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Coexpression cluster:C1763

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Full id: C1763_Dendritic_B_migratory_immature_CD19_CD34_acute



Phase1 CAGE Peaks

Hg19::chr16:53096019..53096033,+p@chr16:53096019..53096033
+
Hg19::chr20:42339655..42339667,+p@chr20:42339655..42339667
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Hg19::chr2:8715616..8715650,-p2@ENST00000418358
Hg19::chr4:8203467..8203485,+p@chr4:8203467..8203485
+
Hg19::chrX:22050410..22050411,+p9@PHEX


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004245neprilysin activity0.0189567879430119
GO:0004177aminopeptidase activity0.0236959849287649
GO:0001503ossification0.0236959849287649
GO:0031214biomineral formation0.0236959849287649
GO:0046849bone remodeling0.0236959849287649
GO:0048771tissue remodeling0.0236959849287649
GO:0008238exopeptidase activity0.0314441958737261
GO:0004222metalloendopeptidase activity0.0314441958737261
GO:0001501skeletal development0.0314441958737261
GO:0009888tissue development0.041298716590133
GO:0008237metallopeptidase activity0.0464072016526979



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
tonsil2.41e-141
mucosa-associated lymphoid tissue2.41e-141
lymphoid tissue2.41e-141
tonsillar ring2.41e-141
thymus6.99e-144
hemolymphoid system gland6.99e-144
thymic region6.99e-144
pharyngeal gland6.99e-144
thymus primordium6.99e-144
chordate pharynx2.91e-1210
pharyngeal region of foregut2.91e-1210
pharynx3.34e-1111
pharyngeal epithelium1.44e-096
hemopoietic organ2.49e-087
immune organ2.49e-087


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EBF1#187947.12517347725520.0007230531046774210.00577066660548717
TCF12#693836.380678941311850.007185168653258840.0298303318881261



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.