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Coexpression cluster:C436

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Full id: C436_Sebocyte_Prostate_Keratinocyte_Urothelial_Small_Mammary_salivary



Phase1 CAGE Peaks

Hg19::chr16:68729719..68729736,+p@chr16:68729719..68729736
+
Hg19::chr17:38632848..38632877,-p@chr17:38632848..38632877
-
Hg19::chr17:38633713..38633724,-p@chr17:38633713..38633724
-
Hg19::chr17:38643526..38643552,-p@chr17:38643526..38643552
-
Hg19::chr17:38643557..38643572,-p@chr17:38643557..38643572
-
Hg19::chr17:38644869..38644880,-p6@TNS4
Hg19::chr17:38644941..38644954,-p3@TNS4
Hg19::chr17:38644978..38645006,-p2@TNS4
Hg19::chr17:38645025..38645036,-p5@TNS4
Hg19::chr17:38645088..38645099,-p20@TNS4
Hg19::chr17:38652289..38652317,-p4@TNS4
Hg19::chr17:38652332..38652344,-p18@TNS4
Hg19::chr17:38652393..38652403,-p16@TNS4
Hg19::chr17:38652451..38652464,-p8@TNS4
Hg19::chr17:73736444..73736457,+p@chr17:73736444..73736457
+
Hg19::chr17:73746889..73746902,+p@chr17:73746889..73746902
+
Hg19::chr17:73747066..73747079,+p@chr17:73747066..73747079
+
Hg19::chr17:73748563..73748616,+p@chr17:73748563..73748616
+
Hg19::chr17:73750773..73750793,+p@chr17:73750773..73750793
+
Hg19::chr17:73750800..73750821,+p@chr17:73750800..73750821
+
Hg19::chr17:73750858..73750868,+p@chr17:73750858..73750868
+
Hg19::chr17:73753525..73753536,+p@chr17:73753525..73753536
+
Hg19::chr5:93905715..93905716,+p2@uc003kkq.1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell1.36e-30254
endo-epithelial cell5.88e-1743
endodermal cell2.36e-1659
respiratory epithelial cell4.27e-0913
epithelial cell of alimentary canal1.59e-0821
ecto-epithelial cell2.02e-0733
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure1.81e-22169
endoderm1.81e-22169
presumptive endoderm1.81e-22169
digestive system1.55e-16155
digestive tract1.55e-16155
primitive gut1.55e-16155
mixed endoderm/mesoderm-derived structure5.26e-16130
subdivision of digestive tract6.40e-15129
endodermal part of digestive tract6.40e-15129
organ part2.13e-14219
foregut1.25e-1398
respiratory system3.21e-1372
ectoderm6.94e-13173
presumptive ectoderm6.94e-13173
ectoderm-derived structure1.43e-12169
organ9.54e-12511
anterior region of body2.62e-11129
craniocervical region2.62e-11129
respiratory tract4.29e-1153
head6.00e-11123
adult organism8.57e-11115
organ segment1.84e-0997
respiratory primordium2.29e-0938
endoderm of foregut2.29e-0938
segment of respiratory tract2.95e-0946
multi-tissue structure3.52e-09347
primordium4.47e-09168
neural tube5.58e-0857
neural rod5.58e-0857
future spinal cord5.58e-0857
neural keel5.58e-0857
neurectoderm8.56e-0890
neural plate1.54e-0786
presumptive neural plate1.54e-0786
embryo2.47e-07612
Disease
Ontology termp-valuen
carcinoma5.53e-20106
cell type cancer2.02e-14143
cancer1.42e-07235
squamous cell carcinoma5.65e-0714
adenocarcinoma8.95e-0725


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.