MCL coexpression mm9:168
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0045045 | secretory pathway | 0.000457623209854216 |
| GO:0007269 | neurotransmitter secretion | 0.000457623209854216 |
| GO:0032940 | secretion by cell | 0.000457623209854216 |
| GO:0045055 | regulated secretory pathway | 0.000457623209854216 |
| GO:0005246 | calcium channel regulator activity | 0.000597317262859314 |
| GO:0046903 | secretion | 0.000597317262859314 |
| GO:0003001 | generation of a signal involved in cell-cell signaling | 0.000597317262859314 |
| GO:0001505 | regulation of neurotransmitter levels | 0.000597317262859314 |
| GO:0042734 | presynaptic membrane | 0.000599258709996223 |
| GO:0016247 | channel regulator activity | 0.000779172411882122 |
| GO:0015457 | auxiliary transport protein activity | 0.000779172411882122 |
| GO:0044456 | synapse part | 0.000959641592216027 |
| GO:0007416 | synaptogenesis | 0.000959641592216027 |
| GO:0007268 | synaptic transmission | 0.00336985056220335 |
| GO:0050808 | synapse organization and biogenesis | 0.00484547315251145 |
| GO:0019226 | transmission of nerve impulse | 0.00484547315251145 |
| GO:0016081 | synaptic vesicle docking during exocytosis | 0.00787713265980194 |
| GO:0007154 | cell communication | 0.00787713265980194 |
| GO:0051649 | establishment of cellular localization | 0.00953371527333145 |
| GO:0051641 | cellular localization | 0.00964482068496454 |
| GO:0007267 | cell-cell signaling | 0.0107642795175801 |
| GO:0043062 | extracellular structure organization and biogenesis | 0.0170006521667474 |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | 0.0170006521667474 |
| GO:0004965 | GABA-B receptor activity | 0.0170006521667474 |
| GO:0035235 | ionotropic glutamate receptor signaling pathway | 0.0217542782711481 |
| GO:0001504 | neurotransmitter uptake | 0.0365726831518397 |
| GO:0016020 | membrane | 0.0381004874793611 |
| GO:0007215 | glutamate signaling pathway | 0.0466392475381137 |
| GO:0005391 | sodium:potassium-exchanging ATPase activity | 0.0466392475381137 |
| GO:0007399 | nervous system development | 0.0466392475381137 |
| GO:0016079 | synaptic vesicle exocytosis | 0.0466392475381137 |
| GO:0004016 | adenylate cyclase activity | 0.0466392475381137 |
| GO:0007190 | adenylate cyclase activation | 0.0489652615281346 |
| GO:0045762 | positive regulation of adenylate cyclase activity | 0.0489652615281346 |
| GO:0031281 | positive regulation of cyclase activity | 0.0489652615281346 |
| GO:0051349 | positive regulation of lyase activity | 0.0489652615281346 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| CNS neuron (sensu Vertebrata) | 4.36e-25 | 23 |
| neuroblast (sensu Vertebrata) | 4.36e-25 | 23 |
| neuron | 1.88e-15 | 33 |
| neuronal stem cell | 1.88e-15 | 33 |
| neuroblast | 1.88e-15 | 33 |
| electrically signaling cell | 1.88e-15 | 33 |
| electrically responsive cell | 4.31e-12 | 39 |
| electrically active cell | 4.31e-12 | 39 |
| neural cell | 2.16e-10 | 43 |
| ectodermal cell | 5.11e-10 | 44 |
| neurectodermal cell | 5.11e-10 | 44 |
| non-terminally differentiated cell | 2.17e-08 | 49 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.114859 |
| MA0004.1 | 0.052639 |
| MA0006.1 | 0.023578 |
| MA0007.1 | 1.00351 |
| MA0009.1 | 0.160008 |
| MA0014.1 | 0.233806 |
| MA0017.1 | 0.662865 |
| MA0019.1 | 0.542391 |
| MA0024.1 | 0.136175 |
| MA0025.1 | 0.312699 |
| MA0027.1 | 1.61241 |
| MA0028.1 | 0.070568 |
| MA0029.1 | 0.125003 |
| MA0030.1 | 0.128331 |
| MA0031.1 | 0.357432 |
| MA0038.1 | 0.147549 |
| MA0040.1 | 0.966531 |
| MA0041.1 | 0.491425 |
| MA0042.1 | 1.23711 |
| MA0043.1 | 0.218486 |
| MA0046.1 | 0.180835 |
| MA0048.1 | 0.212688 |
| MA0050.1 | 0.369143 |
| MA0051.1 | 0.356522 |
| MA0052.1 | 0.511731 |
| MA0055.1 | 0.0692889 |
| MA0056.1 | 0 |
| MA0057.1 | 1.50142 |
| MA0058.1 | 0.0604986 |
| MA0059.1 | 0.692236 |
| MA0060.1 | 0.00112439 |
| MA0061.1 | 0.129085 |
| MA0063.1 | 0 |
| MA0066.1 | 0.323968 |
| MA0067.1 | 0.397426 |
| MA0068.1 | 0.182419 |
| MA0069.1 | 0.171998 |
| MA0070.1 | 0.963471 |
| MA0071.1 | 0.187661 |
| MA0072.1 | 0.161558 |
| MA0073.1 | 3.86115 |
| MA0074.1 | 0.501007 |
| MA0076.1 | 0.0439233 |
| MA0077.1 | 0.893139 |
| MA0078.1 | 0.184832 |
| MA0081.1 | 1.42644 |
| MA0083.1 | 0.217977 |
| MA0084.1 | 0.676467 |
| MA0087.1 | 0.191005 |
| MA0088.1 | 0.453428 |
| MA0089.1 | 0 |
| MA0090.1 | 0.230817 |
| MA0091.1 | 0.317185 |
| MA0092.1 | 0.0381485 |
| MA0093.1 | 0.0309119 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.102771 |
| MA0101.1 | 0.0754506 |
| MA0103.1 | 0.498741 |
| MA0105.1 | 0.69487 |
| MA0106.1 | 0.192185 |
| MA0107.1 | 0.036574 |
| MA0108.2 | 0.0821349 |
| MA0109.1 | 0 |
| MA0111.1 | 0.443356 |
| MA0113.1 | 0.377765 |
| MA0114.1 | 0.333946 |
| MA0115.1 | 0.628067 |
| MA0116.1 | 1.59125 |
| MA0117.1 | 0.199875 |
| MA0119.1 | 0.0758923 |
| MA0122.1 | 0.212337 |
| MA0124.1 | 0.35604 |
| MA0125.1 | 0.300895 |
| MA0130.1 | 0 |
| MA0131.1 | 0.0713666 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.24238 |
| MA0136.1 | 0.0307086 |
| MA0139.1 | 0.671048 |
| MA0140.1 | 0.102691 |
| MA0141.1 | 0.812029 |
| MA0142.1 | 0.104015 |
| MA0143.1 | 0.18103 |
| MA0144.1 | 1.15315 |
| MA0145.1 | 0.167947 |
| MA0146.1 | 0.145848 |
| MA0147.1 | 0.0126688 |
| MA0148.1 | 0.0606046 |
| MA0149.1 | 0.00459441 |
| MA0062.2 | 0.00872224 |
| MA0035.2 | 0.258662 |
| MA0039.2 | 0.137923 |
| MA0138.2 | 0.518074 |
| MA0002.2 | 0.0973547 |
| MA0137.2 | 0.221616 |
| MA0104.2 | 0.0123631 |
| MA0047.2 | 0.146907 |
| MA0112.2 | 1.57915 |
| MA0065.2 | 0.99016 |
| MA0150.1 | 0.456843 |
| MA0151.1 | 0 |
| MA0152.1 | 0.615133 |
| MA0153.1 | 0.253603 |
| MA0154.1 | 1.92129 |
| MA0155.1 | 1.2092 |
| MA0156.1 | 0.012816 |
| MA0157.1 | 0.625308 |
| MA0158.1 | 0 |
| MA0159.1 | 2.73793 |
| MA0160.1 | 0.165189 |
| MA0161.1 | 0 |
| MA0162.1 | 0.0296111 |
| MA0163.1 | 6.09427 |
| MA0164.1 | 0.126099 |
| MA0080.2 | 0.0911242 |
| MA0018.2 | 0.314542 |
| MA0099.2 | 0.0660857 |
| MA0079.2 | 3.10455 |
| MA0102.2 | 0.723908 |
| MA0258.1 | 0.591756 |
| MA0259.1 | 0.507279 |
| MA0442.1 | 0 |
