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Coexpression cluster:C4493

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Full id: C4493_merkel_non_pancreatic_oral_salivary_teratocarcinoma_large



Phase1 CAGE Peaks

Hg19::chr5:2751762..2751784,-p1@IRX2
Hg19::chr5:2751785..2751808,-p2@IRX2
Hg19::chr5:2751993..2752042,+p1@C5orf38


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
endo-epithelial cell6.87e-0943
fibroblast9.27e-0975
epithelial cell of alimentary canal1.74e-0821
skin fibroblast4.27e-0823
epithelial cell2.33e-07254
general ecto-epithelial cell2.65e-0713
Uber Anatomy
Ontology termp-valuen
surface structure1.73e-2095
organism subdivision7.32e-17365
integument3.38e-1445
integumental system3.38e-1445
skin of body1.56e-1240
organ part1.70e-12219
ectoderm-derived structure6.49e-12169
ectoderm3.73e-11173
presumptive ectoderm3.73e-11173
organ component layer4.24e-1057
multi-cellular organism1.66e-09659
organ7.89e-09511
respiratory system1.18e-0872
posterior neural tube2.24e-0815
chordal neural plate2.24e-0815
thoracic segment of trunk3.21e-0852
epithelial fold8.31e-0851
head1.35e-07123
anterior region of body2.07e-07129
craniocervical region2.07e-07129
segmental subdivision of hindbrain2.90e-0712
hindbrain2.90e-0712
presumptive hindbrain2.90e-0712
segmental subdivision of nervous system3.63e-0713
mouth4.61e-0728
stomodeum4.61e-0728
thoracic segment organ6.28e-0735
thoracic cavity element6.42e-0734
thoracic cavity6.42e-0734
oral opening9.29e-0721


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SP1#666735.69838137814090.005403962701712170.0247613065679865
TAF7#6879311.43306940492390.0006690181981945830.00544977705336901



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.