MCL coexpression mm9:1569

Phase1 CAGE Peaks

	Short description
Mm9::chr11:53583544..53583559,+	p1@Irf1
Mm9::chr17:34324776..34324812,+	p3@Tap1
Mm9::chr4:147315035..147315040,+	p2@2510039O18Rik
Mm9::chr7:134519511..134519534,-	p2@Zfp747
Mm9::chr7:134537118..134537177,-	p1@E430018J23Rik p1@LOC100044339

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0045084	positive regulation of interleukin-12 biosynthetic process	0.0350425629681184
GO:0042090	interleukin-12 biosynthetic process	0.0350425629681184
GO:0045075	regulation of interleukin-12 biosynthetic process	0.0350425629681184
GO:0015198	oligopeptide transporter activity	0.0350425629681184
GO:0006857	oligopeptide transport	0.0350425629681184
GO:0015197	peptide transporter activity	0.0350425629681184
GO:0032615	interleukin-12 production	0.0450399136048616

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
connective tissue cell	1.86e-08	46
mesenchymal cell	1.86e-08	46
hematopoietic cell	2.63e-08	32
hematopoietic oligopotent progenitor cell	2.63e-08	32
hematopoietic stem cell	2.63e-08	32
angioblastic mesenchymal cell	2.63e-08	32
hematopoietic multipotent progenitor cell	2.63e-08	32
lymphoid lineage restricted progenitor cell	1.82e-07	12
motile cell	5.04e-07	54
leukocyte	5.09e-07	17
nongranular leukocyte	5.09e-07	17
T cell	6.13e-07	11
pro-T cell	6.13e-07	11
lymphocyte	9.06e-07	13
common lymphoid progenitor	9.06e-07	13

Uber Anatomy

Ontology term	p-value	n
digestive system	5.79e-16	116
digestive tract	5.79e-16	116
primitive gut	5.79e-16	116
endoderm-derived structure	1.85e-15	118
endoderm	1.85e-15	118
presumptive endoderm	1.85e-15	118
subdivision of digestive tract	7.01e-15	114
intestine	8.92e-13	31
gastrointestinal system	3.94e-12	47
mucosa	2.49e-10	15
hemolymphoid system	6.27e-10	48
immune system	6.27e-10	48
organ component layer	3.14e-09	24
intestinal mucosa	4.00e-09	13
anatomical wall	4.00e-09	13
wall of intestine	4.00e-09	13
gastrointestinal system mucosa	4.00e-09	13
hematopoietic system	1.20e-08	45
blood island	1.20e-08	45
connective tissue	1.86e-08	46
unilaminar epithelium	4.46e-08	66
gut epithelium	4.14e-07	55

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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