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Coexpression cluster:C2371: Difference between revisions

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|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0003914!4.27e-31!118;UBERON:0000490!1.60e-23!138;UBERON:0000055!9.46e-23!69;UBERON:0004872!2.17e-20!84;UBERON:0005256!2.73e-18!143;UBERON:0001981!4.21e-18!60;UBERON:0007500!4.21e-18!60;UBERON:0004537!4.21e-18!60;UBERON:0006965!4.21e-18!60;UBERON:0004111!5.18e-18!241;UBERON:0002049!1.18e-17!79;UBERON:0007798!1.18e-17!79;UBERON:0001009!5.56e-17!113;UBERON:0004535!2.92e-16!110;UBERON:0002100!4.07e-15!216;UBERON:0003104!5.84e-15!238;UBERON:0009142!5.84e-15!238;UBERON:0000483!1.91e-14!309;UBERON:0000119!6.09e-14!312;UBERON:0000477!1.35e-13!286;UBERON:0002417!2.47e-13!61;UBERON:0000916!2.47e-13!61;UBERON:0005172!3.61e-13!55;UBERON:0005173!3.61e-13!55;UBERON:0000025!5.17e-13!194;UBERON:0003103!3.13e-12!69;UBERON:0001637!1.38e-11!42;UBERON:0003509!1.38e-11!42;UBERON:0004572!1.38e-11!42;UBERON:0000466!1.08e-10!126;UBERON:0003929!2.96e-10!54;UBERON:0000481!4.49e-10!347;UBERON:0004573!5.19e-10!33;UBERON:0004571!5.19e-10!33;UBERON:0009569!8.01e-10!113;UBERON:0003886!9.74e-10!63;UBERON:0001008!3.09e-09!45;UBERON:0000486!3.25e-09!82;UBERON:0002385!4.48e-09!63;UBERON:0001015!4.48e-09!63;UBERON:0000383!4.48e-09!63;UBERON:0006554!5.38e-09!44;UBERON:0003064!6.05e-09!37;UBERON:0001134!9.68e-09!61;UBERON:0002036!9.68e-09!61;UBERON:0003082!9.68e-09!61;UBERON:0000353!1.20e-08!17;UBERON:0004876!2.64e-08!20;UBERON:0001986!3.18e-08!18;UBERON:0004638!3.18e-08!18;UBERON:0004852!3.18e-08!18;UBERON:0003887!3.59e-08!21;UBERON:0004211!3.98e-08!16;UBERON:0001285!3.98e-08!16;UBERON:0007684!3.98e-08!16;UBERON:0003220!3.98e-08!16;UBERON:0004208!3.98e-08!16;UBERON:0006555!4.13e-08!17;UBERON:0005103!4.13e-08!17;UBERON:0000083!4.13e-08!17;UBERON:0009201!4.13e-08!17;UBERON:0004819!4.13e-08!17;UBERON:0006553!4.13e-08!17;UBERON:0003074!4.13e-08!17;UBERON:0003060!4.13e-08!17;UBERON:0002553!5.10e-08!70;UBERON:0005177!5.19e-08!107;UBERON:0005911!5.19e-08!82;UBERON:0005057!6.56e-08!26;UBERON:0000080!1.17e-07!18;UBERON:0002120!1.17e-07!18;UBERON:0004875!1.17e-07!18;UBERON:0005721!1.17e-07!18;UBERON:0005754!1.17e-07!18;UBERON:0007297!1.17e-07!18;UBERON:0009497!1.31e-07!25;UBERON:0000015!1.31e-07!25;UBERON:0002423!1.31e-07!25;UBERON:0006235!1.31e-07!25;UBERON:0004161!1.31e-07!25;UBERON:0002107!1.67e-07!19;UBERON:0006925!1.67e-07!19;UBERON:0008836!1.67e-07!19;UBERON:0000947!1.80e-07!21;UBERON:0010191!1.80e-07!21;UBERON:0009854!3.37e-07!23;UBERON:0008835!4.14e-07!22;UBERON:0003894!4.14e-07!22;UBERON:0000487!5.08e-07!22;UBERON:0004290!7.21e-07!70;UBERON:0000926!9.13e-07!448;UBERON:0004120!9.13e-07!448;UBERON:0006603!9.13e-07!448;UBERON:0006914!9.99e-07!25
|ontology_enrichment_uberon=UBERON:0003914!4.27e-31!118;UBERON:0000490!1.60e-23!138;UBERON:0000055!9.46e-23!69;UBERON:0004872!2.17e-20!84;UBERON:0005256!2.73e-18!143;UBERON:0001981!4.21e-18!60;UBERON:0007500!4.21e-18!60;UBERON:0004537!4.21e-18!60;UBERON:0006965!4.21e-18!60;UBERON:0004111!5.18e-18!241;UBERON:0002049!1.18e-17!79;UBERON:0007798!1.18e-17!79;UBERON:0001009!5.56e-17!113;UBERON:0004535!2.92e-16!110;UBERON:0002100!4.07e-15!216;UBERON:0003104!5.84e-15!238;UBERON:0009142!5.84e-15!238;UBERON:0000483!1.91e-14!309;UBERON:0000119!6.09e-14!312;UBERON:0000477!1.35e-13!286;UBERON:0002417!2.47e-13!61;UBERON:0000916!2.47e-13!61;UBERON:0005172!3.61e-13!55;UBERON:0005173!3.61e-13!55;UBERON:0000025!5.17e-13!194;UBERON:0003103!3.13e-12!69;UBERON:0001637!1.38e-11!42;UBERON:0003509!1.38e-11!42;UBERON:0004572!1.38e-11!42;UBERON:0000466!1.08e-10!126;UBERON:0003929!2.96e-10!54;UBERON:0000481!4.49e-10!347;UBERON:0004573!5.19e-10!33;UBERON:0004571!5.19e-10!33;UBERON:0009569!8.01e-10!113;UBERON:0003886!9.74e-10!63;UBERON:0001008!3.09e-09!45;UBERON:0000486!3.25e-09!82;UBERON:0002385!4.48e-09!63;UBERON:0001015!4.48e-09!63;UBERON:0000383!4.48e-09!63;UBERON:0006554!5.38e-09!44;UBERON:0003064!6.05e-09!37;UBERON:0001134!9.68e-09!61;UBERON:0002036!9.68e-09!61;UBERON:0003082!9.68e-09!61;UBERON:0000353!1.20e-08!17;UBERON:0004876!2.64e-08!20;UBERON:0001986!3.18e-08!18;UBERON:0004638!3.18e-08!18;UBERON:0004852!3.18e-08!18;UBERON:0003887!3.59e-08!21;UBERON:0004211!3.98e-08!16;UBERON:0001285!3.98e-08!16;UBERON:0007684!3.98e-08!16;UBERON:0003220!3.98e-08!16;UBERON:0004208!3.98e-08!16;UBERON:0006555!4.13e-08!17;UBERON:0005103!4.13e-08!17;UBERON:0000083!4.13e-08!17;UBERON:0009201!4.13e-08!17;UBERON:0004819!4.13e-08!17;UBERON:0006553!4.13e-08!17;UBERON:0003074!4.13e-08!17;UBERON:0003060!4.13e-08!17;UBERON:0002553!5.10e-08!70;UBERON:0005177!5.19e-08!107;UBERON:0005911!5.19e-08!82;UBERON:0005057!6.56e-08!26;UBERON:0000080!1.17e-07!18;UBERON:0002120!1.17e-07!18;UBERON:0004875!1.17e-07!18;UBERON:0005721!1.17e-07!18;UBERON:0005754!1.17e-07!18;UBERON:0007297!1.17e-07!18;UBERON:0009497!1.31e-07!25;UBERON:0000015!1.31e-07!25;UBERON:0002423!1.31e-07!25;UBERON:0006235!1.31e-07!25;UBERON:0004161!1.31e-07!25;UBERON:0002107!1.67e-07!19;UBERON:0006925!1.67e-07!19;UBERON:0008836!1.67e-07!19;UBERON:0000947!1.80e-07!21;UBERON:0010191!1.80e-07!21;UBERON:0009854!3.37e-07!23;UBERON:0008835!4.14e-07!22;UBERON:0003894!4.14e-07!22;UBERON:0000487!5.08e-07!22;UBERON:0004290!7.21e-07!70;UBERON:0000926!9.13e-07!448;UBERON:0004120!9.13e-07!448;UBERON:0006603!9.13e-07!448;UBERON:0006914!9.99e-07!25
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}}
}}

Revision as of 12:47, 5 September 2012


Full id: C2371_Renal_Lymphatic_Alveolar_migratory_Endothelial_heart_tongue



Phase1 CAGE Peaks

Hg19::chr16:3115299..3115312,+p5@IL32
Hg19::chr16:3115324..3115364,+p3@IL32
Hg19::chr16:3115386..3115412,+p2@IL32
Hg19::chr16:3115418..3115429,+p4@IL32


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
epithelial tube4.27e-31118
unilaminar epithelium1.60e-23138
vessel9.46e-2369
splanchnic layer of lateral plate mesoderm2.17e-2084
trunk mesenchyme2.73e-18143
blood vessel4.21e-1860
epithelial tube open at both ends4.21e-1860
blood vasculature4.21e-1860
vascular cord4.21e-1860
anatomical conduit5.18e-18241
vasculature1.18e-1779
vascular system1.18e-1779
circulatory system5.56e-17113
cardiovascular system2.92e-16110
trunk4.07e-15216
mesenchyme5.84e-15238
entire embryonic mesenchyme5.84e-15238
epithelium1.91e-14309
cell layer6.09e-14312
anatomical cluster1.35e-13286
abdominal segment of trunk2.47e-1361
abdomen2.47e-1361
abdomen element3.61e-1355
abdominal segment element3.61e-1355
tube5.17e-13194
compound organ3.13e-1269
artery1.38e-1142
arterial blood vessel1.38e-1142
arterial system1.38e-1142
immaterial anatomical entity1.08e-10126
gut epithelium2.96e-1054
multi-tissue structure4.49e-10347
systemic artery5.19e-1033
systemic arterial system5.19e-1033
subdivision of trunk8.01e-10113
body cavity precursor9.74e-1063
renal system3.09e-0945
multilaminar epithelium3.25e-0982
muscle tissue4.48e-0963
musculature4.48e-0963
musculature of body4.48e-0963
urinary system structure5.38e-0944
intermediate mesoderm6.05e-0937
skeletal muscle tissue9.68e-0961
striated muscle tissue9.68e-0961
myotome9.68e-0961
parenchyma1.20e-0817
urogenital ridge2.64e-0820
endothelium3.18e-0818
blood vessel endothelium3.18e-0818
cardiovascular system endothelium3.18e-0818
intraembryonic coelom3.59e-0821
nephron epithelium3.98e-0816
nephron3.98e-0816
uriniferous tubule3.98e-0816
metanephric mesenchyme3.98e-0816
nephrogenic mesenchyme3.98e-0816
excretory tube4.13e-0817
mesonephric epithelium4.13e-0817
mesonephric tubule4.13e-0817
nephric duct4.13e-0817
kidney epithelium4.13e-0817
renal duct4.13e-0817
mesonephric duct4.13e-0817
pronephric duct4.13e-0817
anatomical cavity5.10e-0870
trunk region element5.19e-08107
endo-epithelium5.19e-0882
immune organ6.56e-0826
mesonephros1.17e-0718
pronephros1.17e-0718
nephrogenic cord1.17e-0718
pronephric mesoderm1.17e-0718
rostral part of nephrogenic cord1.17e-0718
presumptive pronephric mesoderm1.17e-0718
epithelium of foregut-midgut junction1.31e-0725
anatomical boundary1.31e-0725
hepatobiliary system1.31e-0725
foregut-midgut junction1.31e-0725


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203346.77394172622320.0004748459821442640.00433879610928826
FOSL2#2355416.93020060456171.2165416097647e-050.00030330482020104
HDAC2#3066413.41562023662633.0859005065161e-050.00062616740431326
HEY1#2346244.040111043105710.00375304636917980.0185835582093101
HNF4A#3172423.13229036295373.48990320893214e-060.000115452011795269
HNF4G#3174428.75342252644681.46167379934821e-065.66230526447062e-05
HSF1#32974164.2906666666671.36534966436082e-091.22715794833201e-07
JUN#3725412.51282919233634.07770316866756e-050.000742582809472487
JUND#372746.994663941871030.000417684217818580.00391338674304788
NFKB1#479045.488063424193840.001102199566301980.0076751980600755
PPARGC1A#108914350.0511363636366.58479147384085e-117.28505335525915e-09
RXRA#6256420.07461713913336.1537798808435e-060.00018211805524948
SIN3A#2594245.408884726815140.001168172384885160.00795531792547084
SP1#666745.69838137814090.0009482606065333980.0068370997228679
TCF12#6938410.63446490218647.8163066689251e-050.00119977550293338
ZNF263#1012736.166381227758010.006539814347975980.0279670653790952



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.