MCL coexpression mm9:249
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0043565 | sequence-specific DNA binding | 4.66219642927358e-10 |
GO:0003700 | transcription factor activity | 3.58983629733356e-08 |
GO:0006355 | regulation of transcription, DNA-dependent | 8.15457988534263e-06 |
GO:0006351 | transcription, DNA-dependent | 8.15457988534263e-06 |
GO:0032774 | RNA biosynthetic process | 8.15457988534263e-06 |
GO:0003677 | DNA binding | 8.15457988534263e-06 |
GO:0045449 | regulation of transcription | 8.15457988534263e-06 |
GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 8.17833195692428e-06 |
GO:0006350 | transcription | 8.17833195692428e-06 |
GO:0010468 | regulation of gene expression | 9.52377099101757e-06 |
GO:0031323 | regulation of cellular metabolic process | 1.18398879549564e-05 |
GO:0019222 | regulation of metabolic process | 1.35026510106574e-05 |
GO:0005667 | transcription factor complex | 1.35026510106574e-05 |
GO:0016070 | RNA metabolic process | 1.51097115166252e-05 |
GO:0044451 | nucleoplasm part | 3.49430956486395e-05 |
GO:0007389 | pattern specification process | 3.87818823351528e-05 |
GO:0005654 | nucleoplasm | 3.87818823351528e-05 |
GO:0010467 | gene expression | 4.71955645572212e-05 |
GO:0003676 | nucleic acid binding | 5.37328013617935e-05 |
GO:0031981 | nuclear lumen | 7.65794779702869e-05 |
GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 8.64219204453706e-05 |
GO:0031974 | membrane-enclosed lumen | 0.000119410850917134 |
GO:0043233 | organelle lumen | 0.000119410850917134 |
GO:0050794 | regulation of cellular process | 0.000128489435236984 |
GO:0007275 | multicellular organismal development | 0.000128489435236984 |
GO:0050789 | regulation of biological process | 0.000271072154718551 |
GO:0048731 | system development | 0.000362869330720921 |
GO:0044428 | nuclear part | 0.000385792860398734 |
GO:0009887 | organ morphogenesis | 0.000438275391251869 |
GO:0065007 | biological regulation | 0.000489557220292832 |
GO:0005634 | nucleus | 0.000553179326799751 |
GO:0032502 | developmental process | 0.000610335707727658 |
GO:0009653 | anatomical structure morphogenesis | 0.000610335707727658 |
GO:0043283 | biopolymer metabolic process | 0.000634737226865075 |
GO:0048856 | anatomical structure development | 0.000666403870768045 |
GO:0001764 | neuron migration | 0.00138249730469124 |
GO:0043234 | protein complex | 0.00268018557224522 |
GO:0043170 | macromolecule metabolic process | 0.00430030132281161 |
GO:0032501 | multicellular organismal process | 0.00462409006547361 |
GO:0032991 | macromolecular complex | 0.00713615806975326 |
GO:0048665 | neuron fate specification | 0.00840996362120453 |
GO:0016048 | detection of temperature stimulus | 0.00984924320142664 |
GO:0044238 | primary metabolic process | 0.0107087141513915 |
GO:0044237 | cellular metabolic process | 0.0107487238965365 |
GO:0043231 | intracellular membrane-bound organelle | 0.010792233213583 |
GO:0043227 | membrane-bound organelle | 0.010792233213583 |
GO:0048513 | organ development | 0.0108488712215354 |
GO:0044446 | intracellular organelle part | 0.0117221798027382 |
GO:0044422 | organelle part | 0.0117221798027382 |
GO:0045665 | negative regulation of neuron differentiation | 0.0220079944178839 |
GO:0016477 | cell migration | 0.0228919786313328 |
GO:0030182 | neuron differentiation | 0.0230886866595075 |
GO:0005184 | neuropeptide hormone activity | 0.0241807241083434 |
GO:0007585 | respiratory gaseous exchange | 0.0241807241083434 |
GO:0048663 | neuron fate commitment | 0.0257588656760298 |
GO:0009593 | detection of chemical stimulus | 0.0257588656760298 |
GO:0048699 | generation of neurons | 0.0269494900472055 |
GO:0001708 | cell fate specification | 0.0270170432208276 |
GO:0051674 | localization of cell | 0.0270170432208276 |
GO:0006928 | cell motility | 0.0270170432208276 |
GO:0022008 | neurogenesis | 0.0288057512136958 |
GO:0045664 | regulation of neuron differentiation | 0.0298693434670383 |
GO:0043229 | intracellular organelle | 0.0337707392262282 |
GO:0043226 | organelle | 0.0337707392262282 |
GO:0009582 | detection of abiotic stimulus | 0.0462354691560304 |
GO:0009266 | response to temperature stimulus | 0.0475812774093105 |
GO:0009581 | detection of external stimulus | 0.0488849198894495 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
cavitated compound organ | 3.57e-17 | 21 |
kidney | 1.29e-10 | 14 |
kidney mesenchyme | 1.29e-10 | 14 |
upper urinary tract | 1.29e-10 | 14 |
kidney rudiment | 1.29e-10 | 14 |
kidney field | 1.29e-10 | 14 |
spinal cord | 1.34e-09 | 6 |
dorsal region element | 1.34e-09 | 6 |
dorsum | 1.34e-09 | 6 |
adrenal gland | 1.43e-08 | 7 |
adrenal/interrenal gland | 1.43e-08 | 7 |
regional part of spinal cord | 2.68e-08 | 5 |
gray matter of spinal cord | 2.68e-08 | 5 |
urinary system structure | 1.53e-07 | 18 |
intermediate mesoderm | 2.24e-07 | 14 |
posterior neural tube | 4.48e-07 | 12 |
chordal neural plate | 4.48e-07 | 12 |
renal system | 5.54e-07 | 19 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.388584 |
MA0004.1 | 0.236932 |
MA0006.1 | 0.199863 |
MA0007.1 | 0.060952 |
MA0009.1 | 0.337492 |
MA0014.1 | 0.016048 |
MA0017.1 | 0.0224649 |
MA0019.1 | 0.205515 |
MA0024.1 | 0.303927 |
MA0025.1 | 0.530879 |
MA0027.1 | 1.89129 |
MA0028.1 | 0.0191049 |
MA0029.1 | 0.287662 |
MA0030.1 | 0.292547 |
MA0031.1 | 0.266391 |
MA0038.1 | 0.425709 |
MA0040.1 | 0.917619 |
MA0041.1 | 1.00075 |
MA0042.1 | 0.947573 |
MA0043.1 | 0.415031 |
MA0046.1 | 0.365786 |
MA0048.1 | 0.187496 |
MA0050.1 | 0.0833996 |
MA0051.1 | 0.142335 |
MA0052.1 | 0.353618 |
MA0055.1 | 0.0825613 |
MA0056.1 | 0 |
MA0057.1 | 3.90503 |
MA0058.1 | 0.920372 |
MA0059.1 | 0.620066 |
MA0060.1 | 2.33424 |
MA0061.1 | 0.466178 |
MA0063.1 | 0 |
MA0066.1 | 0.131108 |
MA0067.1 | 0.629308 |
MA0068.1 | 5.48706 |
MA0069.1 | 0.932273 |
MA0070.1 | 0.346258 |
MA0071.1 | 0.282567 |
MA0072.1 | 0.900621 |
MA0073.1 | 33.7428 |
MA0074.1 | 0.111914 |
MA0076.1 | 0.026875 |
MA0077.1 | 1.55553 |
MA0078.1 | 0.161775 |
MA0081.1 | 1.50661 |
MA0083.1 | 0.414379 |
MA0084.1 | 0.934141 |
MA0087.1 | 0.379309 |
MA0088.1 | 0.217787 |
MA0089.1 | 0 |
MA0090.1 | 0.439111 |
MA0091.1 | 0.0722516 |
MA0092.1 | 0.198903 |
MA0093.1 | 0.435418 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.106017 |
MA0101.1 | 0.360528 |
MA0103.1 | 0.106012 |
MA0105.1 | 1.52244 |
MA0106.1 | 0.166496 |
MA0107.1 | 0.468235 |
MA0108.2 | 0.629361 |
MA0109.1 | 0 |
MA0111.1 | 0.214084 |
MA0113.1 | 0.149628 |
MA0114.1 | 0.0460994 |
MA0115.1 | 0.417336 |
MA0116.1 | 0.387363 |
MA0117.1 | 0.390961 |
MA0119.1 | 0.0405474 |
MA0122.1 | 1.04923 |
MA0124.1 | 0.581749 |
MA0125.1 | 0.516802 |
MA0130.1 | 0 |
MA0131.1 | 0.202517 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 1.97829 |
MA0136.1 | 0.12239 |
MA0139.1 | 0.02135 |
MA0140.1 | 0.105959 |
MA0141.1 | 0.292243 |
MA0142.1 | 0.255956 |
MA0143.1 | 0.159321 |
MA0144.1 | 1.375 |
MA0145.1 | 0.15673 |
MA0146.1 | 0.281818 |
MA0147.1 | 0.0544343 |
MA0148.1 | 1.38886 |
MA0149.1 | 1.4608 |
MA0062.2 | 0.0113082 |
MA0035.2 | 0.108338 |
MA0039.2 | 0.309308 |
MA0138.2 | 0.197313 |
MA0002.2 | 0.0223058 |
MA0137.2 | 2.14269 |
MA0104.2 | 0.18206 |
MA0047.2 | 0.839106 |
MA0112.2 | 0.0177147 |
MA0065.2 | 2.05074 |
MA0150.1 | 0.219664 |
MA0151.1 | 0 |
MA0152.1 | 0.424765 |
MA0153.1 | 0.459241 |
MA0154.1 | 1.10689 |
MA0155.1 | 0.0085214 |
MA0156.1 | 0.0266647 |
MA0157.1 | 0.233393 |
MA0158.1 | 0 |
MA0159.1 | 0.32227 |
MA0160.1 | 0.0748272 |
MA0161.1 | 0 |
MA0162.1 | 0.274014 |
MA0163.1 | 4.90757 |
MA0164.1 | 0.122585 |
MA0080.2 | 0.101795 |
MA0018.2 | 0.401707 |
MA0099.2 | 0.193216 |
MA0079.2 | 24.4512 |
MA0102.2 | 0.984244 |
MA0258.1 | 0.0394148 |
MA0259.1 | 0.0485446 |
MA0442.1 | 0 |