Coexpression cluster:C648

Full id: C648_caudate_corpus_diencephalon_medulla_occipital_nucleus_thalamus

Phase1 CAGE Peaks

Hg19::chr10:1588921..1588932,+	p@chr10:1588921..1588932 +
Hg19::chr10:73479518..73479527,-	p5@C10orf105
Hg19::chr10:97236225..97236232,-	p@chr10:97236225..97236232 -
Hg19::chr14:33926303..33926307,-	p@chr14:33926303..33926307 -
Hg19::chr14:36462819..36462832,+	p@chr14:36462819..36462832 +
Hg19::chr14:36462843..36462863,+	p@chr14:36462843..36462863 +
Hg19::chr17:72823919..72823924,-	p@chr17:72823919..72823924 -
Hg19::chr18:24521807..24521809,+	p@chr18:24521807..24521809 +
Hg19::chr2:115219219..115219230,+	p7@DPP10
Hg19::chr2:232548018..232548022,-	p@chr2:232548018..232548022 -
Hg19::chr5:60927228..60927236,-	p3@BC032909 p3@BC032910
Hg19::chr9:87605893..87605904,+	p@chr9:87605893..87605904 +
Hg19::chr9:87655746..87655753,-	p@chr9:87655746..87655753 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004274	dipeptidyl-peptidase IV activity	0.0041014168530947
GO:0016806	dipeptidyl-peptidase and tripeptidyl-peptidase activity	0.0041014168530947
GO:0008239	dipeptidyl-peptidase activity	0.0041014168530947
GO:0008238	exopeptidase activity	0.0302749322971859
GO:0008236	serine-type peptidase activity	0.0406903724635975
GO:0017171	serine hydrolase activity	0.0406903724635975

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
neural tube	8.77e-113	57
neural rod	8.77e-113	57
future spinal cord	8.77e-113	57
neural keel	8.77e-113	57
regional part of brain	4.49e-95	59
central nervous system	7.61e-94	82
regional part of forebrain	5.20e-91	41
forebrain	5.20e-91	41
future forebrain	5.20e-91	41
brain	2.46e-89	69
future brain	2.46e-89	69
anterior neural tube	1.25e-88	42
neural plate	5.52e-86	86
presumptive neural plate	5.52e-86	86
regional part of nervous system	3.69e-82	94
nervous system	3.69e-82	94
neurectoderm	1.47e-81	90
telencephalon	9.64e-74	34
gray matter	4.28e-73	34
brain grey matter	4.28e-73	34
regional part of telencephalon	4.75e-71	33
cerebral hemisphere	2.03e-68	32
pre-chordal neural plate	2.46e-67	61
adult organism	3.14e-57	115
anterior region of body	3.91e-54	129
craniocervical region	3.91e-54	129
head	4.96e-51	123
cerebral cortex	1.71e-50	25
pallium	1.71e-50	25
regional part of cerebral cortex	1.41e-48	22
neocortex	2.78e-43	20
ectoderm-derived structure	4.39e-43	169
ectoderm	9.24e-42	173
presumptive ectoderm	9.24e-42	173
tube	2.32e-26	194
basal ganglion	4.38e-24	9
nuclear complex of neuraxis	4.38e-24	9
aggregate regional part of brain	4.38e-24	9
collection of basal ganglia	4.38e-24	9
cerebral subcortex	4.38e-24	9
posterior neural tube	5.96e-24	15
chordal neural plate	5.96e-24	15
nucleus of brain	9.30e-24	9
neural nucleus	9.30e-24	9
telencephalic nucleus	4.40e-19	7
epithelium	8.86e-19	309
anatomical conduit	1.39e-18	241
cell layer	1.87e-18	312
diencephalon	4.22e-18	7
future diencephalon	4.22e-18	7
segmental subdivision of hindbrain	4.89e-17	12
hindbrain	4.89e-17	12
presumptive hindbrain	4.89e-17	12
anatomical cluster	6.19e-17	286
brainstem	1.41e-16	8
gyrus	2.47e-16	6
temporal lobe	2.52e-16	7
segmental subdivision of nervous system	1.40e-15	13
limbic system	1.06e-14	5
organism subdivision	1.92e-14	365
organ part	4.19e-14	219
parietal lobe	9.28e-14	5
corpus striatum	5.89e-12	4
striatum	5.89e-12	4
ventral part of telencephalon	5.89e-12	4
future corpus striatum	5.89e-12	4
gland of diencephalon	3.00e-10	4
neuroendocrine gland	3.00e-10	4
regional part of metencephalon	4.32e-10	9
metencephalon	4.32e-10	9
future metencephalon	4.32e-10	9
medulla oblongata	1.41e-09	3
myelencephalon	1.41e-09	3
future myelencephalon	1.41e-09	3
occipital lobe	2.92e-09	5
caudate-putamen	3.07e-09	3
dorsal striatum	3.07e-09	3
spinal cord	5.01e-09	3
middle temporal gyrus	6.05e-09	3
pons	7.50e-09	3
brainstem nucleus	8.81e-09	3
organ	1.11e-08	511
multi-tissue structure	1.72e-08	347
Ammon's horn	5.80e-07	2
lobe parts of cerebral cortex	5.80e-07	2
hippocampal formation	5.80e-07	2
limbic lobe	5.80e-07	2
caudate nucleus	6.31e-07	2
future caudate nucleus	6.31e-07	2
dorsal plus ventral thalamus	7.91e-07	2

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.