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Coexpression cluster:C1206

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Full id: C1206_Fibroblast_CD14_Small_Olfactory_Preadipocyte_Adipocyte_hepatic



Phase1 CAGE Peaks

Hg19::chr15:39877759..39877772,+p33@THBS1
Hg19::chr15:39878273..39878285,+p40@THBS1
Hg19::chr15:39878313..39878333,+p34@THBS1
Hg19::chr15:39878338..39878368,+p@chr15:39878338..39878368
+
Hg19::chr15:39878388..39878413,+p@chr15:39878388..39878413
+
Hg19::chr15:39880996..39881011,+p41@THBS1
Hg19::chr15:39884701..39884704,+p@chr15:39884701..39884704
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
fibroblast6.01e-1776
skin fibroblast1.34e-1023
somatic cell3.94e-09588
preadipocyte1.48e-0812
mesenchymal cell6.37e-07354
endothelial cell of vascular tree8.83e-0724
Uber Anatomy
Ontology termp-valuen
surface structure7.41e-1099
skin of body4.32e-0941
organ component layer6.81e-0966
integument6.84e-0946
integumental system6.84e-0946
multi-cellular organism4.85e-07656
omentum9.19e-076
peritoneum9.19e-076
abdominal cavity9.19e-076
visceral peritoneum9.19e-076
Disease
Ontology termp-valuen
musculoskeletal system disease9.08e-075
myotonic disease9.08e-075
muscle tissue disease9.08e-075
myopathy9.08e-075
muscular disease9.08e-075
myotonic dystrophy9.08e-075


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
POLR2A#543072.147453176558070.004747636447610280.0223390882569819



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.