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Coexpression cluster:C1696

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Full id: C1696_Endothelial_Renal_chronic_Lymphatic_Fibroblast_Hepatic_Mesenchymal



Phase1 CAGE Peaks

Hg19::chr12:96830523..96830532,+p@chr12:96830523..96830532
+
Hg19::chr17:8216873..8216875,+p@chr17:8216873..8216875
+
Hg19::chr7:139741849..139741879,-p12@PARP12
Hg19::chr9:139559213..139559241,+p5@EGFL7
Hg19::chr9:139563124..139563129,+p@chr9:139563124..139563129
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0001570vasculogenesis0.0370800874571462
GO:0003950NAD+ ADP-ribosyltransferase activity0.0391285678131703
GO:0016763transferase activity, transferring pentosyl groups0.0426519646402055
GO:0001525angiogenesis0.0426519646402055
GO:0048514blood vessel morphogenesis0.0426519646402055
GO:0048646anatomical structure formation0.0426519646402055
GO:0001568blood vessel development0.0426519646402055
GO:0001944vasculature development0.0426519646402055



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
blood vessel endothelium2.85e-13718
endothelium2.85e-13718
cardiovascular system endothelium2.85e-13718
simple squamous epithelium7.34e-11222
squamous epithelium3.91e-9825
endothelial tube4.15e-779
arterial system endothelium4.15e-779
endothelium of artery4.15e-779
vessel3.39e-5368
vasculature5.45e-4678
vascular system5.45e-4678
epithelial tube open at both ends4.66e-4059
blood vessel4.66e-4059
blood vasculature4.66e-4059
vascular cord4.66e-4059
cardiovascular system2.45e-35109
vein7.42e-359
venous blood vessel7.42e-359
venous system7.42e-359
circulatory system2.63e-34112
splanchnic layer of lateral plate mesoderm3.83e-3183
epithelial tube7.01e-24117
segment of aorta1.43e-182
thoracic aorta1.43e-182
lymphatic vessel3.23e-178
lymph vasculature3.23e-178
lymphatic part of lymphoid system3.23e-178
umbilical vein2.59e-165
anatomical conduit8.48e-16240
artery1.37e-1542
arterial blood vessel1.37e-1542
arterial system1.37e-1542
aorta1.08e-1421
aortic system1.08e-1421
unilaminar epithelium2.90e-14148
lymphoid system7.96e-1410
tube3.01e-13192
microcirculatory vessel1.05e-123
endothelium of capillary1.05e-123
capillary1.05e-123
lateral plate mesoderm2.32e-12203
umbilical blood vessel2.64e-099
systemic artery3.50e-0933
systemic arterial system3.50e-0933
anatomical cluster7.64e-09373
epithelium4.04e-07306
cell layer5.10e-07309
mesoderm8.02e-07315
mesoderm-derived structure8.02e-07315
presumptive mesoderm8.02e-07315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.136928
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.161847
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.569896
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.11.01397
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.791444
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.215829
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.412364
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.11.12656
MA0105.10.520776
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.759606
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.11.39943
MA0146.10.143081
MA0147.11.00307
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.0575907
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.858845
MA0047.20.767096
MA0112.21.96224
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.98952
MA0155.11.91168
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.11.77901
MA0160.10.669748
MA0161.10
MA0162.10.469165
MA0163.10.382496
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.230892
MA0102.21.66336
MA0258.10.914277
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.