MCL coexpression mm9:314
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0016757 | transferase activity, transferring glycosyl groups | 0.0011194633290528 |
| GO:0008375 | acetylglucosaminyltransferase activity | 0.0011194633290528 |
| GO:0008194 | UDP-glycosyltransferase activity | 0.00565137585170196 |
| GO:0005794 | Golgi apparatus | 0.00565137585170196 |
| GO:0016758 | transferase activity, transferring hexosyl groups | 0.00673005426702396 |
| GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity | 0.00673005426702396 |
| GO:0003829 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity | 0.00673005426702396 |
| GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity | 0.00706578264803484 |
| GO:0042910 | xenobiotic transporter activity | 0.00706578264803484 |
| GO:0008559 | xenobiotic-transporting ATPase activity | 0.00706578264803484 |
| GO:0015239 | multidrug transporter activity | 0.0085636465461218 |
| GO:0046581 | intercellular canaliculus | 0.0137330008805963 |
| GO:0016021 | integral to membrane | 0.017698505694749 |
| GO:0031224 | intrinsic to membrane | 0.017698505694749 |
| GO:0015893 | drug transport | 0.0193728996622652 |
| GO:0006493 | protein amino acid O-linked glycosylation | 0.0193728996622652 |
| GO:0015238 | drug transporter activity | 0.0193728996622652 |
| GO:0044425 | membrane part | 0.0206057324480722 |
| GO:0016740 | transferase activity | 0.0328944759667272 |
| GO:0042493 | response to drug | 0.0352245386378794 |
| GO:0016020 | membrane | 0.0417803696323778 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| intestinal epithelial cell | 1.04e-12 | 9 |
| epithelial cell of alimentary canal | 1.04e-12 | 9 |
| brush border epithelial cell | 5.16e-09 | 6 |
| gut absorptive cell | 5.16e-09 | 6 |
| absorptive cell | 5.16e-09 | 6 |
| enterocyte | 5.16e-09 | 6 |
| columnar/cuboidal epithelial cell | 1.32e-07 | 7 |
| endo-epithelial cell | 7.04e-07 | 15 |
| Ontology term | p-value | n |
|---|---|---|
| gastrointestinal system | 4.16e-42 | 47 |
| intestine | 2.62e-41 | 31 |
| mucosa | 4.42e-22 | 15 |
| intestinal mucosa | 4.86e-19 | 13 |
| anatomical wall | 4.86e-19 | 13 |
| wall of intestine | 4.86e-19 | 13 |
| gastrointestinal system mucosa | 4.86e-19 | 13 |
| digestive system | 6.55e-13 | 116 |
| digestive tract | 6.55e-13 | 116 |
| primitive gut | 6.55e-13 | 116 |
| epithelium of mucosa | 1.04e-12 | 9 |
| gastrointestinal system epithelium | 1.04e-12 | 9 |
| intestinal epithelium | 1.04e-12 | 9 |
| endoderm-derived structure | 1.63e-12 | 118 |
| endoderm | 1.63e-12 | 118 |
| presumptive endoderm | 1.63e-12 | 118 |
| organ component layer | 3.06e-12 | 24 |
| subdivision of digestive tract | 2.65e-11 | 114 |
| simple columnar epithelium | 4.75e-10 | 11 |
| small intestine | 5.90e-08 | 4 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 7.92629e-06 |
| MA0004.1 | 0.377695 |
| MA0006.1 | 0.0416362 |
| MA0007.1 | 0.356106 |
| MA0009.1 | 0.438777 |
| MA0014.1 | 0.000494543 |
| MA0017.1 | 0.190692 |
| MA0019.1 | 0.790934 |
| MA0024.1 | 0.401898 |
| MA0025.1 | 0.645374 |
| MA0027.1 | 2.02409 |
| MA0028.1 | 0.0452573 |
| MA0029.1 | 0.383872 |
| MA0030.1 | 0.389298 |
| MA0031.1 | 0.360121 |
| MA0038.1 | 0.209603 |
| MA0040.1 | 0.449452 |
| MA0041.1 | 0.0795363 |
| MA0042.1 | 0.0734808 |
| MA0043.1 | 0.522621 |
| MA0046.1 | 2.05979 |
| MA0048.1 | 0.0033318 |
| MA0050.1 | 0.435264 |
| MA0051.1 | 1.16012 |
| MA0052.1 | 1.15587 |
| MA0055.1 | 0.065572 |
| MA0056.1 | 0 |
| MA0057.1 | 0.12338 |
| MA0058.1 | 0.24722 |
| MA0059.1 | 0.0759876 |
| MA0060.1 | 0.085477 |
| MA0061.1 | 0.0263971 |
| MA0063.1 | 0 |
| MA0066.1 | 0.20204 |
| MA0067.1 | 0.748059 |
| MA0068.1 | 0.246947 |
| MA0069.1 | 0.456647 |
| MA0070.1 | 0.448343 |
| MA0071.1 | 0.433998 |
| MA0072.1 | 1.12297 |
| MA0073.1 | 0.000352331 |
| MA0074.1 | 0.178027 |
| MA0076.1 | 0.0586682 |
| MA0077.1 | 0.422739 |
| MA0078.1 | 0.672666 |
| MA0081.1 | 1.02579 |
| MA0083.1 | 0.521922 |
| MA0084.1 | 1.0607 |
| MA0087.1 | 0.484199 |
| MA0088.1 | 0.062577 |
| MA0089.1 | 0 |
| MA0090.1 | 0.674294 |
| MA0091.1 | 0.396925 |
| MA0092.1 | 0.100239 |
| MA0093.1 | 0.181765 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.508591 |
| MA0101.1 | 0.0801429 |
| MA0103.1 | 0.447794 |
| MA0105.1 | 0.105475 |
| MA0106.1 | 0.244965 |
| MA0107.1 | 0.0529506 |
| MA0108.2 | 0.308463 |
| MA0109.1 | 0 |
| MA0111.1 | 1.71244 |
| MA0113.1 | 0.224694 |
| MA0114.1 | 0.793821 |
| MA0115.1 | 0.525089 |
| MA0116.1 | 0.161005 |
| MA0117.1 | 0.496768 |
| MA0119.1 | 0.579392 |
| MA0122.1 | 0.514153 |
| MA0124.1 | 0.698593 |
| MA0125.1 | 0.630583 |
| MA0130.1 | 0 |
| MA0131.1 | 0.287321 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.554905 |
| MA0136.1 | 0.191208 |
| MA0139.1 | 0.165104 |
| MA0140.1 | 0.50841 |
| MA0141.1 | 0.491507 |
| MA0142.1 | 0.34839 |
| MA0143.1 | 0.236381 |
| MA0144.1 | 2.06957 |
| MA0145.1 | 0.150193 |
| MA0146.1 | 0.0981829 |
| MA0147.1 | 0.123349 |
| MA0148.1 | 1.30031 |
| MA0149.1 | 0.0827548 |
| MA0062.2 | 0.00745981 |
| MA0035.2 | 0.515842 |
| MA0039.2 | 0.000757165 |
| MA0138.2 | 0.281269 |
| MA0002.2 | 0.169578 |
| MA0137.2 | 1.76689 |
| MA0104.2 | 0.0744814 |
| MA0047.2 | 1.13392 |
| MA0112.2 | 0.414515 |
| MA0065.2 | 0.151106 |
| MA0150.1 | 0.110236 |
| MA0151.1 | 0 |
| MA0152.1 | 0.209147 |
| MA0153.1 | 0.569763 |
| MA0154.1 | 1.20003 |
| MA0155.1 | 0.491393 |
| MA0156.1 | 0.212038 |
| MA0157.1 | 0.322822 |
| MA0158.1 | 0 |
| MA0159.1 | 0.313465 |
| MA0160.1 | 0.807296 |
| MA0161.1 | 0 |
| MA0162.1 | 0.000333298 |
| MA0163.1 | 0.000236511 |
| MA0164.1 | 0.191451 |
| MA0080.2 | 1.16684 |
| MA0018.2 | 0.197998 |
| MA0099.2 | 0.276491 |
| MA0079.2 | 3.47252e-09 |
| MA0102.2 | 1.11159 |
| MA0258.1 | 0.7371 |
| MA0259.1 | 0.273672 |
| MA0442.1 | 0 |
