Coexpression cluster:C86

Full id: C86_colon_carcinoid_small_neuroectodermal_giant_large_neuroepithelioma

Phase1 CAGE Peaks

Hg19::chr10:2328652..2328660,+	p@chr10:2328652..2328660 +
Hg19::chr10:7144649..7144656,-	p@chr10:7144649..7144656 -
Hg19::chr10:72303802..72303817,+	p@chr10:72303802..72303817 +
Hg19::chr11:90181710..90181723,+	p@chr11:90181710..90181723 +
Hg19::chr12:27932408..27932428,+	p17@KLHDC5
Hg19::chr12:65277536..65277559,+	p1@FLJ41278
Hg19::chr12:65277574..65277589,+	p2@FLJ41278
Hg19::chr12:65447288..65447294,+	p@chr12:65447288..65447294 +
Hg19::chr12:65466870..65466883,-	p@chr12:65466870..65466883 -
Hg19::chr12:65466889..65466894,-	p@chr12:65466889..65466894 -
Hg19::chr12:68155058..68155064,-	p@chr12:68155058..68155064 -
Hg19::chr12:77730114..77730120,-	p@chr12:77730114..77730120 -
Hg19::chr13:110258158..110258170,-	p@chr13:110258158..110258170 -
Hg19::chr13:28541425..28541439,-	p@chr13:28541425..28541439 -
Hg19::chr13:28541442..28541451,-	p@chr13:28541442..28541451 -
Hg19::chr13:28541455..28541475,-	p7@CDX2
Hg19::chr13:28541477..28541493,-	p6@CDX2
Hg19::chr13:28542963..28542973,-	p1@CU677005
Hg19::chr13:28543253..28543276,-	p5@CDX2
Hg19::chr13:28543285..28543314,-	p2@CDX2
Hg19::chr13:28543316..28543329,-	p4@CDX2
Hg19::chr13:28543388..28543406,-	p3@CDX2
Hg19::chr13:28543409..28543420,-	p8@CDX2
Hg19::chr13:28543431..28543487,-	p1@CDX2
Hg19::chr13:35865840..35865849,-	p@chr13:35865840..35865849 -
Hg19::chr13:48703799..48703838,-	p@chr13:48703799..48703838 -
Hg19::chr13:54830821..54830841,+	p@chr13:54830821..54830841 +
Hg19::chr13:99661014..99661016,-	p@chr13:99661014..99661016 -
Hg19::chr13:99661025..99661033,-	p@chr13:99661025..99661033 -
Hg19::chr14:26793376..26793387,-	p@chr14:26793376..26793387 -
Hg19::chr14:26793415..26793426,-	p@chr14:26793415..26793426 -
Hg19::chr14:76289395..76289406,+	p@chr14:76289395..76289406 +
Hg19::chr15:45950466..45950474,+	p@chr15:45950466..45950474 +
Hg19::chr15:45950495..45950505,+	p@chr15:45950495..45950505 +
Hg19::chr15:45950558..45950561,+	p@chr15:45950558..45950561 +
Hg19::chr15:71524066..71524082,-	p@chr15:71524066..71524082 -
Hg19::chr15:89755108..89755155,-	p@chr15:89755108..89755155 -
Hg19::chr16:50278603..50278615,+	p@chr16:50278603..50278615 +
Hg19::chr16:50278618..50278635,+	p@chr16:50278618..50278635 +
Hg19::chr16:50278652..50278662,+	p@chr16:50278652..50278662 +
Hg19::chr16:53671764..53671771,-	p@chr16:53671764..53671771 -
Hg19::chr16:55344418..55344442,+	p@chr16:55344418..55344442 +
Hg19::chr17:39123197..39123201,-	p2@KRT39
Hg19::chr17:39556122..39556149,+	p@chr17:39556122..39556149 +
Hg19::chr17:50822847..50822851,-	p@chr17:50822847..50822851 -
Hg19::chr17:50906109..50906121,-	p@chr17:50906109..50906121 -
Hg19::chr17:50906130..50906141,-	p@chr17:50906130..50906141 -
Hg19::chr17:63557759..63557774,-	p4@AXIN2
Hg19::chr17:63771073..63771114,-	p@chr17:63771073..63771114 -
Hg19::chr18:13542298..13542308,+	p@chr18:13542298..13542308 +
Hg19::chr18:28720966..28720970,+	p@chr18:28720966..28720970 +
Hg19::chr18:28860939..28860953,-	p@chr18:28860939..28860953 -
Hg19::chr18:30792468..30792481,-	p@chr18:30792468..30792481 -
Hg19::chr18:39550015..39550034,+	p@chr18:39550015..39550034 +
Hg19::chr18:52421471..52421476,+	p@chr18:52421471..52421476 +
Hg19::chr18:53252911..53252918,-	p106@TCF4
Hg19::chr1:118656031..118656034,-	p@chr1:118656031..118656034 -
Hg19::chr1:118656052..118656062,-	p@chr1:118656052..118656062 -
Hg19::chr1:118658073..118658082,-	p@chr1:118658073..118658082 -
Hg19::chr1:119837610..119837621,+	p@chr1:119837610..119837621 +
Hg19::chr1:119837632..119837659,+	p@chr1:119837632..119837659 +
Hg19::chr1:119837700..119837705,+	p@chr1:119837700..119837705 +
Hg19::chr1:119869755..119869768,-	p2@ENST00000457719
Hg19::chr1:119869778..119869800,-	p3@ENST00000457719
Hg19::chr1:119869827..119869830,-	p7@ENST00000457719
Hg19::chr1:119869834..119869845,-	p4@ENST00000457719
Hg19::chr1:119869846..119869867,-	p1@ENST00000457719
Hg19::chr1:163338283..163338286,+	p@chr1:163338283..163338286 +
Hg19::chr1:198324710..198324721,+	p@chr1:198324710..198324721 +
Hg19::chr1:198324725..198324738,+	p@chr1:198324725..198324738 +
Hg19::chr1:198324742..198324745,+	p@chr1:198324742..198324745 +
Hg19::chr1:219739282..219739288,-	p@chr1:219739282..219739288 -
Hg19::chr1:47183812..47183848,-	p3@KIAA0494
Hg19::chr1:47183850..47183861,-	p12@KIAA0494
Hg19::chr1:47183863..47183866,-	p20@KIAA0494
Hg19::chr1:55404829..55404833,-	p@chr1:55404829..55404833 -
Hg19::chr1:78621016..78621042,+	p@chr1:78621016..78621042 +
Hg19::chr1:93128331..93128338,-	p@chr1:93128331..93128338 -
Hg19::chr1:93128346..93128356,-	p@chr1:93128346..93128356 -
Hg19::chr20:10092229..10092265,-	p@chr20:10092229..10092265 -
Hg19::chr20:22034809..22034813,+	p1@ENST00000449427
Hg19::chr21:37143915..37143924,-	p@chr21:37143915..37143924 -
Hg19::chr2:109223595..109223610,+	p19@LIMS1
Hg19::chr2:127711416..127711419,+	p@chr2:127711416..127711419 +
Hg19::chr2:127711472..127711475,+	p@chr2:127711472..127711475 +
Hg19::chr2:148148505..148148515,-	p@chr2:148148505..148148515 -
Hg19::chr2:159306961..159306975,+	p@chr2:159306961..159306975 +
Hg19::chr2:159306978..159306987,+	p@chr2:159306978..159306987 +
Hg19::chr2:163302780..163302789,-	p@chr2:163302780..163302789 -
Hg19::chr2:163302793..163302800,-	p@chr2:163302793..163302800 -
Hg19::chr2:165424899..165424913,-	p6@GRB14
Hg19::chr2:171565187..171565198,-	p@chr2:171565187..171565198 -
Hg19::chr2:172822844..172822852,+	p@chr2:172822844..172822852 +
Hg19::chr2:191230499..191230510,+	p@chr2:191230499..191230510 +
Hg19::chr2:19707156..19707203,+	p@chr2:19707156..19707203 +
Hg19::chr2:205036975..205037009,-	p@chr2:205036975..205037009 -
Hg19::chr2:205099653..205099688,-	p1@ENST00000419860
Hg19::chr2:205099700..205099708,-	p2@ENST00000419860
Hg19::chr2:225543308..225543324,+	p@chr2:225543308..225543324 +
Hg19::chr2:50452322..50452343,+	p@chr2:50452322..50452343 +
Hg19::chr2:66794374..66794383,+	p@chr2:66794374..66794383 +
Hg19::chr2:66794389..66794398,+	p@chr2:66794389..66794398 +
Hg19::chr2:740879..740895,+	p@chr2:740879..740895 +
Hg19::chr2:740910..740923,+	p@chr2:740910..740923 +
Hg19::chr2:747715..747728,+	p@chr2:747715..747728 +
Hg19::chr3:140054665..140054678,-	p@chr3:140054665..140054678 -
Hg19::chr3:140054724..140054735,-	p@chr3:140054724..140054735 -
Hg19::chr3:148164659..148164667,-	p@chr3:148164659..148164667 -
Hg19::chr3:148164872..148164919,-	p@chr3:148164872..148164919 -
Hg19::chr3:148165064..148165071,-	p@chr3:148165064..148165071 -
Hg19::chr3:156822661..156822696,-	p@chr3:156822661..156822696 -
Hg19::chr3:171088092..171088113,-	p@chr3:171088092..171088113 -
Hg19::chr3:185772095..185772119,-	p@chr3:185772095..185772119 -
Hg19::chr3:185823495..185823511,-	p12@ETV5
Hg19::chr3:185823573..185823578,-	p26@ETV5
Hg19::chr3:191000073..191000089,-	p5@UTS2D
Hg19::chr3:191000091..191000117,-	p1@UTS2D
Hg19::chr3:193356854..193356864,+	p@chr3:193356854..193356864 +
Hg19::chr3:24797750..24797759,-	p@chr3:24797750..24797759 -
Hg19::chr3:24797832..24797838,-	p@chr3:24797832..24797838 -
Hg19::chr3:66354424..66354472,+	p@chr3:66354424..66354472 +
Hg19::chr4:138999555..138999575,-	p@chr4:138999555..138999575 -
Hg19::chr4:157174023..157174034,+	p@chr4:157174023..157174034 +
Hg19::chr4:157174062..157174071,+	p@chr4:157174062..157174071 +
Hg19::chr4:157174075..157174084,+	p@chr4:157174075..157174084 +
Hg19::chr4:157174108..157174136,+	p@chr4:157174108..157174136 +
Hg19::chr4:157174324..157174332,+	p@chr4:157174324..157174332 +
Hg19::chr4:169552329..169552340,+	p34@PALLD
Hg19::chr4:169559850..169559856,-	p@chr4:169559850..169559856 -
Hg19::chr4:71222797..71222807,+	p@chr4:71222797..71222807 +
Hg19::chr5:121814761..121814765,-	p4@ENST00000503529
Hg19::chr5:121814774..121814793,-	p1@ENST00000503529 p1@ENST00000510972 p1@uc003ktb.1
Hg19::chr5:57619538..57619575,-	p@chr5:57619538..57619575 -
Hg19::chr5:71987749..71987774,-	p@chr5:71987749..71987774 -
Hg19::chr5:97747048..97747059,+	p@chr5:97747048..97747059 +
Hg19::chr6:104674708..104674749,-	p@chr6:104674708..104674749 -
Hg19::chr6:372660..372670,-	p@chr6:372660..372670 -
Hg19::chr6:5491056..5491061,+	p@chr6:5491056..5491061 +
Hg19::chr6:5491081..5491106,+	p@chr6:5491081..5491106 +
Hg19::chr6:8389087..8389116,-	p@chr6:8389087..8389116 -
Hg19::chr6:8389389..8389429,-	p@chr6:8389389..8389429 -
Hg19::chr6:91774965..91774974,+	p@chr6:91774965..91774974 +
Hg19::chr7:110230449..110230452,-	p@chr7:110230449..110230452 -
Hg19::chr7:110230549..110230565,-	p@chr7:110230549..110230565 -
Hg19::chr7:138064518..138064531,-	p@chr7:138064518..138064531 -
Hg19::chr7:141499716..141499722,+	p@chr7:141499716..141499722 +
Hg19::chr7:30499737..30499761,+	p@chr7:30499737..30499761 +
Hg19::chr7:80253387..80253419,+	p4@CD36
Hg19::chr7:87049573..87049608,-	p@chr7:87049573..87049608 -
Hg19::chr7:87232406..87232409,-	p@chr7:87232406..87232409 -
Hg19::chr7:87232419..87232430,-	p@chr7:87232419..87232430 -
Hg19::chr7:87232440..87232448,-	p@chr7:87232440..87232448 -
Hg19::chr7:89797154..89797172,+	p9@STEAP2
Hg19::chr8:107630340..107630359,+	p12@OXR1
Hg19::chr8:107667666..107667673,+	p@chr8:107667666..107667673 +
Hg19::chr8:127438794..127438800,+	p@chr8:127438794..127438800 +
Hg19::chr8:127440115..127440120,+	p@chr8:127440115..127440120 +
Hg19::chr8:127445866..127445873,+	p@chr8:127445866..127445873 +
Hg19::chr8:127449395..127449424,+	p@chr8:127449395..127449424 +
Hg19::chr8:127450087..127450092,+	p@chr8:127450087..127450092 +
Hg19::chr8:127472815..127472822,+	p@chr8:127472815..127472822 +
Hg19::chr8:127508635..127508640,+	p@chr8:127508635..127508640 +
Hg19::chr8:127566297..127566307,-	p@chr8:127566297..127566307 -
Hg19::chr8:127567083..127567087,-	p6@FAM84B
Hg19::chr8:127568784..127568794,+	p6@ENST00000524320
Hg19::chr8:127568810..127568821,+	p2@ENST00000524320
Hg19::chr8:127569936..127570038,-	p3@FAM84B
Hg19::chr8:127570603..127570648,-	p1@FAM84B
Hg19::chr8:127570656..127570667,-	p5@FAM84B
Hg19::chr8:127570676..127570690,-	p4@FAM84B
Hg19::chr8:127570706..127570729,-	p2@FAM84B
Hg19::chr8:127681013..127681042,-	p@chr8:127681013..127681042 -
Hg19::chr8:127817393..127817400,+	p@chr8:127817393..127817400 +
Hg19::chr8:127836882..127836885,+	p@chr8:127836882..127836885 +
Hg19::chr8:127881773..127881775,+	p@chr8:127881773..127881775 +
Hg19::chr8:128118744..128118753,-	p@chr8:128118744..128118753 -
Hg19::chr8:128259602..128259609,-	p@chr8:128259602..128259609 -
Hg19::chr8:128260156..128260173,+	p@chr8:128260156..128260173 +
Hg19::chr8:128269499..128269507,-	p@chr8:128269499..128269507 -
Hg19::chr8:128415915..128415922,+	p@chr8:128415915..128415922 +
Hg19::chr8:128415944..128415958,+	p@chr8:128415944..128415958 +
Hg19::chr8:128418204..128418209,-	p@chr8:128418204..128418209 -
Hg19::chr8:128418747..128418756,-	p@chr8:128418747..128418756 -
Hg19::chr8:128418776..128418790,-	p@chr8:128418776..128418790 -
Hg19::chr8:128418828..128418839,-	p@chr8:128418828..128418839 -
Hg19::chr8:128419359..128419367,-	p@chr8:128419359..128419367 -
Hg19::chr8:128691603..128691614,-	p@chr8:128691603..128691614 -
Hg19::chr8:128747729..128747748,+	p14@MYC
Hg19::chr8:128747757..128747800,+	p7@MYC
Hg19::chr8:128806214..128806243,+	p@chr8:128806214..128806243 +
Hg19::chr8:128806244..128806266,+	p@chr8:128806244..128806266 +
Hg19::chr8:128806307..128806348,+	p9@PVT1
Hg19::chr8:128806753..128806815,+	p1@PVT1
Hg19::chr8:128807259..128807281,+	p@chr8:128807259..128807281 +
Hg19::chr8:128807937..128807941,+	p20@PVT1
Hg19::chr8:128900203..128900207,+	p@chr8:128900203..128900207 +
Hg19::chr8:128908624..128908634,+	p@chr8:128908624..128908634 +
Hg19::chr8:128908649..128908661,+	p@chr8:128908649..128908661 +
Hg19::chr8:128908678..128908696,+	p@chr8:128908678..128908696 +
Hg19::chr8:128909509..128909531,+	p@chr8:128909509..128909531 +
Hg19::chr8:128909572..128909583,+	p@chr8:128909572..128909583 +
Hg19::chr8:128909594..128909613,+	p@chr8:128909594..128909613 +
Hg19::chr8:128909653..128909681,+	p@chr8:128909653..128909681 +
Hg19::chr8:128910010..128910030,+	p@chr8:128910010..128910030 +
Hg19::chr8:130284717..130284721,-	p@chr8:130284717..130284721 -
Hg19::chr8:39792165..39792176,+	p1@IDO2
Hg19::chr8:39792182..39792188,+	p14@IDO2
Hg19::chr9:104610923..104610939,-	p@chr9:104610923..104610939 -
Hg19::chr9:120162674..120162685,-	p@chr9:120162674..120162685 -
Hg19::chr9:125898916..125898941,-	p14@STRBP
Hg19::chr9:95166976..95166979,-	p8@OGN
Hg19::chr9:97766409..97766428,+	p20@C9orf3
Hg19::chr9:98505341..98505348,+	p@chr9:98505341..98505348 +
Hg19::chrX:138909080..138909093,-	p@chrX:138909080..138909093 -
Hg19::chrX:138914394..138914405,-	p10@ATP11C
Hg19::chrX:42162203..42162241,+	p@chrX:42162203..42162241 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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p.value	FDR	nGenes	nPathway	Name
2.05892215321743e-05	0.00651648861493316	6	740	TGF beta receptor down reg. targets (Netpath):NetPath_7
1.47712332636225e-06	0.000935019065587306	3	28	Wnt down reg. targets (Netpath):NetPath_8

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell of large intestine	1.55e-98	2
intestinal epithelial cell	3.10e-50	4
epithelial cell of alimentary canal	2.29e-11	20

Uber Anatomy

Ontology term	p-value	n
rectum	3.10e-50	4
intestinal mucosa	3.10e-50	4
wall of intestine	3.10e-50	4
gastrointestinal system mucosa	3.10e-50	4
gastrointestinal system epithelium	3.10e-50	4
intestinal epithelium	3.10e-50	4
lower digestive tract	1.48e-40	5
epithelium of mucosa	5.22e-26	8
colon	2.62e-23	9
simple columnar epithelium	2.62e-23	9
large intestine	2.25e-19	11
anatomical wall	6.76e-18	12
intestine	1.85e-12	17
hindgut	6.95e-12	19
mucosa	2.29e-11	20
gastrointestinal system	4.34e-09	25

Disease

Ontology term	p-value	n
gastrointestinal system cancer	1.43e-15	14
adenocarcinoma	2.15e-09	25

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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