Coexpression cluster:C2423

Full id: C2423_small_signet_papillotubular_malignant_hepatocellular_maxillary_colon

Phase1 CAGE Peaks

Hg19::chr17:56494853..56494874,-	p3@RNF43
Hg19::chr17:56494882..56494902,-	p1@RNF43
Hg19::chr17:56494908..56494949,-	p2@RNF43
Hg19::chr17:56494950..56494961,-	p6@RNF43

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell	4.37e-22	254
endodermal cell	8.34e-19	59
endo-epithelial cell	3.92e-15	43
epithelial cell of alimentary canal	1.67e-09	21
respiratory epithelial cell	2.61e-07	13

Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	4.26e-26	169
endoderm	4.26e-26	169
presumptive endoderm	4.26e-26	169
digestive system	1.02e-21	155
digestive tract	1.02e-21	155
primitive gut	1.02e-21	155
subdivision of digestive tract	5.01e-21	129
endodermal part of digestive tract	5.01e-21	129
adult organism	7.39e-21	115
mixed endoderm/mesoderm-derived structure	7.40e-19	130
foregut	1.05e-15	98
respiratory system	3.64e-15	72
endo-epithelium	8.89e-15	82
organ part	1.97e-13	219
multi-tissue structure	3.36e-13	347
respiratory tract	1.11e-12	53
organ	5.12e-12	511
primordium	3.65e-10	168
trunk region element	3.70e-10	107
immaterial anatomical entity	6.51e-10	126
organ segment	7.28e-10	97
respiratory primordium	1.04e-09	38
endoderm of foregut	1.04e-09	38
neural tube	1.46e-09	57
neural rod	1.46e-09	57
future spinal cord	1.46e-09	57
neural keel	1.46e-09	57
segment of respiratory tract	1.91e-09	46
anterior region of body	1.96e-09	129
craniocervical region	1.96e-09	129
gland	3.39e-09	59
head	1.36e-08	123
exocrine gland	3.24e-08	31
exocrine system	3.24e-08	31
anatomical conduit	3.69e-08	241
epithelial bud	5.29e-08	37
ectoderm-derived structure	5.74e-08	169
gut epithelium	6.80e-08	54
subdivision of trunk	8.38e-08	113
ectoderm	1.78e-07	173
presumptive ectoderm	1.78e-07	173
thoracic cavity element	1.88e-07	34
thoracic cavity	1.88e-07	34
epithelial fold	2.38e-07	51
regional part of brain	2.54e-07	59
organism subdivision	2.92e-07	365
anatomical cluster	3.65e-07	286
neural plate	3.91e-07	86
presumptive neural plate	3.91e-07	86
anatomical space	4.24e-07	104
lung	5.68e-07	22
respiratory tube	5.68e-07	22
respiration organ	5.68e-07	22
pair of lungs	5.68e-07	22
lung primordium	5.68e-07	22
lung bud	5.68e-07	22
thoracic segment organ	5.82e-07	35

Disease

Ontology term	p-value	n
carcinoma	3.02e-24	106
cell type cancer	5.79e-16	143
squamous cell carcinoma	9.61e-09	14
cancer	1.58e-08	235
disease of cellular proliferation	1.17e-07	239
adenocarcinoma	1.69e-07	25

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.