MCL coexpression mm9:1309

Phase1 CAGE Peaks

	Short description
Mm9::chr11:94254231..94254297,-	p1@Abcc3
Mm9::chr11:94463110..94463136,-	p1@Acsf2
Mm9::chr13:4278666..4278696,-	p3@Akr1c12
Mm9::chr15:82451361..82451377,-	p1@Cyp2d34
Mm9::chr4:102887741..102887746,-	p5@Slc35d1
Mm9::chr4:102887752..102887806,-	p1@Slc35d1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015722	canalicular bile acid transport	0.00788868188536945
GO:0015721	bile acid and bile salt transport	0.00788868188536945
GO:0015718	monocarboxylic acid transport	0.0157739062236469
GO:0006805	xenobiotic metabolic process	0.0197076607374247
GO:0009410	response to xenobiotic stimulus	0.0197076607374247
GO:0004033	aldo-keto reductase activity	0.0197076607374247

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
gastrointestinal system	2.26e-16	47
endoderm-derived structure	9.68e-16	118
endoderm	9.68e-16	118
presumptive endoderm	9.68e-16	118
digestive system	1.11e-15	116
digestive tract	1.11e-15	116
primitive gut	1.11e-15	116
intestine	6.24e-15	31
subdivision of digestive tract	1.19e-14	114
trunk region element	9.18e-14	79
digestive tract diverticulum	1.90e-12	23
sac	1.90e-12	23
abdomen element	9.96e-12	49
abdominal segment element	9.96e-12	49
abdominal segment of trunk	9.96e-12	49
abdomen	9.96e-12	49
liver	1.02e-11	22
epithelial sac	1.02e-11	22
digestive gland	1.02e-11	22
epithelium of foregut-midgut junction	1.02e-11	22
anatomical boundary	1.02e-11	22
hepatobiliary system	1.02e-11	22
foregut-midgut junction	1.02e-11	22
hepatic diverticulum	1.02e-11	22
liver primordium	1.02e-11	22
septum transversum	1.02e-11	22
liver bud	1.02e-11	22
subdivision of trunk	2.55e-11	66
trunk	2.61e-10	90
exocrine gland	1.03e-09	25
exocrine system	1.03e-09	25
mucosa	2.10e-09	15
immaterial anatomical entity	2.40e-08	79
intestinal mucosa	2.76e-08	13
anatomical wall	2.76e-08	13
wall of intestine	2.76e-08	13
gastrointestinal system mucosa	2.76e-08	13
mesenchyme	1.00e-07	61
entire embryonic mesenchyme	1.00e-07	61
organ component layer	1.56e-07	24
trunk mesenchyme	2.97e-07	45

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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