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Coexpression cluster:C2436

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Full id: C2436_serous_gastric_argyrophil_gall_smallcell_gastrointestinal_acantholytic



Phase1 CAGE Peaks

Hg19::chr17:74136040..74136061,-p2@AB463648
p2@AB464532
Hg19::chr17:74136069..74136082,-p3@AB463648
p3@AB464532
Hg19::chr17:74136083..74136116,-p1@AB463648
p1@AB464532
Hg19::chr17:74136122..74136132,-p4@AB463648
p4@AB464532


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
male reproductive organ4.17e-1611
testis1.51e-138
cavitated compound organ3.43e-1131
male organism1.98e-1022
male reproductive system1.98e-1022
kidney3.18e-1026
kidney mesenchyme3.18e-1026
upper urinary tract3.18e-1026
kidney rudiment3.18e-1026
kidney field3.18e-1026
excretory tube6.60e-1016
kidney epithelium6.60e-1016
reproductive organ1.35e-0948
reproductive structure4.99e-0959
reproductive system4.99e-0959
anatomical space6.55e-0995
male genital duct1.84e-083
internal male genitalia1.84e-083
duct1.89e-0819
nephron epithelium2.59e-0815
renal tubule2.59e-0815
nephron tubule2.59e-0815
nephron2.59e-0815
uriniferous tubule2.59e-0815
nephrogenic mesenchyme2.59e-0815
urinary system structure2.91e-0847
cortex of kidney3.76e-0812
renal parenchyma3.76e-0812
adult organism4.30e-08114
renal system5.19e-0848
immaterial anatomical entity1.46e-07117
nephron tubule epithelium1.55e-0710
gonad2.54e-0721
indifferent external genitalia2.54e-0721
indifferent gonad2.54e-0721
gonad primordium2.54e-0721
trunk region element3.16e-07101
medulla oblongata3.18e-073
myelencephalon3.18e-073
future myelencephalon3.18e-073
external genitalia6.59e-0722
body cavity precursor6.63e-0754
Disease
Ontology termp-valuen
carcinoma1.10e-08106
cell type cancer3.15e-07143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066445.360256373075030.001211145381643620.00817176901049669
SUZ12#23512450.11578091106291.5827390373096e-078.80190001691043e-06



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.