MCL coexpression mm9:2801

Phase1 CAGE Peaks

	Short description
Mm9::chr12:85029073..85029199,+	p1@Psen1
Mm9::chr2:163245244..163245284,-	p1@3230401D17Rik
Mm9::chr3:30754868..30754924,+	p1@Gpr160

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0032469	endoplasmic reticulum calcium ion homeostasis	0.0119794377064345
GO:0042987	amyloid precursor protein catabolic process	0.0119794377064345
GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis	0.0119794377064345
GO:0007220	Notch receptor processing	0.0134764982208395
GO:0042982	amyloid precursor protein metabolic process	0.0143745376234029
GO:0050435	beta-amyloid metabolic process	0.0163320167618723
GO:0035253	ciliary rootlet	0.0163320167618723
GO:0051605	protein maturation via proteolysis	0.0163320167618723
GO:0042640	anagen	0.0163320167618723
GO:0006516	glycoprotein catabolic process	0.0163320167618723
GO:0051604	protein maturation	0.0163320167618723
GO:0048820	hair follicle maturation	0.0193450377908991
GO:0044441	cilium part	0.0193450377908991
GO:0007613	memory	0.0218107238491664
GO:0001708	cell fate specification	0.0275368557853909
GO:0001756	somitogenesis	0.0329646854011658
GO:0022404	molting cycle process	0.0329646854011658
GO:0001942	hair follicle development	0.0329646854011658
GO:0022405	hair cycle process	0.0329646854011658
GO:0035282	segmentation	0.0329646854011658
GO:0042633	hair cycle	0.0329646854011658
GO:0042303	molting cycle	0.0329646854011658
GO:0048589	developmental growth	0.0329646854011658
GO:0030425	dendrite	0.0329646854011658
GO:0007219	Notch signaling pathway	0.0329646854011658
GO:0001764	neuron migration	0.0329646854011658
GO:0043025	cell soma	0.0329646854011658
GO:0006874	cellular calcium ion homeostasis	0.0329646854011658
GO:0055074	calcium ion homeostasis	0.0329646854011658
GO:0030424	axon	0.0329646854011658
GO:0030326	embryonic limb morphogenesis	0.0329646854011658
GO:0035113	embryonic appendage morphogenesis	0.0329646854011658
GO:0006875	cellular metal ion homeostasis	0.0329646854011658
GO:0005929	cilium	0.0329646854011658
GO:0055065	metal ion homeostasis	0.0329646854011658
GO:0007611	learning and/or memory	0.0329646854011658
GO:0044463	cell projection part	0.0329646854011658
GO:0035107	appendage morphogenesis	0.034550461439192
GO:0035108	limb morphogenesis	0.034550461439192
GO:0060173	limb development	0.034550461439192
GO:0048736	appendage development	0.034550461439192
GO:0045860	positive regulation of protein kinase activity	0.0348069740923052
GO:0033674	positive regulation of kinase activity	0.0348069740923052
GO:0051347	positive regulation of transferase activity	0.0348069740923052
GO:0021700	developmental maturation	0.0348069740923052
GO:0009952	anterior/posterior pattern formation	0.0348069740923052
GO:0030005	cellular di-, tri-valent inorganic cation homeostasis	0.0348069740923052
GO:0008544	epidermis development	0.0348069740923052
GO:0055066	di-, tri-valent inorganic cation homeostasis	0.0348069740923052
GO:0009100	glycoprotein metabolic process	0.0348069740923052
GO:0045165	cell fate commitment	0.0348069740923052
GO:0007398	ectoderm development	0.0348069740923052
GO:0030003	cellular cation homeostasis	0.0351617043957099
GO:0055080	cation homeostasis	0.0355031324513295
GO:0043005	neuron projection	0.0377802262895967
GO:0045859	regulation of protein kinase activity	0.0406119316614535
GO:0043549	regulation of kinase activity	0.0409660595577061
GO:0043085	positive regulation of catalytic activity	0.0409660595577061
GO:0051338	regulation of transferase activity	0.0409660595577061
GO:0055082	cellular chemical homeostasis	0.0424350545411579
GO:0006873	cellular ion homeostasis	0.0424350545411579
GO:0003002	regionalization	0.0424350545411579
GO:0043065	positive regulation of apoptosis	0.0450445480303585
GO:0043068	positive regulation of programmed cell death	0.0450445480303585
GO:0050801	ion homeostasis	0.0450445480303585
GO:0007166	cell surface receptor linked signal transduction	0.0450445480303585
GO:0007507	heart development	0.0453835450904017
GO:0007420	brain development	0.0483799974998719

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
intestine	5.76e-12	31
gastrointestinal system	4.30e-11	47
mucosa	3.05e-08	15
organ component layer	9.58e-08	24
intestinal mucosa	3.20e-07	13
anatomical wall	3.20e-07	13
wall of intestine	3.20e-07	13
gastrointestinal system mucosa	3.20e-07	13

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}