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Coexpression cluster:C2168

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Full id: C2168_hippocampus_occipital_temporal_parietal_neuroectodermal_amygdala_medial



Phase1 CAGE Peaks

Hg19::chr11:83167766..83167847,-p1@ENST00000420284
Hg19::chr11:84244945..84244949,-p@chr11:84244945..84244949
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Hg19::chr17:7787702..7787722,+p7@CHD3
Hg19::chr2:50155392..50155397,-p@chr2:50155392..50155397
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
neural tube1.08e-5656
neural rod1.08e-5656
future spinal cord1.08e-5656
neural keel1.08e-5656
central nervous system3.44e-5681
nervous system2.83e-5589
adult organism4.44e-54114
regional part of nervous system4.76e-5353
regional part of brain4.76e-5353
neurectoderm6.85e-4886
regional part of forebrain7.08e-4741
forebrain7.08e-4741
anterior neural tube7.08e-4741
future forebrain7.08e-4741
brain5.19e-4668
future brain5.19e-4668
neural plate8.09e-4482
presumptive neural plate8.09e-4482
brain grey matter6.44e-3934
gray matter6.44e-3934
telencephalon7.89e-3934
cerebral hemisphere3.91e-3732
regional part of telencephalon8.58e-3732
pre-chordal neural plate1.23e-3461
ecto-epithelium7.81e-33104
ectoderm-derived structure4.61e-31171
ectoderm4.61e-31171
presumptive ectoderm4.61e-31171
regional part of cerebral cortex4.79e-3122
cerebral cortex2.20e-2825
pallium2.20e-2825
neocortex2.86e-2820
structure with developmental contribution from neural crest1.29e-26132
organ system subdivision1.90e-24223
anatomical cluster4.13e-13373
basal ganglion1.49e-129
nuclear complex of neuraxis1.49e-129
aggregate regional part of brain1.49e-129
collection of basal ganglia1.49e-129
cerebral subcortex1.49e-129
neural nucleus7.27e-129
nucleus of brain7.27e-129
tube1.13e-11192
posterior neural tube4.34e-1115
chordal neural plate4.34e-1115
temporal lobe1.69e-106
telencephalic nucleus7.75e-107
diencephalon2.67e-097
future diencephalon2.67e-097
gyrus4.00e-096
segmental subdivision of nervous system6.15e-0913
limbic system2.27e-085
organ part2.56e-08218
embryo4.61e-08592
parietal lobe4.93e-085
multi-tissue structure5.51e-08342
segmental subdivision of hindbrain6.04e-0812
hindbrain6.04e-0812
presumptive hindbrain6.04e-0812
occipital lobe7.05e-085
brainstem1.10e-076
anatomical conduit1.25e-07240
developing anatomical structure3.18e-07581
embryonic structure4.56e-07564
epithelium5.66e-07306
germ layer5.73e-07560
germ layer / neural crest5.73e-07560
embryonic tissue5.73e-07560
presumptive structure5.73e-07560
germ layer / neural crest derived structure5.73e-07560
epiblast (generic)5.73e-07560
corpus striatum9.93e-074
striatum9.93e-074
ventral part of telencephalon9.93e-074
future corpus striatum9.93e-074
Disease
Ontology termp-valuen
neuroectodermal tumor9.73e-0710


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.11.28333
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.11.52107
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.380957
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.11.33363
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.20937
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.