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{{Coexpression_clusters
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|full_id=C4487_Neural_testicular_hippocampus_amygdala_maxillary_parietal_caudate
|id=C4487
}}

Latest revision as of 12:46, 17 September 2013


Full id: C4487_Neural_testicular_hippocampus_amygdala_maxillary_parietal_caudate



Phase1 CAGE Peaks

Hg19::chr5:16742010..16742025,-p3@MYO10
Hg19::chr5:16742041..16742054,-p11@MYO10
Hg19::chr5:16742330..16742344,-p6@MYO10


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
neuronal stem cell5.63e-138
neuron1.13e-096
neuroblast1.13e-096
electrically signaling cell1.13e-096
embryonic stem cell3.38e-085
neural cell3.62e-0825
Uber Anatomy
Ontology termp-valuen
central nervous system4.09e-8081
neural tube9.17e-7456
neural rod9.17e-7456
future spinal cord9.17e-7456
neural keel9.17e-7456
nervous system4.31e-7289
regional part of nervous system2.88e-6953
regional part of brain2.88e-6953
brain3.83e-6168
future brain3.83e-6168
neural plate1.17e-5982
presumptive neural plate1.17e-5982
regional part of forebrain1.22e-5941
forebrain1.22e-5941
anterior neural tube1.22e-5941
future forebrain1.22e-5941
neurectoderm5.80e-5686
telencephalon1.35e-4934
brain grey matter3.55e-4934
gray matter3.55e-4934
ecto-epithelium9.28e-48104
pre-chordal neural plate5.17e-4761
cerebral hemisphere8.94e-4732
regional part of telencephalon1.85e-4632
ectoderm-derived structure4.96e-42171
ectoderm4.96e-42171
presumptive ectoderm4.96e-42171
structure with developmental contribution from neural crest3.29e-36132
cerebral cortex7.17e-3625
pallium7.17e-3625
adult organism2.49e-33114
regional part of cerebral cortex2.31e-3222
organ system subdivision6.07e-32223
neocortex1.77e-2920
anatomical cluster7.13e-20373
tube2.85e-17192
basal ganglion3.86e-159
nuclear complex of neuraxis3.86e-159
aggregate regional part of brain3.86e-159
collection of basal ganglia3.86e-159
cerebral subcortex3.86e-159
anatomical conduit5.38e-15240
posterior neural tube5.69e-1515
chordal neural plate5.69e-1515
neural nucleus1.58e-149
nucleus of brain1.58e-149
telencephalic nucleus6.11e-127
epithelium3.33e-11306
diencephalon3.54e-117
future diencephalon3.54e-117
segmental subdivision of hindbrain5.13e-1112
hindbrain5.13e-1112
presumptive hindbrain5.13e-1112
organ part5.68e-11218
cell layer6.64e-11309
embryo7.23e-11592
gyrus2.08e-106
segmental subdivision of nervous system5.49e-1013
multi-cellular organism9.06e-10656
limbic system2.62e-095
brainstem3.73e-096
parietal lobe3.78e-095
occipital lobe5.42e-095
temporal lobe7.81e-096
embryonic structure1.25e-08564
germ layer2.02e-08560
germ layer / neural crest2.02e-08560
embryonic tissue2.02e-08560
presumptive structure2.02e-08560
germ layer / neural crest derived structure2.02e-08560
epiblast (generic)2.02e-08560
multi-tissue structure2.48e-08342
corpus striatum3.56e-084
striatum3.56e-084
ventral part of telencephalon3.56e-084
future corpus striatum3.56e-084
developing anatomical structure5.36e-08581
anatomical system1.29e-07624
anatomical group1.48e-07625
regional part of metencephalon1.86e-079
metencephalon1.86e-079
future metencephalon1.86e-079
gland of diencephalon7.66e-074
neuroendocrine gland7.66e-074
regional part of diencephalon9.08e-074


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.11.36919
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.11.6959
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.22.23118
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.12.08673
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.21.55139
MA0018.20.987913
MA0099.20.902716
MA0079.20.00160703
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203336.77394172622320.003216880500103790.016813521296684
FOXA1#3169311.08141974938550.000734755275698670.00583286000598155
MAX#414936.452555509007120.003721913834265510.0187223272775674
SP1#666735.69838137814090.005403962701712170.0247591340471207



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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