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{{Coexpression_clusters
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|coexpression_dpi_cluster_scores_median=0,

Latest revision as of 12:03, 17 September 2013


Full id: C2315_occipital_parietal_temporal_duodenum_medial_brain_putamen



Phase1 CAGE Peaks

Hg19::chr14:78640068..78640069,+p@chr14:78640068..78640069
+
Hg19::chr16:6069184..6069193,+p29@RBFOX1
Hg19::chr16:6550901..6550907,+p@chr16:6550901..6550907
+
Hg19::chr16:7217007..7217010,+p@chr16:7217007..7217010
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube9.83e-11856
neural rod9.83e-11856
future spinal cord9.83e-11856
neural keel9.83e-11856
regional part of nervous system1.30e-10853
regional part of brain1.30e-10853
central nervous system1.52e-10081
brain9.46e-9468
future brain9.46e-9468
nervous system3.60e-9389
brain grey matter7.41e-8934
gray matter7.41e-8934
telencephalon9.18e-8934
regional part of forebrain9.19e-8841
forebrain9.19e-8841
anterior neural tube9.19e-8841
future forebrain9.19e-8841
neural plate1.78e-8482
presumptive neural plate1.78e-8482
neurectoderm1.44e-8386
cerebral hemisphere5.53e-8332
regional part of telencephalon8.22e-8332
regional part of cerebral cortex1.29e-6922
ecto-epithelium2.08e-64104
pre-chordal neural plate1.83e-6361
neocortex4.46e-6320
cerebral cortex7.12e-6125
pallium7.12e-6125
structure with developmental contribution from neural crest8.05e-51132
adult organism5.29e-50114
ectoderm-derived structure1.44e-47171
ectoderm1.44e-47171
presumptive ectoderm1.44e-47171
organ system subdivision5.03e-37223
basal ganglion7.99e-309
nuclear complex of neuraxis7.99e-309
aggregate regional part of brain7.99e-309
collection of basal ganglia7.99e-309
cerebral subcortex7.99e-309
posterior neural tube3.24e-2915
chordal neural plate3.24e-2915
neural nucleus4.91e-299
nucleus of brain4.91e-299
tube2.05e-28192
telencephalic nucleus3.15e-237
gyrus3.82e-216
segmental subdivision of hindbrain6.17e-2112
hindbrain6.17e-2112
presumptive hindbrain6.17e-2112
anatomical conduit1.57e-20240
anatomical cluster2.54e-19373
segmental subdivision of nervous system3.41e-1913
brainstem3.44e-196
organ part1.28e-18218
temporal lobe3.57e-186
limbic system7.01e-185
parietal lobe8.05e-185
occipital lobe1.65e-175
epithelium1.69e-15306
cell layer3.07e-15309
corpus striatum1.29e-144
striatum1.29e-144
ventral part of telencephalon1.29e-144
future corpus striatum1.29e-144
multi-tissue structure1.89e-13342
regional part of metencephalon6.19e-139
metencephalon6.19e-139
future metencephalon6.19e-139
frontal cortex1.59e-113
caudate-putamen1.90e-113
dorsal striatum1.90e-113
medulla oblongata1.77e-103
myelencephalon1.77e-103
future myelencephalon1.77e-103
pons1.96e-103
spinal cord2.09e-103
dorsal region element2.09e-103
dorsum2.09e-103
germ layer1.06e-08560
germ layer / neural crest1.06e-08560
embryonic tissue1.06e-08560
presumptive structure1.06e-08560
germ layer / neural crest derived structure1.06e-08560
epiblast (generic)1.06e-08560
developing anatomical structure1.47e-08581
embryonic structure1.51e-08564
middle frontal gyrus2.17e-082
middle temporal gyrus2.50e-082
amygdala2.59e-082
embryo3.65e-08592
caudate nucleus3.95e-082
future caudate nucleus3.95e-082
Ammon's horn4.24e-082
lobe parts of cerebral cortex4.24e-082
hippocampal formation4.24e-082
limbic lobe4.24e-082
organ9.58e-08503
globus pallidus1.55e-072
pallidum1.55e-072
locus ceruleus1.65e-072


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.11.31813
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.841508
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.380957
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.11.46638
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.10559
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.10.533581
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.309472
MA0163.10.253219
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.21.11128
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.