2;;chr2:157189180..157189290,-!p1@NR4A2!1.72!253.26!NR4A2;;chr22:38597987..38598021,+!p2@MAFF!1.71!290.44!MAFF;;chr19:50432132..50432217,+!p2@ATF5!1.71!59.29!ATF5;;chr11:47400032..47400043,-!p5@SPI1!1.69!47.49!SPI1;;chr2:145275162..145275202,-!p2@ZEB2!1.68!262.05!ZEB2;;chr12:72056749..72056767,+!p6@THAP2!1.68!52.01!THAP2;;chr19:33793430..33793447,-!p1@CEBPA!1.67!186.43!CEBPA;;chr12:72056800..72056834,+!p1@THAP2!1.67!60.30!THAP2;;chr21:30671690..30671762,+!p2@BACH1!1.66!146.98!BACH1;;chr2:97202480..97202499,+!p1@ARID5A!1.65!422.35!ARID5A;;chr8:22550982..22550999,-!p1@EGR3!1.65!120.35!EGR3;;chr9:102584159..102584174,+!p2@NR4A3!1.64!74.62!NR4A3;;chr16:79634624..79634642,-!p1@MAF!1.62!153.26!MAF;;chr11:65430535..65430549,-!p4@RELA!1.62!46.73!RELA;;chr14:75988831..75988847,+!p2@BATF!1.61!39.70!BATF;;chr12:54778351..54778378,-!p6@ZNF385A!1.59!37.69!ZNF385A;;chr1:212782094..212782109,+!p1@ATF3!1.58!959.77!ATF3;;chr14:75988771..75988826,+!p1@BATF!1.58!49.24!BATF;;chr10:31288370..31288393,-!p3@ZNF438!1.58!37.18!ZNF438;;chr21:30671235..30671253,+!p1@BACH1!1.57!433.91!BACH1;;chr1:158979872..158979898,+!p3@IFI16!1.57!108.04!IFI16;;chr12:72056773..72056796,+!p3@THAP2!1.57!46.73!THAP2;;chr2:191885737..191885750,-!p4@STAT1!1.57!36.43!STAT1;;chr3:12330560..12330579,+!p1@PPARG!1.56!39.95!PPARG;;chr10:35484804..35484902,+!p2@CREM!1.54!124.37!CREM;;chr6:15246200..15246214,+!p2@JARID2!1.54!91.20!JARID2;;chr17:38497662..38497713,+!p4@RARA!1.52!37.18!RARA;;chr2:231090471..231090504,+!p2@SP140!1.52!32.16!SP140;;chr21:36421535..36421610,-!p2@RUNX1!1.49!103.01!RUNX1;;chr9:110252035..110252057,-!p1@KLF4!1.48!447.73!KLF4;;chr11:615570..615721,-!p2@IRF7!1.48!56.78!IRF7;;chr4:185395590..185395627,-!p3@IRF2!1.48!35.93!IRF2;;chr9:102584262..102584276,+!p1@NR4A3!1.47!62.56!NR4A3;;chrX:129244454..129244488,-!p1@ELF4!1.46!193.21!ELF4;;chr13:41593425..41593480,-!p1@ELF1!1.46!170.35!ELF1;;chr12:48298765..48298783,-!p2@VDR!1.45!56.03!VDR;;chr19:36391434..36391450,-!p1@NFKBID!1.44!51.76!NFKBID;;chr3:39195139..39195150,-!p3@CSRNP1!1.44!33.67!CSRNP1;;chr11:65430038..65430053,-!p12@RELA!1.44!26.38!RELA;;chr6:391743..391759,+!p1@IRF4!1.44!26.38!IRF4;;chr21:36260343..36260402,-!p6@RUNX1!1.43!41.20!RUNX1;;chr19:45251395..45251432,+!p8@BCL3!1.43!25.88!BCL3;;chr6:106535598..106535637,+!p7@PRDM1!1.43!25.63!PRDM1;;chr6:144385698..144385742,-!p2@PLAGL1!1.41!29.65!PLAGL1;;chr9:102584128..102584144,+!p3@NR4A3!1.40!44.97!NR4A3;;chr20:48807351..48807384,+!p1@CEBPB!1.39!2320.78!CEBPB;;chr4:185395633..185395651,-!p2@IRF2!1.39!37.69!IRF2;;chr11:47400045..47400060,-!p6@SPI1!1.38!23.11!SPI1;;chr12:11802753..11802834,+!p2@ETV6!1.37!107.53!ETV6;;chr8:116681123..116681143,-!p4@TRPS1!1.36!41.46!TRPS1;;chr2:28618532..28618610,+!p4@FOSL2!1.36!37.44!FOSL2;;chr14:35872453..35872485,-!p2@NFKBIA!1.34!50.75!NFKBIA;;chr2:70167296..70167306,+!p3@MXD1!1.34!31.91!MXD1;;chr10:51572408..51572454,+!p3@NCOA4!1.33!115.83!NCOA4;;chr2:145277882..145277967,-!p3@ZEB2!1.33!35.17!ZEB2;;chr21:30672433..30672464,+!p6@BACH1!1.33!20.60!BACH1;;chr4:106068026..106068084,+!p1@TET2!1.31!169.34!TET2;;chr11:65429891..65429915,-!p7@RELA!1.31!19.60!RELA;;chr11:47399920..47399931,-!p7@SPI1!1.31!19.35!SPI1;;chr3:187463179..187463201,-!p2@BCL6!1.30!75.88!BCL6;;chr6:126240380..126240430,+!p2@NCOA7!1.30!48.74!NCOA7;;chr9:110250697..110250738,-!p2@KLF4!1.30!22.36!KLF4;;chr7:50344289..50344323,+!p1@IKZF1!1.29!18.59!IKZF1;;chrX:153305787..153305807,-!p3@MECP2!1.29!18.59!MECP2;;chr21:36260325..36260341,-!p14@RUNX1!1.29!18.34!RUNX1;;chr3:39195037..39195069,-!p2@CSRNP1!1.28!110.05!CSRNP1;;chr18:3449720..3449749,+!p2@TGIF1!1.28!37.94!TGIF1;;chrX:2418949..2419024,-!p1@DHRSX,p1@ZBED1!1.28!18.09!ZBED1;;chr12:52445218..52445237,+!p1@NR4A1!1.26!213.31!NR4A1;;chr19:45250948..45250998,+!p3@BCL3!1.26!43.47!BCL3;;chr16:79634595..79634620,-!p2@MAF!1.26!31.15!MAF;;chr9:129567282..129567353,+!p1@ZBTB43!1.25!216.33!ZBTB43;;chr1:221052840..221052875,+!p4@HLX!1.25!19.85!HLX;;chr14:75745523..75745537,+!p1@FOS!1.24!1889.14!FOS;;chr21:36260980..36261011,-!p1@RUNX1!1.24!455.77!RUNX1;;chr1:158979792..158979814,+!p2@IFI16!1.24!153.76!IFI16;;chr2:61108695..61108753,+!p1@REL!1.24!111.55!REL;;chr10:104155480..104155534,+!p2@NFKB2!1.24!103.26!NFKB2;;chr18:3449586..3449617,+!p8@TGIF1!1.24!26.38!TGIF1;;chr1:25256439..25256476,-!p3@RUNX3!1.24!16.33!RUNX3;;chr2:70314240..70314256,+!p4@PCBP1!1.23!33.16!PCBP1;;chr2:145271342..145271377,-!p5@ZEB2!1.23!15.83!ZEB2;;chr3:187455680..187455700,-!p4@BCL6!1.23!15.83!BCL6;;chr10:51572339..51572376,+!p4@NCOA4!1.22!35.17!NCOA4;;chr12:48298785..48298828,-!p1@VDR!1.21!80.40!VDR;;chr1:221053049..221053075,+!p3@HLX!1.21!26.63!HLX;;chr20:48809000..48809053,+!p12@CEBPB!1.21!20.35!CEBPB;;chr18:3449618..3449634,+!p13@TGIF1!1.21!18.84!TGIF1;;chr2:231090433..231090469,+!p1@SP140!1.21!15.33!SP140;;chr3:187455486..187455504,-!p6@BCL6!1.21!15.33!BCL6;;chrX:129244430..129244442,-!p5@ELF4!1.21!15.33!ELF4;;chr19:54058073..54058088,+!p1@ZNF331!1.21!15.07!ZNF331;;chr22:38598086..38598105,+!p1@MAFF!1.20!156.28!MAFF;;chr6:126240463..126240489,+!p6@NCOA7!1.20!16.58!NCOA7;;chr22:38598057..38598071,+!p3@MAFF!1.19!33.42!MAFF;;chr14:35873947..35873965,-!p1@NFKBIA!1.18!875.85!NFKBIA;;chr6:44233252..44233296,-!p1@NFKBIE!1.18!137.68!NFKBIE;;chr7:28725740..28725778,+!p1@CREB5!1.18!124.87!CREB5;;chr10:3827371..3827386,-!p2@KLF6!1.18!117.33!KLF6;;chr1:221052994..221053008,+!p6@HLX!1.18!16.58!HLX;;chr1:212738742..212738755,+!p2@ATF3!1.18!14.07!ATF3;;chr17:38497715..38497734,+!p8@RARA!1.18!14.07!RARA;;chr20:48599506..48599526,+!p1@SNAI1!1.17!87.18!SNAI1;;chr16:3285119..3285133,-!p2@ZNF200!1.17!27.64!ZNF200;;chr21:30672734..30672748,+!p11@BACH1!1.17!13.82!BACH1;;chr2:28615716..28615733,+!p1@FOSL2!1.16!635.16!FOSL2;;chr2:231084659..231084721,-!p1@SP110!1.16!311.05!SP110;;chr16:3285144..3285191,-!p1@ZNF200!1.16!66.08!ZNF200;;chr7:149470641..149470694,-!p1@ZNF467!1.16!60.05!ZNF467;;chr19:45252008..45252024,+!p2@BCL3!1.16!44.22!BCL3;;chr10:64575812..64575824,-!p4@EGR2!1.16!13.57!EGR2;;chr1:158979922..158979933,+!p13@IFI16!1.16!13.32!IFI16;;chr4:103422499..103422632,+!p1@NFKB1!1.15!273.11!NFKB1;;chr8:116681150..116681164,-!p5@TRPS1!1.15!25.63!TRPS1;;chr4:81118647..81118666,+!p1@PRDM8!1.15!17.34!PRDM8;;chr17:38474489..38474548,+!p1@RARA!1.14!400.24!RARA;;chr8:116681194..116681214,-!p1@TRPS1!1.14!118.84!TRPS1;;chr3:39195075..39195088,-!p1@CSRNP1!1.14!79.14!CSRNP1;;chr14:35872962..35873025,-!p3@NFKBIA!1.14!32.16!NFKBIA;;chr18:3449527..3449582,+!p6@TGIF1!1.14!24.37!TGIF1;;chr6:15246261..15246312,+!p1@JARID2!1.13!300.24!JARID2;;chr1:161736038..161736056,+!p4@ATF6!1.13!29.65!ATF6;;chr18:3448455..3448480,+!p5@TGIF1!1.13!23.11!TGIF1;;chr6:15246217..15246228,+!p3@JARID2!1.13!22.36!JARID2;;chr1:8484007..8484061,-!p13@RERE!1.13!16.08!RERE;;chr2:145275228..145275241,-!p11@ZEB2!1.13!15.33!ZEB2;;chr19:54041669..54041697,+!p2@ZNF331!1.13!12.56!ZNF331;;chr19:19496539..19496576,+!p8@GATAD2A!1.12!21.36!GATAD2A;;chr4:185395191..185395226,-!p4@IRF2!1.12!17.08!IRF2;;chr8:53373491..53373506,-!p4@ST18!1.12!12.31!ST18;;chr12:56415246..56415286,+!p2@IKZF4!1.12!12.06!IKZF4;;chr21:40177845..40177863,+!p1@ETS2!1.11!708.02!ETS2;;chr20:48807456..48807475,+!p3@CEBPB!1.11!23.11!CEBPB;;chr2:231280954..231280965,+!p2@SP100!1.11!22.11!SP100;;chr3:187455634..187455651,-!p7@BCL6!1.11!11.81!BCL6;;chr4:106066712..106066728,+!p8@TET2!1.11!11.81!TET2;;chr13:41593392..41593403,-!p7@ELF1!1.11!11.81!ELF1;;chr7:17338266..17338282,+!p1@AHR!1.10!124.12!AHR;;chr8:72756063..72756125,-!p1@MSC!1.10!23.62!MSC;;chr20:48807615..48807644,+!p6@CEBPB!1.10!19.35!CEBPB;;chr3:150126101..150126118,+!p6@TSC22D2!1.10!18.84!TSC22D2;;chr5:142782823..142782854,-!p3@NR3C1!1.10!16.58!NR3C1;;chr21:34398234..34398250,+!p1@OLIG2!1.10!11.56!OLIG2;;chr9:88969303..88969335,-!p1@ZCCHC6!1.09!105.02!ZCCHC6;;chr10:35416142..35416169,+!p3@CREM!1.09!30.40!CREM;;chr1:158979851..158979865,+!p5@IFI16!1.09!25.12!IFI16;;chr12:54785074..54785122,-!p2@ZNF385A!1.09!17.59!ZNF385A;;chr9:88969339..88969422,-!p2@ZCCHC6!1.08!87.18!ZCCHC6;;chr10:104154246..104154347,+!p3@NFKB2!1.08!67.33!NFKB2;;chr14:62162285..621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| |||
|fantom_cat=http://fantom.gsc.riken.jp/5/suppl/Hon_et_al_2016/vis/#/ontologies/CL:0000222;;http://fantom.gsc.riken.jp/5/suppl/Hon_et_al_2016/vis/#/ontologies/CL:0000234;;http://fantom.gsc.riken.jp/5/suppl/Hon_et_al_2016/vis/#/ontologies/CL:0000576;;http://fantom.gsc.riken.jp/5/suppl/Hon_et_al_2016/vis/#/ontologies/CL:0000738;;http://fantom.gsc.riken.jp/5/suppl/Hon_et_al_2016/vis/#/ontologies/CL:0000763;;http://fantom.gsc.riken.jp/5/suppl/Hon_et_al_2016/vis/#/ontologies/CL:0000766;;http://fantom.gsc.riken.jp/5/suppl/Hon_et_al_2016/vis/#/ontologies/CL:0000860;;http://fantom.gsc.riken.jp/5/suppl/Hon_et_al_2016/vis/#/ontologies/CL:0000988;;http://fantom.gsc.riken.jp/5/suppl/Hon_et_al_2016/vis/#/ontologies/UBERON:0002193;;http://fantom.gsc.riken.jp/5/suppl/Hon_et_al_2016/vis/#/ontologies/UBERON:0002390;;http://fantom.gsc.riken.jp/5/suppl/Hon_et_al_2016/vis/#/ontologies/UBERON:0002405 | |||
|ffid_belonging_in_development=CL:0000049,CL:0000134,CL:0002057 | |||
|fonse_cell_line= | |fonse_cell_line= | ||
|fonse_cell_line_closure= | |fonse_cell_line_closure= | ||
Line 66: | Line 41: | ||
|fonse_treatment=EFO:0000369,FF:0000625,FF:0000631,FF:0011444,FF:11862-125A8 | |fonse_treatment=EFO:0000369,FF:0000625,FF:0000631,FF:0011444,FF:11862-125A8 | ||
|fonse_treatment_closure=EFO:0000369,FF:0000625,FF:0000631,FF:0011444,FF:11862-125A8 | |fonse_treatment_closure=EFO:0000369,FF:0000625,FF:0000631,FF:0011444,FF:11862-125A8 | ||
|has_quality= | |has_quality= | ||
|is_a=EFO:0002091;;FF: | |hg19bam=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.primary_cell.hCAGE/CD14%252b%2520monocytes%2520-%2520treated%2520with%2520Trehalose%2520dimycolate%2520%2528TDM%2529%252c%2520donor1.CNhs13467.11862-125A8.hg19.nobarcode.bam | ||
|hg19ctss=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.primary_cell.hCAGE/CD14%252b%2520monocytes%2520-%2520treated%2520with%2520Trehalose%2520dimycolate%2520%2528TDM%2529%252c%2520donor1.CNhs13467.11862-125A8.hg19.ctss.bed.gz | |||
|hg19fasta=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.primary_cell.hCAGE/CD14%252b%2520monocytes%2520-%2520treated%2520with%2520Trehalose%2520dimycolate%2520%2528TDM%2529%252c%2520donor1.CNhs13467.11862-125A8.hg19.nobarcode.rdna.fa.gz | |||
|hg38bam=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.primary_cell.hCAGE/CD14%252b%2520monocytes%2520-%2520treated%2520with%2520Trehalose%2520dimycolate%2520%2528TDM%2529%252c%2520donor1.CNhs13467.11862-125A8.hg38.nobarcode.bam | |||
|hg38ctss=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.primary_cell.hCAGE/CD14%252b%2520monocytes%2520-%2520treated%2520with%2520Trehalose%2520dimycolate%2520%2528TDM%2529%252c%2520donor1.CNhs13467.11862-125A8.hg38.nobarcode.ctss.bed.gz | |||
|id=FF:11862-125A8 | |||
|is_a=EFO:0002091;;FF:0011444 | |||
|is_obsolete= | |||
|library_id=CNhs13467 | |||
|library_id_phase_based=2:CNhs13467 | |||
|microRNAs= | |||
|microRNAs_nn= | |||
|microRNAs_nonnovel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer/#/human#cage;sample;11862 | |||
|microRNAs_novel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer_novel/#/human#cage;sample;11862 | |||
|name=CD14+ monocytes - treated with Trehalose dimycolate (TDM), donor1 | |||
|namespace= | |namespace= | ||
|part_of= | |part_of= | ||
|profile_cagescan=,,, | |||
|profile_hcage=CNhs13467,LSID1024,release012,COMPLETED | |||
|profile_rnaseq= | |||
|profile_srnaseq=,,, | |||
|refex=http://refex.dbcls.jp/genelist.php?lang | |||
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| |||
|rna_box=125 | |||
|rna_catalog_number= | |||
|rna_concentration=0.69819 | |||
|rna_extraction_protocol=OP-RNA-extraction-totalRNA-miRNeasy_Mini-v1.0 | |||
|rna_lot_number=D3-3 | |||
|rna_od260/230=1.14 | |||
|rna_od260/280=2.02 | |||
|rna_position=A8 | |||
|rna_rin=8.8 | |||
|rna_sample_type=total RNA | |||
|rna_tube_id=125A8 | |||
|rna_weight_ug=3.49095 | |||
|sample_age=69 | |||
|sample_category=primary cells | |||
|sample_cell_catalog= | |||
|sample_cell_line= | |||
|sample_cell_lot= | |||
|sample_cell_type=monocyte | |||
|sample_collaboration=Christine Wells (University of Queensland) | |||
|sample_company= | |||
|sample_description= | |||
|sample_dev_stage= | |||
|sample_disease= | |||
|sample_donor(cell lot)=donor1 | |||
|sample_ethnicity= | |||
|sample_experimental_condition= | |||
|sample_gostat=GO:0044464;cell part;0!GO:0005622;intracellular;0!GO:0044424;intracellular part;1.11550986833546e-274!GO:0005737;cytoplasm;8.38822454392541e-129!GO:0043227;membrane-bound organelle;1.25177979215859e-114!GO:0043231;intracellular membrane-bound organelle;2.26640758062294e-114!GO:0043226;organelle;6.57606473527404e-106!GO:0043229;intracellular organelle;3.67211862110826e-105!GO:0044444;cytoplasmic part;2.01816568758697e-84!GO:0044422;organelle part;1.72230811610019e-69!GO:0005515;protein binding;2.26191461783185e-69!GO:0044446;intracellular organelle part;5.82535299962324e-68!GO:0044237;cellular metabolic process;1.67717807676566e-64!GO:0044238;primary metabolic process;7.43013649455172e-63!GO:0043170;macromolecule metabolic process;9.40000464725954e-61!GO:0032991;macromolecular complex;1.29793708887025e-55!GO:0003723;RNA binding;9.97282795639438e-53!GO:0019538;protein metabolic process;4.5491457740022e-48!GO:0044267;cellular protein metabolic process;8.08898356494799e-45!GO:0044260;cellular macromolecule metabolic process;8.08898356494799e-45!GO:0030529;ribonucleoprotein complex;1.29685767858194e-44!GO:0005634;nucleus;2.65550562130109e-44!GO:0044428;nuclear part;6.91176321191162e-44!GO:0033036;macromolecule localization;1.65350301221416e-42!GO:0045184;establishment of protein localization;1.4194026260116e-41!GO:0015031;protein transport;1.73005394974614e-41!GO:0008104;protein localization;1.1149397005142e-39!GO:0043233;organelle lumen;2.09477882517042e-36!GO:0031974;membrane-enclosed lumen;2.09477882517042e-36!GO:0006412;translation;4.43055192899403e-36!GO:0005829;cytosol;9.4745286134025e-36!GO:0031090;organelle membrane;2.14277204337518e-34!GO:0043283;biopolymer metabolic process;5.46252584006981e-33!GO:0006915;apoptosis;5.07125055011819e-32!GO:0012501;programmed cell death;6.31684560326262e-32!GO:0008219;cell death;1.16088332986502e-30!GO:0016265;death;1.16088332986502e-30!GO:0016071;mRNA metabolic process;4.76503006647353e-30!GO:0010467;gene expression;3.10269534896009e-29!GO:0043234;protein complex;3.26977822790279e-29!GO:0031981;nuclear lumen;1.26351340800539e-27!GO:0009059;macromolecule biosynthetic process;1.36599839657956e-27!GO:0006396;RNA processing;1.60370420264861e-27!GO:0046907;intracellular transport;2.21446962204408e-27!GO:0006886;intracellular protein transport;2.36791559890553e-27!GO:0009058;biosynthetic process;1.68320946228791e-26!GO:0016043;cellular component organization and biogenesis;1.89338842027428e-26!GO:0005739;mitochondrion;4.47059517480047e-26!GO:0044249;cellular biosynthetic process;9.50244308977753e-26!GO:0008380;RNA splicing;9.53583432239505e-26!GO:0006397;mRNA processing;1.82694159716107e-25!GO:0031967;organelle envelope;2.03460195773945e-25!GO:0031975;envelope;3.90127863592406e-25!GO:0005840;ribosome;6.46189393981117e-23!GO:0005830;cytosolic ribosome (sensu Eukaryota);3.09222663476673e-22!GO:0006139;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;1.71677081042049e-21!GO:0051649;establishment of cellular localization;1.71677081042049e-21!GO:0033279;ribosomal subunit;2.43704935478545e-21!GO:0003735;structural constituent of ribosome;2.83587921895662e-21!GO:0000166;nucleotide binding;3.91754900029649e-21!GO:0042981;regulation of apoptosis;4.08897934025619e-21!GO:0044445;cytosolic part;6.47579307343792e-21!GO:0065003;macromolecular complex assembly;8.59672548535383e-21!GO:0043067;regulation of programmed cell death;1.00088216692799e-20!GO:0051641;cellular localization;1.07904541776183e-20!GO:0005654;nucleoplasm;1.60965298424323e-20!GO:0044429;mitochondrial part;4.47434180611613e-20!GO:0005681;spliceosome;2.03657750831857e-19!GO:0008134;transcription factor binding;6.44080537992192e-19!GO:0016192;vesicle-mediated transport;9.14121918505741e-18!GO:0007243;protein kinase cascade;9.21802539593828e-18!GO:0043412;biopolymer modification;2.09136064863029e-17!GO:0044265;cellular macromolecule catabolic process;2.62374826970809e-17!GO:0022607;cellular component assembly;2.75721862976949e-17!GO:0006512;ubiquitin cycle;2.95641406438116e-17!GO:0044451;nucleoplasm part;3.78817252402543e-17!GO:0002376;immune system process;4.9307824732974e-17!GO:0016818;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;1.62739710167887e-16!GO:0006119;oxidative phosphorylation;1.70979079352971e-16!GO:0006464;protein modification process;1.79846189013797e-16!GO:0016462;pyrophosphatase activity;1.84947969932964e-16!GO:0016817;hydrolase activity, acting on acid anhydrides;2.15394767592689e-16!GO:0048523;negative regulation of cellular process;2.22091364022422e-16!GO:0005740;mitochondrial envelope;3.73166386451129e-16!GO:0005773;vacuole;3.7944033530108e-16!GO:0017111;nucleoside-triphosphatase activity;4.9269440407681e-16!GO:0043687;post-translational protein modification;5.72500166331171e-16!GO:0031966;mitochondrial membrane;8.49235264390914e-16!GO:0007249;I-kappaB kinase/NF-kappaB cascade;9.10182312834729e-16!GO:0032553;ribonucleotide binding;1.43482503205158e-15!GO:0032555;purine ribonucleotide binding;1.43482503205158e-15!GO:0048770;pigment granule;1.54915110972055e-15!GO:0042470;melanosome;1.54915110972055e-15!GO:0022613;ribonucleoprotein complex biogenesis and assembly;4.68996459615484e-15!GO:0043285;biopolymer catabolic process;5.26808618357792e-15!GO:0019866;organelle inner membrane;8.64858508533158e-15!GO:0017076;purine nucleotide binding;8.64858508533158e-15!GO:0007242;intracellular signaling cascade;1.08384736788286e-14!GO:0019941;modification-dependent protein catabolic process;1.19117475910556e-14!GO:0043632;modification-dependent macromolecule catabolic process;1.19117475910556e-14!GO:0051603;proteolysis involved in cellular protein catabolic process;1.54589555954415e-14!GO:0044257;cellular protein catabolic process;1.67273148720549e-14!GO:0000323;lytic vacuole;1.68390713060804e-14!GO:0005764;lysosome;1.68390713060804e-14!GO:0022618;protein-RNA complex assembly;1.76627848076038e-14!GO:0048519;negative regulation of biological process;1.93256456222605e-14!GO:0006511;ubiquitin-dependent protein catabolic process;2.38006207276898e-14!GO:0006955;immune response;2.9136998511137e-14!GO:0006605;protein targeting;3.68393485144436e-14!GO:0009057;macromolecule catabolic process;4.95841508492581e-14!GO:0050794;regulation of cellular process;1.66261453555236e-13!GO:0043122;regulation of I-kappaB kinase/NF-kappaB cascade;2.21152743124556e-13!GO:0044248;cellular catabolic process;2.40208617349293e-13!GO:0012505;endomembrane system;2.57931327799273e-13!GO:0016070;RNA metabolic process;3.79290853362068e-13!GO:0006793;phosphorus metabolic process;4.59013208646518e-13!GO:0006796;phosphate metabolic process;4.59013208646518e-13!GO:0006913;nucleocytoplasmic transport;5.25638698514188e-13!GO:0005794;Golgi apparatus;5.27611904082493e-13!GO:0043069;negative regulation of programmed cell death;6.24547496686761e-13!GO:0043066;negative regulation of apoptosis;6.44310793292537e-13!GO:0003676;nucleic acid binding;8.20109476433091e-13!GO:0016604;nuclear body;8.89118425648415e-13!GO:0051169;nuclear transport;9.78491550496709e-13!GO:0065009;regulation of a molecular function;1.1095235731471e-12!GO:0016874;ligase activity;1.2266173898499e-12!GO:0005768;endosome;1.38934789995863e-12!GO:0000502;proteasome complex (sensu Eukaryota);1.52364245899538e-12!GO:0005743;mitochondrial inner membrane;2.8198965211836e-12!GO:0006950;response to stress;2.90438008651844e-12!GO:0030163;protein catabolic process;3.66382412478903e-12!GO:0006996;organelle organization and biogenesis;5.09705389719185e-12!GO:0005842;cytosolic large ribosomal subunit (sensu Eukaryota);6.6879994179441e-12!GO:0051246;regulation of protein metabolic process;7.55622190486356e-12!GO:0006366;transcription from RNA polymerase II promoter;8.57218265525455e-12!GO:0016310;phosphorylation;1.00868727886033e-11!GO:0008135;translation factor activity, nucleic acid binding;1.08261911025718e-11!GO:0043123;positive regulation of I-kappaB kinase/NF-kappaB cascade;1.16059894755125e-11!GO:0015934;large ribosomal subunit;1.24275554863639e-11!GO:0006457;protein folding;1.4400908527077e-11!GO:0044455;mitochondrial membrane part;1.53708626984475e-11!GO:0003712;transcription cofactor activity;1.85247437413316e-11!GO:0006916;anti-apoptosis;2.34064250105555e-11!GO:0005843;cytosolic small ribosomal subunit (sensu Eukaryota);4.31749486048705e-11!GO:0009615;response to virus;6.36743506397814e-11!GO:0050789;regulation of biological process;6.53333112620143e-11!GO:0016607;nuclear speck;7.02670352135937e-11!GO:0005524;ATP binding;9.72995663929675e-11!GO:0015935;small ribosomal subunit;1.16565459068111e-10!GO:0032559;adenyl ribonucleotide binding;1.16565459068111e-10!GO:0003743;translation initiation factor activity;1.91730310403375e-10!GO:0005783;endoplasmic reticulum;2.84693104530629e-10!GO:0006413;translational initiation;4.20568666872074e-10!GO:0051186;cofactor metabolic process;4.69382606835847e-10!GO:0031324;negative regulation of cellular metabolic process;5.29023910350994e-10!GO:0048522;positive regulation of cellular process;5.32939001284905e-10!GO:0030554;adenyl nucleotide binding;6.65209440565957e-10!GO:0006446;regulation of translational initiation;7.48986695438478e-10!GO:0046961;hydrogen ion transporting ATPase activity, rotational mechanism;1.53648198911459e-09!GO:0065007;biological regulation;1.55121131522315e-09!GO:0006259;DNA metabolic process;1.57690717085512e-09!GO:0016787;hydrolase activity;1.63588882924403e-09!GO:0008639;small protein conjugating enzyme activity;1.67422134370142e-09!GO:0009967;positive regulation of signal transduction;2.16734127604961e-09!GO:0005635;nuclear envelope;2.2544373302315e-09!GO:0019787;small conjugating protein ligase activity;2.26950042573211e-09!GO:0050790;regulation of catalytic activity;2.60785304253281e-09!GO:0048518;positive regulation of biological process;2.70998492449047e-09!GO:0004842;ubiquitin-protein ligase activity;2.72581141302739e-09!GO:0005746;mitochondrial respiratory chain;3.15328167291679e-09!GO:0009607;response to biotic stimulus;3.79645678734679e-09!GO:0051082;unfolded protein binding;4.27737180604106e-09!GO:0048193;Golgi vesicle transport;4.76563515918562e-09!GO:0015986;ATP synthesis coupled proton transport;5.06133947642071e-09!GO:0015985;energy coupled proton transport, down electrochemical gradient;5.06133947642071e-09!GO:0006732;coenzyme metabolic process;5.06133947642071e-09!GO:0009056;catabolic process;5.51845225028494e-09!GO:0046933;hydrogen ion transporting ATP synthase activity, rotational mechanism;7.21238723445506e-09!GO:0043065;positive regulation of apoptosis;7.96352015050942e-09!GO:0017038;protein import;9.13081612398119e-09!GO:0019829;cation-transporting ATPase activity;1.02345349763532e-08!GO:0005770;late endosome;1.03924964526369e-08!GO:0009892;negative regulation of metabolic process;1.04210090460534e-08!GO:0043068;positive regulation of programmed cell death;1.17882917183146e-08!GO:0016655;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor;1.43353420709394e-08!GO:0051170;nuclear import;1.77800493101296e-08!GO:0050136;NADH dehydrogenase (quinone) activity;1.95163256775944e-08!GO:0003954;NADH dehydrogenase activity;1.95163256775944e-08!GO:0008137;NADH dehydrogenase (ubiquinone) activity;1.95163256775944e-08!GO:0000398;nuclear mRNA splicing, via spliceosome;2.06677229218971e-08!GO:0000375;RNA splicing, via transesterification reactions;2.06677229218971e-08!GO:0000377;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;2.06677229218971e-08!GO:0006417;regulation of translation;2.88486360090303e-08!GO:0003924;GTPase activity;3.33921855715799e-08!GO:0045934;negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;4.06690037515941e-08!GO:0016564;transcription repressor activity;4.14686122031507e-08!GO:0006606;protein import into nucleus;4.17768982691765e-08!GO:0048468;cell development;4.44449513878897e-08!GO:0016881;acid-amino acid ligase activity;5.72521749636315e-08!GO:0042623;ATPase activity, coupled;5.83275342242878e-08!GO:0044432;endoplasmic reticulum part;5.89051575335026e-08!GO:0006754;ATP biosynthetic process;6.86933586275752e-08!GO:0006753;nucleoside phosphate metabolic process;6.86933586275752e-08!GO:0016887;ATPase activity;7.11071393136257e-08!GO:0005525;GTP binding;9.16788146098961e-08!GO:0016481;negative regulation of transcription;9.24483038618673e-08!GO:0051726;regulation of cell cycle;9.83907192712092e-08!GO:0009150;purine ribonucleotide metabolic process;1.11665106660606e-07!GO:0000074;regulation of progression through cell cycle;1.13972473687213e-07!GO:0006163;purine nucleotide metabolic process;1.14558446149496e-07!GO:0005774;vacuolar membrane;1.17449789267628e-07!GO:0005730;nucleolus;1.22778117350022e-07!GO:0007049;cell cycle;1.26578870739346e-07!GO:0009152;purine ribonucleotide biosynthetic process;1.4884593546993e-07!GO:0016879;ligase activity, forming carbon-nitrogen bonds;1.6393069931955e-07!GO:0006164;purine nucleotide biosynthetic process;1.66007701603179e-07!GO:0009259;ribonucleotide metabolic process;1.70995335170738e-07!GO:0009966;regulation of signal transduction;1.7788960557685e-07!GO:0009055;electron carrier activity;2.09954706036032e-07!GO:0006917;induction of apoptosis;2.21925949233094e-07!GO:0019899;enzyme binding;2.23905839229915e-07!GO:0046034;ATP metabolic process;2.42494461957587e-07!GO:0008047;enzyme activator activity;2.46945389238674e-07!GO:0031965;nuclear membrane;2.5226953877391e-07!GO:0016469;proton-transporting two-sector ATPase complex;2.94218235473057e-07!GO:0007264;small GTPase mediated signal transduction;3.08653415277847e-07!GO:0009889;regulation of biosynthetic process;3.10210058368176e-07!GO:0042775;organelle ATP synthesis coupled electron transport;3.19808168688545e-07!GO:0042773;ATP synthesis coupled electron transport;3.19808168688545e-07!GO:0009206;purine ribonucleoside triphosphate biosynthetic process;3.31927710069608e-07!GO:0009145;purine nucleoside triphosphate biosynthetic process;3.31927710069608e-07!GO:0005793;ER-Golgi intermediate compartment;3.34443561157948e-07!GO:0012502;induction of programmed cell death;3.57068146146008e-07!GO:0015078;hydrogen ion transmembrane transporter activity;3.93870745764266e-07!GO:0044440;endosomal part;4.13910341921184e-07!GO:0010008;endosome membrane;4.13910341921184e-07!GO:0003713;transcription coactivator activity;4.19477207687115e-07!GO:0030964;NADH dehydrogenase complex (quinone);4.20515714991464e-07!GO:0045271;respiratory chain complex I;4.20515714991464e-07!GO:0005747;mitochondrial respiratory chain complex I;4.20515714991464e-07!GO:0044453;nuclear membrane part;4.36475672673784e-07!GO:0009142;nucleoside triphosphate biosynthetic process;4.57901840261269e-07!GO:0009201;ribonucleoside triphosphate biosynthetic process;4.57901840261269e-07!GO:0031326;regulation of cellular biosynthetic process;5.1424685359407e-07!GO:0045786;negative regulation of progression through cell cycle;5.14494375510432e-07!GO:0008565;protein transporter activity;5.19812720647906e-07!GO:0009260;ribonucleotide biosynthetic process;5.35645931876755e-07!GO:0051188;cofactor biosynthetic process;5.45097965894773e-07!GO:0009205;purine ribonucleoside triphosphate metabolic process;5.71884442774098e-07!GO:0009144;purine nucleoside triphosphate metabolic process;5.71884442774098e-07!GO:0044437;vacuolar part;5.71884442774098e-07!GO:0006461;protein complex assembly;5.90072769560968e-07!GO:0019222;regulation of metabolic process;6.55821717266123e-07!GO:0016651;oxidoreductase activity, acting on NADH or NADPH;7.02257419888512e-07!GO:0009199;ribonucleoside triphosphate metabolic process;7.52848344831344e-07!GO:0005765;lysosomal membrane;7.53540590362152e-07!GO:0006120;mitochondrial electron transport, NADH to ubiquinone;8.87749359032757e-07!GO:0009108;coenzyme biosynthetic process;1.0506199036893e-06!GO:0042175;nuclear envelope-endoplasmic reticulum network;1.80232645678274e-06!GO:0032561;guanyl ribonucleotide binding;1.80719442029652e-06!GO:0019001;guanyl nucleotide binding;1.80719442029652e-06!GO:0005789;endoplasmic reticulum membrane;1.80921792186773e-06!GO:0009141;nucleoside triphosphate metabolic process;1.81588327955785e-06!GO:0005839;proteasome core complex (sensu Eukaryota);2.46847141638948e-06!GO:0016044;membrane organization and biogenesis;2.47090915093885e-06!GO:0031982;vesicle;2.6753925094247e-06!GO:0032446;protein modification by small protein conjugation;2.72333382065187e-06!GO:0042625;ATPase activity, coupled to transmembrane movement of ions;2.72333382065187e-06!GO:0006752;group transfer coenzyme metabolic process;3.28364611221354e-06!GO:0016563;transcription activator activity;3.53388778292243e-06!GO:0016567;protein ubiquitination;5.02092235610951e-06!GO:0031980;mitochondrial lumen;5.16780384384284e-06!GO:0005759;mitochondrial matrix;5.16780384384284e-06!GO:0043228;non-membrane-bound organelle;5.19158918019865e-06!GO:0043232;intracellular non-membrane-bound organelle;5.19158918019865e-06!GO:0016591;DNA-directed RNA polymerase II, holoenzyme;5.81810847115622e-06!GO:0006325;establishment and/or maintenance of chromatin architecture;6.33829276117585e-06!GO:0050657;nucleic acid transport;7.07184461665937e-06!GO:0051236;establishment of RNA localization;7.07184461665937e-06!GO:0050658;RNA transport;7.07184461665937e-06!GO:0016568;chromatin modification;7.84426623123802e-06!GO:0016772;transferase activity, transferring phosphorus-containing groups;8.09633948645385e-06!GO:0006403;RNA localization;9.24198385950037e-06!GO:0004386;helicase activity;1.000243615571e-05!GO:0004298;threonine endopeptidase activity;1.0299817085335e-05!GO:0015405;P-P-bond-hydrolysis-driven transmembrane transporter activity;1.08350091639348e-05!GO:0015399;primary active transmembrane transporter activity;1.08350091639348e-05!GO:0015077;monovalent inorganic cation transmembrane transporter activity;1.09695132145444e-05!GO:0048475;coated membrane;1.18124199795275e-05!GO:0030117;membrane coat;1.18124199795275e-05!GO:0008026;ATP-dependent helicase activity;1.29373147675134e-05!GO:0031252;leading edge;1.41590400438113e-05!GO:0005643;nuclear pore;1.42689021919062e-05!GO:0006323;DNA packaging;1.46734261858247e-05!GO:0006357;regulation of transcription from RNA polymerase II promoter;1.62478149652189e-05!GO:0031410;cytoplasmic vesicle;1.67281197298027e-05!GO:0051336;regulation of hydrolase activity;1.78397784763314e-05!GO:0006888;ER to Golgi vesicle-mediated transport;1.93054073774566e-05!GO:0006974;response to DNA damage stimulus;1.93212680423239e-05!GO:0016197;endosome transport;1.97381716621371e-05!GO:0031902;late endosome membrane;2.36087087524072e-05!GO:0030695;GTPase regulator activity;2.42866405765047e-05!GO:0030120;vesicle coat;2.47025343391378e-05!GO:0030662;coated vesicle membrane;2.47025343391378e-05!GO:0006954;inflammatory response;2.7842378222762e-05!GO:0030099;myeloid cell differentiation;3.05779313176414e-05!GO:0008632;apoptotic program;3.31441824620635e-05!GO:0051707;response to other organism;3.55755652759309e-05!GO:0031988;membrane-bound vesicle;3.77325707582206e-05!GO:0005096;GTPase activator activity;4.01449096994969e-05!GO:0003714;transcription corepressor activity;4.10188402755027e-05!GO:0006897;endocytosis;5.29696820241877e-05!GO:0010324;membrane invagination;5.29696820241877e-05!GO:0006401;RNA catabolic process;5.58550818715311e-05!GO:0031323;regulation of cellular metabolic process;6.76456808360689e-05!GO:0005769;early endosome;7.50746542809218e-05!GO:0051028;mRNA transport;7.62732466402945e-05!GO:0001816;cytokine production;7.7063626288312e-05!GO:0045259;proton-transporting ATP synthase complex;8.0584228842247e-05!GO:0051789;response to protein stimulus;8.75752888357322e-05!GO:0006986;response to unfolded protein;8.75752888357322e-05!GO:0051338;regulation of transferase activity;9.18300714842056e-05!GO:0022402;cell cycle process;9.18904604178515e-05!GO:0044431;Golgi apparatus part;0.000103613698088152!GO:0006952;defense response;0.000104222016092251!GO:0046822;regulation of nucleocytoplasmic transport;0.000116466758713285!GO:0016023;cytoplasmic membrane-bound vesicle;0.000116684012402666!GO:0008234;cysteine-type peptidase activity;0.000117517163677719!GO:0006613;cotranslational protein targeting to membrane;0.000119211207979463!GO:0043492;ATPase activity, coupled to movement of substances;0.000119577197078624!GO:0042626;ATPase activity, coupled to transmembrane movement of substances;0.000130368916857041!GO:0045892;negative regulation of transcription, DNA-dependent;0.000130368916857041!GO:0046930;pore complex;0.000134034346227598!GO:0005083;small GTPase regulator activity;0.000134034346227598!GO:0043566;structure-specific DNA binding;0.000144170481546238!GO:0009893;positive regulation of metabolic process;0.000144900061004071!GO:0009060;aerobic respiration;0.000156746097465991!GO:0003724;RNA helicase activity;0.000163094367956388!GO:0004674;protein serine/threonine kinase activity;0.000164226829631035!GO:0032940;secretion by cell;0.000166655325914964!GO:0051427;hormone receptor binding;0.000179751890138097!GO:0016740;transferase activity;0.00018010770253765!GO:0005798;Golgi-associated vesicle;0.000180441126490342!GO:0005057;receptor signaling protein activity;0.000183094765679041!GO:0016820;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;0.000184856831886454!GO:0043549;regulation of kinase activity;0.000190133322737325!GO:0051168;nuclear export;0.000190133322737325!GO:0003697;single-stranded DNA binding;0.00022706631633634!GO:0015931;nucleobase, nucleoside, nucleotide and nucleic acid transport;0.00022828809752189!GO:0005885;Arp2/3 protein complex;0.000271771350281793!GO:0045859;regulation of protein kinase activity;0.000273677861109387!GO:0035257;nuclear hormone receptor binding;0.000282717256346934!GO:0000151;ubiquitin ligase complex;0.000285176792270616!GO:0006281;DNA repair;0.000290212869018682!GO:0051276;chromosome organization and biogenesis;0.000297060834040793!GO:0030097;hemopoiesis;0.000321765614173275!GO:0045935;positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;0.000329624682652126!GO:0055086;nucleobase, nucleoside and nucleotide metabolic process;0.000336403924027016!GO:0006818;hydrogen transport;0.000344776888211813!GO:0065002;intracellular protein transport across a membrane;0.000348822662170129!GO:0045321;leukocyte activation;0.000353405902458211!GO:0030532;small nuclear ribonucleoprotein complex;0.000361071754336585!GO:0000245;spliceosome assembly;0.000388128962159666!GO:0046519;sphingoid metabolic process;0.000390164363008637!GO:0007034;vacuolar transport;0.0004061308050417!GO:0030530;heterogeneous nuclear ribonucleoprotein complex;0.000406618095312476!GO:0006402;mRNA catabolic process;0.000429922708490443!GO:0007050;cell cycle arrest;0.000448757507039457!GO:0005852;eukaryotic translation initiation factor 3 complex;0.000466129529983593!GO:0007265;Ras protein signal transduction;0.000479201665363864!GO:0031202;RNA splicing factor activity, transesterification mechanism;0.000498702984878635!GO:0015992;proton transport;0.000499994067738786!GO:0046983;protein dimerization activity;0.000604560748968456!GO:0022890;inorganic cation transmembrane transporter activity;0.000622725300015341!GO:0007041;lysosomal transport;0.000622828349917793!GO:0051223;regulation of protein transport;0.000639941287525163!GO:0045941;positive regulation of transcription;0.000644931782139459!GO:0006643;membrane lipid metabolic process;0.00066825804011079!GO:0006672;ceramide metabolic process;0.000668607724674216!GO:0045333;cellular respiration;0.000673044498853862!GO:0010468;regulation of gene expression;0.000680524728532049!GO:0045893;positive regulation of transcription, DNA-dependent;0.000690008577272483!GO:0007259;JAK-STAT cascade;0.000714693154974557!GO:0007040;lysosome organization and biogenesis;0.000724716233667881!GO:0006612;protein targeting to membrane;0.000732631486455422!GO:0016773;phosphotransferase activity, alcohol group as acceptor;0.000732631486455422!GO:0005741;mitochondrial outer membrane;0.000754255055368088!GO:0002474;antigen processing and presentation of peptide antigen via MHC class I;0.000776819004331283!GO:0007005;mitochondrion organization and biogenesis;0.000776819004331283!GO:0008654;phospholipid biosynthetic process;0.000776886272727013!GO:0016281;eukaryotic translation initiation factor 4F complex;0.000796076142576424!GO:0000122;negative regulation of transcription from RNA polymerase II promoter;0.000861867322421804!GO:0033157;regulation of intracellular protein transport;0.000911964297057471!GO:0042306;regulation of protein import into nucleus;0.000911964297057471!GO:0005667;transcription factor complex;0.000930189224438221!GO:0003729;mRNA binding;0.000965822652708226!GO:0016301;kinase activity;0.00101838337934755!GO:0005099;Ras GTPase activator activity;0.00105934246163884!GO:0045637;regulation of myeloid cell differentiation;0.00111323567921553!GO:0001726;ruffle;0.00122916634649167!GO:0005637;nuclear inner membrane;0.00128914023187209!GO:0033116;ER-Golgi intermediate compartment membrane;0.00129747536354662!GO:0065004;protein-DNA complex assembly;0.00135835067099833!GO:0043281;regulation of caspase activity;0.00135916286218554!GO:0030149;sphingolipid catabolic process;0.00136836106078886!GO:0030036;actin cytoskeleton organization and biogenesis;0.00137079699006594!GO:0033178;proton-transporting two-sector ATPase complex, catalytic domain;0.00139011294205592!GO:0043085;positive regulation of catalytic activity;0.00144398623964253!GO:0006919;caspase activation;0.00146954002521664!GO:0007033;vacuole organization and biogenesis;0.00147591821950201!GO:0006468;protein amino acid phosphorylation;0.00147839472671439!GO:0044262;cellular carbohydrate metabolic process;0.00148443264789835!GO:0031325;positive regulation of cellular metabolic process;0.00148628228546343!GO:0043280;positive regulation of caspase activity;0.00156640680006382!GO:0008186;RNA-dependent ATPase activity;0.0016358145748262!GO:0002757;immune response-activating signal transduction;0.0016358145748262!GO:0009117;nucleotide metabolic process;0.00176340997140631!GO:0051090;regulation of transcription factor activity;0.00200577655488489!GO:0019221;cytokine and chemokine mediated signaling pathway;0.00201201394377855!GO:0043087;regulation of GTPase activity;0.00213122880488173!GO:0060090;molecular adaptor activity;0.0021356687792041!GO:0000139;Golgi membrane;0.00241976176957765!GO:0002520;immune system development;0.00246652096894984!GO:0018193;peptidyl-amino acid modification;0.00249595832092686!GO:0042990;regulation of transcription factor import into nucleus;0.0026079210091345!GO:0042991;transcription factor import into nucleus;0.0026079210091345!GO:0002274;myeloid leukocyte activation;0.0026141409731074!GO:0005761;mitochondrial ribosome;0.00261659457606128!GO:0000313;organellar ribosome;0.00261659457606128!GO:0009611;response to wounding;0.0026897204924355!GO:0009719;response to endogenous stimulus;0.00305987658652377!GO:0031968;organelle outer membrane;0.00321217353973944!GO:0031072;heat shock protein binding;0.00321268238918839!GO:0022415;viral reproductive process;0.00323902948361128!GO:0042254;ribosome biogenesis and assembly;0.00340224934875516!GO:0006350;transcription;0.0034944979684504!GO:0045261;proton-transporting ATP synthase complex, catalytic core F(1);0.00352190379889509!GO:0019867;outer membrane;0.00352806738576804!GO:0045454;cell redox homeostasis;0.00353185766467161!GO:0002764;immune response-regulating signal transduction;0.00360910026858871!GO:0042110;T cell activation;0.00363205513806806!GO:0016876;ligase activity, forming aminoacyl-tRNA and related compounds;0.00370410160755013!GO:0004812;aminoacyl-tRNA ligase activity;0.00370410160755013!GO:0016875;ligase activity, forming carbon-oxygen bonds;0.00370410160755013!GO:0006099;tricarboxylic acid cycle;0.00392141184456592!GO:0046356;acetyl-CoA catabolic process;0.00392141184456592!GO:0002521;leukocyte differentiation;0.00416102995899381!GO:0016251;general RNA polymerase II transcription factor activity;0.00421544663344838!GO:0004004;ATP-dependent RNA helicase activity;0.0042293196242825!GO:0048487;beta-tubulin binding;0.00432643716087537!GO:0006352;transcription initiation;0.00445113792563104!GO:0043623;cellular protein complex assembly;0.00450060592013795!GO:0006091;generation of precursor metabolites and energy;0.00450844577476864!GO:0046649;lymphocyte activation;0.00461895473660901!GO:0003702;RNA polymerase II transcription factor activity;0.00464039745024818!GO:0048534;hemopoietic or lymphoid organ development;0.00465862337378871!GO:0030658;transport vesicle membrane;0.00481359050332562!GO:0045045;secretory pathway;0.00492180780269164!GO:0004437;inositol or phosphatidylinositol phosphatase activity;0.00493807796857933!GO:0005753;mitochondrial proton-transporting ATP synthase complex;0.00494970893377558!GO:0019377;glycolipid catabolic process;0.00521168580418556!GO:0002252;immune effector process;0.00529637154749727!GO:0033673;negative regulation of kinase activity;0.00537667907475396!GO:0006469;negative regulation of protein kinase activity;0.00537667907475396!GO:0016679;oxidoreductase activity, acting on diphenols and related substances as donors;0.0054468459891258!GO:0016681;oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor;0.0054468459891258!GO:0008121;ubiquinol-cytochrome-c reductase activity;0.0054468459891258!GO:0004185;serine carboxypeptidase activity;0.0054468459891258!GO:0043038;amino acid activation;0.00548516201854226!GO:0006418;tRNA aminoacylation for protein translation;0.00548516201854226!GO:0043039;tRNA aminoacylation;0.00548516201854226!GO:0051187;cofactor catabolic process;0.0057083975564867!GO:0004197;cysteine-type endopeptidase activity;0.00573704109726354!GO:0005813;centrosome;0.00607472070930114!GO:0006607;NLS-bearing substrate import into nucleus;0.00607472070930114!GO:0019904;protein domain specific binding;0.0062232460515479!GO:0001775;cell activation;0.0062232460515479!GO:0006891;intra-Golgi vesicle-mediated transport;0.00630800066288313!GO:0001817;regulation of cytokine production;0.00642109397184874!GO:0006458;'de novo' protein folding;0.0064700614760474!GO:0051084;'de novo' posttranslational protein folding;0.0064700614760474!GO:0008383;manganese superoxide dismutase activity;0.00664815025590335!GO:0001315;age-dependent response to reactive oxygen species;0.00664815025590335!GO:0051348;negative regulation of transferase activity;0.00686410845488689!GO:0046966;thyroid hormone receptor binding;0.00697567500855694!GO:0030029;actin filament-based process;0.00731535976722028!GO:0016363;nuclear matrix;0.00753912248170617!GO:0042802;identical protein binding;0.00753912248170617!GO:0002429;immune response-activating cell surface receptor signaling pathway;0.00770184639348101!GO:0051345;positive regulation of hydrolase activity;0.00782002123363364!GO:0031901;early endosome membrane;0.00792982969682121!GO:0030218;erythrocyte differentiation;0.00796792059590144!GO:0002440;production of molecular mediator of immune response;0.00823349773897782!GO:0006333;chromatin assembly or disassembly;0.00833066414907126!GO:0032386;regulation of intracellular transport;0.0085913767851067!GO:0003725;double-stranded RNA binding;0.00886049038454971!GO:0006399;tRNA metabolic process;0.0092649303594005!GO:0006084;acetyl-CoA metabolic process;0.0095809361174825!GO:0006665;sphingolipid metabolic process;0.0097791648219833!GO:0019883;antigen processing and presentation of endogenous antigen;0.00980942107049309!GO:0031625;ubiquitin protein ligase binding;0.00995486680415689!GO:0030867;rough endoplasmic reticulum membrane;0.010486894413369!GO:0046467;membrane lipid biosynthetic process;0.0106139599766946!GO:0001819;positive regulation of cytokine production;0.0106210454630576!GO:0009165;nucleotide biosynthetic process;0.0106210454630576!GO:0005484;SNAP receptor activity;0.0106647410355116!GO:0033367;protein localization in mast cell secretory granule;0.0106647410355116!GO:0033365;protein localization in organelle;0.0106647410355116!GO:0033371;T cell secretory granule organization and biogenesis;0.0106647410355116!GO:0033373;maintenance of protease localization in mast cell secretory granule;0.0106647410355116!GO:0033375;protease localization in T cell secretory granule;0.0106647410355116!GO:0042629;mast cell granule;0.0106647410355116!GO:0033377;maintenance of protein localization in T cell secretory granule;0.0106647410355116!GO:0033364;mast cell secretory granule organization and biogenesis;0.0106647410355116!GO:0033380;granzyme B localization in T cell secretory granule;0.0106647410355116!GO:0033379;maintenance of protease localization in T cell secretory granule;0.0106647410355116!GO:0033370;maintenance of protein localization in mast cell secretory granule;0.0106647410355116!GO:0033368;protease localization in mast cell secretory granule;0.0106647410355116!GO:0033366;protein localization in secretory granule;0.0106647410355116!GO:0033382;maintenance of granzyme B localization in T cell secretory granule;0.0106647410355116!GO:0033374;protein localization in T cell secretory granule;0.0106647410355116!GO:0032318;regulation of Ras GTPase activity;0.0109039071151341!GO:0019219;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;0.0110235349425757!GO:0009109;coenzyme catabolic process;0.0111111712051477!GO:0005070;SH3/SH2 adaptor activity;0.0112377964435693!GO:0043021;ribonucleoprotein binding;0.0112377964435693!GO:0046466;membrane lipid catabolic process;0.0112525857436502!GO:0002237;response to molecule of bacterial origin;0.0112632622385232!GO:0005838;proteasome regulatory particle (sensu Eukaryota);0.0114986546866496!GO:0005062;hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity;0.0116285146526951!GO:0030660;Golgi-associated vesicle membrane;0.0116632836404528!GO:0019882;antigen processing and presentation;0.0119872823203106!GO:0006749;glutathione metabolic process;0.012038854510792!GO:0030518;steroid hormone receptor signaling pathway;0.0120757924400899!GO:0030134;ER to Golgi transport vesicle;0.0122266314447584!GO:0000209;protein polyubiquitination;0.0122332029742533!GO:0030127;COPII vesicle coat;0.0125166757087406!GO:0012507;ER to Golgi transport vesicle membrane;0.0125166757087406!GO:0015631;tubulin binding;0.0125174664480644!GO:0016779;nucleotidyltransferase activity;0.0126107034315164!GO:0030041;actin filament polymerization;0.0127210356567556!GO:0000785;chromatin;0.0127282669204493!GO:0046479;glycosphingolipid catabolic process;0.0127357403826931!GO:0000287;magnesium ion binding;0.0129868109640022!GO:0051252;regulation of RNA metabolic process;0.0131227071263565!GO:0051098;regulation of binding;0.0134281636183873!GO:0032763;regulation of mast cell cytokine production;0.0134777740403325!GO:0032762;mast cell cytokine production;0.0134777740403325!GO:0008637;apoptotic mitochondrial changes;0.0134777740403325!GO:0002504;antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;0.0135050274065565!GO:0051092;activation of NF-kappaB transcription factor;0.0138620283596766!GO:0045792;negative regulation of cell size;0.01400647954384!GO:0002467;germinal center formation;0.0143383111162655!GO:0043433;negative regulation of transcription factor activity;0.0145620186003915!GO:0030118;clathrin coat;0.0147651983759297!GO:0006368;RNA elongation from RNA polymerase II promoter;0.0147809661541072!GO:0019079;viral genome replication;0.0147935808269927!GO:0002768;immune response-regulating cell surface receptor signaling pathway;0.0149212469733856!GO:0004860;protein kinase inhibitor activity;0.0149212469733856!GO:0019220;regulation of phosphate metabolic process;0.0149228751021857!GO:0051174;regulation of phosphorus metabolic process;0.0149228751021857!GO:0030027;lamellipodium;0.0150192021649859!GO:0019210;kinase inhibitor activity;0.0154048886509992!GO:0030521;androgen receptor signaling pathway;0.0156877653576568!GO:0030133;transport vesicle;0.0156940140656223!GO:0005815;microtubule organizing center;0.0160741571248443!GO:0048500;signal recognition particle;0.016140247297786!GO:0043621;protein self-association;0.0162104984733378!GO:0006611;protein export from nucleus;0.016239319500012!GO:0030308;negative regulation of cell growth;0.0165094919448742!GO:0045639;positive regulation of myeloid cell differentiation;0.016541742837033!GO:0016791;phosphoric monoester hydrolase activity;0.0183717297352058!GO:0019318;hexose metabolic process;0.0189496506669655!GO:0051085;chaperone cofactor-dependent protein folding;0.0193699577911594!GO:0008139;nuclear localization sequence binding;0.0194076366684637!GO:0005048;signal sequence binding;0.0197466906590482!GO:0003690;double-stranded DNA binding;0.0200740265282429!GO:0002250;adaptive immune response;0.0202066317373876!GO:0002460;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;0.0202066317373876!GO:0000082;G1/S transition of mitotic cell cycle;0.0204279186912651!GO:0017091;AU-rich element binding;0.0205753922393649!GO:0050779;RNA destabilization;0.0205753922393649!GO:0000289;poly(A) tail shortening;0.0205753922393649!GO:0019901;protein kinase binding;0.0206561202403266!GO:0003727;single-stranded RNA binding;0.0206561202403266!GO:0006354;RNA elongation;0.0206733418431966!GO:0004177;aminopeptidase activity;0.0208908174796966!GO:0030224;monocyte differentiation;0.0210438189085429!GO:0046979;TAP2 binding;0.0214463613920939!GO:0046977;TAP binding;0.0214463613920939!GO:0046978;TAP1 binding;0.0214463613920939!GO:0048002;antigen processing and presentation of peptide antigen;0.0214498601728486!GO:0006614;SRP-dependent cotranslational protein targeting to membrane;0.021510901357792!GO:0045047;protein targeting to ER;0.021510901357792!GO:0030503;regulation of cell redox homeostasis;0.0215712722372363!GO:0002224;toll-like receptor signaling pathway;0.0215987990755908!GO:0002221;pattern recognition receptor signaling pathway;0.0215987990755908!GO:0050900;leukocyte migration;0.021662782041623!GO:0006644;phospholipid metabolic process;0.0218883517718063!GO:0002763;positive regulation of myeloid leukocyte differentiation;0.0219649469767079!GO:0016667;oxidoreductase activity, acting on sulfur group of donors;0.0221661947939836!GO:0005996;monosaccharide metabolic process;0.0221773064941892!GO:0006367;transcription initiation from RNA polymerase II promoter;0.0229191880911323!GO:0030693;caspase activity;0.0229195703460496!GO:0030176;integral to endoplasmic reticulum membrane;0.0229195703460496!GO:0002443;leukocyte mediated immunity;0.0229555295862971!GO:0006414;translational elongation;0.0231786887724796!GO:0008629;induction of apoptosis by intracellular signals;0.0233643033484144!GO:0019843;rRNA binding;0.0236526340281223!GO:0006650;glycerophospholipid metabolic process;0.024189374695045!GO:0043022;ribosome binding;0.0248029900482504!GO:0008333;endosome to lysosome transport;0.0250770576755969!GO:0043488;regulation of mRNA stability;0.0254681836855666!GO:0043487;regulation of RNA stability;0.0254681836855666!GO:0045646;regulation of erythrocyte differentiation;0.0256768951547568!GO:0051059;NF-kappaB binding;0.0257518257205815!GO:0045263;proton-transporting ATP synthase complex, coupling factor F(o);0.0261398844176677!GO:0033177;proton-transporting two-sector ATPase complex, proton-transporting domain;0.0261398844176677!GO:0016072;rRNA metabolic process;0.0262675630748499!GO:0043071;positive regulation of non-apoptotic programmed cell death;0.0269354506572293!GO:0005905;coated pit;0.027588882855403!GO:0008361;regulation of cell size;0.0278483880727408!GO:0045113;regulation of integrin biosynthetic process;0.0280711219399002!GO:0045112;integrin biosynthetic process;0.0280711219399002!GO:0019783;small conjugating protein-specific protease activity;0.028077609565472!GO:0008286;insulin receptor signaling pathway;0.0282535572692604!GO:0030663;COPI coated vesicle membrane;0.0283489099867611!GO:0030126;COPI vesicle coat;0.0283489099867611!GO:0042613;MHC class II protein complex;0.0284215870449127!GO:0015036;disulfide oxidoreductase activity;0.0284215870449127!GO:0005788;endoplasmic reticulum lumen;0.0285668024310138!GO:0006364;rRNA processing;0.0285668024310138!GO:0043300;regulation of leukocyte degranulation;0.0288435359497731!GO:0000118;histone deacetylase complex;0.028943293453765!GO:0050851;antigen receptor-mediated signaling pathway;0.028943293453765!GO:0000339;RNA cap binding;0.0291454192442977!GO:0051091;positive regulation of transcription factor activity;0.0291706654113655!GO:0017166;vinculin binding;0.0291706654113655!GO:0030137;COPI-coated vesicle;0.0293892732065569!GO:0015923;mannosidase activity;0.0295012434293348!GO:0050811;GABA receptor binding;0.0295012434293348!GO:0000165;MAPKKK cascade;0.0295012434293348!GO:0042348;NF-kappaB import into nucleus;0.0295610126991218!GO:0042345;regulation of NF-kappaB import into nucleus;0.0295610126991218!GO:0002822;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.;0.0303381952390253!GO:0002819;regulation of adaptive immune response;0.0303381952390253!GO:0030384;phosphoinositide metabolic process;0.0312425677017883!GO:0016605;PML body;0.0334962288238464!GO:0051247;positive regulation of protein metabolic process;0.0336322265781783!GO:0048146;positive regulation of fibroblast proliferation;0.0343902208042903!GO:0006007;glucose catabolic process;0.0346104209312905!GO:0042221;response to chemical stimulus;0.0348105564223824!GO:0032760;positive regulation of tumor necrosis factor production;0.0348634028229104!GO:0004843;ubiquitin-specific protease activity;0.0349825055207938!GO:0048471;perinuclear region of cytoplasm;0.0353532214904872!GO:0006405;RNA export from nucleus;0.0360498147495279!GO:0005786;signal recognition particle, endoplasmic reticulum targeting;0.0362404876414157!GO:0045944;positive regulation of transcription from RNA polymerase II promoter;0.0363490693771141!GO:0043407;negative regulation of MAP kinase activity;0.0365596280272374!GO:0008287;protein serine/threonine phosphatase complex;0.0367591274028027!GO:0004722;protein serine/threonine phosphatase activity;0.0370247282995416!GO:0016491;oxidoreductase activity;0.0374962675751658!GO:0002682;regulation of immune system process;0.0375865013330865!GO:0008312;7S RNA binding;0.0377752643002134!GO:0044255;cellular lipid metabolic process;0.038107858470629!GO:0005694;chromosome;0.0384053659316501!GO:0006914;autophagy;0.0386677895226433!GO:0004563;beta-N-acetylhexosaminidase activity;0.0386677895226433!GO:0005152;interleukin-1 receptor antagonist activity;0.0389051160668492!GO:0030353;fibroblast growth factor receptor antagonist activity;0.0389051160668492!GO:0003746;translation elongation factor activity;0.0391990489320031!GO:0051101;regulation of DNA binding;0.0394033525120637!GO:0008624;induction of apoptosis by extracellular signals;0.0394453328860713!GO:0048144;fibroblast proliferation;0.0396939307132875!GO:0048145;regulation of fibroblast proliferation;0.0396939307132875!GO:0046426;negative regulation of JAK-STAT cascade;0.0398074483791984!GO:0000096;sulfur amino acid metabolic process;0.0399006258729372!GO:0045449;regulation of transcription;0.0401904827248158!GO:0006984;ER-nuclear signaling pathway;0.0402737393884122!GO:0006689;ganglioside catabolic process;0.0404850760066369!GO:0002444;myeloid leukocyte mediated immunity;0.0404850760066369!GO:0000278;mitotic cell cycle;0.041205715264783!GO:0006509;membrane protein ectodomain proteolysis;0.0414094172231619!GO:0033619;membrane protein proteolysis;0.0414094172231619!GO:0005869;dynactin complex;0.0419055989384016!GO:0009306;protein secretion;0.0423004371149175!GO:0035035;histone acetyltransferase binding;0.04242228405064!GO:0046578;regulation of Ras protein signal transduction;0.0429881648543297!GO:0005669;transcription factor TFIID complex;0.043099096311766!GO:0030258;lipid modification;0.043099096311766!GO:0033033;negative regulation of myeloid cell apoptosis;0.043099096311766!GO:0001803;regulation of type III hypersensitivity;0.043099096311766!GO:0032733;positive regulation of interleukin-10 production;0.043099096311766!GO:0033025;regulation of mast cell apoptosis;0.043099096311766!GO:0001805;positive regulation of type III hypersensitivity;0.043099096311766!GO:0033023;mast cell homeostasis;0.043099096311766!GO:0002431;Fc receptor mediated stimulatory signaling pathway;0.043099096311766!GO:0033032;regulation of myeloid cell apoptosis;0.043099096311766!GO:0001802;type III hypersensitivity;0.043099096311766!GO:0033028;myeloid cell apoptosis;0.043099096311766!GO:0042590;antigen processing and presentation of exogenous peptide antigen via MHC class I;0.043099096311766!GO:0033026;negative regulation of mast cell apoptosis;0.043099096311766!GO:0033024;mast cell apoptosis;0.043099096311766!GO:0042611;MHC protein complex;0.0432486127153275!GO:0016311;dephosphorylation;0.0437925216013084!GO:0015980;energy derivation by oxidation of organic compounds;0.0446757077626045!GO:0000184;mRNA catabolic process, nonsense-mediated decay;0.0446757077626045!GO:0006465;signal peptide processing;0.0446757077626045!GO:0051056;regulation of small GTPase mediated signal transduction;0.0447149609207082!GO:0008538;proteasome activator activity;0.0448047252371762!GO:0004715;non-membrane spanning protein tyrosine kinase activity;0.0450282794636733!GO:0051235;maintenance of localization;0.0457488619221991!GO:0005684;U2-dependent spliceosome;0.0461203764441545!GO:0006351;transcription, DNA-dependent;0.0461203764441545!GO:0045926;negative regulation of growth;0.0466284070515057!GO:0004702;receptor signaling protein serine/threonine kinase activity;0.0473744821074126!GO:0008656;caspase activator activity;0.0474215065952372!GO:0030522;intracellular receptor-mediated signaling pathway;0.0477145295211471!GO:0002697;regulation of immune effector process;0.0479720935954828!GO:0042108;positive regulation of cytokine biosynthetic process;0.0480511324340411!GO:0030217;T cell differentiation;0.0483187119100037!GO:0042325;regulation of phosphorylation;0.0483187119100037!GO:0007162;negative regulation of cell adhesion;0.0483457249786512!GO:0045576;mast cell activation;0.0483744067563492!GO:0032774;RNA biosynthetic process;0.0492160606738689!GO:0002684;positive regulation of immune system process;0.0492160606738689!GO:0004218;cathepsin S activity;0.0492160606738689!GO:0008017;microtubule binding;0.0496465381558668 | |||
|sample_id=11862 | |||
|sample_note= | |||
|sample_sex=female | |||
|sample_species=Human (Homo sapiens) | |||
|sample_strain= | |||
|sample_tissue= | |||
|top_motifs=STAT2,4,6:5.45297593062;STAT5{A,B}:4.62149317811;FOSL2:4.48547695172;NFE2:4.21591678191;NFE2L2:4.18187291448;IRF7:4.11582861704;BACH2:4.06153033299;IRF1,2:3.94178398762;FOS_FOS{B,L1}_JUN{B,D}:3.92615483362;CEBPA,B_DDIT3:3.87116035644;SREBF1,2:3.70632806903;STAT1,3:3.57931852275;PAX2:3.35835019254;HLF:3.33742767075;SPIB:3.1126349864;EP300:2.87988418288;SPI1:2.83265300068;ATF4:2.79397778213;ATF5_CREB3:2.6046800988;ATF6:2.6030106435;NFIL3:2.55504109993;NFE2L1:2.52968455886;FOXP3:2.50278038622;ETS1,2:2.48659197548;NANOG{mouse}:2.36020663155;DMAP1_NCOR{1,2}_SMARC:2.23670717718;CREB1:2.11608145402;ZBTB16:2.09850222636;FOXN1:2.09653199408;CDX1,2,4:2.07689092599;NR1H4:1.8955931006;RUNX1..3:1.8381749355;HIF1A:1.72828835236;ARNT_ARNT2_BHLHB2_MAX_MYC_USF1:1.64758557295;NFKB1_REL_RELA:1.63051990108;JUN:1.58014677565;PITX1..3:1.47292781513;HMGA1,2:1.35854833821;ELF1,2,4:1.32856726417;NR6A1:1.31292682713;PAX4:1.28427897238;HBP1_HMGB_SSRP1_UBTF:1.25782423259;HSF1,2:1.23321560652;ALX4:1.17564936601;PDX1:1.15548660097;TGIF1:1.15001225817;PAX3,7:1.05979574107;MAFB:0.971254758896;ATF2:0.914482927133;ESRRA:0.87066489268;BPTF:0.789570630813;IKZF2:0.746235833183;NFATC1..3:0.715444582034;FOXP1:0.706512223678;FOXD3:0.650059169209;RXRA_VDR{dimer}:0.627484881111;SRF:0.62586467092;HMX1:0.611700509913;XBP1:0.560632673206;HOX{A5,B5}:0.474680095625;PRDM1:0.450919900861;TLX2:0.428918764864;PAX8:0.378002669883;FOXO1,3,4:0.346576375012;TFCP2:0.230151480054;GLI1..3:0.189242470116;PPARG:0.179121872317;GATA4:0.118538521637;RXR{A,B,G}:0.0722471909329;RFX2..5_RFXANK_RFXAP:-0.0149375780741;MYB:-0.0227900297553;DBP:-0.0443018999624;HES1:-0.0611436094763;NKX6-1,2:-0.0697000973878;PAX1,9:-0.083147832648;TBP:-0.0867144851264;AHR_ARNT_ARNT2:-0.103438156999;EN1,2:-0.107848661477;EGR1..3:-0.120023980267;FOX{D1,D2}:-0.125297398182;FOXL1:-0.139031057782;IKZF1:-0.188541530017;NKX2-2,8:-0.196750872543;MEF2{A,B,C,D}:-0.217236103457;ESR1:-0.274264082355;FOXM1:-0.359759253981;ALX1:-0.431443481911;NKX3-2:-0.442518370083;NANOG:-0.500894792522;SMAD1..7,9:-0.517687407913;HOX{A6,A7,B6,B7}:-0.536775994927;T:-0.578587613205;RREB1:-0.589032396543;TAL1_TCF{3,4,12}:-0.598746698845;OCT4_SOX2{dimer}:-0.670209566724;MZF1:-0.684668181293;SPZ1:-0.689702587426;POU2F1..3:-0.716917743314;HOXA9_MEIS1:-0.807129790861;RBPJ:-0.815676350969;REST:-0.873866571419;TFAP4:-0.898681886598;NKX3-1:-0.934077604495;FOX{F1,F2,J1}:-0.957338681417;TEF:-0.970535407182;VSX1,2:-1.00312135932;NR3C1:-1.02462246947;HNF4A_NR2F1,2:-1.02642653952;ZNF384:-1.05740936792;AIRE:-1.06399326667;HNF1A:-1.10477999593;RORA:-1.13248267338;SOX2:-1.15007076415;POU5F1:-1.1517582445;MED-1{core}:-1.16577519305;MYFfamily:-1.19020749467;GZF1:-1.24530508683;TOPORS:-1.26053077817;ZNF238:-1.26625306929;PRRX1,2:-1.27404609436;PATZ1:-1.27887595265;NHLH1,2:-1.29369044394;POU6F1:-1.35819568691;CUX2:-1.36725120106;SP1:-1.36978884804;GATA6:-1.3726478664;PAX6:-1.39269034091;ZBTB6:-1.40154549138;RFX1:-1.40154571403;XCPE1{core}:-1.40513471496;FOXA2:-1.43369399798;UFEwm:-1.49926123097;MAZ:-1.50871431784;SOX5:-1.51681617619;TFAP2B:-1.53038127633;ZFP161:-1.5579454956;RXR{A,B,G}_{NR1H2,PPAR}dimers:-1.55939201815;MTE{core}:-1.56117688686;MYOD1:-1.59318316163;TEAD1:-1.60132646763;MTF1:-1.60396901205;ZEB1:-1.61445873698;SOX{8,9,10}:-1.61758688916;POU1F1:-1.64016379068;NKX2-3_NKX2-5:-1.6819063722;GTF2A1,2:-1.71909685506;NKX2-1,4:-1.71920378123;TP53:-1.75269295685;E2F1..5:-1.75539116954;TFAP2{A,C}:-1.7608280266;BREu{core}:-1.79097323352;GTF2I:-1.81467896134;GCM1,2:-1.84483975081;MYBL2:-1.85397474306;ZIC1..3:-1.88365371522;EVI1:-1.88772775348;TLX1..3_NFIC{dimer}:-1.89139419606;NFIX:-1.89577583902;SNAI1..3:-1.89946733385;ELK1,4_GABP{A,B1}:-1.93030394228;KLF4:-1.93987550307;CRX:-1.96403162113;HOX{A4,D4}:-1.98544473281;ARID5B:-2.00004470397;TFDP1:-2.00344097217;ZNF148:-2.04205964199;ADNP_IRX_SIX_ZHX:-2.05457839864;ONECUT1,2:-2.0999931741;GFI1B:-2.13845101951;HIC1:-2.20862516939;LMO2:-2.24284795743;NFY{A,B,C}:-2.24983580747;FOX{I1,J2}:-2.2672454031;TBX4,5:-2.30906890731;POU3F1..4:-2.31067848783;bHLH_family:-2.31916468992;ZNF423:-2.33519270979;EBF1:-2.363385924;HAND1,2:-2.41897852041;CDC5L:-2.54136279137;PAX5:-2.56515510662;PBX1:-2.58143990483;SOX17:-2.72698729119;AR:-2.76786029215;FOXQ1:-2.85508254385;GFI1:-2.87036007989;NRF1:-2.92457674693;NR5A1,2:-2.99624410319;YY1:-3.01574507341;LEF1_TCF7_TCF7L1,2:-3.48653484713;ZNF143:-3.54104977063;LHX3,4:-3.59610803315 | |||
|xref= | |||
|zenbu_report=https://fantom.gsc.riken.jp/zenbu/reports/#miRNA_expression_atlas_human;search_select_hide=table111:FF:11862-125A8;search_select_hide=table117:FF:11862-125A8 | |||
}} | }} |
Latest revision as of 18:24, 4 June 2020
Name: | CD14+ monocytes - treated with Trehalose dimycolate (TDM), donor1 |
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Species: | Human (Homo sapiens) |
Library ID: | CNhs13467 |
Sample type: | primary cells |
Genomic View: | UCSC |
RefEX: | Specific genes |
FANTOM CAT: | 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 |
CAGEd-oPOSSUM: | link |
ZENBU report : | link |
Additional information | ||||||||||||||||||||||||||||
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Sample information
RNA information
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CAGE Accession numbers | ||||||||||||||||||||||||||||||||||||||||||||||
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Download raw sequence, BAM & CTSS | ||||||||||||||
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Relative expression to median (log10)
Transcription factors with enriched expression in this sampleRanked list of transcription factor promoter expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed.
Co-expression clusters with enriched expression in this sampleRanked list of co-expression cluster expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed. <br>Analyst:NA <br><br>link to dataset.<br>data
Repeat families with enriched expression in this sample<b>Summary:</b>Ranked list of repeat family expression in this sample relative tothe median expression in the FANTOM5 collection is shown. Value is log10transformed.<br><b>Analyst:</b>NA<br><br>link to dataset.<br>data
TFBS(DNA)motifs over-represented in proximal region of promoters active in this sample
JASPAR motifs<b>Summary:</b>Association of JASPAR motif to the promoter expression in thissample. Pearson's correlation between the number of TFBSs estimated byusing the position-weight matrix for each promoter and its expression isexpressed as Z-score by taking the ones based on random position-weightmatrix, and the tail probability of the normal distribution correspondingto the Z-score is taken as the resulting P-value. Lower P-value indicatesmore (non-random) association of the motif to promoter expression<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data
library id: CNhs13467
FANTOM5 phase1 novel unique motifs<b>Summary:</b>Association of the 169 novel and unique motifs discovered in FANTOM5 phase1 in this sample. Among the de-novo motifs discovered by DMF, HOMER,ChIPMunk, and ScanAll, only novel motifs are selected after comparison with known motif sets, and their clustering based on MACRO-APE resulted in169 novel and unique motifs. Their association to the promoter expression is evaluated in the same way to the JASPAR motif above<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data
library id: CNhs13467
Novel motif | Logo | P-value |
---|---|---|
1 | 1 | 0.0898 |
10 | 10 | 0.0129 |
100 | 100 | 0.934 |
101 | 101 | 0.988 |
102 | 102 | 0.822 |
103 | 103 | 0.401 |
104 | 104 | 0.604 |
105 | 105 | 0.204 |
106 | 106 | 9.23421e-4 |
107 | 107 | 0.27 |
108 | 108 | 0.938 |
109 | 109 | 0.294 |
11 | 11 | 0.15 |
110 | 110 | 0.121 |
111 | 111 | 0.0256 |
112 | 112 | 0.376 |
113 | 113 | 0.523 |
114 | 114 | 0.0134 |
115 | 115 | 0.288 |
116 | 116 | 0.821 |
117 | 117 | 0.0385 |
118 | 118 | 0.168 |
119 | 119 | 0.137 |
12 | 12 | 0.349 |
120 | 120 | 0.968 |
121 | 121 | 0.501 |
122 | 122 | 0.736 |
123 | 123 | 0.0807 |
124 | 124 | 0.637 |
125 | 125 | 0.358 |
126 | 126 | 0.292 |
127 | 127 | 0.421 |
128 | 128 | 0.039 |
129 | 129 | 0.492 |
13 | 13 | 0.0767 |
130 | 130 | 0.0724 |
131 | 131 | 0.768 |
132 | 132 | 0.0765 |
133 | 133 | 0.569 |
134 | 134 | 0.596 |
135 | 135 | 0.746 |
136 | 136 | 0.887 |
137 | 137 | 0.0152 |
138 | 138 | 0.223 |
139 | 139 | 0.0543 |
14 | 14 | 0.421 |
140 | 140 | 0.316 |
141 | 141 | 0.271 |
142 | 142 | 0.0982 |
143 | 143 | 0.0457 |
144 | 144 | 0.812 |
145 | 145 | 0.269 |
146 | 146 | 0.547 |
147 | 147 | 0.516 |
148 | 148 | 0.0176 |
149 | 149 | 0.823 |
15 | 15 | 0.177 |
150 | 150 | 0.438 |
151 | 151 | 0.418 |
152 | 152 | 0.216 |
153 | 153 | 0.734 |
154 | 154 | 0.435 |
155 | 155 | 0.719 |
156 | 156 | 0.499 |
157 | 157 | 0.53 |
158 | 158 | 0.0165 |
159 | 159 | 0.929 |
16 | 16 | 0.294 |
160 | 160 | 0.408 |
161 | 161 | 0.605 |
162 | 162 | 0.223 |
163 | 163 | 0.124 |
164 | 164 | 0.0727 |
165 | 165 | 0.179 |
166 | 166 | 0.633 |
167 | 167 | 0.104 |
168 | 168 | 0.346 |
169 | 169 | 0.0117 |
17 | 17 | 0.229 |
18 | 18 | 0.175 |
19 | 19 | 0.428 |
2 | 2 | 0.507 |
20 | 20 | 0.157 |
21 | 21 | 0.512 |
22 | 22 | 0.365 |
23 | 23 | 0.0437 |
24 | 24 | 0.321 |
25 | 25 | 0.421 |
26 | 26 | 0.0476 |
27 | 27 | 0.536 |
28 | 28 | 0.48 |
29 | 29 | 0.212 |
3 | 3 | 0.101 |
30 | 30 | 0.393 |
31 | 31 | 0.888 |
32 | 32 | 0.929 |
33 | 33 | 0.284 |
34 | 34 | 0.786 |
35 | 35 | 0.151 |
36 | 36 | 0.0885 |
37 | 37 | 0.0724 |
38 | 38 | 0.407 |
39 | 39 | 0.863 |
4 | 4 | 0.812 |
40 | 40 | 0.207 |
41 | 41 | 0.0123 |
42 | 42 | 0.366 |
43 | 43 | 0.032 |
44 | 44 | 0.941 |
45 | 45 | 0.965 |
46 | 46 | 0.184 |
47 | 47 | 0.539 |
48 | 48 | 0.526 |
49 | 49 | 0.123 |
5 | 5 | 0.327 |
50 | 50 | 0.976 |
51 | 51 | 0.523 |
52 | 52 | 0.398 |
53 | 53 | 0.465 |
54 | 54 | 0.404 |
55 | 55 | 0.551 |
56 | 56 | 0.711 |
57 | 57 | 0.742 |
58 | 58 | 0.138 |
59 | 59 | 0.355 |
6 | 6 | 0.674 |
60 | 60 | 0.0518 |
61 | 61 | 0.704 |
62 | 62 | 0.0728 |
63 | 63 | 0.482 |
64 | 64 | 0.397 |
65 | 65 | 0.26 |
66 | 66 | 0.24 |
67 | 67 | 0.619 |
68 | 68 | 0.803 |
69 | 69 | 0.462 |
7 | 7 | 0.295 |
70 | 70 | 0.0343 |
71 | 71 | 0.0305 |
72 | 72 | 0.217 |
73 | 73 | 0.166 |
74 | 74 | 0.0896 |
75 | 75 | 0.093 |
76 | 76 | 0.133 |
77 | 77 | 0.57 |
78 | 78 | 0.0784 |
79 | 79 | 0.2 |
8 | 8 | 0.394 |
80 | 80 | 0.381 |
81 | 81 | 0.377 |
82 | 82 | 0.173 |
83 | 83 | 0.0697 |
84 | 84 | 0.246 |
85 | 85 | 0.0191 |
86 | 86 | 0.0677 |
87 | 87 | 0.98 |
88 | 88 | 0.578 |
89 | 89 | 0.327 |
9 | 9 | 0.531 |
90 | 90 | 0.0665 |
91 | 91 | 0.255 |
92 | 92 | 0.26 |
93 | 93 | 0.445 |
94 | 94 | 0.0684 |
95 | 95 | 0.348 |
96 | 96 | 0.666 |
97 | 97 | 0.792 |
98 | 98 | 0.135 |
99 | 99 | 0.0406 |
de novo motifs identified by HOMER in promoters active in this sample<b>Summary:</b>The result of HOMER in this sample is shown.<br><b>Analyst:</b>NA <br>
library id: CNhs13467
FANTOM5 (FF) ontology
Direct parent terms
is_a relathionship
EFO:0002091 biological replicate
FF:0011444 CD14-positive monocytes - treated with Trehalose dimycolate (TDM) sample
Ancestor terms (non development)<b>Summary:</b>Connected ontology terms with is_a, part_of or located_in relationship <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source data<br>data
CL: Cell type
0000000 (cell), 0000000 (cell)
0000003 (native cell)
0000988 (hematopoietic cell)
0000548 (animal cell)
0000763 (myeloid cell)
0002371 (somatic cell)
0000766 (myeloid leukocyte)
0000219 (motile cell)
0000325 (stuff accumulating cell)
0000473 (defensive cell)
0000234 (phagocyte)
0000738 (leukocyte)
0002087 (nongranular leukocyte)
0000255 (eukaryotic cell)
0000576 (monocyte)
0000860 (classical monocyte)
0002057 (CD14-positive, CD16-negative classical monocyte)
FF: FANTOM5
0000102 (sample by type)
0000210 (human sample)
0000002 (in vivo cell sample)
0000101 (sample by species)
0000001 (sample)
0000625 (experimental infection sample)
0000350 (experimentally modified sample)
0000631 (trehalose dimycolate (TDM) treatment sample)
0011444 (CD14-positive monocytes - treated with Trehalose dimycolate (TDM) sample)
Ancestor terms (development)<b>Summary:</b>Connected ontology terms with develops_from, derives_from or preceded_by relationship <br><b>Analyst:</b> Hideya Kawaji <br><br>link to source data<br>data
CL:0000049 (common myeloid progenitor)
CL:0000134 (mesenchymal cell)
CL:0002057 (CD14-positive, CD16-negative classical monocyte)