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Coexpression cluster:C4099: Difference between revisions

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|ontology_enrichment_disease=DOID:0050687!2.82e-23!143;DOID:305!1.04e-14!106;DOID:162!1.71e-09!235;DOID:3095!4.76e-09!22;DOID:2994!4.76e-09!22;DOID:14566!6.70e-09!239
|ontology_enrichment_disease=DOID:0050687!2.82e-23!143;DOID:305!1.04e-14!106;DOID:162!1.71e-09!235;DOID:3095!4.76e-09!22;DOID:2994!4.76e-09!22;DOID:14566!6.70e-09!239
|ontology_enrichment_uberon=UBERON:0004119!7.53e-15!169;UBERON:0000925!7.53e-15!169;UBERON:0006595!7.53e-15!169;UBERON:0000468!6.01e-13!659;UBERON:0001007!1.45e-12!155;UBERON:0001555!1.45e-12!155;UBERON:0007026!1.45e-12!155;UBERON:0004921!2.67e-11!129;UBERON:0004185!2.67e-11!129;UBERON:0000077!4.80e-11!130;UBERON:0000466!2.42e-10!126;UBERON:0000062!1.85e-09!511;UBERON:0000922!3.15e-09!612;UBERON:0005177!1.90e-08!107;UBERON:0001041!2.27e-08!98;UBERON:0000467!4.43e-08!625;UBERON:0000481!6.19e-08!347;UBERON:0005409!8.07e-08!35;UBERON:0000480!8.36e-08!626;UBERON:0000064!8.98e-08!219;UBERON:0002050!1.65e-07!605;UBERON:0005423!1.65e-07!605;UBERON:0000160!2.37e-07!27;UBERON:0000464!2.52e-07!104;UBERON:0001048!2.97e-07!168;UBERON:0000923!3.10e-07!604;UBERON:0005291!3.10e-07!604;UBERON:0006598!3.10e-07!604;UBERON:0002532!3.10e-07!604
|ontology_enrichment_uberon=UBERON:0004119!7.53e-15!169;UBERON:0000925!7.53e-15!169;UBERON:0006595!7.53e-15!169;UBERON:0000468!6.01e-13!659;UBERON:0001007!1.45e-12!155;UBERON:0001555!1.45e-12!155;UBERON:0007026!1.45e-12!155;UBERON:0004921!2.67e-11!129;UBERON:0004185!2.67e-11!129;UBERON:0000077!4.80e-11!130;UBERON:0000466!2.42e-10!126;UBERON:0000062!1.85e-09!511;UBERON:0000922!3.15e-09!612;UBERON:0005177!1.90e-08!107;UBERON:0001041!2.27e-08!98;UBERON:0000467!4.43e-08!625;UBERON:0000481!6.19e-08!347;UBERON:0005409!8.07e-08!35;UBERON:0000480!8.36e-08!626;UBERON:0000064!8.98e-08!219;UBERON:0002050!1.65e-07!605;UBERON:0005423!1.65e-07!605;UBERON:0000160!2.37e-07!27;UBERON:0000464!2.52e-07!104;UBERON:0001048!2.97e-07!168;UBERON:0000923!3.10e-07!604;UBERON:0005291!3.10e-07!604;UBERON:0006598!3.10e-07!604;UBERON:0002532!3.10e-07!604
|tf_chipseq_enrich=TAF7#6879;3:11.4330694049239:0.000669018198194583:0.00544086525473011
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}}
}}

Revision as of 11:49, 5 September 2012


Full id: C4099_malignant_Reticulocytes_rectal_neuroblastoma_choriocarcinoma_small_hepatocellular



Phase1 CAGE Peaks

Hg19::chr22:38201228..38201242,+p1@H1F0
Hg19::chr22:38201615..38201680,-p@chr22:38201615..38201680
-
Hg19::chr22:38201945..38202027,-p@chr22:38201945..38202027
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell2.07e-14254
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure7.53e-15169
endoderm7.53e-15169
presumptive endoderm7.53e-15169
multi-cellular organism6.01e-13659
digestive system1.45e-12155
digestive tract1.45e-12155
primitive gut1.45e-12155
subdivision of digestive tract2.67e-11129
endodermal part of digestive tract2.67e-11129
mixed endoderm/mesoderm-derived structure4.80e-11130
immaterial anatomical entity2.42e-10126
organ1.85e-09511
embryo3.15e-09612
trunk region element1.90e-08107
foregut2.27e-0898
anatomical system4.43e-08625
multi-tissue structure6.19e-08347
gastrointestinal system8.07e-0835
anatomical group8.36e-08626
organ part8.98e-08219
embryonic structure1.65e-07605
developing anatomical structure1.65e-07605
intestine2.37e-0727
anatomical space2.52e-07104
primordium2.97e-07168
germ layer3.10e-07604
embryonic tissue3.10e-07604
presumptive structure3.10e-07604
epiblast (generic)3.10e-07604
Disease
Ontology termp-valuen
cell type cancer2.82e-23143
carcinoma1.04e-14106
cancer1.71e-09235
germ cell and embryonal cancer4.76e-0922
germ cell cancer4.76e-0922
disease of cellular proliferation6.70e-09239


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
TAF7#6879311.43306940492390.0006690181981945830.00544086525473011



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.