MCL coexpression mm9:2636

Phase1 CAGE Peaks

	Short description
Mm9::chr11:115939241..115939266,-	p6@Unc13d
Mm9::chr7:150191582..150191608,+	p1@Tspan32
Mm9::chr7:150191623..150191640,+	p4@Tspan32

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0002432	granuloma formation	0.0053323106864007
GO:0002544	chronic inflammatory response	0.0053323106864007
GO:0043320	natural killer cell degranulation	0.0053323106864007
GO:0002467	germinal center formation	0.0133260291583405
GO:0051607	defense response to virus	0.0133260291583405
GO:0043299	leukocyte degranulation	0.0133260291583405
GO:0030101	natural killer cell activation	0.0133260291583405
GO:0042267	natural killer cell mediated cytotoxicity	0.0133260291583405
GO:0002228	natural killer cell mediated immunity	0.0133260291583405
GO:0001909	leukocyte mediated cytotoxicity	0.015988167337366
GO:0001906	cell killing	0.015988167337366
GO:0006909	phagocytosis	0.0253034963031704
GO:0009615	response to virus	0.0301092466608259
GO:0045055	regulated secretory pathway	0.0365023118205945
GO:0006887	exocytosis	0.0386339251212221
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.0386339251212221
GO:0045087	innate immune response	0.0386339251212221
GO:0002250	adaptive immune response	0.0386339251212221
GO:0002449	lymphocyte mediated immunity	0.0386339251212221
GO:0002443	leukocyte mediated immunity	0.0394871973167848
GO:0006917	induction of apoptosis	0.0467369230396592
GO:0012502	induction of programmed cell death	0.0467369230396592
GO:0002252	immune effector process	0.0467764630209545
GO:0043065	positive regulation of apoptosis	0.0477725546038868
GO:0051707	response to other organism	0.0477725546038868
GO:0043068	positive regulation of programmed cell death	0.0477725546038868
GO:0010324	membrane invagination	0.0477725546038868
GO:0006897	endocytosis	0.0477725546038868
GO:0045045	secretory pathway	0.0480378536669127
GO:0046649	lymphocyte activation	0.0488882263578446
GO:0045321	leukocyte activation	0.0488882263578446
GO:0032940	secretion by cell	0.0488882263578446
GO:0006954	inflammatory response	0.0488882263578446
GO:0009607	response to biotic stimulus	0.0488882263578446

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
hematopoietic cell	1.42e-09	32
hematopoietic oligopotent progenitor cell	1.42e-09	32
hematopoietic stem cell	1.42e-09	32
angioblastic mesenchymal cell	1.42e-09	32
hematopoietic multipotent progenitor cell	1.42e-09	32
hematopoietic lineage restricted progenitor cell	4.52e-08	25
nucleate cell	7.15e-08	16
megakaryocyte-erythroid progenitor cell	3.06e-07	9

Uber Anatomy

Ontology term	p-value	n
hemopoietic organ	6.41e-11	29
immune organ	6.41e-11	29
hematopoietic system	1.83e-10	45
blood island	1.83e-10	45
hemolymphoid system	7.03e-10	48
immune system	7.03e-10	48
foregut	7.76e-09	80
mixed endoderm/mesoderm-derived structure	1.59e-08	35
thymus	3.80e-07	23
neck	3.80e-07	23
respiratory system epithelium	3.80e-07	23
hemolymphoid system gland	3.80e-07	23
pharyngeal epithelium	3.80e-07	23
thymic region	3.80e-07	23
pharyngeal gland	3.80e-07	23
entire pharyngeal arch endoderm	3.80e-07	23
thymus primordium	3.80e-07	23
early pharyngeal endoderm	3.80e-07	23

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}