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Coexpression cluster:C1696

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Full id: C1696_Endothelial_Renal_chronic_Lymphatic_Fibroblast_Hepatic_Mesenchymal



Phase1 CAGE Peaks

Hg19::chr12:96830523..96830532,+p@chr12:96830523..96830532
+
Hg19::chr17:8216873..8216875,+p@chr17:8216873..8216875
+
Hg19::chr7:139741849..139741879,-p12@PARP12
Hg19::chr9:139559213..139559241,+p5@EGFL7
Hg19::chr9:139563124..139563129,+p@chr9:139563124..139563129
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0001570vasculogenesis0.0370800874571462
GO:0003950NAD+ ADP-ribosyltransferase activity0.0391285678131703
GO:0016763transferase activity, transferring pentosyl groups0.0426519646402055
GO:0001525angiogenesis0.0426519646402055
GO:0048514blood vessel morphogenesis0.0426519646402055
GO:0048646anatomical structure formation0.0426519646402055
GO:0001568blood vessel development0.0426519646402055
GO:0001944vasculature development0.0426519646402055



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
blood vessel endothelium2.85e-13718
endothelium2.85e-13718
cardiovascular system endothelium2.85e-13718
simple squamous epithelium7.34e-11222
squamous epithelium3.91e-9825
endothelial tube4.15e-779
arterial system endothelium4.15e-779
endothelium of artery4.15e-779
vessel3.39e-5368
vasculature5.45e-4678
vascular system5.45e-4678
epithelial tube open at both ends4.66e-4059
blood vessel4.66e-4059
blood vasculature4.66e-4059
vascular cord4.66e-4059
cardiovascular system2.45e-35109
vein7.42e-359
venous blood vessel7.42e-359
venous system7.42e-359
circulatory system2.63e-34112
splanchnic layer of lateral plate mesoderm3.83e-3183
epithelial tube7.01e-24117
segment of aorta1.43e-182
thoracic aorta1.43e-182
lymphatic vessel3.23e-178
lymph vasculature3.23e-178
lymphatic part of lymphoid system3.23e-178
umbilical vein2.59e-165
anatomical conduit8.48e-16240
artery1.37e-1542
arterial blood vessel1.37e-1542
arterial system1.37e-1542
aorta1.08e-1421
aortic system1.08e-1421
unilaminar epithelium2.90e-14148
lymphoid system7.96e-1410
tube3.01e-13192
microcirculatory vessel1.05e-123
endothelium of capillary1.05e-123
capillary1.05e-123
lateral plate mesoderm2.32e-12203
umbilical blood vessel2.64e-099
systemic artery3.50e-0933
systemic arterial system3.50e-0933
anatomical cluster7.64e-09373
epithelium4.04e-07306
cell layer5.10e-07309
mesoderm8.02e-07315
mesoderm-derived structure8.02e-07315
presumptive mesoderm8.02e-07315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.