UBERON:0000059

Name:	large intestine
Namespace:	FANTOM
Definition:	"The large intestine consists of the cecum and colon[WP]. Organ with organ cavity which is continuous proximally with the small intestine and distally with the anal canal.[FMA]." [FMA:7201, Wikipedia:Large_intestine_(anatomy)]
Xrefs:	Expandlinks: AAO:0010396 BTO:0000706 EFO:0000840 EMAPA:19252 EV:0100077 FMA:7201 GAID:306 galen:LargeIntestine MA:0000333 MESH:A.03.492.411.495 MIAA:0000046 ncithesaurus:Large_Intestine OpenCyc:Mx4rvVkF5pwpEbGdrcN5Y29ycA SCTID:181254001 VHOG:0000054 XAO:0000131
Synonyms:	"intestinum crassum" RELATED [BTO:0000706]
Subset:	major_organ organ_slim

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

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Parents

is_a:	UBERON:0004921(subdivision of digestive tract),UBERON:0013765(digestive system element)
part_of:	UBERON:0000160(intestine),UBERON:0004907(lower digestive tract)

Children

part of:	UBERON:0001052 (rectum),UBERON:0001153 (caecum),UBERON:0001155 (colon),CL:0002253 (epithelial cell of large intestine),CL:1000279 (smooth muscle cell of large intestine)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

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Human (Homo sapiens)

• 10014-101C5 (colon, adult, pool1)
• 10067-101I4 (rectum, fetal, donor1)
• 10070-101I7 (colon, fetal, donor1)
• 10082-102B1 (colon, adult, donor1)
• 10189-103D9 (appendix, adult)
• 10208-103G1
• 10420-106C6 (colon carcinoma cell line:COLO-320)
• 10469-106I1 (rectal cancer cell line:TT1TKB)
• 10511-107D7
• 10513-107D9 (colon carcinoma cell line:CACO-2)

... further results Mouse (Mus musculus)

• 10014-101C5 (colon, adult, pool1)
• 10067-101I4 (rectum, fetal, donor1)
• 10070-101I7 (colon, fetal, donor1)
• 10082-102B1 (colon, adult, donor1)
• 10189-103D9 (appendix, adult)
• 10208-103G1
• 10420-106C6 (colon carcinoma cell line:COLO-320)
• 10469-106I1 (rectal cancer cell line:TT1TKB)
• 10511-107D7
• 10513-107D9 (colon carcinoma cell line:CACO-2)

... further results

Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0000059 (large intestine), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

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P-value	FFCP	Short description

P-value	FFCP	Short description
1.93e-89	FFCP PHASE2:Hg19::chr11:114430570..114430581,-	p2@FAM55A
1.93e-89	FFCP PHASE1:Hg19::chr11:114430570..114430581,-	p2@FAM55A
1.93e-89	FFCP PHASE2:Hg19::chr7:100612647..100612650,+	p8@MUC12
1.93e-89	FFCP PHASE2:Hg19::chr2:200333534..200333558,+	p1@ENST00000446911
1.93e-89	FFCP PHASE1:Hg19::chr7:100612647..100612650,+	p8@MUC12
1.93e-89	FFCP PHASE1:Hg19::chr2:200333534..200333558,+	p1@ENST00000446911
8.79e-75	FFCP PHASE2:Hg19::chr11:114522262..114522267,-	p@chr11:114522262..114522267, -
8.79e-75	FFCP PHASE1:Hg19::chr11:114522262..114522267,-	p@chr11:114522262..114522267, -
6.65e-72	FFCP PHASE2:Hg19::chr11:60260248..60260251,+	p1@MS4A12
6.65e-72	FFCP PHASE2:Hg19::chr2:200329672..200329678,-	p50@SATB2
6.65e-72	FFCP PHASE2:Hg19::chr4:150822397..150822409,-	p@chr4:150822397..150822409, -
6.65e-72	FFCP PHASE1:Hg19::chr13:28541477..28541493,-	p6@CDX2
6.65e-72	FFCP PHASE1:Hg19::chr2:200329672..200329678,-	p50@SATB2
6.65e-72	FFCP PHASE1:Hg19::chr4:150822397..150822409,-	p@chr4:150822397..150822409, -
6.65e-72	FFCP PHASE1:Hg19::chr11:60260248..60260251,+	p1@MS4A12
6.65e-72	FFCP PHASE2:Hg19::chr13:28541477..28541493,-	p6@CDX2
1.86e-64	FFCP PHASE1:Hg19::chr17:46716676..46716698,-	p1@ENST00000438772
1.86e-64	FFCP PHASE2:Hg19::chr17:46716676..46716698,-	p1@ENST00000438772
2.63e-64	FFCP PHASE2:Hg19::chr8:86253920..86253944,-	p2@CA1
2.63e-64	FFCP PHASE1:Hg19::chr8:86253920..86253944,-	p2@CA1
2.63e-64	FFCP PHASE2:Hg19::chr7:100612686..100612700,+	p3@MUC12
2.63e-64	FFCP PHASE1:Hg19::chr7:100612686..100612700,+	p3@MUC12
2.99e-64	FFCP PHASE2:Hg19::chr7:100612141..100612155,-	p@chr7:100612141..100612155, -
2.99e-64	FFCP PHASE1:Hg19::chr7:100612141..100612155,-	p@chr7:100612141..100612155, -
3.21e-64	FFCP PHASE2:Hg19::chr1:167059763..167059776,-	p4@GPA33
3.21e-64	FFCP PHASE1:Hg19::chr1:167059763..167059776,-	p4@GPA33
5.05e-64	FFCP PHASE1:Hg19::chr3:108476254..108476257,-	p1@RETNLB
5.05e-64	FFCP PHASE2:Hg19::chr3:108476254..108476257,-	p1@RETNLB
6.55e-64	FFCP PHASE1:Hg19::chr6:168479694..168479708,-	p3@FRMD1
6.55e-64	FFCP PHASE2:Hg19::chr6:168479694..168479708,-	p3@FRMD1
1.57e-58	FFCP PHASE1:Hg19::chr2:128293323..128293332,+	p4@MYO7B
1.57e-58	FFCP PHASE2:Hg19::chr2:128293323..128293332,+	p4@MYO7B
2.84e-58	FFCP PHASE2:Hg19::chr13:28543409..28543420,-	p8@CDX2
2.84e-58	FFCP PHASE1:Hg19::chr13:28543409..28543420,-	p8@CDX2
2.85e-58	FFCP PHASE1:Hg19::chr4:120243266..120243277,-	p2@FABP2
2.85e-58	FFCP PHASE2:Hg19::chr4:120243266..120243277,-	p2@FABP2
8.62e-58	FFCP PHASE1:Hg19::chr16:67463701..67463709,+	p@chr16:67463701..67463709, +
8.62e-58	FFCP PHASE2:Hg19::chr16:67463701..67463709,+	p@chr16:67463701..67463709, +
1.15e-57	FFCP PHASE1:Hg19::chr6:168479679..168479688,-	p6@FRMD1
1.15e-57	FFCP PHASE1:Hg19::chr16:25228264..25228273,+	p1@AQP8
1.15e-57	FFCP PHASE2:Hg19::chr16:25228264..25228273,+	p1@AQP8
1.15e-57	FFCP PHASE2:Hg19::chr6:168479679..168479688,-	p6@FRMD1
1.34e-57	FFCP PHASE2:Hg19::chr17:26800296..26800314,+	p4@SLC13A2
1.34e-57	FFCP PHASE1:Hg19::chr17:26800296..26800314,+	p4@SLC13A2
1.55e-57	FFCP PHASE1:Hg19::chr21:44151910..44151921,+	p7@PDE9A
1.55e-57	FFCP PHASE2:Hg19::chr21:44151910..44151921,+	p7@PDE9A
1.91e-56	FFCP PHASE2:Hg19::chr11:114430588..114430608,-	p1@FAM55A
1.91e-56	FFCP PHASE1:Hg19::chr11:114430588..114430608,-	p1@FAM55A
3.01e-56	FFCP PHASE2:Hg19::chr11:114466397..114466426,-	p2@FAM55D
3.01e-56	FFCP PHASE1:Hg19::chr11:114466397..114466426,-	p2@FAM55D
2.16e-54	FFCP PHASE1:Hg19::chr15:45950466..45950474,+	p@chr15:45950466..45950474, +
2.16e-54	FFCP PHASE2:Hg19::chr1:38201159..38201166,-	p@chr1:38201159..38201166, -
2.16e-54	FFCP PHASE1:Hg19::chr1:38201159..38201166,-	p@chr1:38201159..38201166, -
2.16e-54	FFCP PHASE2:Hg19::chr15:45950466..45950474,+	p@chr15:45950466..45950474, +
5.44e-54	FFCP PHASE1:Hg19::chr10:101292731..101292741,+	p2@NKX2-3
5.44e-54	FFCP PHASE2:Hg19::chr10:101292731..101292741,+	p2@NKX2-3
5.49e-54	FFCP PHASE2:Hg19::chr3:150966718..150966738,-	p9@P2RY14
5.49e-54	FFCP PHASE1:Hg19::chr3:150966718..150966738,-	p9@P2RY14
2.22e-52	FFCP PHASE1:Hg19::chr13:28543388..28543406,-	p3@CDX2
2.22e-52	FFCP PHASE2:Hg19::chr13:28543388..28543406,-	p3@CDX2
2.2e-51	FFCP PHASE1:Hg19::chr11:69294647..69294668,-	p1@ENST00000542064
2.2e-51	FFCP PHASE2:Hg19::chr11:69294647..69294668,-	p1@ENST00000542064
1.86e-50	FFCP PHASE2:Hg19::chr13:28543253..28543276,-	p5@CDX2
1.86e-50	FFCP PHASE1:Hg19::chr13:28543253..28543276,-	p5@CDX2
4.97e-50	FFCP PHASE2:Hg19::chrX:100129340..100129353,-	p2@NOX1
4.97e-50	FFCP PHASE1:Hg19::chrX:100129340..100129353,-	p2@NOX1
6.89e-50	FFCP PHASE1:Hg19::chr4:2038275..2038288,+	p@chr4:2038275..2038288, +
6.89e-50	FFCP PHASE2:Hg19::chr4:2038275..2038288,+	p@chr4:2038275..2038288, +
8.44e-50	FFCP PHASE1:Hg19::chr9:22113541..22113546,+	p3@CDKN2B-AS
8.44e-50	FFCP PHASE2:Hg19::chr9:22113541..22113546,+	p3@CDKN2B-AS
1.62e-49	FFCP PHASE2:Hg19::chrX:65382664..65382675,+	p8@HEPH
1.62e-49	FFCP PHASE1:Hg19::chrX:65382664..65382675,+	p8@HEPH
1.89e-49	FFCP PHASE2:Hg19::chr5:180415839..180415851,+	p2@BTNL3
1.89e-49	FFCP PHASE1:Hg19::chr5:180415839..180415851,+	p2@BTNL3
5.62e-49	FFCP PHASE1:Hg19::chr17:48844868..48844891,-	p1@LINC00483
5.62e-49	FFCP PHASE2:Hg19::chr17:48844868..48844891,-	p1@LINC00483
2.86e-48	FFCP PHASE1:Hg19::chr16:29748234..29748245,-	p@chr16:29748234..29748245, -
2.86e-48	FFCP PHASE2:Hg19::chr16:29748234..29748245,-	p@chr16:29748234..29748245, -
3.24e-48	FFCP PHASE2:Hg19::chr1:155912696..155912738,-	p@chr1:155912696..155912738, -
3.24e-48	FFCP PHASE1:Hg19::chr1:155912696..155912738,-	p@chr1:155912696..155912738, -
4.13e-48	FFCP PHASE1:Hg19::chr21:44151895..44151908,+	p6@PDE9A
4.13e-48	FFCP PHASE2:Hg19::chr21:44151895..44151908,+	p6@PDE9A
1.96e-46	FFCP PHASE2:Hg19::chrX:100129320..100129329,-	p3@NOX1
1.96e-46	FFCP PHASE1:Hg19::chrX:100129320..100129329,-	p3@NOX1
2.21e-46	FFCP PHASE1:Hg19::chr17:48844903..48844922,-	p2@LINC00483
2.21e-46	FFCP PHASE2:Hg19::chr17:48844903..48844922,-	p2@LINC00483
5.02e-46	FFCP PHASE1:Hg19::chrX:65382622..65382653,+	p3@HEPH
5.02e-46	FFCP PHASE2:Hg19::chrX:65382622..65382653,+	p3@HEPH
1.1e-45	FFCP PHASE2:Hg19::chr5:180326145..180326166,+	p1@BTNL8
1.1e-45	FFCP PHASE1:Hg19::chr5:180326145..180326166,+	p1@BTNL8
3.4e-45	FFCP PHASE1:Hg19::chr16:1275258..1275289,-	p1@TPSG1
3.4e-45	FFCP PHASE2:Hg19::chr16:1275258..1275289,-	p1@TPSG1
4.08e-45	FFCP PHASE1:Hg19::chr16:29789573..29789606,+	p1@ZG16
4.08e-45	FFCP PHASE2:Hg19::chr16:29789573..29789606,+	p1@ZG16
4.9e-45	FFCP PHASE1:Hg19::chr14:103389369..103389380,+	p3@AMN
4.9e-45	FFCP PHASE2:Hg19::chr14:103389369..103389380,+	p3@AMN
6.44e-45	FFCP PHASE2:Hg19::chr1:167059674..167059697,-	p3@GPA33
6.44e-45	FFCP PHASE1:Hg19::chr1:167059674..167059697,-	p3@GPA33
4.52e-44	FFCP PHASE2:Mm9::chr14:93595014..93595015,-	p@chr14:93595014..93595015, -
4.52e-44	FFCP PHASE1:Mm9::chr18:44716456..44716461,+	p@chr18:44716456..44716461, +

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