Coexpression cluster:C1341

Full id: C1341_smallcell_small_gall_colon_temporal_signet_adenocarcinoma

Phase1 CAGE Peaks

Hg19::chr11:441952..441963,-	p2@ANO9
Hg19::chr19:49118307..49118336,-	p@chr19:49118307..49118336 -
Hg19::chr19:55720851..55720860,-	p4@PTPRH
Hg19::chr19:55720862..55720880,-	p1@PTPRH
Hg19::chr1:16083098..16083119,+	p5@FBLIM1
Hg19::chr1:16083123..16083144,+	p4@FBLIM1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019198	transmembrane receptor protein phosphatase activity	0.0316304946493676
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	0.0316304946493676
GO:0022603	regulation of anatomical structure morphogenesis	0.0316304946493676
GO:0008360	regulation of cell shape	0.0316304946493676
GO:0022604	regulation of cell morphogenesis	0.0316304946493676
GO:0044459	plasma membrane part	0.0482371433811814

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell	6.05e-36	254
endodermal cell	3.82e-12	59
squamous epithelial cell	6.83e-12	62
endo-epithelial cell	1.73e-11	43
endothelial cell of vascular tree	4.11e-10	24
blood vessel endothelial cell	2.73e-08	18
embryonic blood vessel endothelial progenitor cell	2.73e-08	18
meso-epithelial cell	1.11e-07	44
kidney cell	2.96e-07	18
kidney epithelial cell	2.96e-07	18

Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	8.02e-16	169
endoderm	8.02e-16	169
presumptive endoderm	8.02e-16	169
digestive system	8.90e-15	155
digestive tract	8.90e-15	155
primitive gut	8.90e-15	155
subdivision of digestive tract	1.35e-13	129
endodermal part of digestive tract	1.35e-13	129
anatomical space	6.56e-13	104
immaterial anatomical entity	2.95e-12	126
trunk region element	1.66e-11	107
mixed endoderm/mesoderm-derived structure	7.76e-11	130
gastrointestinal system	3.04e-09	35
foregut	1.13e-08	98
renal system	1.42e-08	45
subdivision of trunk	1.64e-08	113
anatomical cavity	2.13e-08	70
intraembryonic coelom	2.25e-08	21
endothelium	2.73e-08	18
blood vessel endothelium	2.73e-08	18
cardiovascular system endothelium	2.73e-08	18
urinary system structure	3.97e-08	44
duct	4.73e-08	26
intermediate mesoderm	4.75e-08	37
simple squamous epithelium	8.02e-08	22
endo-epithelium	2.29e-07	82
mesonephros	3.29e-07	18
pronephros	3.29e-07	18
nephrogenic cord	3.29e-07	18
pronephric mesoderm	3.29e-07	18
rostral part of nephrogenic cord	3.29e-07	18
presumptive pronephric mesoderm	3.29e-07	18
respiratory system	4.16e-07	72
urogenital ridge	5.33e-07	20
viscus	7.90e-07	18
kidney	9.89e-07	27
kidney mesenchyme	9.89e-07	27
kidney rudiment	9.89e-07	27
kidney field	9.89e-07	27

Disease

Ontology term	p-value	n
carcinoma	2.87e-18	106
cell type cancer	6.06e-12	143
adenocarcinoma	8.85e-09	25

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
SMARCC1#6599	2	14.5544531065438	0.00739807938314051	0.0305636080971445

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.