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Coexpression cluster:C1379

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Full id: C1379_pineal_cerebellum_small_occipital_parietal_temporal_hippocampus



Phase1 CAGE Peaks

Hg19::chr13:25745685..25745777,-p1@FAM123A
Hg19::chr15:51973635..51973646,+p4@SCG3
Hg19::chr19:42470940..42470980,-p@chr19:42470940..42470980
-
Hg19::chr5:11903337..11903377,-p18@CTNND2
Hg19::chr6:127837142..127837208,-p1@C6orf174
Hg19::chr6:25279289..25279415,+p3@LRRC16A


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0007158neuron adhesion0.0296662538128231



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
neuronal stem cell1.12e-078
Uber Anatomy
Ontology termp-valuen
nervous system2.76e-6889
central nervous system3.10e-6781
neural tube1.89e-6556
neural rod1.89e-6556
future spinal cord1.89e-6556
neural keel1.89e-6556
regional part of nervous system1.62e-6153
regional part of brain1.62e-6153
neurectoderm1.75e-5686
neural plate1.41e-5482
presumptive neural plate1.41e-5482
regional part of forebrain4.52e-5441
forebrain4.52e-5441
anterior neural tube4.52e-5441
future forebrain4.52e-5441
brain4.76e-5468
future brain4.76e-5468
adult organism1.30e-47114
brain grey matter3.45e-4534
gray matter3.45e-4534
telencephalon6.01e-4534
ecto-epithelium1.89e-44104
ectoderm-derived structure2.59e-43171
ectoderm2.59e-43171
presumptive ectoderm2.59e-43171
cerebral hemisphere1.15e-4232
regional part of telencephalon1.87e-4232
pre-chordal neural plate3.36e-4261
cerebral cortex8.78e-3425
pallium8.78e-3425
structure with developmental contribution from neural crest2.18e-33132
regional part of cerebral cortex1.59e-3122
organ system subdivision6.00e-29223
neocortex6.63e-2920
anatomical cluster3.32e-15373
tube8.49e-14192
basal ganglion1.09e-129
nuclear complex of neuraxis1.09e-129
aggregate regional part of brain1.09e-129
collection of basal ganglia1.09e-129
cerebral subcortex1.09e-129
neural nucleus1.17e-129
nucleus of brain1.17e-129
posterior neural tube1.40e-1215
chordal neural plate1.40e-1215
organ part4.85e-11218
temporal lobe2.50e-106
diencephalon2.61e-107
future diencephalon2.61e-107
segmental subdivision of nervous system3.93e-1013
telencephalic nucleus4.90e-107
anatomical conduit4.93e-10240
gyrus1.42e-096
segmental subdivision of hindbrain3.65e-0912
hindbrain3.65e-0912
presumptive hindbrain3.65e-0912
brainstem6.98e-096
occipital lobe1.85e-085
limbic system4.32e-085
parietal lobe4.84e-085
embryo1.06e-07592
multi-tissue structure1.42e-07342
epithelium4.16e-07306
organ6.51e-07503
multi-cellular organism6.99e-07656
cell layer7.33e-07309
gland of diencephalon8.45e-074
neuroendocrine gland8.45e-074
regional part of diencephalon8.82e-074


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.