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Coexpression cluster:C3205

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Full id: C3205_optic_occipital_parietal_middle_hippocampus_amygdala_temporal



Phase1 CAGE Peaks

Hg19::chr11:83818154..83818183,-p@chr11:83818154..83818183
-
Hg19::chr22:26635956..26635999,+p@chr22:26635956..26635999
+
Hg19::chr9:8501305..8501323,-p19@PTPRD


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube1.19e-9356
neural rod1.19e-9356
future spinal cord1.19e-9356
neural keel1.19e-9356
regional part of nervous system8.96e-8953
regional part of brain8.96e-8953
nervous system2.87e-7889
central nervous system7.83e-7681
brain4.12e-7468
future brain4.12e-7468
regional part of forebrain9.09e-7041
forebrain9.09e-7041
anterior neural tube9.09e-7041
future forebrain9.09e-7041
brain grey matter4.44e-6834
gray matter4.44e-6834
telencephalon1.63e-6734
neural plate3.73e-6582
presumptive neural plate3.73e-6582
neurectoderm9.97e-6286
regional part of telencephalon2.98e-6132
cerebral hemisphere4.50e-6132
regional part of cerebral cortex2.54e-5622
ecto-epithelium2.24e-52104
cerebral cortex2.97e-4925
pallium2.97e-4925
neocortex3.79e-4920
pre-chordal neural plate1.66e-4861
structure with developmental contribution from neural crest1.73e-41132
adult organism1.52e-39114
ectoderm-derived structure1.28e-38171
ectoderm1.28e-38171
presumptive ectoderm1.28e-38171
organ system subdivision2.60e-30223
posterior neural tube1.15e-2315
chordal neural plate1.15e-2315
segmental subdivision of nervous system1.39e-2213
tube1.62e-22192
brainstem2.01e-226
basal ganglion6.18e-209
nuclear complex of neuraxis6.18e-209
aggregate regional part of brain6.18e-209
collection of basal ganglia6.18e-209
cerebral subcortex6.18e-209
neural nucleus7.78e-209
nucleus of brain7.78e-209
temporal lobe1.45e-196
limbic system1.99e-195
segmental subdivision of hindbrain3.21e-1912
hindbrain3.21e-1912
presumptive hindbrain3.21e-1912
parietal lobe4.75e-195
anatomical conduit3.52e-16240
gyrus9.20e-166
anatomical cluster4.44e-14373
epithelium2.07e-13306
telencephalic nucleus3.13e-137
cell layer3.46e-13309
organ part4.75e-13218
pons3.92e-123
medulla oblongata4.92e-123
myelencephalon4.92e-123
future myelencephalon4.92e-123
regional part of metencephalon1.53e-109
metencephalon1.53e-109
future metencephalon1.53e-109
multi-tissue structure3.93e-10342
middle temporal gyrus3.12e-092
Ammon's horn4.45e-092
lobe parts of cerebral cortex4.45e-092
hippocampal formation4.45e-092
limbic lobe4.45e-092
amygdala5.01e-092
dorsal plus ventral thalamus5.01e-092
thalamic complex5.01e-092
locus ceruleus6.85e-092
brainstem nucleus6.85e-092
hindbrain nucleus6.85e-092
multi cell component structure8.64e-092
neuron projection bundle8.64e-092
corpus striatum9.20e-094
striatum9.20e-094
ventral part of telencephalon9.20e-094
future corpus striatum9.20e-094
occipital lobe7.76e-085
germ layer1.08e-07560
germ layer / neural crest1.08e-07560
embryonic tissue1.08e-07560
presumptive structure1.08e-07560
germ layer / neural crest derived structure1.08e-07560
epiblast (generic)1.08e-07560
embryonic structure1.46e-07564
developing anatomical structure5.11e-07581


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.