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Coexpression cluster:C2318

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Full id: C2318_extraskeletal_adrenal_Lymphatic_Endothelial_leiomyoblastoma_Preadipocyte_occipital



Phase1 CAGE Peaks

Hg19::chr14:85996451..85996468,+p2@FLRT2
Hg19::chr14:85996471..85996497,+p1@FLRT2
Hg19::chr14:85996507..85996521,+p3@FLRT2
Hg19::chr14:85999686..85999701,+p@chr14:85999686..85999701
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
multi-cellular organism2.28e-22659
organism subdivision5.56e-19365
ectoderm2.69e-18173
presumptive ectoderm2.69e-18173
cell layer2.62e-17312
epithelium8.77e-17309
ectoderm-derived structure1.72e-16169
anatomical system3.77e-16625
anatomical group7.60e-16626
anatomical cluster4.53e-15286
head6.15e-15123
anterior region of body2.65e-14129
craniocervical region2.65e-14129
embryo1.95e-13612
embryonic structure1.04e-12605
developing anatomical structure1.04e-12605
vasculature1.06e-1279
vascular system1.06e-1279
anatomical conduit1.11e-12241
germ layer1.52e-12604
embryonic tissue1.52e-12604
presumptive structure1.52e-12604
epiblast (generic)1.52e-12604
multi-tissue structure2.93e-12347
vessel4.79e-1069
splanchnic layer of lateral plate mesoderm5.48e-1084
neurectoderm7.25e-1090
neocortex1.24e-0920
surface structure1.45e-0995
regional part of cerebral cortex1.83e-0922
pre-chordal neural plate4.56e-0961
cerebral hemisphere1.33e-0832
regional part of nervous system1.66e-0894
nervous system1.66e-0894
tube2.20e-08194
cardiovascular system2.34e-08110
telencephalon2.77e-0834
neural plate2.93e-0886
presumptive neural plate2.93e-0886
cerebral cortex4.93e-0825
pallium4.93e-0825
organ part5.44e-08219
subdivision of head6.11e-0848
circulatory system6.62e-08113
regional part of telencephalon6.76e-0833
blood vessel8.65e-0860
epithelial tube open at both ends8.65e-0860
blood vasculature8.65e-0860
vascular cord8.65e-0860
central nervous system9.06e-0882
gray matter1.16e-0734
brain grey matter1.16e-0734
endothelium2.41e-0718
blood vessel endothelium2.41e-0718
cardiovascular system endothelium2.41e-0718
multilaminar epithelium3.28e-0782
regional part of forebrain4.65e-0741
forebrain4.65e-0741
future forebrain4.65e-0741
anterior neural tube5.54e-0742
brain6.93e-0769
future brain6.93e-0769
skin of body7.09e-0740


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.