Coexpression cluster:C4503

Full id: C4503_merkel_neuroblastoma_argyrophil_stomach_duodenum_small_eye

Phase1 CAGE Peaks

Hg19::chr5:50679089..50679107,-	p1@uc003joq.1
Hg19::chr5:50679228..50679288,+	p1@ISL1
Hg19::chr5:50686515..50686516,+	p@chr5:50686515..50686516 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001755	neural crest cell migration	0.00718238549393618
GO:0014033	neural crest cell differentiation	0.00718238549393618
GO:0014032	neural crest cell development	0.00718238549393618
GO:0003007	heart morphogenesis	0.00718238549393618
GO:0048762	mesenchymal cell differentiation	0.00718238549393618
GO:0014031	mesenchymal cell development	0.00718238549393618
GO:0007507	heart development	0.0241122941582143

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

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Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	2.15e-18	169
endoderm	2.15e-18	169
presumptive endoderm	2.15e-18	169
subdivision of digestive tract	2.23e-18	129
endodermal part of digestive tract	2.23e-18	129
digestive system	9.63e-16	155
digestive tract	9.63e-16	155
primitive gut	9.63e-16	155
gastrointestinal system	7.23e-13	35
intestine	1.68e-12	27
mixed endoderm/mesoderm-derived structure	2.19e-12	130
foregut	2.96e-08	98
hindgut	9.22e-08	19
reproductive structure	1.71e-07	59
reproductive system	1.71e-07	59
embryo	3.84e-07	612
male organism	4.93e-07	22
male reproductive system	4.93e-07	22
small intestine	5.68e-07	14
respiratory tract	9.28e-07	53

Disease

Ontology term	p-value	n
cell type cancer	2.54e-12	143
carcinoma	3.98e-09	106
germ cell and embryonal cancer	2.38e-07	22
germ cell cancer	2.38e-07	22
cancer	8.13e-07	235

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
NANOG#79923	2	19.4965189873418	0.00342725564850102	0.0174595947843421

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.