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Coexpression cluster:C3686

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Full id: C3686_CD14_Mesenchymal_liposarcoma_renal_amniotic_anaplastic_immature



Phase1 CAGE Peaks

Hg19::chr17:75315624..75315648,+p11@SEPT9
Hg19::chr17:75315654..75315688,+p6@SEPT9
Hg19::chr17:75315696..75315710,+p19@SEPT9


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
connective tissue3.64e-19371
musculoskeletal system7.62e-17167
bone marrow9.01e-1676
bone element1.24e-1582
skeletal system2.09e-14100
skeletal element3.51e-1490
immune system1.06e-1193
lateral plate mesoderm7.71e-11203
mesoderm1.35e-10315
mesoderm-derived structure1.35e-10315
presumptive mesoderm1.35e-10315
hematopoietic system2.96e-0898
blood island2.96e-0898
skin of body6.50e-0841
integument7.27e-0846
integumental system7.27e-0846
hemolymphoid system1.84e-07108
organ2.59e-07503
tissue5.45e-07773
surface structure5.71e-0799


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.10.826076
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.14.06645
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.12.15449
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.11.70054
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.12.19699
MA0101.11.55947
MA0103.10.628063
MA0105.13.21605
MA0106.10.986396
MA0107.11.36919
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.15.73745
MA0145.10.273764
MA0146.10.107247
MA0147.11.38767
MA0148.10.854239
MA0149.10.884158
MA0062.21.141
MA0035.20.894194
MA0039.20.432958
MA0138.22.38017
MA0002.20.476938
MA0137.22.70092
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.12.30945
MA0155.10.711948
MA0156.12.7096
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.05956
MA0163.13.19905
MA0164.11.01792
MA0080.21.55139
MA0018.20.987913
MA0099.22.08754
MA0079.20.481578
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187635.017155731697390.00791769806886330.0321845042857593
EBF1#187938.9064668465690.00141523283560980.00914524824392107
ELF1#199734.258097958807540.01295179875054610.0461820727111056
EP300#203336.77394172622320.003216880500103790.0167364642099402
FOS#235338.99795530889440.001372499272417130.00897011586432869
FOSL1#8061339.7135797163731.59554825631833e-050.000370882404499511
GABPB1#255337.067683836182170.002832212825417420.0153978904359068
GTF2B#2959331.94382993432423.06634405746243e-050.000627686999249939
GTF2F1#2962312.73966087675770.0004835525047438590.00433528543591243
HDAC2#3066313.41562023662630.0004140761399857210.00391009927522321
JUN#3725312.51282919233630.0005103313992726250.00443895236184173
JUNB#3726330.61063265982113.4847716247536e-050.000680018803657776
JUND#372736.994663941871030.002921845042734990.0156609994569258
MAX#414936.452555509007120.003721913834265510.018636156819295
MXI1#460139.96157162875930.001011470541259020.00719843079104266
MYC#460935.22228187160940.007020843755740150.0294265150094609
NFKB1#479035.488063424193840.006049381815655430.0269409145642078
NR3C1#2908314.9730233311730.0002978331194675480.00308738393688052
REST#597839.650028716128020.001112636247114590.0076691273107445
RFX5#5993312.04791082719510.0005717246050312580.00484268824208107
SIN3A#2594235.408884726815140.006318961977991520.0276405624903441
SPI1#668838.204323508522730.001810593189410520.0109014494470682
STAT1#6772320.70658749719920.0001125992441046670.00154815066548806
STAT3#6774310.51946499715420.0008589184530415310.00642490934803069
TCF7L2#6934310.77017656313730.0008003181298398380.00613238629217483
TFAP2C#7022310.80922860986020.0007916746575753130.00615374438542037
YY1#752834.911170749853860.008441455341808260.0329023009682072
ZBTB7A#5134137.35190930787590.002516255860282270.0140052891596685



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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