Coexpression cluster:C685
From FANTOM5_SSTAR
Full id: C685_Alveolar_Mesenchymal_Renal_Smooth_Hepatic_Fibroblast_Keratocytes
Phase1 CAGE Peaks
| Hg19::chr11:1968548..1968589,+ | p1@MRPL23 |
| Hg19::chr11:57508973..57509018,+ | p3@C11orf31 |
| Hg19::chr16:1359622..1359697,+ | p1@UBE2I |
| Hg19::chr19:13885252..13885293,+ | p1@C19orf53 |
| Hg19::chr19:17970677..17970686,+ | p2@RPL18A |
| Hg19::chr19:18043810..18043835,+ | p1@CCDC124 |
| Hg19::chr19:2427539..2427591,- | p1@TIMM13 |
| Hg19::chr19:45582497..45582551,+ | p1@GEMIN7 |
| Hg19::chr19:6361517..6361640,+ | p1@CLPP |
| Hg19::chr1:54665832..54665877,+ | p1@MRPL37 |
| Hg19::chr3:49059510..49059579,+ | p1@NDUFAF3 |
| Hg19::chr7:44163126..44163155,- | p1@POLD2 |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0031974 | membrane-enclosed lumen | 0.000193512463740142 |
| GO:0043233 | organelle lumen | 0.000193512463740142 |
| GO:0000313 | organellar ribosome | 0.00299085559287461 |
| GO:0005761 | mitochondrial ribosome | 0.00299085559287461 |
| GO:0005739 | mitochondrion | 0.00299085559287461 |
| GO:0030529 | ribonucleoprotein complex | 0.00411426777240149 |
| GO:0044446 | intracellular organelle part | 0.00435327555541477 |
| GO:0044422 | organelle part | 0.00435327555541477 |
| GO:0043398 | HLH domain binding | 0.00526904509596138 |
| GO:0015934 | large ribosomal subunit | 0.00578115676195091 |
| GO:0016604 | nuclear body | 0.00578115676195091 |
| GO:0044429 | mitochondrial part | 0.00595076123775477 |
| GO:0043229 | intracellular organelle | 0.00840756935025863 |
| GO:0043226 | organelle | 0.00840756935025863 |
| GO:0008462 | endopeptidase Clp activity | 0.00948204782553061 |
| GO:0003735 | structural constituent of ribosome | 0.0100779420613185 |
| GO:0031980 | mitochondrial lumen | 0.0100779420613185 |
| GO:0005759 | mitochondrial matrix | 0.0100779420613185 |
| GO:0005840 | ribosome | 0.0109967187094474 |
| GO:0033279 | ribosomal subunit | 0.0123026770219084 |
| GO:0042719 | mitochondrial intermembrane space protein transporter complex | 0.0123026770219084 |
| GO:0045039 | protein import into mitochondrial inner membrane | 0.0123026770219084 |
| GO:0032991 | macromolecular complex | 0.0123026770219084 |
| GO:0043231 | intracellular membrane-bound organelle | 0.0123026770219084 |
| GO:0043227 | membrane-bound organelle | 0.0123026770219084 |
| GO:0007007 | inner mitochondrial membrane organization and biogenesis | 0.0145791802178139 |
| GO:0000387 | spliceosomal snRNP biogenesis | 0.0157922524412481 |
| GO:0044424 | intracellular part | 0.0170194352354491 |
| GO:0006412 | translation | 0.0197456222733237 |
| GO:0000795 | synaptonemal complex | 0.0197456222733237 |
| GO:0043681 | protein import into mitochondrion | 0.0197456222733237 |
| GO:0044444 | cytoplasmic part | 0.0197456222733237 |
| GO:0000315 | organellar large ribosomal subunit | 0.0202899870466734 |
| GO:0005762 | mitochondrial large ribosomal subunit | 0.0202899870466734 |
| GO:0005744 | mitochondrial inner membrane presequence translocase complex | 0.0202899870466734 |
| GO:0016605 | PML body | 0.0210389911498501 |
| GO:0043232 | intracellular non-membrane-bound organelle | 0.0227072814930335 |
| GO:0043228 | non-membrane-bound organelle | 0.0227072814930335 |
| GO:0005737 | cytoplasm | 0.0235427243499324 |
| GO:0007006 | mitochondrial membrane organization and biogenesis | 0.0236577228278529 |
| GO:0006626 | protein targeting to mitochondrion | 0.0253827994317314 |
| GO:0044451 | nucleoplasm part | 0.02547497433364 |
| GO:0009059 | macromolecule biosynthetic process | 0.0276297379577305 |
| GO:0005758 | mitochondrial intermembrane space | 0.029801120846867 |
| GO:0043170 | macromolecule metabolic process | 0.029801120846867 |
| GO:0005654 | nucleoplasm | 0.0303935112857104 |
| GO:0031970 | organelle envelope lumen | 0.0305183546678942 |
| GO:0000794 | condensed nuclear chromosome | 0.0305183546678942 |
| GO:0044267 | cellular protein metabolic process | 0.0307394584809551 |
| GO:0044260 | cellular macromolecule metabolic process | 0.0318604052842707 |
| GO:0005842 | cytosolic large ribosomal subunit (sensu Eukaryota) | 0.0356935228895277 |
| GO:0019538 | protein metabolic process | 0.0356935228895277 |
| GO:0044249 | cellular biosynthetic process | 0.0405523371864651 |
| GO:0006839 | mitochondrial transport | 0.0413585107437134 |
| GO:0003887 | DNA-directed DNA polymerase activity | 0.0413585107437134 |
| GO:0005622 | intracellular | 0.0413585107437134 |
| GO:0008430 | selenium binding | 0.0413585107437134 |
| GO:0031981 | nuclear lumen | 0.0415450125925671 |
| GO:0000793 | condensed chromosome | 0.0415450125925671 |
| GO:0007059 | chromosome segregation | 0.0463138328989554 |
| GO:0044237 | cellular metabolic process | 0.0482158782953958 |
| GO:0044454 | nuclear chromosome part | 0.0498887043556976 |
| GO:0065002 | intracellular protein transport across a membrane | 0.0498887043556976 |
| GO:0000398 | nuclear mRNA splicing, via spliceosome | 0.0498887043556976 |
| GO:0000375 | RNA splicing, via transesterification reactions | 0.0498887043556976 |
| GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 0.0498887043556976 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| animal cell | 7.69e-29 | 679 |
| eukaryotic cell | 7.69e-29 | 679 |
| embryonic cell | 4.86e-27 | 250 |
| mesodermal cell | 1.23e-22 | 121 |
| somatic cell | 1.15e-17 | 588 |
| contractile cell | 1.78e-17 | 59 |
| non-terminally differentiated cell | 3.14e-17 | 106 |
| native cell | 9.66e-17 | 722 |
| muscle cell | 3.73e-15 | 55 |
| electrically responsive cell | 4.54e-15 | 61 |
| electrically active cell | 4.54e-15 | 61 |
| muscle precursor cell | 8.22e-15 | 58 |
| myoblast | 8.22e-15 | 58 |
| multi-potent skeletal muscle stem cell | 8.22e-15 | 58 |
| epithelial cell | 2.61e-14 | 253 |
| smooth muscle cell | 6.60e-13 | 43 |
| smooth muscle myoblast | 6.60e-13 | 43 |
| vascular associated smooth muscle cell | 3.07e-10 | 32 |
| meso-epithelial cell | 2.07e-08 | 45 |
| epithelial cell of nephron | 4.16e-08 | 15 |
| lining cell | 5.37e-08 | 58 |
| barrier cell | 5.37e-08 | 58 |
| endothelial cell | 8.55e-08 | 36 |
| ectodermal cell | 2.59e-07 | 72 |
| kidney cortical cell | 3.37e-07 | 12 |
| renal cortical epithelial cell | 3.37e-07 | 12 |
| kidney cell | 4.13e-07 | 17 |
| kidney epithelial cell | 4.13e-07 | 17 |
| blood vessel endothelial cell | 4.37e-07 | 18 |
| embryonic blood vessel endothelial progenitor cell | 4.37e-07 | 18 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 2.56508 |
| MA0004.1 | 1.55339 |
| MA0006.1 | 0.552945 |
| MA0007.1 | 0.305951 |
| MA0009.1 | 0.756202 |
| MA0014.1 | 3.50505 |
| MA0017.1 | 0.220105 |
| MA0019.1 | 0.45566 |
| MA0024.1 | 0.654931 |
| MA0025.1 | 0.886436 |
| MA0027.1 | 2.35633 |
| MA0028.1 | 2.45278 |
| MA0029.1 | 0.673506 |
| MA0030.1 | 0.662482 |
| MA0031.1 | 0.600685 |
| MA0038.1 | 0.414169 |
| MA0040.1 | 0.67914 |
| MA0041.1 | 0.338572 |
| MA0042.1 | 0.310552 |
| MA0043.1 | 0.756508 |
| MA0046.1 | 0.745626 |
| MA0048.1 | 0.357781 |
| MA0050.1 | 0.311321 |
| MA0051.1 | 0.410316 |
| MA0052.1 | 0.682867 |
| MA0055.1 | 0.107116 |
| MA0056.1 | 0 |
| MA0057.1 | 0.3421 |
| MA0058.1 | 1.94628 |
| MA0059.1 | 2.71991 |
| MA0060.1 | 1.13897 |
| MA0061.1 | 0.605357 |
| MA0063.1 | 0 |
| MA0066.1 | 0.414559 |
| MA0067.1 | 1.06751 |
| MA0068.1 | 0.0633085 |
| MA0069.1 | 0.741884 |
| MA0070.1 | 0.731026 |
| MA0071.1 | 0.379038 |
| MA0072.1 | 0.726666 |
| MA0073.1 | 0.142258 |
| MA0074.1 | 0.40963 |
| MA0076.1 | 2.81657 |
| MA0077.1 | 0.719193 |
| MA0078.1 | 0.502027 |
| MA0081.1 | 0.67392 |
| MA0083.1 | 0.763502 |
| MA0084.1 | 1.25286 |
| MA0087.1 | 0.724294 |
| MA0088.1 | 1.76419 |
| MA0089.1 | 0 |
| MA0090.1 | 0.734839 |
| MA0091.1 | 0.324543 |
| MA0092.1 | 0.291716 |
| MA0093.1 | 3.15425 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.426863 |
| MA0101.1 | 0.19375 |
| MA0103.1 | 0.535462 |
| MA0105.1 | 0.890241 |
| MA0106.1 | 1.14663 |
| MA0107.1 | 0.137948 |
| MA0108.2 | 0.597764 |
| MA0109.1 | 0 |
| MA0111.1 | 0.277713 |
| MA0113.1 | 0.467266 |
| MA0114.1 | 0.418165 |
| MA0115.1 | 0.992167 |
| MA0116.1 | 0.140463 |
| MA0117.1 | 0.792789 |
| MA0119.1 | 0.226505 |
| MA0122.1 | 0.818044 |
| MA0124.1 | 0.951337 |
| MA0125.1 | 0.868909 |
| MA0130.1 | 0 |
| MA0131.1 | 0.519055 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.785738 |
| MA0136.1 | 0.420617 |
| MA0139.1 | 0.567946 |
| MA0140.1 | 0.376643 |
| MA0141.1 | 0.238287 |
| MA0142.1 | 0.570448 |
| MA0143.1 | 0.467429 |
| MA0144.1 | 0.39221 |
| MA0145.1 | 0.232227 |
| MA0146.1 | 1.65937 |
| MA0147.1 | 2.69996 |
| MA0148.1 | 0.344198 |
| MA0149.1 | 0.367947 |
| MA0062.2 | 3.32063 |
| MA0035.2 | 0.376007 |
| MA0039.2 | 0.991464 |
| MA0138.2 | 0.503176 |
| MA0002.2 | 0.0954816 |
| MA0137.2 | 0.595725 |
| MA0104.2 | 3.65997 |
| MA0047.2 | 0.440861 |
| MA0112.2 | 0.216805 |
| MA0065.2 | 0.452385 |
| MA0150.1 | 0.723395 |
| MA0151.1 | 0 |
| MA0152.1 | 0.382565 |
| MA0153.1 | 0.852412 |
| MA0154.1 | 0.126936 |
| MA0155.1 | 0.392911 |
| MA0156.1 | 0.208455 |
| MA0157.1 | 0.544523 |
| MA0158.1 | 0 |
| MA0159.1 | 0.867657 |
| MA0160.1 | 0.357736 |
| MA0161.1 | 0 |
| MA0162.1 | 0.894383 |
| MA0163.1 | 0.936674 |
| MA0164.1 | 0.478818 |
| MA0080.2 | 0.191221 |
| MA0018.2 | 1.14938 |
| MA0099.2 | 0.382887 |
| MA0079.2 | 0.990475 |
| MA0102.2 | 1.28978 |
| MA0258.1 | 0.117513 |
| MA0259.1 | 2.76095 |
| MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
| TF | #promoters | Enrichment | p-value | q-value |
|---|---|---|---|---|
| ATF3#467 | 5 | 9.35965605250365 | 0.000106266926151988 | 0.00148117062596923 |
| BCLAF1#9774 | 6 | 10.8263238050609 | 7.02962092283241e-06 | 0.000202864487305801 |
| BHLHE40#8553 | 3 | 11.2179533867444 | 0.00209247176715069 | 0.0121193244725738 |
| BRCA1#672 | 5 | 8.41009610134324 | 0.000176031908775319 | 0.00214048160677442 |
| CCNT2#905 | 12 | 6.33620157696263 | 2.3835512786724e-10 | 2.44054619601242e-08 |
| CHD2#1106 | 8 | 6.89601522274457 | 2.63477013316703e-06 | 9.24018663323811e-05 |
| CTCF#10664 | 6 | 2.68012818653751 | 0.0138537507481115 | 0.0487277093719736 |
| E2F1#1869 | 8 | 3.27159280991955 | 0.00066387851376683 | 0.00542695742793472 |
| E2F4#1874 | 4 | 4.22268677176148 | 0.0114651023744674 | 0.0419405893830824 |
| E2F6#1876 | 8 | 3.34477048779826 | 0.000566924613343246 | 0.00483378559008533 |
| EGR1#1958 | 8 | 3.32545272987342 | 0.000590880184228549 | 0.00494597543966061 |
| ELF1#1997 | 11 | 3.90325646224024 | 1.12752972864617e-06 | 4.63432024124665e-05 |
| ELK4#2005 | 4 | 5.41189388615601 | 0.00476866333190955 | 0.0224107649606849 |
| ESR1#2099 | 3 | 7.69215082403862 | 0.00605532558288018 | 0.0268608625785943 |
| ETS1#2113 | 12 | 9.72876092220234 | 1.38661421527458e-12 | 1.92064458924485e-10 |
| GABPB1#2553 | 10 | 5.88973653015181 | 1.60938692426694e-07 | 8.91685734660555e-06 |
| GATA1#2623 | 5 | 5.65012839325018 | 0.00111039311334309 | 0.00771219966512199 |
| GTF2F1#2962 | 5 | 5.30819203198235 | 0.00147356422806945 | 0.00942711022452345 |
| HEY1#23462 | 12 | 4.04011104310571 | 5.2821272507085e-08 | 3.35763900144093e-06 |
| HMGN3#9324 | 8 | 5.45236514890039 | 1.56099565068508e-05 | 0.000365699472323686 |
| IRF1#3659 | 8 | 5.09144250237593 | 2.6084996882713e-05 | 0.000563219141913099 |
| IRF3#3661 | 3 | 11.7454880528724 | 0.00183538959802164 | 0.0108628728452784 |
| IRF4#3662 | 5 | 9.13104695281005 | 0.000119452296579471 | 0.00162124475665541 |
| JUND#3727 | 7 | 4.0802206327581 | 0.000497020645947162 | 0.0043941707645878 |
| MAX#4149 | 8 | 4.30170367267141 | 9.11628330297238e-05 | 0.0013293710023445 |
| MEF2A#4205 | 4 | 6.24774363654802 | 0.00283471242741202 | 0.0153722691316519 |
| MXI1#4601 | 6 | 4.98078581437965 | 0.00055237738783609 | 0.0047162967632614 |
| MYC#4609 | 11 | 4.78709171564195 | 1.25420998476009e-07 | 7.18532290720566e-06 |
| NANOG#79923 | 5 | 12.1853243670886 | 3.02153395836246e-05 | 0.000620948416130297 |
| NFKB1#4790 | 9 | 4.11604756814538 | 2.84752237283376e-05 | 0.000599944299165595 |
| NRF1#4899 | 5 | 5.08761643654621 | 0.00178414175698768 | 0.0109460130974585 |
| PAX5#5079 | 9 | 5.00217414838337 | 5.4522949797447e-06 | 0.000165292376020191 |
| POLR2A#5430 | 12 | 2.14745317655807 | 0.000103929203846201 | 0.00145246381914805 |
| POU2F2#5452 | 8 | 6.07074937182835 | 6.94099287930325e-06 | 0.000200528452371107 |
| RDBP#7936 | 2 | 25.6064006650042 | 0.00267532742987202 | 0.0147476259605407 |
| REST#5978 | 5 | 4.02084529838668 | 0.00505569111168918 | 0.0235477556086922 |
| RFX5#5993 | 7 | 7.02794798253047 | 1.47424002832586e-05 | 0.000349768637706326 |
| RXRA#6256 | 4 | 6.69153904637776 | 0.00220495472409808 | 0.0127038818574546 |
| SIN3A#25942 | 10 | 4.50740393901261 | 2.12990021740309e-06 | 7.75338615564175e-05 |
| SIX5#147912 | 8 | 11.391143570306 | 5.49078835696466e-08 | 3.46496945748056e-06 |
| SMARCB1#6598 | 4 | 6.08423859371914 | 0.00312231975637376 | 0.0164096192147705 |
| SMC3#9126 | 4 | 5.01497761497761 | 0.00626178397702115 | 0.0276288321409426 |
| SP1#6667 | 10 | 4.74865114845075 | 1.29045571010307e-06 | 5.15190764172227e-05 |
| SP2#6668 | 6 | 13.0767652469223 | 2.36047960027179e-06 | 8.379542113283e-05 |
| SRF#6722 | 6 | 6.8985891310839 | 9.12062420494223e-05 | 0.0013298183321792 |
| TAF1#6872 | 12 | 3.34304628574529 | 5.12776278934579e-07 | 2.39721762737907e-05 |
| TAF7#6879 | 8 | 7.62204626994928 | 1.22550270089133e-06 | 4.94552846129788e-05 |
| TBP#6908 | 12 | 3.70677068709639 | 1.48467551517722e-07 | 8.36343183007517e-06 |
| TCF12#6938 | 6 | 5.31723245109321 | 0.000386542592763444 | 0.00378245309150392 |
| THAP1#55145 | 5 | 13.0704769178547 | 2.15728753020685e-05 | 0.000475126428442162 |
| USF1#7391 | 8 | 4.24099951813864 | 0.000101216949978379 | 0.00142408689731805 |
| USF2#7392 | 6 | 6.4960986925348 | 0.000127663267259117 | 0.00169760936710911 |
| YY1#7528 | 12 | 4.91117074985386 | 5.07192667060765e-09 | 4.07780561625552e-07 |
| ZBTB33#10009 | 3 | 7.91618125749529 | 0.00559052109277224 | 0.025278972698101 |
| ZBTB7A#51341 | 8 | 4.90127287191726 | 3.46590017012669e-05 | 0.000679893215379154 |
| ZEB1#6935 | 5 | 7.0368466739766 | 0.000404901771733203 | 0.00389495589371317 |
| ZNF143#7702 | 12 | 13.5008765522279 | 2.71467069397623e-14 | 4.52903342824574e-12 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.
