MCL coexpression mm9:1335

Phase1 CAGE Peaks

	Short description
Mm9::chr13:117814154..117814171,-	p7@Parp8
Mm9::chr14:79915502..79915514,+	p4@Elf1
Mm9::chr14:79915521..79915539,+	p5@Elf1
Mm9::chr17:33102742..33102771,+	p1@Zfp472
Mm9::chr1:173612135..173612202,+	p1@Cd48
Mm9::chrX:50341332..50341376,+	p1@Hprt

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007184	SMAD protein nuclear translocation	0.0429326255162258
GO:0007182	common-partner SMAD protein phosphorylation	0.0429326255162258
GO:0003950	NAD+ ADP-ribosyltransferase activity	0.0429326255162258
GO:0000060	protein import into nucleus, translocation	0.0429326255162258
GO:0051016	barbed-end actin filament capping	0.0429326255162258
GO:0051693	actin filament capping	0.0429326255162258
GO:0030835	negative regulation of actin filament depolymerization	0.0429326255162258
GO:0030834	regulation of actin filament depolymerization	0.0429326255162258
GO:0030042	actin filament depolymerization	0.0429326255162258
GO:0008064	regulation of actin polymerization and/or depolymerization	0.0429326255162258
GO:0051261	protein depolymerization	0.0429326255162258
GO:0032535	regulation of cellular component size	0.0429326255162258
GO:0032956	regulation of actin cytoskeleton organization and biogenesis	0.0429326255162258
GO:0030832	regulation of actin filament length	0.0429326255162258
GO:0016763	transferase activity, transferring pentosyl groups	0.0429326255162258
GO:0051493	regulation of cytoskeleton organization and biogenesis	0.0429326255162258
GO:0033043	regulation of organelle organization and biogenesis	0.0429326255162258
GO:0051129	negative regulation of cellular component organization and biogenesis	0.0429326255162258
GO:0008154	actin polymerization and/or depolymerization	0.0478270065441988

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic cell	6.40e-10	32
hematopoietic oligopotent progenitor cell	6.40e-10	32
hematopoietic stem cell	6.40e-10	32
angioblastic mesenchymal cell	6.40e-10	32
hematopoietic multipotent progenitor cell	6.40e-10	32
lymphoid lineage restricted progenitor cell	3.79e-08	12
T cell	1.58e-07	11
pro-T cell	1.58e-07	11
hematopoietic lineage restricted progenitor cell	3.09e-07	25
connective tissue cell	5.27e-07	46
mesenchymal cell	5.27e-07	46
lymphocyte	9.26e-07	13
common lymphoid progenitor	9.26e-07	13

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	4.88e-15	48
immune system	4.88e-15	48
hematopoietic system	1.60e-13	45
blood island	1.60e-13	45
digestive system	3.56e-12	116
digestive tract	3.56e-12	116
primitive gut	3.56e-12	116
endoderm-derived structure	8.98e-12	118
endoderm	8.98e-12	118
presumptive endoderm	8.98e-12	118
subdivision of digestive tract	2.06e-11	114
foregut	8.58e-10	80
mixed endoderm/mesoderm-derived structure	2.90e-09	35
hemopoietic organ	5.68e-09	29
immune organ	5.68e-09	29
lateral plate mesoderm	9.51e-08	87
pharynx	3.33e-07	24
upper respiratory tract	3.33e-07	24
chordate pharynx	3.33e-07	24
pharyngeal arch system	3.33e-07	24
pharyngeal region of foregut	3.33e-07	24
connective tissue	5.27e-07	46
thymus	6.70e-07	23
neck	6.70e-07	23
respiratory system epithelium	6.70e-07	23
hemolymphoid system gland	6.70e-07	23
pharyngeal epithelium	6.70e-07	23
thymic region	6.70e-07	23
pharyngeal gland	6.70e-07	23
entire pharyngeal arch endoderm	6.70e-07	23
thymus primordium	6.70e-07	23
early pharyngeal endoderm	6.70e-07	23

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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