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Coexpression cluster:C640

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Full id: C640_amniotic_salivary_chorionic_Keratinocyte_Urothelial_Prostate_Mammary



Phase1 CAGE Peaks

Hg19::chr10:105791560..105791576,-p7@COL17A1
Hg19::chr10:105819927..105819974,+p@chr10:105819927..105819974
+
Hg19::chr10:105824227..105824253,+p@chr10:105824227..105824253
+
Hg19::chr10:105824310..105824328,-p12@COL17A1
Hg19::chr10:105830210..105830215,-p@chr10:105830210..105830215
-
Hg19::chr10:105830255..105830294,-p@chr10:105830255..105830294
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Hg19::chr10:105836085..105836093,-p@chr10:105836085..105836093
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Hg19::chr10:105836134..105836160,-p@chr10:105836134..105836160
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Hg19::chr10:105836165..105836175,-p@chr10:105836165..105836175
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Hg19::chr10:105845551..105845581,-p2@COL17A1
Hg19::chr10:105845611..105845645,-p1@COL17A1
Hg19::chr10:105845674..105845722,-p3@COL17A1
Hg19::chr6:7586117..7586135,+p9@DSP


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


p.valueFDRnGenesnPathwayName
5.75814629513173e-060.00364490660481838269Alpha6-Beta4 Integrin Signaling Pathway (Wikipathways):WP244



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0008544epidermis development0.000567241222222142
GO:0007398ectoderm development0.000567241222222142
GO:0005911intercellular junction0.000567241222222142
GO:0009888tissue development0.00132564708271702
GO:0030054cell junction0.00210012693832474
GO:0005913cell-cell adherens junction0.00841721083028887
GO:0048513organ development0.010626908581125
GO:0001533cornified envelope0.0106819675426817
GO:0018149peptide cross-linking0.0112207999992292
GO:0030216keratinocyte differentiation0.0116516829588302
GO:0048731system development0.0133844707925655
GO:0005912adherens junction0.0174713479979979
GO:0048856anatomical structure development0.017675968976235
GO:0044459plasma membrane part0.0201424468047065
GO:0007275multicellular organismal development0.0201424468047065
GO:0005200structural constituent of cytoskeleton0.0206164785855694
GO:0030674protein binding, bridging0.0207715838525679
GO:0007160cell-matrix adhesion0.0210321636243287
GO:0031589cell-substrate adhesion0.0210321636243287
GO:0006817phosphate transport0.027723638321343
GO:0032502developmental process0.0304983850393752
GO:0005886plasma membrane0.0363123514587199
GO:0032501multicellular organismal process0.0363123514587199
GO:0005882intermediate filament0.0365527498515394
GO:0045111intermediate filament cytoskeleton0.0365527498515394
GO:0015698inorganic anion transport0.0387074078945368
GO:0006820anion transport0.0462624270633432



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell5.23e-28254
endo-epithelial cell1.65e-1943
endodermal cell8.54e-1959
epithelial cell of alimentary canal2.00e-1021
respiratory epithelial cell1.88e-0713
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure8.03e-24169
endoderm8.03e-24169
presumptive endoderm8.03e-24169
digestive system3.99e-18155
digestive tract3.99e-18155
primitive gut3.99e-18155
mixed endoderm/mesoderm-derived structure5.36e-16130
subdivision of digestive tract1.51e-15129
endodermal part of digestive tract1.51e-15129
respiratory system9.80e-1572
foregut1.18e-1198
organ2.70e-10511
respiratory tract5.68e-1053
extraembryonic membrane7.07e-1014
membranous layer7.07e-1014
immaterial anatomical entity4.43e-09126
endo-epithelium1.08e-0882
anatomical space1.29e-08104
reproductive structure1.41e-0859
reproductive system1.41e-0859
orifice1.64e-0835
reproductive organ2.05e-0848
surface structure3.07e-0895
segment of respiratory tract3.91e-0846
oral opening5.36e-0821
internal genitalia6.07e-0825
multi-cellular organism6.45e-08659
organ component layer1.34e-0757
embryonic uterus4.95e-0722
female organism5.90e-0741
respiratory primordium6.85e-0738
endoderm of foregut6.85e-0738
internal female genitalia8.15e-0722
Disease
Ontology termp-valuen
carcinoma1.97e-20106
cell type cancer1.29e-14143
squamous cell carcinoma1.18e-0914
adenocarcinoma9.98e-0825


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.