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Coexpression cluster:C1723: Difference between revisions

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|full_id=C1723_adenocarcinoma_Intestinal_Prostate_rectal_colon_small_duodenum
|full_id=C1723_adenocarcinoma_Intestinal_Prostate_rectal_colon_small_duodenum
|id=C1723
|id=C1723
|ontology_enrichment_celltype=
|ontology_enrichment_celltype=CL:0002563!1.33e-11!4
|ontology_enrichment_disease=DOID:305!6.48e-08!106;DOID:1036!1.60e-07!8;DOID:8692!2.19e-07!31;DOID:14566!5.63e-07!239;DOID:3119!9.29e-07!14
|ontology_enrichment_disease=DOID:3119!3.19e-07!14;DOID:299!5.87e-07!25
|ontology_enrichment_uberon=UBERON:0005409!8.33e-13!35;UBERON:0004921!4.28e-10!129;UBERON:0004185!4.28e-10!129;UBERON:0000059!4.69e-10!11;UBERON:0004907!1.02e-09!5;UBERON:0000160!1.40e-09!27;UBERON:0001052!4.02e-08!4;UBERON:0001007!9.22e-08!155;UBERON:0001555!9.22e-08!155;UBERON:0007026!9.22e-08!155;UBERON:0001155!3.43e-07!9;UBERON:0001737!3.52e-07!9
|ontology_enrichment_uberon=UBERON:0000160!6.67e-57!17;UBERON:0005409!4.34e-47!25;UBERON:0000059!1.21e-33!11;UBERON:0001155!8.73e-29!9;UBERON:0002108!6.95e-20!4;UBERON:0004907!2.63e-19!5;UBERON:0004921!5.29e-13!118;UBERON:0001007!5.10e-12!145;UBERON:0001555!5.10e-12!145;UBERON:0007026!5.10e-12!145;UBERON:0001154!1.32e-11!1;UBERON:0001153!1.32e-11!1;UBERON:0001045!1.32e-11!1;UBERON:0001242!1.33e-11!4;UBERON:0001262!1.33e-11!4;UBERON:0004786!1.33e-11!4;UBERON:0004808!1.33e-11!4;UBERON:0001277!1.33e-11!4;UBERON:0001052!1.92e-11!4;UBERON:0004119!1.06e-10!160;UBERON:0000925!1.06e-10!160;UBERON:0006595!1.06e-10!160;UBERON:0001046!4.27e-09!19;UBERON:0011216!5.54e-07!223
|tf_chipseq_enrich=JUNB#3726;2:12.2442530639285:0.00999049059334596:0.0374675684817028!SMARCA4#6597;2:62.7063613231552:0.000401412085940533:0.00386601593909474!SMARCB1#6598;3:10.9516294686944:0.00151187284834318:0.00965208682731912!TAL1#6886;2:11.9474466709761:0.010475778180992:0.0388067888285965
|tf_chipseq_enrich=JUNB#3726;2:12.2442530639285:0.00999049059334596:0.0374675684817028!SMARCA4#6597;2:62.7063613231552:0.000401412085940533:0.00386601593909474!SMARCB1#6598;3:10.9516294686944:0.00151187284834318:0.00965208682731912!TAL1#6886;2:11.9474466709761:0.010475778180992:0.0388067888285965
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}}
}}

Revision as of 11:37, 19 October 2012


Full id: C1723_adenocarcinoma_Intestinal_Prostate_rectal_colon_small_duodenum



Phase1 CAGE Peaks

Hg19::chr14:38677383..38677398,+p@chr14:38677383..38677398
+
Hg19::chr18:19664778..19664789,+p@chr18:19664778..19664789
+
Hg19::chr6:26257721..26257733,+p@chr6:26257721..26257733
+
Hg19::chrX:65382336..65382364,+p6@HEPH
Hg19::chrX:65382381..65382392,+p11@HEPH


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
intestinal epithelial cell1.33e-114
Uber Anatomy
Ontology termp-valuen
intestine6.67e-5717
gastrointestinal system4.34e-4725
large intestine1.21e-3311
colon8.73e-299
small intestine6.95e-204
lower digestive tract2.63e-195
subdivision of digestive tract5.29e-13118
digestive system5.10e-12145
digestive tract5.10e-12145
primitive gut5.10e-12145
vermiform appendix1.32e-111
caecum1.32e-111
midgut1.32e-111
intestinal mucosa1.33e-114
wall of intestine1.33e-114
gastrointestinal system mucosa1.33e-114
gastrointestinal system epithelium1.33e-114
intestinal epithelium1.33e-114
rectum1.92e-114
endoderm-derived structure1.06e-10160
endoderm1.06e-10160
presumptive endoderm1.06e-10160
hindgut4.27e-0919
organ system subdivision5.54e-07223
Disease
Ontology termp-valuen
gastrointestinal system cancer3.19e-0714
adenocarcinoma5.87e-0725


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
JUNB#3726212.24425306392850.009990490593345960.0374675684817028
SMARCA4#6597262.70636132315520.0004014120859405330.00386601593909474
SMARCB1#6598310.95162946869440.001511872848343180.00965208682731912
TAL1#6886211.94744667097610.0104757781809920.0388067888285965



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.