FF:10822-111C3: Difference between revisions
From FANTOM5_SSTAR
(Created page with "{{f5samples
|id=FF:10822-111C3
|name=B lymphoblastoid cell line: GM12878 ENCODE, biol_rep2
|sample_id=10822
|rna_tube_id=111C3
|rna_box=111
|rna_position=C3
|sample_cel...") |
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{{f5samples | {{f5samples | ||
| | |DRA_sample_Accession=CAGE@SAMD00005657 | ||
| | |accession_numbers=CAGE;DRX007777;DRR008649;DRZ000074;DRZ001459;DRZ011424;DRZ012809 | ||
| | |ancestors_in_anatomy_facet= | ||
|ancestors_in_cell_lineage_facet=CL:0000000,CL:0000003,CL:0000988,CL:0000548,CL:0002371,CL:0000542,CL:0000219,CL:0000945,CL:0000738,CL:0002087,CL:0002242,CL:0000255 | |||
|ancestors_in_cell_lineage_facet=CL:0000000,CL:0000003,CL: | |||
|ancestors_in_disease_facet= | |ancestors_in_disease_facet= | ||
| | |ancestors_in_ff_facet=FF:0000102,FF:0000003,FF:0000210,FF:0000101,FF:0000001,FF:0101035,FF:0100773,FF:0101522,FF:0102062 | ||
|comment= | |||
|created_by= | |||
|creation_date= | |||
|data_phase=2 | |||
|datafreeze_phase=2 | |||
|def= | |||
|expression_enrichment_score=chr6:391743..391759,+!p1@IRF4!2.60!396.79!IRF4;;chr2:68592406..68592424,+!p1@PLEK!2.47!296.96!PLEK;;chr11:111249993..111250006,-!p1@POU2AF1!2.36!229.06!POU2AF1;;chr1:25291475..25291511,-!p2@RUNX3!2.01!102.46!RUNX3;;chr19:50922187..50922204,+!p1@SPIB!2.01!101.80!SPIB;;chr16:85932760..85932775,+!p1@IRF8!1.97!93.35!IRF8;;chr12:103351444..103351461,+!p1@ASCL1!1.97!92.77!ASCL1;;chr3:27763807..27763822,-!p1@EOMES!1.92!82.51!EOMES;;chr17:38020392..38020477,-!p1@IKZF3!1.87!72.41!IKZF3;;chr2:231090433..231090469,+!p1@SP140!1.78!59.36!SP140;;chr1:25256756..25256774,-!p1@RUNX3!1.74!98.27!RUNX3;;chr2:231090471..231090504,+!p2@SP140!1.72!50.90!SP140;;chr2:68592394..68592405,+!p2@PLEK!1.64!42.69!PLEK;;chr7:28610099..28610113,+!p5@CREB5!1.62!40.72!CREB5;;chr19:36204309..36204335,+!p1@ZBTB32!1.58!36.78!ZBTB32;;chr10:64576105..64576133,-!p1@EGR2!1.52!64.45!EGR2;;chr17:36105042..36105060,-!p1@HNF1B!1.52!31.94!HNF1B;;chr3:27764190..27764208,-!p2@EOMES!1.49!30.13!EOMES;;chr5:88120151..88120177,-!p6@MEF2C!1.47!28.49!MEF2C;;chr8:76319876..76319926,+!p1@HNF4G!1.46!27.75!HNF4G;;chr1:158978768..158978800,+!p8@IFI16!1.46!27.67!IFI16;;chr20:50159198..50159299,-!p1@NFATC2!1.45!39.33!NFATC2;;chr14:75988771..75988826,+!p1@BATF!1.44!35.47!BATF;;chr1:3569072..3569093,+!p1@TP73!1.44!26.68!TP73;;chrX:2418949..2419024,-!p1@DHRSX,p1@ZBED1!1.42!25.53!ZBED1;;chr3:189349162..189349207,+!p2@TP63!1.40!24.14!TP63;;chr12:103352277..103352324,+!p2@ASCL1!1.40!23.89!ASCL1;;chr11:61520075..61520136,+!p1@C11orf9!1.38!47.54!C11orf9;;chr7:50348268..50348366,+!p4@IKZF1!1.38!22.74!IKZF1;;chr9:37034469..37034474,-!p1@PAX5!1.36!21.92!PAX5;;chr11:47400078..47400106,-!p1@SPI1!1.34!20.77!SPI1;;chr19:42636586..42636607,-!p1@POU2F2!1.33!55.01!POU2F2;;chr8:72756637..72756664,-!p3@MSC!1.29!21.18!MSC;;chr8:72756667..72756736,-!p2@MSC!1.28!27.75!MSC;;chr4:185395590..185395627,-!p3@IRF2!1.28!22.50!IRF2;;chr3:101546827..101546847,+!p2@NFKBIZ!1.27!24.63!NFKBIZ;;chr17:45810594..45810608,+!p1@TBX21!1.27!17.57!TBX21;;chr19:19281060..19281078,-!p2@MEF2BNB-MEF2B,p2@MEF2B!1.27!17.49!MEF2B;;chr5:133450365..133450444,+!p1@TCF7!1.23!72.08!TCF7;;chr5:158526917..158526932,-!p1@EBF1!1.23!39.82!EBF1;;chr18:52989031..52989079,-!p2@TCF4!1.20!34.81!TCF4;;chr9:1050331..1050363,+!p1@DMRT2!1.19!14.61!DMRT2;;chr8:76319850..76319870,+!p4@HNF4G!1.17!13.87!HNF4G;;chr13:41593425..41593480,-!p1@ELF1!1.16!84.07!ELF1;;chr5:142780237..142780261,-!p7@NR3C1!1.16!13.46!NR3C1;;chr6:34204973..34204990,+!p4@HMGA1!1.15!171.75!HMGA1;;chr14:75988831..75988847,+!p2@BATF!1.15!13.22!BATF;;chr7:28610060..28610073,+!p9@CREB5!1.13!12.56!CREB5;;chr8:135614084..135614119,-!p4@ZFAT!1.12!12.32!ZFAT;;chr5:88178983..88179012,-!p1@MEF2C!1.10!89.65!MEF2C;;chr1:170632115..170632136,+!p9@PRRX1!1.09!11.25!PRRX1;;chr19:45579725..45579743,-!p1@ZNF296!1.08!49.51!ZNF296;;chr12:54447599..54447630,+!p3@HOXC4!1.07!13.38!HOXC4;;chr9:126774018..126774055,+!p1@LHX2!1.07!10.76!LHX2;;chr1:23857698..23857733,-!p1@E2F2!1.06!19.13!E2F2;;chr2:214015111..214015179,-!p1@IKZF2!1.06!18.72!IKZF2;;chr7:128577972..128578047,+!p1@IRF5!1.06!16.83!IRF5;;chr7:50344251..50344288,+!p3@IKZF1!1.06!10.43!IKZF1;;chr16:85936412..85936431,+!p2@IRF8!1.05!10.26!IRF8;;chr20:42543441..42543497,+!p1@TOX2!1.04!45.24!TOX2;;chr1:38512457..38512474,-!p1@POU3F1!1.03!10.67!POU3F1;;chr7:50344289..50344323,+!p1@IKZF1!1.02!9.36!IKZF1;;chr3:141747950..141748004,-!p7@TFDP2!1.02!9.36!TFDP2;;chr6:135502408..135502459,+!p2@MYB!1.01!10.84!MYB;;chr1:25291620..25291635,-!p4@RUNX3!1.01!9.28!RUNX3;;chr2:214015343..214015366,-!p3@IKZF2!1.01!9.28!IKZF2;;chr10:104155480..104155534,+!p2@NFKB2!1.00!59.69!NFKB2;;chr8:72756063..72756125,-!p1@MSC!1.00!18.47!MSC;;chr7:137620650..137620677,-!p3@CREB3L2!1.00!9.03!CREB3L2;;chr2:68615031..68615055,+!p3@PLEK!1.00!9.03!PLEK;;chr1:92951607..92951661,-!p1@GFI1!1.00!9.03!GFI1;;chr9:126773880..126773895,+!p2@LHX2!1.00!9.03!LHX2;;chr2:231090344..231090361,-!p3@SP110!1.00!8.95!SP110;;chr9:117150254..117150271,-!p1@AKNA!0.99!24.71!AKNA;;chr3:141105705..141105770,+!p4@ZBTB38!0.99!10.76!ZBTB38;;chr20:62680984..62680999,-!p1@SOX18!0.98!11.58!SOX18;;chr7:50343634..50343717,+!p2@IKZF1!0.98!8.54!IKZF1;;chr11:615570..615721,-!p2@IRF7!0.96!16.34!IRF7;;chr8:65492915..65492932,+!p1@BHLHE22!0.96!8.21!BHLHE22;;chr7:137620684..137620711,-!p4@CREB3L2!0.96!8.13!CREB3L2;;chr11:19262421..19262455,-!p3@E2F8!0.96!8.13!E2F8;;chr2:214016254..214016282,-!p7@IKZF2!0.96!8.13!IKZF2;;chr17:1959369..1959388,+!p2@HIC1!0.95!21.35!HIC1;;chr1:170632051..170632081,+!p16@PRRX1!0.95!7.88!PRRX1;;chr17:37934204..37934241,-!p3@IKZF3!0.94!7.80!IKZF3;;chr20:42295713..42295738,+!p2@MYBL2!0.93!45.65!MYBL2;;chr6:41700616..41700664,-!p8@TFEB!0.93!7.55!TFEB;;chr5:142780189..142780223,-!p6@NR3C1!0.92!7.31!NR3C1;;chr20:42295745..42295765,+!p1@MYBL2!0.91!122.00!MYBL2;;chr1:117602932..117602973,+!p1@TTF2!0.91!27.91!TTF2;;chr1:151319654..151319698,-!p2@RFX5!0.91!16.17!RFX5;;chr18:52989001..52989030,-!p10@TCF4!0.91!7.96!TCF4;;chr4:185395633..185395651,-!p2@IRF2!0.90!11.41!IRF2;;chr12:54447637..54447659,+!p4@HOXC4!0.90!6.98!HOXC4;;chr2:70314240..70314256,+!p4@PCBP1!0.89!14.61!PCBP1;;chr16:85936539..85936562,+!p3@IRF8!0.89!6.73!IRF8;;chr1:3569135..3569150,+!p3@TP73!0.89!6.73!TP73;;chr7:156803329..156803362,-!p1@MNX1!0.88!6.65!MNX1;;chr8:135614120..135614149,-!p5@ZFAT!0.88!6.57!ZFAT;;chr1:158979686..158979745,+!p1@IFI16!0.87!224.30!IFI16;;chr1:167298300..167298319,+!p2@POU2F1!0.87!6.40!POU2F1;;chr6:44233252..44233296,-!p1@NFKBIE!0.86!65.60!NFKBIE;;chr10:104154246..104154347,+!p3@NFKB2!0.86!40.56!NFKB2;;chr17:38020557..38020572,-!p4@IKZF3!0.86!6.24!IKZF3;;chr17:41277372..41277418,-!p1@BRCA1!0.85!23.48!BRCA1;;chr19:42627037..42627084,-!p3@POU2F2!0.85!6.08!POU2F2;;chr17:41623692..41623715,-!p1@ETV4!0.84!26.93!ETV4;;chr6:106546731..106546755,+!p5@PRDM1!0.84!5.99!PRDM1;;chr17:70117153..70117174,+!p1@SOX9!0.83!63.14!SOX9;;chr6:126240380..126240430,+!p2@NCOA7!0.83!15.85!NCOA7;;chr6:144385698..144385742,-!p2@PLAGL1!0.83!7.14!PLAGL1;;chr1:201979703..201979721,+!p2@ELF3!0.83!5.83!ELF3;;chr1:156460436..156460462,-!p7@MEF2D!0.83!5.75!MEF2D;;chr5:138609782..138609826,+!p5@MATR3!0.82!38.67!MATR3;;chr12:11802753..11802834,+!p2@ETV6!0.82!29.23!ETV6;;chr12:54785074..54785122,-!p2@ZNF385A!0.82!8.95!ZNF385A;;chr12:103352326..103352351,+!p3@ASCL1!0.82!5.58!ASCL1;;chr18:42260840..42260860,+!p2@SETBP1!0.82!5.58!SETBP1;;chr9:16728161..16728185,-!p4@BNC2!0.82!5.58!BNC2;;chr14:74226961..74227020,-!p1@C14orf43!0.81!39.16!C14orf43;;chr6:20402102..20402152,+!p1@E2F3!0.81!24.06!E2F3;;chr19:45252008..45252024,+!p2@BCL3!0.81!19.13!BCL3;;chr19:50432453..50432468,+!p1@ATF5!0.80!325.69!ATF5;;chr9:20622444..20622468,-!p2@MLLT3!0.80!18.47!MLLT3;;chr17:46655730..46655791,-!p1@HOXB4!0.80!13.96!HOXB4;;chr1:27023752..27023799,+!p4@ARID1A!0.80!7.22!ARID1A;;chr5:142780280..142780294,-!p16@NR3C1!0.80!5.34!NR3C1;;chr2:214013461..214013517,-!p6@IKZF2!0.80!5.25!IKZF2;;chr17:40440359..40440386,+!p4@STAT5A!0.80!5.25!STAT5A;;chr9:2015335..2015370,+!p1@SMARCA2!0.79!68.47!SMARCA2;;chr3:141747459..141747475,-!p1@TFDP2!0.79!47.21!TFDP2;;chr6:135502501..135502546,+!p1@MYB!0.79!6.40!MYB;;chr8:76452129..76452159,+!p5@HNF4G!0.79!5.17!HNF4G;;chr2:68615063..68615089,+!p4@PLEK!0.79!5.17!PLEK;;chr1:3568928..3568946,+!p4@TP73!0.79!5.17!TP73;;chr1:6884943..6884957,+!p7@CAMTA1!0.79!5.17!CAMTA1;;chr18:52989565..52989623,-!p9@TCF4!0.78!6.57!TCF4;;chr9:1050449..1050468,+!p2@DMRT2!0.78!5.09!DMRT2;;chr5:158526756..158526797,-!p3@EBF1!0.78!5.01!EBF1;;chr9:128509878..128509902,+!p5@PBX3!0.78!5.01!PBX3;;chr5:88179017..88179046,-!p2@MEF2C!0.77!21.10!MEF2C;;chr8:22550982..22550999,-!p1@EGR3!0.77!15.02!EGR3;;chr1:212873267..212873332,-!p1@BATF3!0.77!6.73!BATF3;;chr8:76452097..76452126,+!p2@HNF4G!0.77!4.93!HNF4G;;chr1:3569101..3569115,+!p2@TP73!0.77!4.84!TP73;;chr2:97202480..97202499,+!p1@ARID5A!0.76!52.87!ARID5A;;chr7:64126503..64126528,+!p1@ZNF107!0.76!37.03!ZNF107;;chr15:74833584..74833626,+!p1@ARID3B!0.76!11.74!ARID3B;;chr6:106546808..106546833,+!p3@PRDM1!0.76!6.16!PRDM1;;chr6:126240442..126240459,+!p4@NCOA7!0.76!6.16!NCOA7;;chr9:2015306..2015323,+!p3@SMARCA2!0.75!13.14!SMARCA2;;chr14:24630902..24630948,+!p2@IRF9!0.75!5.75!IRF9;;chr9:37034258..37034270,-!p3@PAX5!0.75!4.68!PAX5;;chr17:36105074..36105086,-!p2@HNF1B!0.75!4.68!HNF1B;;chr19:42636625..42636632,-!p2@POU2F2!0.75!4.60!POU2F2;;chr1:170632137..170632172,+!p10@PRRX1!0.75!4.60!PRRX1;;chr1:3568870..3568881,+!p5@TP73!0.75!4.60!TP73;;chr2:231084659..231084721,-!p1@SP110!0.74!116.83!SP110;;chr16:31885093..31885165,+!p1@ZNF267!0.74!77.01!ZNF267;;chr6:43337124..43337144,-!p4@ZNF318!0.74!6.73!ZNF318;;chr1:170633348..170633399,+!p2@PRRX1!0.74!6.32!PRRX1;;chr1:170632028..170632043,+!p20@PRRX1!0.74!4.52!PRRX1;;chr17:41739283..41739297,-!p1@MEOX1!0.74!4.52!MEOX1;;chr19:926001..926046,+!p1@ARID3A!0.73!16.75!ARID3A;;chr19:19729477..19729542,-!p1@PBX4!0.73!10.02!PBX4;;chr12:54447219..54447237,+!p6@HOXC4!0.73!4.35!HOXC4;;chr19:4153613..4153652,+!p1@CREB3L3!0.73!4.35!CREB3L3;;chr1:3568961..3568973,+!p6@TP73!0.73!4.35!TP73;;chr4:146859626..146859669,-!p2@ZNF827!0.72!6.40!ZNF827;;chr3:189348969..189349018,+!p4@TP63!0.72!4.27!TP63;;chr1:25291648..25291665,-!p7@RUNX3!0.71!4.19!RUNX3;;chr1:3568889..3568900,+!p7@TP73!0.71!4.11!TP73;;chr3:141103634..141103665,+!p18@ZBTB38!0.71!4.11!ZBTB38;;chr1:47779762..47779827,-!p1@STIL,p1@TAL1!0.70!20.61!TAL1;;chr3:141121847..141121868,+!p5@ZBTB38!0.70!6.40!ZBTB38;;chr11:19262461..19262476,-!p5@E2F8!0.70!4.02!E2F8;;chr6:43337180..43337244,-!p1@ZNF318!0.69!16.83!ZNF318;;chr17:36104873..36104903,-!p3@HNF1B!0.69!3.86!HNF1B;;chr14:35873947..35873965,-!p1@NFKBIA!0.68!280.70!NFKBIA;;chr9:20622478..20622525,-!p1@MLLT3!0.68!34.24!MLLT3;;chr15:60884706..60884743,-!p1@RORA!0.68!22.17!RORA;;chr11:19263160..19263176,-!p1@E2F8!0.68!4.60!E2F8;;chr6:20402070..20402082,+!p5@E2F3!0.68!4.52!E2F3;;chr8:135613895..135613921,-!p8@ZFAT!0.68!3.78!ZFAT;;chr2:8822176..8822196,+!p1@ID2!0.67!600.98!ID2;;chr14:55493763..55493824,-!p1@WDHD1!0.67!32.18!WDHD1;;chr4:87857491..87857519,+!p10@AFF1!0.67!5.25!AFF1;;c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| |||
|ffid_belonging_in_development=CL:0000134,CL:0000051 | |||
|fonse_cell_line=FF:0101035,FF:0101522 | |fonse_cell_line=FF:0101035,FF:0101522 | ||
|fonse_cell_line_closure=FF:0101035,FF:0101522 | |fonse_cell_line_closure=FF:0101035,FF:0101522 | ||
Line 67: | Line 40: | ||
|fonse_treatment= | |fonse_treatment= | ||
|fonse_treatment_closure= | |fonse_treatment_closure= | ||
|has_quality= | |||
|hg19bam=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/B%2520lymphoblastoid%2520cell%2520line%253a%2520GM12878%2520ENCODE%252c%2520biol_rep2.CNhs12332.10822-111C3.hg19.nobarcode.bam | |||
|hg19ctss=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/B%2520lymphoblastoid%2520cell%2520line%253a%2520GM12878%2520ENCODE%252c%2520biol_rep2.CNhs12332.10822-111C3.hg19.ctss.bed.gz | |||
|hg19fasta=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/B%2520lymphoblastoid%2520cell%2520line%253a%2520GM12878%2520ENCODE%252c%2520biol_rep2.CNhs12332.10822-111C3.hg19.nobarcode.rdna.fa.gz | |||
|hg38bam=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.cell_line.hCAGE/B%2520lymphoblastoid%2520cell%2520line%253a%2520GM12878%2520ENCODE%252c%2520biol_rep2.CNhs12332.10822-111C3.hg38.nobarcode.bam | |||
|hg38ctss=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.cell_line.hCAGE/B%2520lymphoblastoid%2520cell%2520line%253a%2520GM12878%2520ENCODE%252c%2520biol_rep2.CNhs12332.10822-111C3.hg38.nobarcode.ctss.bed.gz | |||
|id=FF:10822-111C3 | |||
|is_a=EFO:0002091;;FF:0000210;;FF:0102062 | |||
|is_obsolete= | |||
|library_id=CNhs12332 | |||
|library_id_phase_based=2:CNhs12332 | |||
|microRNAs= | |||
|microRNAs_nn= | |||
|microRNAs_nonnovel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer/#/human#cage;sample;10822 | |||
|microRNAs_novel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer_novel/#/human#cage;sample;10822 | |||
|name=B lymphoblastoid cell line: GM12878 ENCODE, biol_rep2 | |||
|namespace=FANTOM5 | |||
|part_of= | |||
|profile_cagescan=,,, | |||
|profile_hcage=CNhs12332,LSID913,release011,COMPLETED | |||
|profile_rnaseq= | |||
|profile_srnaseq=,,, | |||
|refex=http://refex.dbcls.jp/genelist.php?lang | |||
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| |||
|rna_box=111 | |||
|rna_catalog_number= | |||
|rna_concentration=1.03327 | |||
|rna_extraction_protocol=OP-RNA-extraction-totalRNA-miRNeasy_Mini-v1.0 | |||
|rna_lot_number= | |||
|rna_od260/230=2.17 | |||
|rna_od260/280=2.02 | |||
|rna_position=C3 | |||
|rna_rin= | |||
|rna_sample_type=total RNA | |||
|rna_tube_id=111C3 | |||
|rna_weight_ug=51.6635 | |||
|sample_age= | |||
|sample_category=cell lines | |||
|sample_cell_catalog= | |||
|sample_cell_line=GM12878 | |||
|sample_cell_lot= | |||
|sample_cell_type=b cell | |||
|sample_collaboration=Carrie Davis (Cold spring Harbor Laboratories) | |||
|sample_company= | |||
|sample_description= | |||
|sample_dev_stage= | |||
|sample_disease= | |||
|sample_donor(cell lot)= | |||
|sample_ethnicity= | |||
|sample_experimental_condition= | |||
|sample_gostat=GO:0044464;cell part;0!GO:0005622;intracellular;0!GO:0044424;intracellular part;1.00410337907594e-276!GO:0043227;membrane-bound organelle;1.25890999708723e-234!GO:0043231;intracellular membrane-bound organelle;3.4298433367938e-234!GO:0043226;organelle;1.92232619309861e-229!GO:0043229;intracellular organelle;1.59575916277714e-228!GO:0005737;cytoplasm;9.18763768262496e-167!GO:0044422;organelle part;2.02857956958209e-163!GO:0044446;intracellular organelle part;1.35760095616045e-161!GO:0005634;nucleus;1.30956268879541e-130!GO:0032991;macromolecular complex;4.08814950255139e-125!GO:0044237;cellular metabolic process;1.79819183171257e-113!GO:0044238;primary metabolic process;4.46271577005513e-111!GO:0043170;macromolecule metabolic process;3.31846434387743e-107!GO:0044444;cytoplasmic part;3.31846434387743e-107!GO:0044428;nuclear part;9.86490636886695e-107!GO:0030529;ribonucleoprotein complex;1.79324473497055e-104!GO:0003723;RNA binding;1.34805118336221e-97!GO:0043233;organelle lumen;4.14579391147612e-93!GO:0031974;membrane-enclosed lumen;4.14579391147612e-93!GO:0005515;protein binding;4.07911796646824e-77!GO:0043283;biopolymer metabolic process;7.32668409701793e-77!GO:0005739;mitochondrion;8.47260921100172e-76!GO:0006139;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;6.1880526528513e-75!GO:0006396;RNA processing;8.34972606919304e-71!GO:0010467;gene expression;1.49492957387311e-69!GO:0043234;protein complex;2.62558707632039e-63!GO:0006412;translation;4.48362019008296e-63!GO:0031981;nuclear lumen;3.7226488401466e-62!GO:0005840;ribosome;1.73549648128333e-55!GO:0016071;mRNA metabolic process;3.27493602803742e-55!GO:0044429;mitochondrial part;2.41040548441585e-53!GO:0006259;DNA metabolic process;2.6904874529597e-51!GO:0031967;organelle envelope;1.24344960506054e-50!GO:0031975;envelope;3.48654310153034e-50!GO:0003676;nucleic acid binding;1.76365574054598e-48!GO:0008380;RNA splicing;3.7310478322473e-48!GO:0003735;structural constituent of ribosome;1.45724593154114e-47!GO:0006397;mRNA processing;4.64699742587427e-47!GO:0019538;protein metabolic process;6.31575917696846e-47!GO:0016043;cellular component organization and biogenesis;7.07347601470641e-47!GO:0006996;organelle organization and biogenesis;3.04425597672925e-45!GO:0031090;organelle membrane;4.23666485278926e-44!GO:0044249;cellular biosynthetic process;6.66951239055004e-44!GO:0044267;cellular protein metabolic process;2.31289986113769e-42!GO:0009059;macromolecule biosynthetic process;5.01593157156019e-42!GO:0033036;macromolecule localization;6.82983770612628e-42!GO:0044260;cellular macromolecule metabolic process;1.44933338333868e-41!GO:0033279;ribosomal subunit;8.15006383915367e-41!GO:0009058;biosynthetic process;1.1114543203753e-40!GO:0022613;ribonucleoprotein complex biogenesis and assembly;1.7574370440057e-40!GO:0043228;non-membrane-bound organelle;2.30452595689305e-40!GO:0043232;intracellular non-membrane-bound organelle;2.30452595689305e-40!GO:0015031;protein transport;3.93008622971701e-40!GO:0007049;cell cycle;1.21871055193058e-39!GO:0005654;nucleoplasm;1.83994262697711e-38!GO:0005829;cytosol;2.16346929619177e-38!GO:0045184;establishment of protein localization;7.79044715737829e-38!GO:0008104;protein localization;1.91344532395815e-37!GO:0046907;intracellular transport;3.44918240324655e-37!GO:0016070;RNA metabolic process;3.44918240324655e-37!GO:0000166;nucleotide binding;1.25124726601256e-36!GO:0005681;spliceosome;2.65155325649424e-36!GO:0065003;macromolecular complex assembly;2.59769913909682e-35!GO:0006974;response to DNA damage stimulus;4.81435502971392e-33!GO:0005740;mitochondrial envelope;1.50523941112708e-32!GO:0022402;cell cycle process;2.87712874177404e-31!GO:0006886;intracellular protein transport;3.95592775955668e-31!GO:0019866;organelle inner membrane;5.67875940961938e-31!GO:0022607;cellular component assembly;7.62301523819166e-31!GO:0031966;mitochondrial membrane;2.22735948235979e-30!GO:0005694;chromosome;7.61903771455452e-30!GO:0044451;nucleoplasm part;1.83189811734502e-29!GO:0000278;mitotic cell cycle;1.08630786328721e-28!GO:0005830;cytosolic ribosome (sensu Eukaryota);1.54084950112325e-28!GO:0005743;mitochondrial inner membrane;1.83767558544961e-28!GO:0006281;DNA repair;2.01930815353131e-28!GO:0051649;establishment of cellular localization;1.11649477616282e-27!GO:0051641;cellular localization;7.32419031370594e-27!GO:0044427;chromosomal part;2.15369123770195e-26!GO:0044445;cytosolic part;3.94582329262708e-26!GO:0022403;cell cycle phase;9.59944543293718e-26!GO:0032553;ribonucleotide binding;3.40361936130725e-25!GO:0032555;purine ribonucleotide binding;3.40361936130725e-25!GO:0005730;nucleolus;4.71299927708798e-25!GO:0017076;purine nucleotide binding;4.71299927708798e-25!GO:0000087;M phase of mitotic cell cycle;9.33767134558522e-25!GO:0007067;mitosis;1.60016498193108e-24!GO:0031980;mitochondrial lumen;1.60016498193108e-24!GO:0005759;mitochondrial matrix;1.60016498193108e-24!GO:0016462;pyrophosphatase activity;9.38866069140047e-24!GO:0051301;cell division;9.40679949368345e-24!GO:0051276;chromosome organization and biogenesis;1.31263304562776e-23!GO:0017111;nucleoside-triphosphatase activity;1.35655960077898e-23!GO:0016818;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;1.38569299652984e-23!GO:0005524;ATP binding;1.79794858234855e-23!GO:0016817;hydrolase activity, acting on acid anhydrides;1.85558440578812e-23!GO:0000279;M phase;5.06502414002994e-23!GO:0006915;apoptosis;5.96915812404363e-23!GO:0032559;adenyl ribonucleotide binding;7.11794123992571e-23!GO:0012501;programmed cell death;7.32129399956774e-23!GO:0044455;mitochondrial membrane part;8.64200982293569e-23!GO:0030554;adenyl nucleotide binding;1.66168037048582e-22!GO:0009719;response to endogenous stimulus;1.76072912833611e-22!GO:0006119;oxidative phosphorylation;6.99097062638056e-22!GO:0044265;cellular macromolecule catabolic process;2.72072210408606e-21!GO:0006512;ubiquitin cycle;3.28728814238167e-21!GO:0015935;small ribosomal subunit;4.99718097608745e-21!GO:0015934;large ribosomal subunit;6.3869328989424e-21!GO:0016874;ligase activity;8.3343568759246e-21!GO:0006260;DNA replication;9.22335317207574e-21!GO:0008134;transcription factor binding;1.01551144025819e-20!GO:0022618;protein-RNA complex assembly;1.38354453863151e-20!GO:0042254;ribosome biogenesis and assembly;1.88861938328703e-20!GO:0008219;cell death;3.55250571051001e-20!GO:0016265;death;3.55250571051001e-20!GO:0005635;nuclear envelope;2.27943204707402e-19!GO:0043285;biopolymer catabolic process;9.68611300171558e-19!GO:0000502;proteasome complex (sensu Eukaryota);1.22413721982571e-18!GO:0016604;nuclear body;1.3936239907964e-18!GO:0019941;modification-dependent protein catabolic process;3.27711419216295e-18!GO:0043632;modification-dependent macromolecule catabolic process;3.27711419216295e-18!GO:0051603;proteolysis involved in cellular protein catabolic process;4.20395867914709e-18!GO:0000398;nuclear mRNA splicing, via spliceosome;6.27949282668459e-18!GO:0000375;RNA splicing, via transesterification reactions;6.27949282668459e-18!GO:0000377;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;6.27949282668459e-18!GO:0006511;ubiquitin-dependent protein catabolic process;7.67783755122037e-18!GO:0044257;cellular protein catabolic process;1.4663343105878e-17!GO:0009057;macromolecule catabolic process;1.86357003684295e-17!GO:0012505;endomembrane system;2.99796062677307e-17!GO:0005746;mitochondrial respiratory chain;3.1553696191627e-17!GO:0031965;nuclear membrane;3.67821999478916e-17!GO:0006457;protein folding;4.19232102547562e-17!GO:0016887;ATPase activity;4.3285607091197e-17!GO:0042623;ATPase activity, coupled;1.08234989156887e-16!GO:0016655;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor;1.54077260939916e-16!GO:0005761;mitochondrial ribosome;1.54410399281027e-16!GO:0000313;organellar ribosome;1.54410399281027e-16!GO:0006325;establishment and/or maintenance of chromatin architecture;1.62230507769596e-16!GO:0043412;biopolymer modification;2.07724397194111e-16!GO:0044248;cellular catabolic process;2.27933844822609e-16!GO:0008135;translation factor activity, nucleic acid binding;4.25507401225182e-16!GO:0006605;protein targeting;4.3838347821047e-16!GO:0004386;helicase activity;6.43268002009976e-16!GO:0006323;DNA packaging;6.81809667949022e-16!GO:0050136;NADH dehydrogenase (quinone) activity;1.08371686366467e-15!GO:0003954;NADH dehydrogenase activity;1.08371686366467e-15!GO:0008137;NADH dehydrogenase (ubiquinone) activity;1.08371686366467e-15!GO:0044453;nuclear membrane part;1.4251050386736e-15!GO:0006913;nucleocytoplasmic transport;4.55762619598705e-15!GO:0050794;regulation of cellular process;7.95895970166338e-15!GO:0003712;transcription cofactor activity;1.06608735574579e-14!GO:0051169;nuclear transport;1.22892155318351e-14!GO:0051726;regulation of cell cycle;1.27397977745536e-14!GO:0005842;cytosolic large ribosomal subunit (sensu Eukaryota);1.28707147968213e-14!GO:0042981;regulation of apoptosis;1.73569678593246e-14!GO:0000074;regulation of progression through cell cycle;2.14684208489507e-14!GO:0005843;cytosolic small ribosomal subunit (sensu Eukaryota);2.45516804575844e-14!GO:0006364;rRNA processing;2.57166349040158e-14!GO:0042775;organelle ATP synthesis coupled electron transport;3.52445720990871e-14!GO:0042773;ATP synthesis coupled electron transport;3.52445720990871e-14!GO:0043067;regulation of programmed cell death;3.73127233136017e-14!GO:0005643;nuclear pore;4.34242528206115e-14!GO:0006464;protein modification process;4.51051346841654e-14!GO:0050657;nucleic acid transport;5.28446787163864e-14!GO:0051236;establishment of RNA localization;5.28446787163864e-14!GO:0050658;RNA transport;5.28446787163864e-14!GO:0006403;RNA localization;6.09411997943873e-14!GO:0016072;rRNA metabolic process;6.17475082374682e-14!GO:0043687;post-translational protein modification;6.84195735037941e-14!GO:0030964;NADH dehydrogenase complex (quinone);9.89307246290423e-14!GO:0045271;respiratory chain complex I;9.89307246290423e-14!GO:0005747;mitochondrial respiratory chain complex I;9.89307246290423e-14!GO:0016607;nuclear speck;1.18221488645608e-13!GO:0006399;tRNA metabolic process;1.1845449983643e-13!GO:0051186;cofactor metabolic process;1.28335871290852e-13!GO:0030163;protein catabolic process;1.60123729748906e-13!GO:0006120;mitochondrial electron transport, NADH to ubiquinone;2.95052004202624e-13!GO:0008026;ATP-dependent helicase activity;5.6613739986194e-13!GO:0065002;intracellular protein transport across a membrane;8.87341104297911e-13!GO:0000785;chromatin;1.30321123053955e-12!GO:0006333;chromatin assembly or disassembly;2.75613484139982e-12!GO:0006413;translational initiation;3.18625423611227e-12!GO:0003743;translation initiation factor activity;3.63301682890811e-12!GO:0051028;mRNA transport;4.46044575127399e-12!GO:0048770;pigment granule;4.62511121826273e-12!GO:0042470;melanosome;4.62511121826273e-12!GO:0006446;regulation of translational initiation;6.36068933726181e-12!GO:0051082;unfolded protein binding;1.16052957716098e-11!GO:0048193;Golgi vesicle transport;1.31536442279458e-11!GO:0046930;pore complex;1.53008102848648e-11!GO:0015931;nucleobase, nucleoside, nucleotide and nucleic acid transport;2.10420776372338e-11!GO:0016651;oxidoreductase activity, acting on NADH or NADPH;2.11089182152463e-11!GO:0019222;regulation of metabolic process;2.12869854377861e-11!GO:0065004;protein-DNA complex assembly;2.70463242372697e-11!GO:0016591;DNA-directed RNA polymerase II, holoenzyme;2.92237528471829e-11!GO:0006732;coenzyme metabolic process;3.04383743128331e-11!GO:0006366;transcription from RNA polymerase II promoter;3.16063045734594e-11!GO:0006261;DNA-dependent DNA replication;3.67459860280031e-11!GO:0003697;single-stranded DNA binding;3.81061993220889e-11!GO:0016779;nucleotidyltransferase activity;4.0629031381076e-11!GO:0051246;regulation of protein metabolic process;5.18441941320384e-11!GO:0016568;chromatin modification;7.86656384632864e-11!GO:0005783;endoplasmic reticulum;9.95850641122447e-11!GO:0000775;chromosome, pericentric region;9.97180931563664e-11!GO:0043566;structure-specific DNA binding;1.10131865190912e-10!GO:0009055;electron carrier activity;1.2685083079471e-10!GO:0017038;protein import;2.25017398238648e-10!GO:0030532;small nuclear ribonucleoprotein complex;3.59293928365484e-10!GO:0016876;ligase activity, forming aminoacyl-tRNA and related compounds;3.67312454940113e-10!GO:0004812;aminoacyl-tRNA ligase activity;3.67312454940113e-10!GO:0016875;ligase activity, forming carbon-oxygen bonds;3.67312454940113e-10!GO:0008639;small protein conjugating enzyme activity;4.66340980165634e-10!GO:0044432;endoplasmic reticulum part;6.7904093328938e-10!GO:0043038;amino acid activation;7.15811916407242e-10!GO:0006418;tRNA aminoacylation for protein translation;7.15811916407242e-10!GO:0043039;tRNA aminoacylation;7.15811916407242e-10!GO:0019787;small conjugating protein ligase activity;7.98627911667224e-10!GO:0004842;ubiquitin-protein ligase activity;8.66766224807547e-10!GO:0003713;transcription coactivator activity;9.33262507241484e-10!GO:0016879;ligase activity, forming carbon-nitrogen bonds;1.06883398030325e-09!GO:0009259;ribonucleotide metabolic process;1.36182776333737e-09!GO:0009056;catabolic process;2.21902066509314e-09!GO:0050789;regulation of biological process;2.68605211146465e-09!GO:0006163;purine nucleotide metabolic process;2.79866140603501e-09!GO:0031323;regulation of cellular metabolic process;3.37276894396873e-09!GO:0005819;spindle;3.48134548672133e-09!GO:0009615;response to virus;4.46342333469439e-09!GO:0006164;purine nucleotide biosynthetic process;4.83939046782796e-09!GO:0008094;DNA-dependent ATPase activity;5.07712289264444e-09!GO:0006461;protein complex assembly;5.33468268710269e-09!GO:0009260;ribonucleotide biosynthetic process;5.74201006655371e-09!GO:0007005;mitochondrion organization and biogenesis;5.76192508657168e-09!GO:0007249;I-kappaB kinase/NF-kappaB cascade;6.38353267133437e-09!GO:0008565;protein transporter activity;7.0795233728721e-09!GO:0043122;regulation of I-kappaB kinase/NF-kappaB cascade;7.70110035991321e-09!GO:0016563;transcription activator activity;9.43310053612524e-09!GO:0046961;hydrogen ion transporting ATPase activity, rotational mechanism;9.67877621437417e-09!GO:0016740;transferase activity;1.14069821805817e-08!GO:0006793;phosphorus metabolic process;1.29558705548619e-08!GO:0006796;phosphate metabolic process;1.29558705548619e-08!GO:0016881;acid-amino acid ligase activity;1.80580229751762e-08!GO:0042175;nuclear envelope-endoplasmic reticulum network;2.15206510965554e-08!GO:0005839;proteasome core complex (sensu Eukaryota);2.20740850275959e-08!GO:0009150;purine ribonucleotide metabolic process;2.26882649559972e-08!GO:0006916;anti-apoptosis;2.39725794701705e-08!GO:0005789;endoplasmic reticulum membrane;3.03319130343974e-08!GO:0043123;positive regulation of I-kappaB kinase/NF-kappaB cascade;3.1373227816872e-08!GO:0051188;cofactor biosynthetic process;3.5372362310634e-08!GO:0009152;purine ribonucleotide biosynthetic process;3.9558005963501e-08!GO:0016787;hydrolase activity;4.06147324926933e-08!GO:0009060;aerobic respiration;4.67749094220787e-08!GO:0046933;hydrogen ion transporting ATP synthase activity, rotational mechanism;4.68983003347835e-08!GO:0006350;transcription;5.22517033367877e-08!GO:0006310;DNA recombination;5.57062497918682e-08!GO:0000245;spliceosome assembly;5.95680714282033e-08!GO:0007051;spindle organization and biogenesis;6.27662409570758e-08!GO:0015630;microtubule cytoskeleton;8.2524109172476e-08!GO:0005657;replication fork;8.47118087232174e-08!GO:0015078;hydrogen ion transmembrane transporter activity;8.52457211545482e-08!GO:0043069;negative regulation of programmed cell death;9.00673116546874e-08!GO:0005794;Golgi apparatus;9.08996713545866e-08!GO:0055086;nucleobase, nucleoside and nucleotide metabolic process;9.83721582615328e-08!GO:0043066;negative regulation of apoptosis;1.03436585007946e-07!GO:0005813;centrosome;1.04729373175019e-07!GO:0019829;cation-transporting ATPase activity;1.28646350733166e-07!GO:0016192;vesicle-mediated transport;1.42430917321014e-07!GO:0004298;threonine endopeptidase activity;1.5106622029616e-07!GO:0006401;RNA catabolic process;1.97520107658324e-07!GO:0051170;nuclear import;1.97520107658324e-07!GO:0005815;microtubule organizing center;2.12248481146679e-07!GO:0007059;chromosome segregation;2.27851392152978e-07!GO:0016310;phosphorylation;2.47650338649546e-07!GO:0031202;RNA splicing factor activity, transesterification mechanism;2.75770173562407e-07!GO:0000075;cell cycle checkpoint;2.84860791411008e-07!GO:0006334;nucleosome assembly;2.88066281791086e-07!GO:0032446;protein modification by small protein conjugation;2.90208566341343e-07!GO:0051168;nuclear export;3.03910768675114e-07!GO:0016772;transferase activity, transferring phosphorus-containing groups;3.05321178573582e-07!GO:0015986;ATP synthesis coupled proton transport;3.2887333659973e-07!GO:0015985;energy coupled proton transport, down electrochemical gradient;3.2887333659973e-07!GO:0045333;cellular respiration;3.40308933194258e-07!GO:0006099;tricarboxylic acid cycle;3.90453482469988e-07!GO:0046356;acetyl-CoA catabolic process;3.90453482469988e-07!GO:0006606;protein import into nucleus;4.03820217994002e-07!GO:0031497;chromatin assembly;4.14449742613837e-07!GO:0009108;coenzyme biosynthetic process;4.2298670376249e-07!GO:0006888;ER to Golgi vesicle-mediated transport;4.28568894273255e-07!GO:0010468;regulation of gene expression;4.47236254023987e-07!GO:0043065;positive regulation of apoptosis;4.69617182814408e-07!GO:0003899;DNA-directed RNA polymerase activity;4.73559127987453e-07!GO:0048523;negative regulation of cellular process;4.76462225339271e-07!GO:0030120;vesicle coat;5.27521809366238e-07!GO:0030662;coated vesicle membrane;5.27521809366238e-07!GO:0016567;protein ubiquitination;5.47298412357592e-07!GO:0003724;RNA helicase activity;5.6670215536862e-07!GO:0045259;proton-transporting ATP synthase complex;5.82792744629509e-07!GO:0051325;interphase;6.55107163976045e-07!GO:0016363;nuclear matrix;6.62784203186555e-07!GO:0043068;positive regulation of programmed cell death;7.3718719016878e-07!GO:0051329;interphase of mitotic cell cycle;7.98168068840029e-07!GO:0006084;acetyl-CoA metabolic process;8.14514439389067e-07!GO:0019899;enzyme binding;1.26415975090024e-06!GO:0048475;coated membrane;1.32959565212379e-06!GO:0030117;membrane coat;1.32959565212379e-06!GO:0006917;induction of apoptosis;1.40438122849101e-06!GO:0019219;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;1.45647089319396e-06!GO:0006302;double-strand break repair;1.595050688652e-06!GO:0007088;regulation of mitosis;1.87329851525054e-06!GO:0009117;nucleotide metabolic process;1.88156568497077e-06!GO:0009142;nucleoside triphosphate biosynthetic process;2.07066905991102e-06!GO:0009201;ribonucleoside triphosphate biosynthetic process;2.07066905991102e-06!GO:0009199;ribonucleoside triphosphate metabolic process;2.32654725246269e-06!GO:0012502;induction of programmed cell death;2.33016433267568e-06!GO:0051187;cofactor catabolic process;2.45956611569848e-06!GO:0009141;nucleoside triphosphate metabolic process;2.51341326482883e-06!GO:0006402;mRNA catabolic process;2.66350345627756e-06!GO:0016469;proton-transporting two-sector ATPase complex;2.73585902494427e-06!GO:0006754;ATP biosynthetic process;3.00084670859946e-06!GO:0006753;nucleoside phosphate metabolic process;3.00084670859946e-06!GO:0044452;nucleolar part;3.414660688345e-06!GO:0009206;purine ribonucleoside triphosphate biosynthetic process;4.15198982877783e-06!GO:0009145;purine nucleoside triphosphate biosynthetic process;4.15198982877783e-06!GO:0000776;kinetochore;4.3583571817516e-06!GO:0006417;regulation of translation;4.38006781898544e-06!GO:0009205;purine ribonucleoside triphosphate metabolic process;4.4570390971952e-06!GO:0009144;purine nucleoside triphosphate metabolic process;4.4570390971952e-06!GO:0015077;monovalent inorganic cation transmembrane transporter activity;4.76176080087893e-06!GO:0046034;ATP metabolic process;4.77831665656975e-06!GO:0007243;protein kinase cascade;5.03248283092753e-06!GO:0009109;coenzyme catabolic process;5.27707568237705e-06!GO:0005768;endosome;5.34582741705952e-06!GO:0043623;cellular protein complex assembly;8.33736261173185e-06!GO:0005793;ER-Golgi intermediate compartment;9.66798881637051e-06!GO:0006752;group transfer coenzyme metabolic process;9.84058130176687e-06!GO:0006613;cotranslational protein targeting to membrane;1.03108157060739e-05!GO:0048519;negative regulation of biological process;1.08019691272416e-05!GO:0051427;hormone receptor binding;1.27120941550079e-05!GO:0048522;positive regulation of cellular process;1.33440439635113e-05!GO:0051052;regulation of DNA metabolic process;1.52391363425787e-05!GO:0000314;organellar small ribosomal subunit;1.52391363425787e-05!GO:0005763;mitochondrial small ribosomal subunit;1.52391363425787e-05!GO:0000151;ubiquitin ligase complex;1.55784224075358e-05!GO:0005762;mitochondrial large ribosomal subunit;1.63250217787553e-05!GO:0000315;organellar large ribosomal subunit;1.63250217787553e-05!GO:0032774;RNA biosynthetic process;1.85366381468376e-05!GO:0004527;exonuclease activity;1.95070784408836e-05!GO:0003684;damaged DNA binding;2.13098261481946e-05!GO:0016564;transcription repressor activity;2.37867031212029e-05!GO:0006351;transcription, DNA-dependent;2.39694427773916e-05!GO:0030530;heterogeneous nuclear ribonucleoprotein complex;2.49037088663978e-05!GO:0004518;nuclease activity;2.53114429121196e-05!GO:0005667;transcription factor complex;2.63871190582748e-05!GO:0035257;nuclear hormone receptor binding;2.68661519478149e-05!GO:0005770;late endosome;2.88912186657863e-05!GO:0065007;biological regulation;2.90844923788344e-05!GO:0043021;ribonucleoprotein binding;2.90844923788344e-05!GO:0005525;GTP binding;3.17583208040635e-05!GO:0003677;DNA binding;3.19769272447922e-05!GO:0003678;DNA helicase activity;3.42660481082276e-05!GO:0008033;tRNA processing;3.48408797894788e-05!GO:0003924;GTPase activity;3.52973924183869e-05!GO:0045786;negative regulation of progression through cell cycle;3.78148865473679e-05!GO:0016741;transferase activity, transferring one-carbon groups;3.83318041149514e-05!GO:0008186;RNA-dependent ATPase activity;3.86854488343123e-05!GO:0051252;regulation of RNA metabolic process;4.03081801990839e-05!GO:0006839;mitochondrial transport;4.30471778559755e-05!GO:0003714;transcription corepressor activity;4.5142356994133e-05!GO:0003690;double-stranded DNA binding;4.77351349290771e-05!GO:0006357;regulation of transcription from RNA polymerase II promoter;4.77351349290771e-05!GO:0003682;chromatin binding;4.83830049750579e-05!GO:0031326;regulation of cellular biosynthetic process;4.94877066083566e-05!GO:0031324;negative regulation of cellular metabolic process;4.94877066083566e-05!GO:0009165;nucleotide biosynthetic process;5.05216119122632e-05!GO:0007093;mitotic cell cycle checkpoint;5.39149896727027e-05!GO:0008168;methyltransferase activity;6.36348332289104e-05!GO:0003729;mRNA binding;7.00117276072893e-05!GO:0045449;regulation of transcription;8.12002384944008e-05!GO:0005798;Golgi-associated vesicle;8.45392758551941e-05!GO:0045934;negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;9.13714557593852e-05!GO:0006352;transcription initiation;9.81017636604526e-05!GO:0016251;general RNA polymerase II transcription factor activity;0.000108054453013898!GO:0030880;RNA polymerase complex;0.00011183901299177!GO:0004004;ATP-dependent RNA helicase activity;0.000122817067407069!GO:0007006;mitochondrial membrane organization and biogenesis;0.000128226858448946!GO:0006626;protein targeting to mitochondrion;0.000141187183008478!GO:0006383;transcription from RNA polymerase III promoter;0.000147592546637643!GO:0044440;endosomal part;0.000148474204569773!GO:0010008;endosome membrane;0.000148474204569773!GO:0043681;protein import into mitochondrion;0.000150632015695774!GO:0000079;regulation of cyclin-dependent protein kinase activity;0.000155442891286899!GO:0008632;apoptotic program;0.000174398500176379!GO:0005753;mitochondrial proton-transporting ATP synthase complex;0.00018610929841947!GO:0065009;regulation of a molecular function;0.000192990285326346!GO:0006414;translational elongation;0.000202460011466099!GO:0030658;transport vesicle membrane;0.000215842041933847!GO:0006950;response to stress;0.000218440454493531!GO:0005885;Arp2/3 protein complex;0.000220114859460847!GO:0055029;nuclear DNA-directed RNA polymerase complex;0.000252244329492922!GO:0000428;DNA-directed RNA polymerase complex;0.000252244329492922!GO:0007052;mitotic spindle organization and biogenesis;0.000260301244911662!GO:0005048;signal sequence binding;0.000260301244911662!GO:0032561;guanyl ribonucleotide binding;0.00026273070290169!GO:0019001;guanyl nucleotide binding;0.00026273070290169!GO:0015405;P-P-bond-hydrolysis-driven transmembrane transporter activity;0.000262937637890076!GO:0015399;primary active transmembrane transporter activity;0.000262937637890076!GO:0043488;regulation of mRNA stability;0.000285558544176967!GO:0043487;regulation of RNA stability;0.000285558544176967!GO:0007010;cytoskeleton organization and biogenesis;0.000295762093704649!GO:0000786;nucleosome;0.000311821501129337!GO:0005741;mitochondrial outer membrane;0.000326692422935283!GO:0005684;U2-dependent spliceosome;0.000336226051305823!GO:0042625;ATPase activity, coupled to transmembrane movement of ions;0.000337437118529994!GO:0031072;heat shock protein binding;0.000358864602307383!GO:0006612;protein targeting to membrane;0.000379147028359461!GO:0032508;DNA duplex unwinding;0.000384651037140791!GO:0032392;DNA geometric change;0.000384651037140791!GO:0009892;negative regulation of metabolic process;0.000387010754211925!GO:0031968;organelle outer membrane;0.00039884615150817!GO:0009889;regulation of biosynthetic process;0.000402834071113683!GO:0048471;perinuclear region of cytoplasm;0.000446840963175669!GO:0000184;mRNA catabolic process, nonsense-mediated decay;0.000465453212145611!GO:0005852;eukaryotic translation initiation factor 3 complex;0.000492919934760561!GO:0019867;outer membrane;0.000503668815400497!GO:0048468;cell development;0.000516795556953656!GO:0045261;proton-transporting ATP synthase complex, catalytic core F(1);0.000527380485028468!GO:0042770;DNA damage response, signal transduction;0.000527646912268738!GO:0006611;protein export from nucleus;0.000539213013681829!GO:0000228;nuclear chromosome;0.000630264406603932!GO:0004674;protein serine/threonine kinase activity;0.000656415349922155!GO:0006270;DNA replication initiation;0.000707304463167834!GO:0032200;telomere organization and biogenesis;0.000726595624321116!GO:0000723;telomere maintenance;0.000726595624321116!GO:0016853;isomerase activity;0.00074957329172602!GO:0006268;DNA unwinding during replication;0.000757003178100066!GO:0003725;double-stranded RNA binding;0.000757003178100066!GO:0030660;Golgi-associated vesicle membrane;0.000773397080306992!GO:0006405;RNA export from nucleus;0.000777408347860808!GO:0031970;organelle envelope lumen;0.000784895111995012!GO:0033178;proton-transporting two-sector ATPase complex, catalytic domain;0.000786830143614165!GO:0047485;protein N-terminus binding;0.000816874537861663!GO:0000082;G1/S transition of mitotic cell cycle;0.000817667804786328!GO:0043596;nuclear replication fork;0.000832410962880315!GO:0000226;microtubule cytoskeleton organization and biogenesis;0.000873463653403279!GO:0048500;signal recognition particle;0.000908114893515833!GO:0016281;eukaryotic translation initiation factor 4F complex;0.000910467467979767!GO:0033673;negative regulation of kinase activity;0.000914590187854755!GO:0006469;negative regulation of protein kinase activity;0.000914590187854755!GO:0044431;Golgi apparatus part;0.00095111585562506!GO:0000059;protein import into nucleus, docking;0.000982943985948149!GO:0016679;oxidoreductase activity, acting on diphenols and related substances as donors;0.000990989201995824!GO:0016681;oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor;0.000990989201995824!GO:0008121;ubiquinol-cytochrome-c reductase activity;0.000990989201995824!GO:0004532;exoribonuclease activity;0.0010061440322023!GO:0016896;exoribonuclease activity, producing 5'-phosphomonoesters;0.0010061440322023!GO:0000819;sister chromatid segregation;0.00100803189267961!GO:0051348;negative regulation of transferase activity;0.00101500075920796!GO:0030330;DNA damage response, signal transduction by p53 class mediator;0.00110324437162695!GO:0005758;mitochondrial intermembrane space;0.00112724475194876!GO:0016481;negative regulation of transcription;0.00116106439283789!GO:0005769;early endosome;0.00125071046482835!GO:0048518;positive regulation of biological process;0.00125623629475737!GO:0000070;mitotic sister chromatid segregation;0.00126575555259859!GO:0008139;nuclear localization sequence binding;0.00127229100739998!GO:0046483;heterocycle metabolic process;0.00129762497480133!GO:0009967;positive regulation of signal transduction;0.00133011667085945!GO:0005637;nuclear inner membrane;0.00138287394061514!GO:0016796;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters;0.00138901035438741!GO:0045263;proton-transporting ATP synthase complex, coupling factor F(o);0.00144692773807034!GO:0033177;proton-transporting two-sector ATPase complex, proton-transporting domain;0.00144692773807034!GO:0006355;regulation of transcription, DNA-dependent;0.00149464066879848!GO:0004003;ATP-dependent DNA helicase activity;0.00152358836601536!GO:0000049;tRNA binding;0.00153098656252637!GO:0006338;chromatin remodeling;0.0015900442347529!GO:0000725;recombinational repair;0.00159855490194183!GO:0000724;double-strand break repair via homologous recombination;0.00159855490194183!GO:0006891;intra-Golgi vesicle-mediated transport;0.00161165675519993!GO:0005838;proteasome regulatory particle (sensu Eukaryota);0.00164375123348765!GO:0005876;spindle microtubule;0.001684710574089!GO:0009451;RNA modification;0.00172861858864916!GO:0000922;spindle pole;0.0017374316715674!GO:0008312;7S RNA binding;0.00183102816537196!GO:0008408;3'-5' exonuclease activity;0.00187343351242198!GO:0035258;steroid hormone receptor binding;0.00190811784619683!GO:0045941;positive regulation of transcription;0.0019386510583203!GO:0031124;mRNA 3'-end processing;0.00195528601140289!GO:0006595;polyamine metabolic process;0.00202734474824865!GO:0051920;peroxiredoxin activity;0.002075066193694!GO:0030521;androgen receptor signaling pathway;0.00210209573318143!GO:0022890;inorganic cation transmembrane transporter activity;0.00211936389038128!GO:0003711;transcription elongation regulator activity;0.00214555343373036!GO:0045935;positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;0.00216337548011615!GO:0045454;cell redox homeostasis;0.00219312557499056!GO:0006091;generation of precursor metabolites and energy;0.00222730234405171!GO:0006367;transcription initiation from RNA polymerase II promoter;0.00225839210401035!GO:0006289;nucleotide-excision repair;0.00242479930909374!GO:0003755;peptidyl-prolyl cis-trans isomerase activity;0.00249191927754456!GO:0005786;signal recognition particle, endoplasmic reticulum targeting;0.00251968982741651!GO:0006614;SRP-dependent cotranslational protein targeting to membrane;0.00258788637747421!GO:0045047;protein targeting to ER;0.00258788637747421!GO:0009124;nucleoside monophosphate biosynthetic process;0.00264689570963659!GO:0009123;nucleoside monophosphate metabolic process;0.00264689570963659!GO:0007017;microtubule-based process;0.00264689570963659!GO:0051539;4 iron, 4 sulfur cluster binding;0.0028357590754383!GO:0008637;apoptotic mitochondrial changes;0.0028357590754383!GO:0008234;cysteine-type peptidase activity;0.00284538369566463!GO:0016859;cis-trans isomerase activity;0.00295334255796712!GO:0051789;response to protein stimulus;0.00296555571576391!GO:0006986;response to unfolded protein;0.00296555571576391!GO:0046822;regulation of nucleocytoplasmic transport;0.0030085329500046!GO:0042393;histone binding;0.00305784100378834!GO:0000781;chromosome, telomeric region;0.00322201552569112!GO:0016491;oxidoreductase activity;0.00324461071483233!GO:0000178;exosome (RNase complex);0.00325211660592778!GO:0030518;steroid hormone receptor signaling pathway;0.00326911667010529!GO:0003702;RNA polymerase II transcription factor activity;0.0032866790398503!GO:0000793;condensed chromosome;0.00346325872766734!GO:0000323;lytic vacuole;0.00352739201042772!GO:0005764;lysosome;0.00352739201042772!GO:0006818;hydrogen transport;0.00365236796756069!GO:0006284;base-excision repair;0.00366232104706754!GO:0030867;rough endoplasmic reticulum membrane;0.00384415188178879!GO:0051223;regulation of protein transport;0.00397570927499523!GO:0043492;ATPase activity, coupled to movement of substances;0.00397570927499523!GO:0016791;phosphoric monoester hydrolase activity;0.00403597715648022!GO:0015992;proton transport;0.00405406886960713!GO:0043601;nuclear replisome;0.00414628388833682!GO:0030894;replisome;0.00414628388833682!GO:0008629;induction of apoptosis by intracellular signals;0.00416304860071189!GO:0016584;nucleosome positioning;0.00424429799504741!GO:0009112;nucleobase metabolic process;0.00427959732458999!GO:0042802;identical protein binding;0.0043628053793585!GO:0006275;regulation of DNA replication;0.00438444373196394!GO:0000307;cyclin-dependent protein kinase holoenzyme complex;0.0045446776232265!GO:0016676;oxidoreductase activity, acting on heme group of donors, oxygen as acceptor;0.00455076929654525!GO:0015002;heme-copper terminal oxidase activity;0.00455076929654525!GO:0016675;oxidoreductase activity, acting on heme group of donors;0.00455076929654525!GO:0004129;cytochrome-c oxidase activity;0.00455076929654525!GO:0016765;transferase activity, transferring alkyl or aryl (other than methyl) groups;0.00455076929654525!GO:0007242;intracellular signaling cascade;0.00459222742484447!GO:0030118;clathrin coat;0.00463380760694738!GO:0030134;ER to Golgi transport vesicle;0.00464405721851372!GO:0045893;positive regulation of transcription, DNA-dependent;0.0046724048237053!GO:0005665;DNA-directed RNA polymerase II, core complex;0.00471191325979055!GO:0006144;purine base metabolic process;0.00478133493108593!GO:0008654;phospholipid biosynthetic process;0.00480171942964428!GO:0015631;tubulin binding;0.00485536837975233!GO:0042626;ATPase activity, coupled to transmembrane movement of substances;0.00485536837975233!GO:0030127;COPII vesicle coat;0.00487212519608482!GO:0012507;ER to Golgi transport vesicle membrane;0.00487212519608482!GO:0046966;thyroid hormone receptor binding;0.00487212519608482!GO:0005773;vacuole;0.00501462005362994!GO:0016126;sterol biosynthetic process;0.0052470795851447!GO:0031123;RNA 3'-end processing;0.00534126410002039!GO:0003887;DNA-directed DNA polymerase activity;0.00538731193033911!GO:0006520;amino acid metabolic process;0.00541045563998948!GO:0051092;activation of NF-kappaB transcription factor;0.00554812818715672!GO:0000339;RNA cap binding;0.00554812818715672!GO:0032259;methylation;0.005683715553991!GO:0008047;enzyme activator activity;0.00581372547299807!GO:0016820;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;0.00583083714828147!GO:0022411;cellular component disassembly;0.00589203281069156!GO:0000152;nuclear ubiquitin ligase complex;0.00594417134581309!GO:0000175;3'-5'-exoribonuclease activity;0.00595212015049369!GO:0051540;metal cluster binding;0.00595212015049369!GO:0051536;iron-sulfur cluster binding;0.00595212015049369!GO:0008022;protein C-terminus binding;0.00595212015049369!GO:0009161;ribonucleoside monophosphate metabolic process;0.00611081019838312!GO:0009156;ribonucleoside monophosphate biosynthetic process;0.00611081019838312!GO:0005669;transcription factor TFIID complex;0.00614316357651286!GO:0043022;ribosome binding;0.00673376676583904!GO:0009116;nucleoside metabolic process;0.00679106081828512!GO:0000209;protein polyubiquitination;0.00698313048229628!GO:0016197;endosome transport;0.00698313048229628!GO:0016788;hydrolase activity, acting on ester bonds;0.00698313048229628!GO:0030663;COPI coated vesicle membrane;0.00719318998724389!GO:0030126;COPI vesicle coat;0.00719318998724389!GO:0007264;small GTPase mediated signal transduction;0.00746984772195234!GO:0022415;viral reproductive process;0.00753465841280386!GO:0051087;chaperone binding;0.00763355505978219!GO:0030384;phosphoinositide metabolic process;0.0077390730807008!GO:0006376;mRNA splice site selection;0.00774051199455339!GO:0000389;nuclear mRNA 3'-splice site recognition;0.00774051199455339!GO:0000139;Golgi membrane;0.00801379822415927!GO:0005663;DNA replication factor C complex;0.00802382317256741!GO:0051053;negative regulation of DNA metabolic process;0.0080366463213303!GO:0031252;leading edge;0.0081140357096148!GO:0030036;actin cytoskeleton organization and biogenesis;0.0081140357096148!GO:0006695;cholesterol biosynthetic process;0.00823248671357913!GO:0005832;chaperonin-containing T-complex;0.0088820904496756!GO:0016272;prefoldin complex;0.00949615832007758!GO:0019783;small conjugating protein-specific protease activity;0.00950516644982098!GO:0009893;positive regulation of metabolic process;0.0096307425169113!GO:0019752;carboxylic acid metabolic process;0.0100302606594612!GO:0018193;peptidyl-amino acid modification;0.0100302606594612!GO:0000910;cytokinesis;0.0101778543777183!GO:0006007;glucose catabolic process;0.010258509560821!GO:0043161;proteasomal ubiquitin-dependent protein catabolic process;0.0105580522575433!GO:0004843;ubiquitin-specific protease activity;0.0109837575585068!GO:0016891;endoribonuclease activity, producing 5'-phosphomonoesters;0.0110408887881633!GO:0006378;mRNA polyadenylation;0.011757643400613!GO:0030133;transport vesicle;0.011764390780745!GO:0008624;induction of apoptosis by extracellular signals;0.0118099358600568!GO:0006082;organic acid metabolic process;0.0119111606582884!GO:0044454;nuclear chromosome part;0.0119271829079863!GO:0006650;glycerophospholipid metabolic process;0.0119271829079863!GO:0033367;protein localization in mast cell secretory granule;0.0119271829079863!GO:0033365;protein localization in organelle;0.0119271829079863!GO:0033371;T cell secretory granule organization and biogenesis;0.0119271829079863!GO:0033373;maintenance of protease localization in mast cell secretory granule;0.0119271829079863!GO:0033375;protease localization in T cell secretory granule;0.0119271829079863!GO:0042629;mast cell granule;0.0119271829079863!GO:0033377;maintenance of protein localization in T cell secretory granule;0.0119271829079863!GO:0033364;mast cell secretory granule organization and biogenesis;0.0119271829079863!GO:0033380;granzyme B localization in T cell secretory granule;0.0119271829079863!GO:0033379;maintenance of protease localization in T cell secretory granule;0.0119271829079863!GO:0033370;maintenance of protein localization in mast cell secretory granule;0.0119271829079863!GO:0033368;protease localization in mast cell secretory granule;0.0119271829079863!GO:0033366;protein localization in secretory granule;0.0119271829079863!GO:0033382;maintenance of granzyme B localization in T cell secretory granule;0.0119271829079863!GO:0033374;protein localization in T cell secretory granule;0.0119271829079863!GO:0030137;COPI-coated vesicle;0.0119396896540954!GO:0050790;regulation of catalytic activity;0.0125645144903253!GO:0016893;endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters;0.0126952523536451!GO:0032984;macromolecular complex disassembly;0.0128236786382607!GO:0030695;GTPase regulator activity;0.0128584863986206!GO:0000288;mRNA catabolic process, deadenylation-dependent decay;0.0129050881497049!GO:0004721;phosphoprotein phosphatase activity;0.0129050881497049!GO:0007004;telomere maintenance via telomerase;0.0130431153227706!GO:0045892;negative regulation of transcription, DNA-dependent;0.0131635110805002!GO:0006400;tRNA modification;0.0133115970838617!GO:0045045;secretory pathway;0.0133320817599857!GO:0001824;blastocyst development;0.0133320817599857!GO:0009303;rRNA transcription;0.0135057347891897!GO:0015980;energy derivation by oxidation of organic compounds;0.0135602157969597!GO:0031625;ubiquitin protein ligase binding;0.0135631422161369!GO:0051090;regulation of transcription factor activity;0.0136232144129921!GO:0042113;B cell activation;0.0136232144129921!GO:0044450;microtubule organizing center part;0.0139217192835644!GO:0000726;non-recombinational repair;0.0142379076891255!GO:0005850;eukaryotic translation initiation factor 2 complex;0.0142553035144201!GO:0019843;rRNA binding;0.0143020411837145!GO:0003746;translation elongation factor activity;0.0143898985882935!GO:0033116;ER-Golgi intermediate compartment membrane;0.0145958540450607!GO:0008180;signalosome;0.0149222185129989!GO:0031325;positive regulation of cellular metabolic process;0.0149801611463368!GO:0042613;MHC class II protein complex;0.0150239316010653!GO:0046112;nucleobase biosynthetic process;0.0150353877249402!GO:0005744;mitochondrial inner membrane presequence translocase complex;0.0150353877249402!GO:0007050;cell cycle arrest;0.0153069720172948!GO:0006890;retrograde vesicle-mediated transport, Golgi to ER;0.0153489751736148!GO:0031902;late endosome membrane;0.01538222089039!GO:0031570;DNA integrity checkpoint;0.0155550799846465!GO:0005096;GTPase activator activity;0.015971632995991!GO:0008320;protein transmembrane transporter activity;0.0161667804083579!GO:0043414;biopolymer methylation;0.0162084369273857!GO:0031577;spindle checkpoint;0.016342244668978!GO:0046489;phosphoinositide biosynthetic process;0.0165159795207401!GO:0008538;proteasome activator activity;0.0169113096904856!GO:0022884;macromolecule transmembrane transporter activity;0.016969222882277!GO:0015450;P-P-bond-hydrolysis-driven protein transmembrane transporter activity;0.016969222882277!GO:0019904;protein domain specific binding;0.0170422754557834!GO:0004221;ubiquitin thiolesterase activity;0.0170687999250359!GO:0007265;Ras protein signal transduction;0.0172254990759149!GO:0043624;cellular protein complex disassembly;0.0173035395924939!GO:0043621;protein self-association;0.0175259157208974!GO:0050662;coenzyme binding;0.0175651837247978!GO:0016790;thiolester hydrolase activity;0.0178583866930962!GO:0004540;ribonuclease activity;0.0178583866930962!GO:0030125;clathrin vesicle coat;0.0179503562118431!GO:0030665;clathrin coated vesicle membrane;0.0179503562118431!GO:0005791;rough endoplasmic reticulum;0.0184972759451396!GO:0051098;regulation of binding;0.0186979686523717!GO:0008276;protein methyltransferase activity;0.0187454782250794!GO:0009127;purine nucleoside monophosphate biosynthetic process;0.0187894268794708!GO:0009167;purine ribonucleoside monophosphate metabolic process;0.0187894268794708!GO:0009126;purine nucleoside monophosphate metabolic process;0.0187894268794708!GO:0009168;purine ribonucleoside monophosphate biosynthetic process;0.0187894268794708!GO:0000118;histone deacetylase complex;0.0189470317952246!GO:0032039;integrator complex;0.019667026939628!GO:0006368;RNA elongation from RNA polymerase II promoter;0.0197294138719108!GO:0043241;protein complex disassembly;0.0197372632113078!GO:0016605;PML body;0.0198515287060174!GO:0046649;lymphocyte activation;0.0201534735851629!GO:0006278;RNA-dependent DNA replication;0.0201534735851629!GO:0016862;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;0.0202914574175018!GO:0032940;secretion by cell;0.0208483343740844!GO:0005732;small nucleolar ribonucleoprotein complex;0.020947860613395!GO:0008757;S-adenosylmethionine-dependent methyltransferase activity;0.0213250779583855!GO:0006596;polyamine biosynthetic process;0.0214569237346711!GO:0016311;dephosphorylation;0.021989922444636!GO:0051338;regulation of transferase activity;0.0222671295970417!GO:0051656;establishment of organelle localization;0.0226255658131671!GO:0000119;mediator complex;0.0226740050671804!GO:0030522;intracellular receptor-mediated signaling pathway;0.022799811455219!GO:0005874;microtubule;0.0229875050546607!GO:0007007;inner mitochondrial membrane organization and biogenesis;0.0230082586821458!GO:0016301;kinase activity;0.0230859610504113!GO:0002474;antigen processing and presentation of peptide antigen via MHC class I;0.0235713453879774!GO:0030029;actin filament-based process;0.0243426666874194!GO:0000287;magnesium ion binding;0.0244786293207592!GO:0048487;beta-tubulin binding;0.0248686907263205!GO:0043549;regulation of kinase activity;0.0255572393206486!GO:0000738;DNA catabolic process, exonucleolytic;0.0260321308168278!GO:0005083;small GTPase regulator activity;0.0267780293985444!GO:0030433;ER-associated protein catabolic process;0.0268549977939756!GO:0006515;misfolded or incompletely synthesized protein catabolic process;0.0268549977939756!GO:0005788;endoplasmic reticulum lumen;0.0271995429290963!GO:0050681;androgen receptor binding;0.0271995429290963!GO:0044438;microbody part;0.0273555471732085!GO:0044439;peroxisomal part;0.0273555471732085!GO:0043284;biopolymer biosynthetic process;0.0274323085205708!GO:0002504;antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;0.0274524922580218!GO:0046474;glycerophospholipid biosynthetic process;0.0277290745910439!GO:0004748;ribonucleoside-diphosphate reductase activity;0.0278398199589611!GO:0016728;oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor;0.0278398199589611!GO:0030262;apoptotic nuclear changes;0.0283856574506968!GO:0006308;DNA catabolic process;0.0285679674346129!GO:0001836;release of cytochrome c from mitochondria;0.0287654871177213!GO:0033170;DNA-protein loading ATPase activity;0.0287767721016086!GO:0003689;DNA clamp loader activity;0.0287767721016086!GO:0008097;5S rRNA binding;0.0294305955715456!GO:0016407;acetyltransferase activity;0.0294670282353789!GO:0008156;negative regulation of DNA replication;0.0295779990164341!GO:0004177;aminopeptidase activity;0.0295779990164341!GO:0035267;NuA4 histone acetyltransferase complex;0.0295779990164341!GO:0043086;negative regulation of catalytic activity;0.0306240869411546!GO:0004536;deoxyribonuclease activity;0.0313302789941839!GO:0008630;DNA damage response, signal transduction resulting in induction of apoptosis;0.0313302789941839!GO:0006356;regulation of transcription from RNA polymerase I promoter;0.0314842820708229!GO:0032404;mismatch repair complex binding;0.0319507843305403!GO:0000018;regulation of DNA recombination;0.0320809069373271!GO:0008017;microtubule binding;0.032289127269517!GO:0006406;mRNA export from nucleus;0.032378799848088!GO:0031371;ubiquitin conjugating enzyme complex;0.0325456558656131!GO:0001891;phagocytic cup;0.0327307008853897!GO:0042719;mitochondrial intermembrane space protein transporter complex;0.0331021795903856!GO:0045039;protein import into mitochondrial inner membrane;0.0331021795903856!GO:0004448;isocitrate dehydrogenase activity;0.0332508465441108!GO:0006301;postreplication repair;0.0332939638230814!GO:0000122;negative regulation of transcription from RNA polymerase II promoter;0.0338874820746332!GO:0005092;GDP-dissociation inhibitor activity;0.0340087335694551!GO:0042532;negative regulation of tyrosine phosphorylation of STAT protein;0.0340087335694551!GO:0042518;negative regulation of tyrosine phosphorylation of Stat3 protein;0.0340087335694551!GO:0050732;negative regulation of peptidyl-tyrosine phosphorylation;0.0340087335694551!GO:0046426;negative regulation of JAK-STAT cascade;0.0343179549599813!GO:0051881;regulation of mitochondrial membrane potential;0.0348905405715653!GO:0046365;monosaccharide catabolic process;0.0349299965243374!GO:0006096;glycolysis;0.0354085971816851!GO:0043130;ubiquitin binding;0.0355755583712941!GO:0032182;small conjugating protein binding;0.0355755583712941!GO:0008537;proteasome activator complex;0.0356874481868436!GO:0000096;sulfur amino acid metabolic process;0.0356917344283926!GO:0051235;maintenance of localization;0.0363434551416859!GO:0005680;anaphase-promoting complex;0.0363434551416859!GO:0000792;heterochromatin;0.0377058909545982!GO:0007094;mitotic cell cycle spindle assembly checkpoint;0.0377484660438603!GO:0030130;clathrin coat of trans-Golgi network vesicle;0.0377484660438603!GO:0012510;trans-Golgi network transport vesicle membrane;0.0377484660438603!GO:0030508;thiol-disulfide exchange intermediate activity;0.037797328661424!GO:0043407;negative regulation of MAP kinase activity;0.0380688740355294!GO:0042026;protein refolding;0.0383987988918555!GO:0042771;DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis;0.0390654684450525!GO:0006767;water-soluble vitamin metabolic process;0.0391638426095757!GO:0032405;MutLalpha complex binding;0.0394015358030253!GO:0005652;nuclear lamina;0.0396530727073822!GO:0006984;ER-nuclear signaling pathway;0.0396530727073822!GO:0031903;microbody membrane;0.040268113635562!GO:0005778;peroxisomal membrane;0.040268113635562!GO:0043189;H4/H2A histone acetyltransferase complex;0.0412709153390904!GO:0001832;blastocyst growth;0.0413527113008267!GO:0046128;purine ribonucleoside metabolic process;0.0421855655248236!GO:0042278;purine nucleoside metabolic process;0.0421855655248236!GO:0051101;regulation of DNA binding;0.0421855655248236!GO:0005869;dynactin complex;0.0422195061744862!GO:0050178;phenylpyruvate tautomerase activity;0.0423685440501603!GO:0030119;AP-type membrane coat adaptor complex;0.0427127217695816!GO:0045859;regulation of protein kinase activity;0.0429185085009058!GO:0030140;trans-Golgi network transport vesicle;0.0431367490997784!GO:0000077;DNA damage checkpoint;0.043370824827639!GO:0031647;regulation of protein stability;0.0435215943022603!GO:0006672;ceramide metabolic process;0.0446300585926587!GO:0005689;U12-dependent spliceosome;0.0446304999419229!GO:0015036;disulfide oxidoreductase activity;0.0447350911392255!GO:0008287;protein serine/threonine phosphatase complex;0.0449175064970955!GO:0008270;zinc ion binding;0.0450145003091535!GO:0004579;dolichyl-diphosphooligosaccharide-protein glycotransferase activity;0.0450314420407337!GO:0004576;oligosaccharyl transferase activity;0.045242683647077!GO:0000123;histone acetyltransferase complex;0.0453695889449585!GO:0031901;early endosome membrane;0.0453695889449585!GO:0003727;single-stranded RNA binding;0.045749521139909!GO:0043631;RNA polyadenylation;0.0464570063156965!GO:0008250;oligosaccharyl transferase complex;0.0467339702963938!GO:0045815;positive regulation of gene expression, epigenetic;0.0471499653374292!GO:0004659;prenyltransferase activity;0.0480310388148482!GO:0031988;membrane-bound vesicle;0.0483480787081558!GO:0046519;sphingoid metabolic process;0.048402613545431!GO:0006730;one-carbon compound metabolic process;0.0488103094761675!GO:0005784;translocon complex;0.0490860036035849!GO:0004722;protein serine/threonine phosphatase activity;0.0498463096093952 | |||
|sample_id=10822 | |||
|sample_note= | |||
|sample_sex=female | |||
|sample_species=Human (Homo sapiens) | |||
|sample_strain= | |||
|sample_tissue=blood | |||
|top_motifs=HOXA9_MEIS1:2.46827708055;POU2F1..3:2.2824945749;POU5F1:2.0201155114;NFKB1_REL_RELA:1.98254504504;DMAP1_NCOR{1,2}_SMARC:1.76503299187;E2F1..5:1.71910738025;PDX1:1.62546251976;MYB:1.5997475763;NFY{A,B,C}:1.58643844148;PAX6:1.55866308317;ELF1,2,4:1.55181445621;NKX6-1,2:1.54933553356;IRF7:1.49510313753;ELK1,4_GABP{A,B1}:1.47460772221;IRF1,2:1.46668913386;AIRE:1.4199309607;VSX1,2:1.21645265389;TOPORS:1.20843363783;YY1:1.15851616252;CDX1,2,4:1.07172850553;SPI1:1.06381210489;PITX1..3:1.05618570354;RUNX1..3:0.940152062404;RXR{A,B,G}_{NR1H2,PPAR}dimers:0.919831281465;HIF1A:0.899817141961;NRF1:0.835693970747;PAX8:0.828515195219;FOXA2:0.81754910981;SPIB:0.75726288428;PAX3,7:0.728357783781;AHR_ARNT_ARNT2:0.70190316861;OCT4_SOX2{dimer}:0.693011208022;ETS1,2:0.66655498948;ZNF143:0.641278581487;ARNT_ARNT2_BHLHB2_MAX_MYC_USF1:0.63722364481;RBPJ:0.618482444571;SPZ1:0.609489804311;POU1F1:0.599189384278;ZBTB16:0.578706590101;BREu{core}:0.571122174873;FOXP3:0.570876137245;EVI1:0.56281751475;CUX2:0.498689100425;MYOD1:0.477713733436;HNF4A_NR2F1,2:0.472185380488;SNAI1..3:0.46146886368;ZEB1:0.441118523963;GFI1:0.417256894397;NR5A1,2:0.399228278616;STAT1,3:0.399087641675;LMO2:0.394269258785;NKX2-2,8:0.37751233752;ZNF384:0.325108090925;FOXP1:0.311719248387;RORA:0.305224985039;HSF1,2:0.302926364971;HNF1A:0.27321784702;POU3F1..4:0.269500818594;FOXN1:0.258623561881;TFDP1:0.25727759627;PBX1:0.234160543025;RFX2..5_RFXANK_RFXAP:0.205600179072;ESRRA:0.188331353019;FOX{F1,F2,J1}:0.184362507596;ESR1:0.180257491519;NANOG{mouse}:0.176370641435;SOX{8,9,10}:0.171739684084;GATA6:0.164454703001;ATF5_CREB3:0.152456456576;TP53:0.110625715415;PAX4:0.102686404325;HES1:0.0636307982011;EBF1:0.0606688639241;PRRX1,2:0.0576147158661;IKZF2:0.0481094509024;RXRA_VDR{dimer}:0.0384247884114;CREB1:0.0359693117775;ALX4:0.0245585144887;TGIF1:0.0238893267514;CDC5L:0.0184650638678;bHLH_family:0.00791176274905;NKX3-2:-0.0105949834911;PAX2:-0.0253417049777;ARID5B:-0.0451944890788;CRX:-0.0673035273525;SOX5:-0.0696552010571;LHX3,4:-0.114107163925;ATF4:-0.137287420656;PRDM1:-0.185771814873;MEF2{A,B,C,D}:-0.2174610513;NFE2:-0.228282728399;NKX2-3_NKX2-5:-0.236738971768;SRF:-0.252350217833;LEF1_TCF7_TCF7L1,2:-0.26512419674;FOXQ1:-0.268648767937;HOX{A4,D4}:-0.270616741497;BPTF:-0.308831318292;HMGA1,2:-0.335298001327;DBP:-0.34495890564;ALX1:-0.346728581228;NR1H4:-0.361577775012;TLX2:-0.380828577265;HAND1,2:-0.411814836317;NR6A1:-0.415028478442;ADNP_IRX_SIX_ZHX:-0.42850788804;GATA4:-0.435805164735;FOS_FOS{B,L1}_JUN{B,D}:-0.461141958404;NFATC1..3:-0.479898960348;GLI1..3:-0.487374500148;SOX17:-0.488128512461;KLF4:-0.497902774133;AR:-0.507909197774;TFAP4:-0.522348919963;EP300:-0.526916644209;SOX2:-0.526961172944;RXR{A,B,G}:-0.551208393755;ONECUT1,2:-0.564395793677;BACH2:-0.568508721312;FOSL2:-0.577727158933;IKZF1:-0.584731395214;ZFP161:-0.597206598118;HOX{A5,B5}:-0.600566230497;UFEwm:-0.612646250138;GFI1B:-0.630287690181;MYBL2:-0.642990423;EN1,2:-0.646898245869;HOX{A6,A7,B6,B7}:-0.652692797859;NKX2-1,4:-0.666957862082;STAT2,4,6:-0.675326966469;HBP1_HMGB_SSRP1_UBTF:-0.682285429885;CEBPA,B_DDIT3:-0.713471996601;ATF2:-0.738438095994;SMAD1..7,9:-0.740863718286;TEF:-0.742785773565;MZF1:-0.763787037213;NKX3-1:-0.764472017373;ZNF423:-0.769356810364;HLF:-0.791877699918;PAX1,9:-0.816254622583;RREB1:-0.82964787328;GCM1,2:-0.830251683428;ZNF148:-0.84501289566;NHLH1,2:-0.865742369697;TAL1_TCF{3,4,12}:-0.871887048798;NFIL3:-0.882928205655;SREBF1,2:-0.88355580406;EGR1..3:-0.899805371269;MYFfamily:-0.914936293499;FOXD3:-0.922252161891;PPARG:-0.922446081413;ZIC1..3:-0.931495652885;NFIX:-0.937377091175;MTE{core}:-0.945769286306;TBX4,5:-0.947563594796;MTF1:-0.986591721146;STAT5{A,B}:-0.991176055539;TBP:-0.99474022716;RFX1:-1.00381525853;FOXM1:-1.00415551197;REST:-1.0455776192;FOXO1,3,4:-1.04882307684;GTF2I:-1.0626962157;XCPE1{core}:-1.08761652811;T:-1.09796123102;JUN:-1.09918960581;NFE2L2:-1.13187900825;HIC1:-1.13516561748;PAX5:-1.19853631231;MED-1{core}:-1.25203379674;XBP1:-1.25698385602;TFCP2:-1.27478979339;GTF2A1,2:-1.28417445597;NANOG:-1.2898107102;ZNF238:-1.29284524731;NFE2L1:-1.29417361869;TFAP2{A,C}:-1.29535054719;ATF6:-1.31519175134;HMX1:-1.31692243834;MAFB:-1.31839609304;PATZ1:-1.39642354822;TLX1..3_NFIC{dimer}:-1.44687983091;GZF1:-1.49128341327;MAZ:-1.5042513463;POU6F1:-1.61154144892;NR3C1:-1.6266388791;TEAD1:-1.64904270587;ZBTB6:-1.66319844207;FOX{D1,D2}:-1.72092736549;SP1:-1.78078064422;TFAP2B:-1.808530438;FOX{I1,J2}:-2.14310516309;FOXL1:-2.5946263389 | |||
|xref= | |||
|zenbu_report=https://fantom.gsc.riken.jp/zenbu/reports/#miRNA_expression_atlas_human;search_select_hide=table111:FF:10822-111C3;search_select_hide=table117:FF:10822-111C3 | |||
}} | }} |
Latest revision as of 15:07, 3 June 2020
Name: | B lymphoblastoid cell line: GM12878 ENCODE, biol_rep2 |
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Species: | Human (Homo sapiens) |
Library ID: | CNhs12332 |
Sample type: | cell lines |
Genomic View: | UCSC |
RefEX: | Specific genes |
CAGEd-oPOSSUM: | link |
ZENBU report : | link |
Additional information | ||||||||||||||||||||||||||||
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Sample information
RNA information
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CAGE Accession numbers | ||||||||||||||||||||||||||||||||||||||||||||||
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Download raw sequence, BAM & CTSS | ||||||||||||||
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Relative expression to median (log10)
Transcription factors with enriched expression in this sampleRanked list of transcription factor promoter expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed.
Co-expression clusters with enriched expression in this sampleRanked list of co-expression cluster expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed. <br>Analyst:NA <br><br>link to dataset.<br>data
Repeat families with enriched expression in this sample<b>Summary:</b>Ranked list of repeat family expression in this sample relative tothe median expression in the FANTOM5 collection is shown. Value is log10transformed.<br><b>Analyst:</b>NA<br><br>link to dataset.<br>data
TFBS(DNA)motifs over-represented in proximal region of promoters active in this sample
JASPAR motifs<b>Summary:</b>Association of JASPAR motif to the promoter expression in thissample. Pearson's correlation between the number of TFBSs estimated byusing the position-weight matrix for each promoter and its expression isexpressed as Z-score by taking the ones based on random position-weightmatrix, and the tail probability of the normal distribution correspondingto the Z-score is taken as the resulting P-value. Lower P-value indicatesmore (non-random) association of the motif to promoter expression<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data
library id: CNhs12332
FANTOM5 phase1 novel unique motifs<b>Summary:</b>Association of the 169 novel and unique motifs discovered in FANTOM5 phase1 in this sample. Among the de-novo motifs discovered by DMF, HOMER,ChIPMunk, and ScanAll, only novel motifs are selected after comparison with known motif sets, and their clustering based on MACRO-APE resulted in169 novel and unique motifs. Their association to the promoter expression is evaluated in the same way to the JASPAR motif above<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data
library id: CNhs12332
Novel motif | Logo | P-value |
---|---|---|
1 | 1 | 0.00872 |
10 | 10 | 0.0263 |
100 | 100 | 0.498 |
101 | 101 | 0.223 |
102 | 102 | 0.534 |
103 | 103 | 0.232 |
104 | 104 | 0.51 |
105 | 105 | 0.613 |
106 | 106 | 0.969 |
107 | 107 | 0.711 |
108 | 108 | 0.945 |
109 | 109 | 0.0684 |
11 | 11 | 0.22 |
110 | 110 | 0.149 |
111 | 111 | 0.0619 |
112 | 112 | 0.113 |
113 | 113 | 0.566 |
114 | 114 | 0.383 |
115 | 115 | 0.535 |
116 | 116 | 0.411 |
117 | 117 | 0.0233 |
118 | 118 | 0.167 |
119 | 119 | 0.26 |
12 | 12 | 0.985 |
120 | 120 | 0.415 |
121 | 121 | 0.758 |
122 | 122 | 0.429 |
123 | 123 | 6.86378e-5 |
124 | 124 | 0.0943 |
125 | 125 | 0.304 |
126 | 126 | 0.311 |
127 | 127 | 0.336 |
128 | 128 | 0.6 |
129 | 129 | 0.505 |
13 | 13 | 0.0846 |
130 | 130 | 0.535 |
131 | 131 | 0.311 |
132 | 132 | 0.619 |
133 | 133 | 0.827 |
134 | 134 | 0.649 |
135 | 135 | 0.945 |
136 | 136 | 0.125 |
137 | 137 | 0.725 |
138 | 138 | 0.989 |
139 | 139 | 0.521 |
14 | 14 | 0.748 |
140 | 140 | 0.381 |
141 | 141 | 0.0508 |
142 | 142 | 0.896 |
143 | 143 | 0.434 |
144 | 144 | 0.614 |
145 | 145 | 0.0679 |
146 | 146 | 0.62 |
147 | 147 | 0.284 |
148 | 148 | 0.035 |
149 | 149 | 0.37 |
15 | 15 | 0.0521 |
150 | 150 | 0.913 |
151 | 151 | 0.657 |
152 | 152 | 0.0922 |
153 | 153 | 0.886 |
154 | 154 | 0.924 |
155 | 155 | 0.194 |
156 | 156 | 0.755 |
157 | 157 | 0.137 |
158 | 158 | 0.99 |
159 | 159 | 0.0876 |
16 | 16 | 0.812 |
160 | 160 | 0.226 |
161 | 161 | 0.0406 |
162 | 162 | 0.846 |
163 | 163 | 0.647 |
164 | 164 | 0.105 |
165 | 165 | 0.726 |
166 | 166 | 0.218 |
167 | 167 | 0.367 |
168 | 168 | 0.325 |
169 | 169 | 0.712 |
17 | 17 | 0.806 |
18 | 18 | 0.709 |
19 | 19 | 0.609 |
2 | 2 | 0.689 |
20 | 20 | 0.274 |
21 | 21 | 0.175 |
22 | 22 | 0.996 |
23 | 23 | 0.231 |
24 | 24 | 0.171 |
25 | 25 | 0.0967 |
26 | 26 | 0.0506 |
27 | 27 | 0.539 |
28 | 28 | 0.348 |
29 | 29 | 0.0249 |
3 | 3 | 0.0619 |
30 | 30 | 0.112 |
31 | 31 | 0.848 |
32 | 32 | 0.568 |
33 | 33 | 0.29 |
34 | 34 | 0.586 |
35 | 35 | 0.174 |
36 | 36 | 0.0363 |
37 | 37 | 0.348 |
38 | 38 | 0.359 |
39 | 39 | 0.434 |
4 | 4 | 0.738 |
40 | 40 | 0.474 |
41 | 41 | 0.74 |
42 | 42 | 0.0744 |
43 | 43 | 0.473 |
44 | 44 | 0.163 |
45 | 45 | 0.368 |
46 | 46 | 0.26 |
47 | 47 | 0.0354 |
48 | 48 | 0.0576 |
49 | 49 | 0.323 |
5 | 5 | 0.642 |
50 | 50 | 0.859 |
51 | 51 | 0.673 |
52 | 52 | 0.289 |
53 | 53 | 0.354 |
54 | 54 | 0.71 |
55 | 55 | 0.472 |
56 | 56 | 0.742 |
57 | 57 | 0.214 |
58 | 58 | 0.0665 |
59 | 59 | 0.29 |
6 | 6 | 0.84 |
60 | 60 | 0.888 |
61 | 61 | 0.12 |
62 | 62 | 0.0933 |
63 | 63 | 0.693 |
64 | 64 | 0.222 |
65 | 65 | 0.979 |
66 | 66 | 0.348 |
67 | 67 | 0.804 |
68 | 68 | 0.0487 |
69 | 69 | 0.505 |
7 | 7 | 0.116 |
70 | 70 | 0.552 |
71 | 71 | 0.0209 |
72 | 72 | 0.402 |
73 | 73 | 0.951 |
74 | 74 | 0.799 |
75 | 75 | 0.00708 |
76 | 76 | 0.504 |
77 | 77 | 0.621 |
78 | 78 | 0.0245 |
79 | 79 | 0.745 |
8 | 8 | 0.704 |
80 | 80 | 0.0988 |
81 | 81 | 0.46 |
82 | 82 | 0.812 |
83 | 83 | 0.271 |
84 | 84 | 0.22 |
85 | 85 | 0.32 |
86 | 86 | 0.366 |
87 | 87 | 0.0989 |
88 | 88 | 0.719 |
89 | 89 | 0.95 |
9 | 9 | 0.919 |
90 | 90 | 0.417 |
91 | 91 | 0.692 |
92 | 92 | 0.803 |
93 | 93 | 0.306 |
94 | 94 | 0.765 |
95 | 95 | 0.0173 |
96 | 96 | 0.786 |
97 | 97 | 0.169 |
98 | 98 | 0.466 |
99 | 99 | 0.313 |
de novo motifs identified by HOMER in promoters active in this sample<b>Summary:</b>The result of HOMER in this sample is shown.<br><b>Analyst:</b>NA <br>
library id: CNhs12332
FANTOM5 (FF) ontology
Direct parent terms
is_a relathionship
EFO:0002091 biological replicate
FF:0000210 human sample
FF:0102062 B-lymphoblastoid cell line sample
Ancestor terms (non development)<b>Summary:</b>Connected ontology terms with is_a, part_of or located_in relationship <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source data<br>data
CL: Cell type
0000000 (cell), 0000000 (cell)
0000003 (native cell)
0000988 (hematopoietic cell)
0000548 (animal cell)
0002371 (somatic cell)
0000542 (lymphocyte)
0000219 (motile cell)
0000945 (lymphocyte of B lineage)
0000738 (leukocyte)
0002087 (nongranular leukocyte)
0002242 (nucleate cell)
0000255 (eukaryotic cell)
FF: FANTOM5
0000102 (sample by type)
0000003 (cell line sample)
0000210 (human sample)
0000101 (sample by species)
0000001 (sample)
0101035 (hematopoietic cell line sample)
0100773 (lymphoblastoid cell line sample)
0101522 (B-lymphocyte cell line sample)
0102062 (B-lymphoblastoid cell line sample)
Ancestor terms (development)<b>Summary:</b>Connected ontology terms with develops_from, derives_from or preceded_by relationship <br><b>Analyst:</b> Hideya Kawaji <br><br>link to source data<br>data
CL:0000134 (mesenchymal cell)
CL:0000051 (common lymphoid progenitor)