FFCP PHASE1:Hg19::chr1:31883012..31883032,+: Difference between revisions
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{{FFCP | {{FFCP|DPIdataset=robustDPI|EntrezGene=347735|GencodeV16b_All_Build2_RSEM10_CPAT_consensus=gencodeV16_protein_coding|HGNC=23231|TSSclassifier=S|UniProt=B7Z567,F5GZP5,Q96IM8,Q96SA4|association_with_transcript=0bp_to_NM_001199037_5end|coexpression_cluster_id=C3968|description=CAGE_peak_6_at_SERINC2_5end|id=chr1:31883012..31883032,+|ontology_enrichment_celltype=CL:0000057!9.76e-30!75;CL:0000055!1.13e-24!180;CL:0002334!1.13e-16!12;CL:0000048!2.34e-11!430;CL:0002552!6.33e-11!5;CL:0000723!6.51e-11!436;CL:0000034!2.42e-10!444;CL:0002620!2.60e-10!23;CL:0000680!4.54e-09!57;CL:0000056!4.54e-09!57;CL:0000355!4.54e-09!57;CL:0002556!6.91e-09!6;CL:0002371!8.92e-09!591;CL:0000144!5.54e-08!625;CL:0002622!4.15e-07!3;CL:0002504!5.07e-07!3;CL:1000279!5.07e-07!3;CL:1000280!5.07e-07!3;CL:0000183!5.23e-07!59;CL:0000187!5.36e-07!54;CL:0002580!9.33e-07!3|ontology_enrichment_celltype_v019=CL:0002552;6.82e-23;5!CL:0002504;5.20e-14;3!CL:1000279;5.20e-14;3!CL:1000280;5.20e-14;3!CL:0002561;1.12e-10;2!CL:1000487;1.04e-09;2!CL:0002559;5.61e-09;5!CL:0002334;6.62e-09;12!CL:0000136;2.21e-08;13!CL:0000057;7.79e-08;73!CL:0002556;1.21e-07;6!CL:0002622;3.36e-07;3!CL:0002615;9.61e-07;3!CL:0002580;9.61e-07;3|ontology_enrichment_celltype_v019_2=CL:0002552,1.21e-22,5;CL:0000057,4.71e-17,76;CL:0002504,7.31e-14,3;CL:1000279,7.31e-14,3;CL:1000280,7.31e-14,3;CL:0002561,1.05e-10,2;CL:1000487,4.42e-10,2;CL:0002559,5.12e-09,5;CL:0002334,7.51e-09,12;CL:0002556,9.15e-08,6;CL:0000136,2.69e-07,15;CL:0000048,3.24e-07,427;CL:0002622,3.37e-07,3;CL:0000723,5.26e-07,433;CL:0000034,9.85e-07,441;CL:0002615,9.92e-07,3|ontology_enrichment_development_v019=|ontology_enrichment_disease=|ontology_enrichment_disease_v019=|ontology_enrichment_disease_v019_2=|ontology_enrichment_uberon=UBERON:0003102!1.27e-16!95;UBERON:0000914!1.43e-13!83;UBERON:0002329!1.43e-13!83;UBERON:0003077!1.43e-13!83;UBERON:0003059!1.43e-13!83;UBERON:0007282!1.43e-13!83;UBERON:0009618!1.43e-13!83;UBERON:0007285!1.43e-13!83;UBERON:0000475!1.96e-12!365;UBERON:0002100!6.18e-10!216;UBERON:0002199!8.52e-10!45;UBERON:0002416!8.52e-10!45;UBERON:0004290!4.14e-09!70;UBERON:0001134!5.20e-09!61;UBERON:0002036!5.20e-09!61;UBERON:0003082!5.20e-09!61;UBERON:0001758!6.91e-09!6;UBERON:0003672!6.91e-09!6;UBERON:0005256!7.31e-09!143;UBERON:0002385!1.50e-08!63;UBERON:0001015!1.50e-08!63;UBERON:0000383!1.50e-08!63;UBERON:0003129!3.29e-08!11;UBERON:0002097!7.79e-08!40;UBERON:0000486!1.22e-07!82;UBERON:0000075!9.46e-07!13;UBERON:0005944!9.46e-07!13;UBERON:0004288!9.46e-07!13;UBERON:0003089!9.46e-07!13|ontology_enrichment_uberon_v019=UBERON:0001828;3.20e-14;8!UBERON:0005933;1.12e-10;2!UBERON:0005942;1.12e-10;2!UBERON:0005932;1.12e-10;2!UBERON:0005406;1.04e-09;2!UBERON:0000165;2.36e-09;28!UBERON:0002073;5.61e-09;5!UBERON:0003729;1.22e-08;13!UBERON:0000344;9.71e-08;20!UBERON:0001758;1.21e-07;6!UBERON:0003672;1.21e-07;6!UBERON:0000310;3.81e-07;10!UBERON:0003688;4.37e-07;6!UBERON:0002358;4.37e-07;6!UBERON:0003684;4.37e-07;6!UBERON:0001178;4.37e-07;6!UBERON:0011137;6.85e-07;11!UBERON:0010323;6.85e-07;11!UBERON:0001555;7.06e-07;54!UBERON:0002367;9.86e-07;11!UBERON:0010147;9.86e-07;11|ontology_enrichment_uberon_v019_2=UBERON:0003102,1.72e-15,99;UBERON:0001828,4.55e-14,8;UBERON:0000165,3.05e-11,29;UBERON:0000930,3.05e-11,29;UBERON:0005933,1.05e-10,2;UBERON:0005942,1.05e-10,2;UBERON:0005932,1.05e-10,2;UBERON:0000161,1.07e-10,36;UBERON:0005406,5.31e-10,2;UBERON:0002073,5.12e-09,5;UBERON:0005086,5.12e-09,5;UBERON:0003729,1.50e-08,13;UBERON:0001758,9.15e-08,6;UBERON:0003672,9.15e-08,6;UBERON:0000344,1.16e-07,20;UBERON:0001444,1.70e-07,49;UBERON:0000310,4.90e-07,10;UBERON:0003688,5.66e-07,6;UBERON:0002358,5.66e-07,6;UBERON:0003684,5.66e-07,6;UBERON:0001178,5.66e-07,6;UBERON:0010323,6.40e-07,11;UBERON:0001007,6.68e-07,145;UBERON:0001555,6.68e-07,145;UBERON:0007026,6.68e-07,145;UBERON:0002367,7.36e-07,11;UBERON:0010147,7.36e-07,11;UBERON:0009846,7.36e-07,11;UBERON:0003353,7.36e-07,11;UBERON:0004902,7.36e-07,11;UBERON:0003820,7.36e-07,11;UBERON:0009847,7.36e-07,11;UBERON:0000166,8.78e-07,22|phase1_expression=1.45342703416445,0.214100523890983,1.26858963686374,0,1.34088328328186,1.74467704820074,5.06599756336621,0,0,0.491467873003018,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.00267582127178,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.132409180813219,0,0,0,0,0,0,0,0,0,0,0,4.05808099879417,0,0,0,0,0,4.69554593886255,2.21101771161182,1.03325781175765,4.75201142912821,1.23633464639278,0,2.87447256726495,0,0.875829639103749,12.4678851967882,6.58466431321257,1.83892677479412,0.901428353439581,0,0.538168907066586,0.213557388818567,0,1.80054657650641,0.103052529238439,0.515281080091258,0.930584281657949,1.0126579934476,0,0,0.0920498986422993,0.484938170456436,0.355009592516614,0.10075209822764,0.50868177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| ||
|DPIdataset=robustDPI | |||
|EntrezGene=347735 | |||
|GencodeV16b_All_Build2_RSEM10_CPAT_consensus=gencodeV16_protein_coding | |||
|HGNC=23231 | |||
|TSSclassifier=S | |||
|UniProt=B7Z567,F5GZP5,Q96IM8,Q96SA4 | |||
|association_with_transcript=0bp_to_NM_001199037_5end | |||
|coexpression_cluster_id=C3968 | |||
|description=CAGE_peak_6_at_SERINC2_5end | |||
|id=chr1:31883012..31883032,+ | |||
|ontology_enrichment_celltype=CL:0000057!9.76e-30!75;CL:0000055!1.13e-24!180;CL:0002334!1.13e-16!12;CL:0000048!2.34e-11!430;CL:0002552!6.33e-11!5;CL:0000723!6.51e-11!436;CL:0000034!2.42e-10!444;CL:0002620!2.60e-10!23;CL:0000680!4.54e-09!57;CL:0000056!4.54e-09!57;CL:0000355!4.54e-09!57;CL:0002556!6.91e-09!6;CL:0002371!8.92e-09!591;CL:0000144!5.54e-08!625;CL:0002622!4.15e-07!3;CL:0002504!5.07e-07!3;CL:1000279!5.07e-07!3;CL:1000280!5.07e-07!3;CL:0000183!5.23e-07!59;CL:0000187!5.36e-07!54;CL:0002580!9.33e-07!3 | |||
|ontology_enrichment_celltype_v019=CL:0002552;6.82e-23;5!CL:0002504;5.20e-14;3!CL:1000279;5.20e-14;3!CL:1000280;5.20e-14;3!CL:0002561;1.12e-10;2!CL:1000487;1.04e-09;2!CL:0002559;5.61e-09;5!CL:0002334;6.62e-09;12!CL:0000136;2.21e-08;13!CL:0000057;7.79e-08;73!CL:0002556;1.21e-07;6!CL:0002622;3.36e-07;3!CL:0002615;9.61e-07;3!CL:0002580;9.61e-07;3 | |||
|ontology_enrichment_celltype_v019_2=CL:0002552,1.21e-22,5;CL:0000057,4.71e-17,76;CL:0002504,7.31e-14,3;CL:1000279,7.31e-14,3;CL:1000280,7.31e-14,3;CL:0002561,1.05e-10,2;CL:1000487,4.42e-10,2;CL:0002559,5.12e-09,5;CL:0002334,7.51e-09,12;CL:0002556,9.15e-08,6;CL:0000136,2.69e-07,15;CL:0000048,3.24e-07,427;CL:0002622,3.37e-07,3;CL:0000723,5.26e-07,433;CL:0000034,9.85e-07,441;CL:0002615,9.92e-07,3 | |||
|ontology_enrichment_development_v019= | |||
|ontology_enrichment_disease= | |||
|ontology_enrichment_disease_v019= | |||
|ontology_enrichment_disease_v019_2= | |||
|ontology_enrichment_uberon=UBERON:0003102!1.27e-16!95;UBERON:0000914!1.43e-13!83;UBERON:0002329!1.43e-13!83;UBERON:0003077!1.43e-13!83;UBERON:0003059!1.43e-13!83;UBERON:0007282!1.43e-13!83;UBERON:0009618!1.43e-13!83;UBERON:0007285!1.43e-13!83;UBERON:0000475!1.96e-12!365;UBERON:0002100!6.18e-10!216;UBERON:0002199!8.52e-10!45;UBERON:0002416!8.52e-10!45;UBERON:0004290!4.14e-09!70;UBERON:0001134!5.20e-09!61;UBERON:0002036!5.20e-09!61;UBERON:0003082!5.20e-09!61;UBERON:0001758!6.91e-09!6;UBERON:0003672!6.91e-09!6;UBERON:0005256!7.31e-09!143;UBERON:0002385!1.50e-08!63;UBERON:0001015!1.50e-08!63;UBERON:0000383!1.50e-08!63;UBERON:0003129!3.29e-08!11;UBERON:0002097!7.79e-08!40;UBERON:0000486!1.22e-07!82;UBERON:0000075!9.46e-07!13;UBERON:0005944!9.46e-07!13;UBERON:0004288!9.46e-07!13;UBERON:0003089!9.46e-07!13 | |||
|ontology_enrichment_uberon_v019=UBERON:0001828;3.20e-14;8!UBERON:0005933;1.12e-10;2!UBERON:0005942;1.12e-10;2!UBERON:0005932;1.12e-10;2!UBERON:0005406;1.04e-09;2!UBERON:0000165;2.36e-09;28!UBERON:0002073;5.61e-09;5!UBERON:0003729;1.22e-08;13!UBERON:0000344;9.71e-08;20!UBERON:0001758;1.21e-07;6!UBERON:0003672;1.21e-07;6!UBERON:0000310;3.81e-07;10!UBERON:0003688;4.37e-07;6!UBERON:0002358;4.37e-07;6!UBERON:0003684;4.37e-07;6!UBERON:0001178;4.37e-07;6!UBERON:0011137;6.85e-07;11!UBERON:0010323;6.85e-07;11!UBERON:0001555;7.06e-07;54!UBERON:0002367;9.86e-07;11!UBERON:0010147;9.86e-07;11 | |||
|ontology_enrichment_uberon_v019_2=UBERON:0003102,1.72e-15,99;UBERON:0001828,4.55e-14,8;UBERON:0000165,3.05e-11,29;UBERON:0000930,3.05e-11,29;UBERON:0005933,1.05e-10,2;UBERON:0005942,1.05e-10,2;UBERON:0005932,1.05e-10,2;UBERON:0000161,1.07e-10,36;UBERON:0005406,5.31e-10,2;UBERON:0002073,5.12e-09,5;UBERON:0005086,5.12e-09,5;UBERON:0003729,1.50e-08,13;UBERON:0001758,9.15e-08,6;UBERON:0003672,9.15e-08,6;UBERON:0000344,1.16e-07,20;UBERON:0001444,1.70e-07,49;UBERON:0000310,4.90e-07,10;UBERON:0003688,5.66e-07,6;UBERON:0002358,5.66e-07,6;UBERON:0003684,5.66e-07,6;UBERON:0001178,5.66e-07,6;UBERON:0010323,6.40e-07,11;UBERON:0001007,6.68e-07,145;UBERON:0001555,6.68e-07,145;UBERON:0007026,6.68e-07,145;UBERON:0002367,7.36e-07,11;UBERON:0010147,7.36e-07,11;UBERON:0009846,7.36e-07,11;UBERON:0003353,7.36e-07,11;UBERON:0004902,7.36e-07,11;UBERON:0003820,7.36e-07,11;UBERON:0009847,7.36e-07,11;UBERON:0000166,8.78e-07,22 | |||
|phase1_expression=1.45342703416445,0.214100523890983,1.26858963686374,0,1.34088328328186,1.74467704820074,5.06599756336621,0,0,0.491467873003018,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.00267582127178,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.132409180813219,0,0,0,0,0,0,0,0,0,0,0,4.05808099879417,0,0,0,0,0,4.69554593886255,2.21101771161182,1.03325781175765,4.75201142912821,1.23633464639278,0,2.87447256726495,0,0.875829639103749,12.4678851967882,6.58466431321257,1.83892677479412,0.901428353439581,0,0.538168907066586,0.213557388818567,0,1.80054657650641,0.103052529238439,0.515281080091258,0.930584281657949,1.0126579934476,0,0,0.0920498986422993,0.484938170456436,0.355009592516614,0.10075209822764,0.508681776931463,0,0,0,0,0,0,0,0,0,0,0,1.38134921352481,8.35862270457562,3.60939740834793,0,0,0,0,0,0,0,0,0,0,0,0,4.41026134156626,0,0,0,0,0,0.171567810298526,0,0,0,0,0,3.11980435583874,0,0,0,0,0,0,0,0,0,0,0,0,0,0.141775097242386,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.54324424557285,0,0.532844358032199,0.285955987316295,0,0,0.325736184293735,0.355391948742546,0,0,0,0,0,0,0,0,0,0,0.289562613335158,0.205476322550383,0.179060963239896,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.535286966391485,0.630809660135739,0.234282829985426,0,0,0,0,0,0.695068915744663,0,10.6374461381365,0,0,0,0,0,0,0.992431231275107,1.2276957863045,1.12264037773229,1.02511319404561,0,0.804269605718038,1.48418066444991,0.154209693802656,0.177561725313127,0.0821271560138091,1.55776328755086,0.116210378459959,0,0,0,0.918515585316854,3.09554985611419,2.75361271414791,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.307007349452259,0.413509717453592,0,0.870100163485371,0.852266274161009,6.49933860221183,0,0,0,0,0,0.62962469366128,0.6970372701606,0,0,0.869932992075073,0.18532421910392,0,0,0,0.190630193923825,1.27948895655667,0,0,0,2.69808686374972,1.09814811894422,1.29593642580255,0,0,0,1.46290121726877,0,0,1.50149902548784,1.97967604735198,0,0,0,0,0.578775534266688,0,0,0,0,0,0,0,0,0.211107635297664,0,0,0.699869440489966,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.144269212976445,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.568272293612826,0,0,0,0,0,0,0,0,0,0,0,0,0,0.311039587661807,0,0,0,0,0,1.11136990144637,0,0,0,0,1.04951999995435,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.274792780205587,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0801588202515337,0,0,0,0,0,0,0,0,0,0,0.611989305817931,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.72844298240254,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.149254802886874,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.363697318405119,0,0,0.398095888698616,0,0,0,0,0,0,0,0,0.926089897295336,0,0,0,0,0.176689145945881,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.05802783107205,3.062454773532,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0887023701626388,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.801711364730253,0,0,0,0,0,0,0,0.22910686854405,0,0,0,0,0,0,0.102662806856247,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.509781344063451,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.865253124247578,0,0,0,0,0,0,0,0,0,0,0,0,0.714193294391221,0,0,0.112131862580613,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |||
|short_description=p6@SERINC2 | |||
}} |
Revision as of 05:14, 12 September 2013
Short description: | p6@SERINC2 |
---|---|
Species: | Human (Homo sapiens) |
DPI dataset: | NA |
TSS-like-by-RIKEN-classifier(Yes/No): | NA |
DHS support(Yes/No): | NA |
Description: | CAGE_peak_6_at_SERINC2_5end |
Coexpression cluster: | C3968_Fibroblast_Adipocyte_Hair_Pericytes_Preadipocyte_Skeletal_Prostate |
Association with transcript: | 0bp_to_NM_001199037_5end |
EntrezGene: | SERINC2 |
HGNC: | 23231 |
UniProt: | B7Z567F5GZP5Q96IM8Q96SA4 |
Genome view: | ZENBU |
View on UCSC genome browser
CAGE Expression
- Click each plot point to find sample in table
Ontology-based sample term enrichment analysis<b>Summary:</b>This analysis has been performed by utilizing wilcoxon rank sum test.When the number of associated cells/tissues are > n , randomly sampled n cells/tissues are used for P value calculation with rank sum test. this process are repeated several times, and the P values are averaged on the log space <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source dataset<br>data
Ontology term | p-value | n |
---|---|---|
fibroblast of gingiva | 1.21e-22 | 5 |
fibroblast | 4.71e-17 | 76 |
enteric smooth muscle cell | 7.31e-14 | 3 |
smooth muscle cell of large intestine | 7.31e-14 | 3 |
smooth muscle cell of colon | 7.31e-14 | 3 |
outer root sheath cell | 1.05e-10 | 2 |
smooth muscle cell of prostate | 4.42e-10 | 2 |
hair follicle cell | 5.12e-09 | 5 |
preadipocyte | 7.51e-09 | 12 |
fibroblast of periodontium | 9.15e-08 | 6 |
fat cell | 2.69e-07 | 15 |
multi fate stem cell | 3.24e-07 | 427 |
prostate stromal cell | 3.37e-07 | 3 |
somatic stem cell | 5.26e-07 | 433 |
stem cell | 9.85e-07 | 441 |
adipocyte of omentum tissue | 9.92e-07 | 3 |
Ontology term | p-value | n |
---|---|---|
surface structure | 1.72e-15 | 99 |
gingiva | 4.55e-14 | 8 |
mouth | 3.05e-11 | 29 |
stomodeum | 3.05e-11 | 29 |
hair root sheath | 1.05e-10 | 2 |
hair outer root sheath | 1.05e-10 | 2 |
bulb of hair follicle | 1.05e-10 | 2 |
orifice | 1.07e-10 | 36 |
perirenal fat | 5.31e-10 | 2 |
hair follicle | 5.12e-09 | 5 |
hair follicle placode | 5.12e-09 | 5 |
mouth mucosa | 1.50e-08 | 13 |
periodontium | 9.15e-08 | 6 |
dentition | 9.15e-08 | 6 |
mucosa | 1.16e-07 | 20 |
subdivision of head | 1.70e-07 | 49 |
breast | 4.90e-07 | 10 |
omentum | 5.66e-07 | 6 |
peritoneum | 5.66e-07 | 6 |
abdominal cavity | 5.66e-07 | 6 |
visceral peritoneum | 5.66e-07 | 6 |
cranial skeletal system | 6.40e-07 | 11 |
digestive system | 6.68e-07 | 145 |
digestive tract | 6.68e-07 | 145 |
primitive gut | 6.68e-07 | 145 |
prostate gland | 7.36e-07 | 11 |
male accessory sex gland | 7.36e-07 | 11 |
embryonic cloacal epithelium | 7.36e-07 | 11 |
epithelium of hindgut | 7.36e-07 | 11 |
urogenital sinus epithelium | 7.36e-07 | 11 |
prostate bud | 7.36e-07 | 11 |
prostate field | 7.36e-07 | 11 |
oral opening | 8.78e-07 | 22 |
Property "DHS support" (as page type) with input value "{{{DHSsupport}}}" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.