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Coexpression cluster:C435

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Full id: C435_submaxillary_salivary_parotid_small_colon_gall_trachea



Phase1 CAGE Peaks

Hg19::chr16:67470830..67470840,+p@chr16:67470830..67470840
+
Hg19::chr17:4463856..4463896,-p1@GGT6
Hg19::chr19:5838734..5838762,-p2@FUT6
Hg19::chr19:5838768..5838808,-p1@FUT6
Hg19::chr1:207102409..207102415,-p2@AK026320
Hg19::chr1:207102584..207102587,-p5@AK026320
Hg19::chr1:207102614..207102619,-p8@AK026320
Hg19::chr1:207102939..207103053,-p1@AK026320
Hg19::chr1:207103060..207103088,-p4@AK026320
Hg19::chr1:207103091..207103112,-p6@AK026320
Hg19::chr1:207103113..207103134,-p7@AK026320
Hg19::chr1:207103165..207103180,-p9@AK026320
Hg19::chr1:207103182..207103214,-p3@AK026320
Hg19::chr1:207103233..207103243,-p19@PIGR
Hg19::chr1:207103254..207103271,-p15@PIGR
Hg19::chr1:207103317..207103348,-p7@PIGR
Hg19::chr1:207103645..207103668,-p9@PIGR
Hg19::chr1:207104842..207104869,+p@chr1:207104842..207104869
+
Hg19::chr1:207105823..207105837,-p@chr1:207105823..207105837
-
Hg19::chr1:207109152..207109165,-p@chr1:207109152..207109165
-
Hg19::chr1:207112600..207112616,-p10@PIGR
Hg19::chr1:207112651..207112664,-p14@PIGR
Hg19::chr1:207119738..207119839,-p1@PIGR


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:00170603-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity0.0143723137587088
GO:0046920alpha(1,3)-fucosyltransferase activity0.0143723137587088
GO:0019317fucose catabolic process0.0143723137587088
GO:0042355L-fucose catabolic process0.0143723137587088
GO:0042354L-fucose metabolic process0.0143723137587088
GO:0006004fucose metabolic process0.0163302515211526
GO:0008417fucosyltransferase activity0.0167953466229545
GO:0003840gamma-glutamyltransferase activity0.0195911098353632
GO:0016755transferase activity, transferring amino-acyl groups0.0297345746328789
GO:0009306protein secretion0.0371869527356907



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
endodermal cell4.29e-1259
endo-epithelial cell6.97e-1143
respiratory epithelial cell2.22e-0713
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure1.22e-15169
endoderm1.22e-15169
presumptive endoderm1.22e-15169
subdivision of digestive tract3.63e-13129
endodermal part of digestive tract3.63e-13129
digestive system5.13e-13155
digestive tract5.13e-13155
primitive gut5.13e-13155
adult organism6.81e-13115
mixed endoderm/mesoderm-derived structure9.84e-10130
foregut1.30e-0998
immaterial anatomical entity1.81e-09126
exocrine gland6.96e-0931
exocrine system6.96e-0931
gland3.97e-0859
respiratory system1.32e-0772
endo-epithelium3.14e-0782
trunk region element5.64e-07107


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#10664112.563600874079360.001385286952948610.00901645170628193



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.